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This work was supported by Ludwig Cancer Research and the Ludwig Center at Harvard and by NIH NCI grants U2C-CA233280 (Omic and Multidimensional Spatial Atlas of Metastatic Breast and Prostate Cancers) and U2C-CA233262 (Pre-cancer atlases of cutaneous and hematologic origin—PATCH Center) to Peter K. Sorger and Sandro Santagata as part of the Human Tumor Atlas Network. Development of computational methods and image processing software is supported by a Team Science Grant from the Gray Foundation, the Gates Foundation grant INV-027106, the David Liposarcoma Research Initiative, and the Emerson Collective.