USPL1 Data Analysis

HGNC Gene Name
ubiquitin specific peptidase like 1
HGNC Gene Symbol
USPL1
Identifiers
hgnc:20294 NCBIGene:10208 uniprot:Q5W0Q7
Orthologs
mgi:2442342 rgd:1310835
INDRA Statements
deubiquitinations all statements
Pathway Commons
Search for USPL1
Number of Papers
8 retrieved on 2022-05-22

DepMap Analysis

The Dependency Map (DepMap) is a genome-wide pooled CRISPR-Cas9 knockout proliferation screen conducted in more than 700 cancer cell lines spanning many different tumor lineages. Each cell line in the DepMap contains a unique barcode, and each gene knockout is assigned a “dependency score” on a per cell-line basis which quantifies the rate of CRISPR-Cas9 guide drop. It has been found that proteins with similar DepMap scores across cell lines, a phenomenon known as co-dependent genes, have closely related biological functions. This can include activity in the same or parallel pathways or membership in the same protein complex or the same pathway.

We identified the strongest seven co-dependent genes (“Symbol”) for DUBs and ran GO enrichment analysis. We used Biogrid, IntAct, and Pathway Commons PPIDs, and the NURSA protein-protein interaction databases (PPIDs) to determine whether co-dependent genes interact with one another. The “Evidence” column contains the PPIDs in which the interaction appears as well as whether there is support for the association by an INDRA statement. As another approach to identify potential interactors, we looked at proteomics data from the Broad Institute's Cancer Cell Line Encyclopedia (CCLE) for proteins whose expression across ~375 cell lines strongly correlated with the abundance of each DUB; it has previously been observed that proteins in the same complex are frequently significantly co-expressed. The correlations and associated p-values in the CCLE proteomics dataset are provided. And, we determined whether co-dependent genes yield similar transcriptomic signatures in the Broad Institute's Connectivity Map (CMap). A CMap score greater than 90 is considered significantly similar.

DepMap Correlations

Symbol Name DepMap Correlation Evidence CCLE Correlation CCLE Z-score CCLE p-value (adj) CCLE Significant CMAP Score CMAP Type
ICE2 interactor of little elongation complex ELL subunit 2 0.388
MED4 mediator complex subunit 4 0.265
EAF1 ELL associated factor 1 0.262 IntAct INDRA (1)
CD2BP2 CD2 cytoplasmic tail binding protein 2 0.258
SKA3 spindle and kinetochore associated complex subunit 3 0.248
NUP58 nucleoporin 58 0.236
MED26 mediator complex subunit 26 0.226

Dependency GO Term Enrichment

Gene set enrichment analysis was done on the genes correlated with USPL1using the terms from Gene Ontology and gene sets derived from the Gene Ontology Annotations database via MSigDB.

Using the biological processes and other Gene Ontology terms from well characterized DUBs as a positive control, several gene set enrichment analyses were considered. Threshold-less methods like GSEA had relatively poor results. Over-representation analysis with a threshold of of the top 7 highest absolute value Dependency Map correlations yielded the best results and is reported below.

GO Identifier GO Name GO Type p-value p-value (adj.) q-value
GO:0070847 core mediator complex Cellular Component 3.26e-06 3.56e-04 1.61e-04
GO:0016592 mediator complex Cellular Component 7.31e-05 7.96e-03 1.81e-03
GO:0008023 transcription elongation factor complex Cellular Component 1.84e-04 2.01e-02 3.04e-03
GO:0015030 Cajal body Cellular Component 3.28e-04 3.58e-02 4.06e-03

Transcriptomics

The following table shows the significantly differentially expressed genes after knocking out USPL1 using CRISPR-Cas9.

Knockout Differential Expression

Symbol Name log2-fold-change p-value p-value (adj.)
ANKRD1 ankyrin repeat domain 1 1.59e+00 2.10e-88 2.48e-84
H2AC6 H2A clustered histone 6 2.18e+00 6.04e-73 3.56e-69
H2BC11 H2B clustered histone 11 3.66e+00 6.16e-71 2.42e-67
RBM39 RNA binding motif protein 39 1.34e+00 1.02e-51 3.02e-48
H2AC18 H2A clustered histone 18 2.33e+00 1.22e-42 2.89e-39
H2AC19 H2A clustered histone 19 2.33e+00 2.10e-42 4.13e-39
PDRG1 p53 and DNA damage regulated 1 1.67e+00 5.82e-36 9.81e-33
CCN2 cellular communication network factor 2 1.28e+00 8.45e-36 1.25e-32
TM4SF1 transmembrane 4 L six family member 1 1.11e+00 3.18e-28 4.17e-25
H1-2 H1.2 linker histone, cluster member 1.73e+00 7.03e-28 8.29e-25
YTHDF2 YTH N6-methyladenosine RNA binding protein 2 1.31e+00 1.53e-24 1.64e-21
SPANXB1 SPANX family member B1 6.29e-01 1.92e-23 1.89e-20
HSPA8 heat shock protein family A (Hsp70) member 8 9.01e-01 5.91e-23 5.36e-20
SRRM1 serine and arginine repetitive matrix 1 9.60e-01 1.62e-22 1.36e-19
SON SON DNA and RNA binding protein 9.47e-01 2.62e-20 2.06e-17
H4C15 H4 clustered histone 15 1.97e+00 2.97e-20 2.19e-17
RSRP1 arginine and serine rich protein 1 1.77e+00 7.38e-20 5.12e-17
DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 9.53e-01 9.99e-20 6.55e-17
IL18 interleukin 18 1.55e+00 1.45e-18 8.98e-16
RBM6 RNA binding motif protein 6 1.23e+00 4.53e-17 2.67e-14
TMEM242 transmembrane protein 242 1.54e+00 6.57e-17 3.69e-14
RSRC2 arginine and serine rich coiled-coil 2 9.34e-01 1.21e-16 6.48e-14
C4BPB complement component 4 binding protein beta 1.30e+00 2.26e-16 1.16e-13
LIPA lipase A, lysosomal acid type 1.23e+00 5.59e-16 2.75e-13
NEXN nexilin F-actin binding protein 1.24e+00 3.53e-15 1.67e-12
PHAX phosphorylated adaptor for RNA export 8.48e-01 4.49e-15 2.04e-12
FTL ferritin light chain 5.98e-01 5.03e-15 2.12e-12
MED10 mediator complex subunit 10 1.04e+00 5.03e-15 2.12e-12
C12orf57 chromosome 12 open reading frame 57 9.62e-01 5.31e-15 2.16e-12
PCSK5 proprotein convertase subtilisin/kexin type 5 1.57e+00 6.54e-15 2.57e-12
SPANXC SPANX family member C 6.18e-01 8.38e-15 3.19e-12
G0S2 G0/G1 switch 2 -9.05e-01 1.55e-14 5.73e-12
MYL12B myosin light chain 12B 5.68e-01 2.46e-14 8.80e-12
JMJD6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase 1.35e+00 2.84e-14 9.85e-12
LSM3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated 6.54e-01 1.08e-13 3.66e-11
IMPDH2 inosine monophosphate dehydrogenase 2 -1.10e+00 1.38e-13 4.51e-11
CCL26 C-C motif chemokine ligand 26 1.56e+00 2.08e-13 6.63e-11
H4C3 H4 clustered histone 3 -1.02e+00 2.54e-13 7.89e-11
SRPK1 SRSF protein kinase 1 -1.04e+00 2.82e-13 8.54e-11
DGUOK deoxyguanosine kinase 7.33e-01 3.20e-13 9.43e-11
CKS2 CDC28 protein kinase regulatory subunit 2 7.87e-01 3.39e-13 9.74e-11
UQCRC1 ubiquinol-cytochrome c reductase core protein 1 -1.02e+00 3.60e-13 1.01e-10
RND3 Rho family GTPase 3 1.13e+00 5.03e-13 1.38e-10
NNMT nicotinamide N-methyltransferase 1.44e+00 5.26e-13 1.41e-10
H4C8 H4 clustered histone 8 1.43e+00 7.73e-13 1.98e-10
MTPN myotrophin 7.58e-01 7.73e-13 1.98e-10
HINT1 histidine triad nucleotide binding protein 1 4.56e-01 1.38e-12 3.47e-10
H4C14 H4 clustered histone 14 1.58e+00 2.16e-12 5.31e-10
DEF8 differentially expressed in FDCP 8 homolog 9.85e-01 4.32e-12 1.03e-09
SNRNP27 small nuclear ribonucleoprotein U4/U6.U5 subunit 27 1.09e+00 4.37e-12 1.03e-09
RNASEH2A ribonuclease H2 subunit A -1.09e+00 5.65e-12 1.31e-09
AKR1B1 aldo-keto reductase family 1 member B 6.51e-01 1.03e-11 2.35e-09
CENPF centromere protein F 7.33e-01 1.85e-11 4.13e-09
OSER1 oxidative stress responsive serine rich 1 9.97e-01 2.28e-11 4.98e-09
TOMM5 translocase of outer mitochondrial membrane 5 6.36e-01 2.48e-11 5.33e-09
HSPA14 heat shock protein family A (Hsp70) member 14 1.14e+00 4.51e-11 9.50e-09
TROAP trophinin associated protein 1.14e+00 4.98e-11 1.03e-08
H2BC5 H2B clustered histone 5 1.28e+00 6.07e-11 1.24e-08
ATP5MC1 ATP synthase membrane subunit c locus 1 -7.37e-01 7.59e-11 1.52e-08
DDX46 DEAD-box helicase 46 7.05e-01 7.94e-11 1.54e-08
SEM1 SEM1 26S proteasome subunit 4.82e-01 7.82e-11 1.54e-08
CBX5 chromobox 5 9.00e-01 8.46e-11 1.61e-08
ANXA1 annexin A1 5.52e-01 1.10e-10 2.06e-08
TUBB6 tubulin beta 6 class V -1.10e+00 1.25e-10 2.31e-08
MT-ATP6 mitochondrially encoded ATP synthase membrane subunit 6 3.80e-01 1.99e-10 3.62e-08
NECAP2 NECAP endocytosis associated 2 9.54e-01 2.26e-10 4.05e-08
SRGN serglycin 8.63e-01 3.63e-10 6.40e-08
H4C9 H4 clustered histone 9 1.59e+00 3.69e-10 6.40e-08
PIH1D1 PIH1 domain containing 1 -1.21e+00 5.32e-10 9.10e-08
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif 1 1.24e+00 5.66e-10 9.54e-08
CDC5L cell division cycle 5 like 7.80e-01 5.82e-10 9.67e-08
MRPL33 mitochondrial ribosomal protein L33 -8.13e-01 6.95e-10 1.14e-07
FAM133A family with sequence similarity 133 member A 8.57e-01 7.53e-10 1.22e-07
SETD4 SET domain containing 4 1.24e+00 8.55e-10 1.36e-07
TUBG1 tubulin gamma 1 -9.63e-01 9.09e-10 1.43e-07
MRPS16 mitochondrial ribosomal protein S16 -9.17e-01 1.15e-09 1.78e-07
GAPDH glyceraldehyde-3-phosphate dehydrogenase -4.05e-01 1.22e-09 1.87e-07
KRT19 keratin 19 -7.89e-01 1.26e-09 1.91e-07
CDK11A cyclin dependent kinase 11A 9.56e-01 1.29e-09 1.93e-07
PFDN1 prefoldin subunit 1 6.17e-01 1.59e-09 2.34e-07
TMEM14C transmembrane protein 14C -8.75e-01 1.65e-09 2.41e-07
WDR83OS WD repeat domain 83 opposite strand 4.75e-01 1.86e-09 2.68e-07
YTHDC1 YTH domain containing 1 9.17e-01 1.94e-09 2.77e-07
DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 5.27e-01 2.32e-09 3.26e-07
DNMT1 DNA methyltransferase 1 -9.61e-01 2.41e-09 3.34e-07
SBDSP1 SBDS pseudogene 1 1.26e+00 2.46e-09 3.37e-07
PSMC5 proteasome 26S subunit, ATPase 5 -8.12e-01 3.04e-09 4.13e-07
DNAJC2 DnaJ heat shock protein family (Hsp40) member C2 1.15e+00 3.68e-09 4.88e-07
ZC3H15 zinc finger CCCH-type containing 15 7.92e-01 3.68e-09 4.88e-07
TMEM11 transmembrane protein 11 9.97e-01 4.31e-09 5.65e-07
CAVIN2 caveolae associated protein 2 1.11e+00 7.53e-09 9.77e-07
SPCS1 signal peptidase complex subunit 1 -7.55e-01 8.53e-09 1.09e-06
UBR4 ubiquitin protein ligase E3 component n-recognin 4 7.64e-01 8.73e-09 1.11e-06
CCN1 cellular communication network factor 1 6.56e-01 1.24e-08 1.56e-06
UQCC2 ubiquinol-cytochrome c reductase complex assembly factor 2 -7.49e-01 1.77e-08 2.20e-06
LGALS1 galectin 1 -4.46e-01 2.22e-08 2.73e-06
CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 9.90e-01 2.35e-08 2.83e-06
LCOR ligand dependent nuclear receptor corepressor 9.01e-01 2.35e-08 2.83e-06
AMOTL2 angiomotin like 2 1.10e+00 2.66e-08 3.18e-06
CYB5A cytochrome b5 type A 7.77e-01 2.78e-08 3.28e-06
HMGB3 high mobility group box 3 5.20e-01 3.45e-08 3.99e-06
MPP5 protein associated with LIN7 1, MAGUK family member 1.09e+00 4.09e-08 4.69e-06
UROD uroporphyrinogen decarboxylase -7.54e-01 4.58e-08 5.20e-06
MAP1LC3B microtubule associated protein 1 light chain 3 beta 8.59e-01 5.46e-08 6.14e-06
CCDC12 coiled-coil domain containing 12 7.66e-01 5.87e-08 6.54e-06
CRCP CGRP receptor component 9.06e-01 6.65e-08 7.34e-06
RRM2 ribonucleotide reductase regulatory subunit M2 -9.69e-01 6.79e-08 7.42e-06
EIF4A2 eukaryotic translation initiation factor 4A2 7.55e-01 7.15e-08 7.74e-06
EIF4E2 eukaryotic translation initiation factor 4E family member 2 7.99e-01 8.78e-08 9.42e-06
SMC1A structural maintenance of chromosomes 1A -1.02e+00 9.70e-08 1.03e-05
NSA2 NSA2 ribosome biogenesis factor 8.37e-01 1.00e-07 1.05e-05
SAV1 salvador family WW domain containing protein 1 9.59e-01 1.03e-07 1.07e-05
MT-ND2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 3.92e-01 1.23e-07 1.27e-05
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 1.04e+00 1.34e-07 1.37e-05
METAP2 methionyl aminopeptidase 2 6.05e-01 1.59e-07 1.61e-05
RPS14 ribosomal protein S14 -4.33e-01 1.65e-07 1.67e-05
SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1 5.77e-01 1.74e-07 1.74e-05
BRD4 bromodomain containing 4 6.67e-01 1.85e-07 1.83e-05
TIA1 TIA1 cytotoxic granule associated RNA binding protein 1.03e+00 1.87e-07 1.84e-05
FDPS farnesyl diphosphate synthase -7.36e-01 1.95e-07 1.90e-05
FAM133B family with sequence similarity 133 member B 8.85e-01 2.00e-07 1.93e-05
BYSL bystin like 9.93e-01 2.18e-07 2.07e-05
COIL coilin 8.92e-01 2.18e-07 2.07e-05
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -5.65e-01 2.24e-07 2.11e-05
HMGA1 high mobility group AT-hook 1 -6.11e-01 2.51e-07 2.35e-05
DYNLT1 dynein light chain Tctex-type 1 -7.54e-01 2.53e-07 2.35e-05
MRPS25 mitochondrial ribosomal protein S25 -1.06e+00 2.62e-07 2.41e-05
SYF2 SYF2 pre-mRNA splicing factor 6.68e-01 2.63e-07 2.41e-05
ZNF530 zinc finger protein 530 1.09e+00 2.73e-07 2.48e-05
RNF185 ring finger protein 185 1.03e+00 2.77e-07 2.50e-05
ANXA3 annexin A3 -8.82e-01 3.32e-07 2.97e-05
EDN1 endothelin 1 9.00e-01 3.57e-07 3.17e-05
TMEM14B transmembrane protein 14B -6.79e-01 3.65e-07 3.22e-05
RPP30 ribonuclease P/MRP subunit p30 7.44e-01 4.04e-07 3.53e-05
BUD31 BUD31 homolog 8.57e-01 4.20e-07 3.64e-05
ZNF114 zinc finger protein 114 1.01e+00 5.38e-07 4.64e-05
MCFD2 multiple coagulation factor deficiency 2, ER cargo receptor complex subunit -8.27e-01 6.78e-07 5.80e-05
ETFB electron transfer flavoprotein subunit beta -8.63e-01 7.13e-07 6.05e-05
CAVIN1 caveolae associated protein 1 5.48e-01 7.81e-07 6.59e-05
LUC7L LUC7 like 7.32e-01 7.99e-07 6.69e-05
HSPH1 heat shock protein family H (Hsp110) member 1 9.00e-01 8.08e-07 6.71e-05
PCNA proliferating cell nuclear antigen -8.88e-01 8.58e-07 7.08e-05
DUSP10 dual specificity phosphatase 10 1.02e+00 8.68e-07 7.11e-05
SAP18 Sin3A associated protein 18 5.50e-01 8.84e-07 7.20e-05
CCDC137 coiled-coil domain containing 137 8.79e-01 8.96e-07 7.24e-05
CYC1 cytochrome c1 -8.15e-01 9.08e-07 7.29e-05
CDKN3 cyclin dependent kinase inhibitor 3 -1.01e+00 9.35e-07 7.46e-05
GPBP1 GC-rich promoter binding protein 1 8.74e-01 9.54e-07 7.56e-05
CKLF chemokine like factor -7.96e-01 1.06e-06 8.35e-05
CALU calumenin 5.31e-01 1.07e-06 8.35e-05
BRIX1 biogenesis of ribosomes BRX1 6.02e-01 1.13e-06 8.77e-05
HSP90AA1 heat shock protein 90 alpha family class A member 1 4.83e-01 1.18e-06 9.09e-05
ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 -9.79e-01 1.21e-06 9.26e-05
WHAMM WASP homolog associated with actin, golgi membranes and microtubules 9.03e-01 1.23e-06 9.37e-05
RACK1 receptor for activated C kinase 1 -3.25e-01 1.33e-06 1.01e-04
PRPF18 pre-mRNA processing factor 18 9.52e-01 1.36e-06 1.02e-04
ELOC elongin C 5.31e-01 1.46e-06 1.09e-04
BASP1 brain abundant membrane attached signal protein 1 7.46e-01 1.51e-06 1.12e-04
DUSP1 dual specificity phosphatase 1 1.07e+00 1.52e-06 1.12e-04
LUZP1 leucine zipper protein 1 7.15e-01 1.58e-06 1.16e-04
ZWINT ZW10 interacting kinetochore protein -8.06e-01 1.59e-06 1.16e-04
GOLPH3L golgi phosphoprotein 3 like 9.29e-01 1.66e-06 1.20e-04
GNG12 G protein subunit gamma 12 7.10e-01 1.79e-06 1.27e-04
RSL1D1 ribosomal L1 domain containing 1 5.30e-01 1.78e-06 1.27e-04
UPP1 uridine phosphorylase 1 7.88e-01 1.79e-06 1.27e-04
EIF3K eukaryotic translation initiation factor 3 subunit K -6.62e-01 1.82e-06 1.28e-04
RNF4 ring finger protein 4 7.99e-01 1.87e-06 1.31e-04
CINP cyclin dependent kinase 2 interacting protein 7.67e-01 2.01e-06 1.40e-04
MTRNR2L8 MT-RNR2 like 8 4.45e-01 2.05e-06 1.41e-04
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif 12 9.84e-01 2.48e-06 1.70e-04
NDUFS8 NADH:ubiquinone oxidoreductase core subunit S8 -7.34e-01 2.50e-06 1.71e-04
CYP2B7P cytochrome P450 family 2 subfamily B member 7, pseudogene 9.65e-01 2.56e-06 1.73e-04
ARF1 ADP ribosylation factor 1 5.13e-01 2.62e-06 1.77e-04
NANOS1 nanos C2HC-type zinc finger 1 1.01e+00 2.67e-06 1.79e-04
OARD1 O-acyl-ADP-ribose deacylase 1 -1.05e+00 2.68e-06 1.79e-04
S100A11 S100 calcium binding protein A11 3.95e-01 2.70e-06 1.79e-04
GALE UDP-galactose-4-epimerase -8.64e-01 2.80e-06 1.84e-04
POFUT2 protein O-fucosyltransferase 2 1.04e+00 3.27e-06 2.15e-04
RBM25 RNA binding motif protein 25 6.00e-01 3.46e-06 2.25e-04
PLEKHA7 pleckstrin homology domain containing A7 9.62e-01 3.55e-06 2.30e-04
MTRNR2L10 MT-RNR2 like 10 4.91e-01 3.86e-06 2.49e-04
RNF145 ring finger protein 145 9.03e-01 3.89e-06 2.49e-04
LRRC75A leucine rich repeat containing 75A -4.86e-01 4.34e-06 2.77e-04
TGFB2 transforming growth factor beta 2 9.50e-01 4.60e-06 2.92e-04
CCNL1 cyclin L1 9.14e-01 4.75e-06 2.96e-04
OSGEP O-sialoglycoprotein endopeptidase -9.00e-01 4.74e-06 2.96e-04
TK1 thymidine kinase 1 -6.79e-01 4.71e-06 2.96e-04
ARL6IP5 ADP ribosylation factor like GTPase 6 interacting protein 5 5.80e-01 4.89e-06 3.04e-04
AFMID arylformamidase 6.37e-01 4.98e-06 3.06e-04
LY96 lymphocyte antigen 96 8.61e-01 4.97e-06 3.06e-04
LSG1 large 60S subunit nuclear export GTPase 1 7.45e-01 5.22e-06 3.19e-04
ATP5PO ATP synthase peripheral stalk subunit OSCP -6.65e-01 5.63e-06 3.43e-04
METTL5 methyltransferase like 5 -8.51e-01 5.92e-06 3.58e-04
COMMD10 COMM domain containing 10 8.03e-01 5.98e-06 3.60e-04
MRPL24 mitochondrial ribosomal protein L24 -6.35e-01 6.07e-06 3.64e-04
BTN3A2 butyrophilin subfamily 3 member A2 3.77e-01 6.12e-06 3.65e-04
CAV1 caveolin 1 5.20e-01 6.60e-06 3.92e-04
UFD1 ubiquitin recognition factor in ER associated degradation 1 5.84e-01 6.79e-06 4.01e-04
CDKL5 cyclin dependent kinase like 5 7.81e-01 7.26e-06 4.24e-04
CPEB4 cytoplasmic polyadenylation element binding protein 4 8.73e-01 7.37e-06 4.29e-04
AXL AXL receptor tyrosine kinase -5.85e-01 7.47e-06 4.31e-04
H2BC4 H2B clustered histone 4 9.16e-01 7.48e-06 4.31e-04
CDADC1 cytidine and dCMP deaminase domain containing 1 9.19e-01 7.57e-06 4.34e-04
NOP10 NOP10 ribonucleoprotein 3.78e-01 7.98e-06 4.55e-04
MITF melanocyte inducing transcription factor 8.40e-01 8.17e-06 4.63e-04
BIRC3 baculoviral IAP repeat containing 3 -8.87e-01 8.85e-06 4.98e-04
DHX15 DEAH-box helicase 15 7.83e-01 8.84e-06 4.98e-04
ARPC2 actin related protein 2/3 complex subunit 2 -6.46e-01 9.57e-06 5.35e-04
FLCN folliculin 7.13e-01 9.69e-06 5.40e-04
POLR1F RNA polymerase I subunit F 7.82e-01 9.81e-06 5.43e-04
SLC29A1 solute carrier family 29 member 1 (Augustine blood group) -8.89e-01 9.87e-06 5.44e-04
BUB3 BUB3 mitotic checkpoint protein 3.49e-01 1.02e-05 5.62e-04
SRSF4 serine and arginine rich splicing factor 4 6.40e-01 1.03e-05 5.64e-04
HEG1 heart development protein with EGF like domains 1 7.88e-01 1.16e-05 6.32e-04
HNRNPU heterogeneous nuclear ribonucleoprotein U -5.46e-01 1.21e-05 6.54e-04
CHCHD1 coiled-coil-helix-coiled-coil-helix domain containing 1 -7.09e-01 1.24e-05 6.62e-04
MCM3 minichromosome maintenance complex component 3 -8.65e-01 1.23e-05 6.62e-04
NDUFA7 NADH:ubiquinone oxidoreductase subunit A7 -8.77e-01 1.24e-05 6.62e-04
RASAL2 RAS protein activator like 2 8.49e-01 1.30e-05 6.92e-04
PRPF38B pre-mRNA processing factor 38B 7.16e-01 1.32e-05 6.99e-04
TNFRSF10D TNF receptor superfamily member 10d 8.56e-01 1.35e-05 7.09e-04
CWC25 CWC25 spliceosome associated protein homolog 7.37e-01 1.37e-05 7.19e-04
TAF8 TATA-box binding protein associated factor 8 6.50e-01 1.52e-05 7.91e-04
NQO1 NAD(P)H quinone dehydrogenase 1 4.30e-01 1.53e-05 7.94e-04
HNMT histamine N-methyltransferase 8.70e-01 1.53e-05 7.94e-04
MKRN1 makorin ring finger protein 1 7.67e-01 1.60e-05 8.24e-04
TTC1 tetratricopeptide repeat domain 1 4.95e-01 1.62e-05 8.33e-04
SNRPB2 small nuclear ribonucleoprotein polypeptide B2 5.30e-01 1.65e-05 8.42e-04
CSRP2 cysteine and glycine rich protein 2 -9.57e-01 1.66e-05 8.46e-04
SLC39A10 solute carrier family 39 member 10 7.38e-01 1.69e-05 8.54e-04
TOM1L1 target of myb1 like 1 membrane trafficking protein 8.24e-01 1.69e-05 8.54e-04
MYNN myoneurin 8.61e-01 1.71e-05 8.56e-04
ZRSR2 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 8.84e-01 1.75e-05 8.75e-04
TXNL1 thioredoxin like 1 5.54e-01 1.85e-05 9.23e-04
PFKP phosphofructokinase, platelet -1.06e+00 1.88e-05 9.30e-04
B3GALT5 beta-1,3-galactosyltransferase 5 1.12e+00 1.95e-05 9.65e-04
PRKDC protein kinase, DNA-activated, catalytic subunit -8.27e-01 2.03e-05 9.97e-04
ATAD2 ATPase family AAA domain containing 2 -7.69e-01 2.07e-05 1.01e-03
PGBD1 piggyBac transposable element derived 1 9.59e-01 2.08e-05 1.01e-03
TSPAN8 tetraspanin 8 9.24e-01 2.12e-05 1.03e-03
MTRNR2L11 MT-RNR2 like 11 4.66e-01 2.14e-05 1.04e-03
MOB2 MOB kinase activator 2 8.33e-01 2.16e-05 1.04e-03
RTRAF RNA transcription, translation and transport factor 3.75e-01 2.20e-05 1.06e-03
CXCL1 C-X-C motif chemokine ligand 1 -9.68e-01 2.22e-05 1.06e-03
RFC4 replication factor C subunit 4 -8.36e-01 2.25e-05 1.07e-03
SRFBP1 serum response factor binding protein 1 8.54e-01 2.27e-05 1.08e-03
SRP9 signal recognition particle 9 -5.28e-01 2.37e-05 1.12e-03
RPL21 ribosomal protein L21 -4.60e-01 2.39e-05 1.12e-03
PTTG1IP PTTG1 interacting protein 5.30e-01 2.48e-05 1.16e-03
SALL4 spalt like transcription factor 4 7.51e-01 2.52e-05 1.17e-03
ZFAND2A zinc finger AN1-type containing 2A 7.94e-01 2.58e-05 1.20e-03
SARS1 seryl-tRNA synthetase 1 -6.62e-01 2.62e-05 1.21e-03
BOD1L1 biorientation of chromosomes in cell division 1 like 1 5.79e-01 2.74e-05 1.25e-03
OBI1 ORC ubiquitin ligase 1 9.30e-01 2.73e-05 1.25e-03
SNRPA1 small nuclear ribonucleoprotein polypeptide A' 6.27e-01 2.74e-05 1.25e-03
ATRAID all-trans retinoic acid induced differentiation factor -6.40e-01 2.82e-05 1.29e-03
RUNDC3A RUN domain containing 3A 7.35e-01 2.91e-05 1.32e-03
NUDT16L1 nudix hydrolase 16 like 1 8.20e-01 2.93e-05 1.32e-03
CEBPZOS CEBPZ opposite strand -8.90e-01 2.99e-05 1.34e-03
TLE3 TLE family member 3, transcriptional corepressor 7.64e-01 2.98e-05 1.34e-03
ATP6V0E1 ATPase H+ transporting V0 subunit e1 4.03e-01 3.09e-05 1.38e-03
NDUFB10 NADH:ubiquinone oxidoreductase subunit B10 -7.99e-01 3.09e-05 1.38e-03
KCNB1 potassium voltage-gated channel subfamily B member 1 8.26e-01 3.14e-05 1.39e-03
MTO1 mitochondrial tRNA translation optimization 1 7.01e-01 3.14e-05 1.39e-03
C19orf33 chromosome 19 open reading frame 33 -7.94e-01 3.26e-05 1.43e-03
SLC25A11 solute carrier family 25 member 11 -9.02e-01 3.36e-05 1.47e-03
NAA16 N-alpha-acetyltransferase 16, NatA auxiliary subunit 8.44e-01 3.38e-05 1.48e-03
FAM160B1 FHF complex subunit HOOK interacting protein 2A 6.81e-01 3.41e-05 1.49e-03
PSME1 proteasome activator subunit 1 -7.53e-01 3.43e-05 1.49e-03
SRSF11 serine and arginine rich splicing factor 11 6.05e-01 3.44e-05 1.49e-03
FADS1 fatty acid desaturase 1 -7.55e-01 3.53e-05 1.51e-03
SERPINB1 serpin family B member 1 -8.77e-01 3.53e-05 1.51e-03
TMX2 thioredoxin related transmembrane protein 2 -7.12e-01 3.51e-05 1.51e-03
MAGED2 MAGE family member D2 -6.55e-01 3.60e-05 1.53e-03
NOG noggin -8.46e-01 3.68e-05 1.56e-03
H3C10 H3 clustered histone 10 6.77e-01 3.74e-05 1.58e-03
MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 -7.96e-01 3.79e-05 1.60e-03
SNRPC small nuclear ribonucleoprotein polypeptide C 3.24e-01 3.84e-05 1.61e-03
SBDS SBDS ribosome maturation factor 5.06e-01 4.05e-05 1.70e-03
CUEDC2 CUE domain containing 2 -8.21e-01 4.19e-05 1.75e-03
DAP3 death associated protein 3 6.16e-01 4.27e-05 1.77e-03
LGALS3 galectin 3 -8.49e-01 4.28e-05 1.77e-03
RPL31 ribosomal protein L31 -4.05e-01 4.31e-05 1.78e-03
NAP1L1 nucleosome assembly protein 1 like 1 -4.07e-01 4.37e-05 1.80e-03
UBE2L3 ubiquitin conjugating enzyme E2 L3 4.68e-01 4.42e-05 1.81e-03
GPRC5A G protein-coupled receptor class C group 5 member A 6.02e-01 4.56e-05 1.86e-03
EIF3I eukaryotic translation initiation factor 3 subunit I -5.35e-01 4.61e-05 1.87e-03
NCBP2 nuclear cap binding protein subunit 2 6.25e-01 4.61e-05 1.87e-03
TNFRSF11B TNF receptor superfamily member 11b 7.15e-01 4.63e-05 1.87e-03
RPLP0 ribosomal protein lateral stalk subunit P0 -3.50e-01 4.66e-05 1.88e-03
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 3.09e-01 4.76e-05 1.91e-03
BTG1 BTG anti-proliferation factor 1 7.19e-01 4.84e-05 1.94e-03
SOCS7 suppressor of cytokine signaling 7 6.05e-01 4.86e-05 1.94e-03
TEAD1 TEA domain transcription factor 1 7.19e-01 4.88e-05 1.94e-03
ZNF669 zinc finger protein 669 7.64e-01 4.92e-05 1.95e-03
MTPAP mitochondrial poly(A) polymerase 6.54e-01 4.99e-05 1.97e-03
GSTP1 glutathione S-transferase pi 1 -4.10e-01 5.08e-05 2.00e-03
NDUFAF1 NADH:ubiquinone oxidoreductase complex assembly factor 1 8.29e-01 5.14e-05 2.02e-03
EXPH5 exophilin 5 6.98e-01 5.18e-05 2.02e-03
LAS1L LAS1 like ribosome biogenesis factor -8.68e-01 5.35e-05 2.09e-03
GRPEL1 GrpE like 1, mitochondrial 6.25e-01 5.47e-05 2.12e-03
HMGN2 high mobility group nucleosomal binding domain 2 -3.26e-01 5.48e-05 2.12e-03
SRP14 signal recognition particle 14 3.77e-01 5.59e-05 2.16e-03
AKIRIN2 akirin 2 9.66e-01 5.67e-05 2.18e-03
DRG1 developmentally regulated GTP binding protein 1 6.01e-01 5.79e-05 2.22e-03
MMP1 matrix metallopeptidase 1 3.71e-01 5.83e-05 2.23e-03
LBHD1 LBH domain containing 1 -6.26e-01 5.96e-05 2.27e-03
UBE2H ubiquitin conjugating enzyme E2 H 7.03e-01 6.01e-05 2.28e-03
HDAC1 histone deacetylase 1 -6.90e-01 6.21e-05 2.35e-03
PGLS 6-phosphogluconolactonase -8.56e-01 6.25e-05 2.36e-03
TXK TXK tyrosine kinase 7.97e-01 6.28e-05 2.36e-03
SLC25A3 solute carrier family 25 member 3 -5.72e-01 6.36e-05 2.38e-03
TMBIM4 transmembrane BAX inhibitor motif containing 4 -8.42e-01 6.53e-05 2.43e-03
WDR45B WD repeat domain 45B 7.57e-01 6.54e-05 2.43e-03
UBQLN1 ubiquilin 1 8.10e-01 6.72e-05 2.49e-03
RAE1 ribonucleic acid export 1 6.59e-01 6.84e-05 2.53e-03
MRPL32 mitochondrial ribosomal protein L32 5.39e-01 6.87e-05 2.53e-03
POMP proteasome maturation protein 3.09e-01 6.99e-05 2.56e-03
RNPC3 RNA binding region (RNP1, RRM) containing 3 7.02e-01 6.97e-05 2.56e-03
KCNJ15 potassium inwardly rectifying channel subfamily J member 15 6.89e-01 7.16e-05 2.62e-03
LNX2 ligand of numb-protein X 2 7.14e-01 7.30e-05 2.66e-03
HPCAL1 hippocalcin like 1 -6.43e-01 7.38e-05 2.68e-03
DOHH deoxyhypusine hydroxylase 7.33e-01 7.46e-05 2.70e-03
CDK11B cyclin dependent kinase 11B 6.75e-01 7.54e-05 2.72e-03
VSIG1 V-set and immunoglobulin domain containing 1 7.68e-01 7.60e-05 2.73e-03
MED13 mediator complex subunit 13 8.35e-01 7.73e-05 2.77e-03
ARPP19 cAMP regulated phosphoprotein 19 6.73e-01 7.91e-05 2.82e-03
CCNB1 cyclin B1 3.76e-01 7.89e-05 2.82e-03
HMGN1 high mobility group nucleosome binding domain 1 -7.43e-01 7.92e-05 2.82e-03
CCND1 cyclin D1 -4.41e-01 8.34e-05 2.96e-03
CZIB CXXC motif containing zinc binding protein -1.00e+00 8.49e-05 3.00e-03
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 7.11e-01 8.62e-05 3.04e-03
PLEC plectin -6.69e-01 8.68e-05 3.05e-03
IFI16 interferon gamma inducible protein 16 6.23e-01 9.11e-05 3.18e-03
EIF4E eukaryotic translation initiation factor 4E 4.67e-01 9.24e-05 3.22e-03
SUPT5H SPT5 homolog, DSIF elongation factor subunit 7.21e-01 9.30e-05 3.23e-03
UBXN7 UBX domain protein 7 7.29e-01 9.35e-05 3.24e-03
CBWD5 COBW domain containing 5 5.97e-01 9.40e-05 3.24e-03
ANKRD40 ankyrin repeat domain 40 6.21e-01 9.51e-05 3.26e-03
NUPR1 nuclear protein 1, transcriptional regulator 6.26e-01 9.49e-05 3.26e-03
HMGB2 high mobility group box 2 4.33e-01 9.59e-05 3.28e-03
SNW1 SNW domain containing 1 4.74e-01 9.67e-05 3.30e-03
MCM7 minichromosome maintenance complex component 7 -8.74e-01 9.89e-05 3.36e-03
TRIM16 tripartite motif containing 16 6.91e-01 9.98e-05 3.38e-03
EXT1 exostosin glycosyltransferase 1 6.21e-01 1.00e-04 3.38e-03
PEBP1 phosphatidylethanolamine binding protein 1 3.23e-01 1.02e-04 3.43e-03
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -7.49e-01 1.02e-04 3.43e-03
ALDOA aldolase, fructose-bisphosphate A -4.18e-01 1.05e-04 3.52e-03
CST3 cystatin C -4.69e-01 1.05e-04 3.53e-03
SREK1IP1 SREK1 interacting protein 1 6.03e-01 1.07e-04 3.56e-03
DNAJC25 DnaJ heat shock protein family (Hsp40) member C25 7.23e-01 1.08e-04 3.59e-03
BCLAF1 BCL2 associated transcription factor 1 6.48e-01 1.12e-04 3.70e-03
PPME1 protein phosphatase methylesterase 1 7.88e-01 1.12e-04 3.70e-03
FAM171B family with sequence similarity 171 member B 7.76e-01 1.16e-04 3.81e-03
SF3B1 splicing factor 3b subunit 1 5.37e-01 1.16e-04 3.81e-03
SHISA2 shisa family member 2 -9.76e-01 1.20e-04 3.93e-03
HELB DNA helicase B 8.42e-01 1.23e-04 4.03e-03
ZNF335 zinc finger protein 335 6.49e-01 1.25e-04 4.08e-03
KIF13A kinesin family member 13A 7.01e-01 1.27e-04 4.13e-03
GMNN geminin DNA replication inhibitor -6.17e-01 1.28e-04 4.16e-03
PRPF40A pre-mRNA processing factor 40 homolog A 5.31e-01 1.30e-04 4.20e-03
SLC39A9 solute carrier family 39 member 9 6.77e-01 1.33e-04 4.28e-03
LAPTM4B lysosomal protein transmembrane 4 beta 6.57e-01 1.34e-04 4.31e-03
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 6.64e-01 1.35e-04 4.34e-03
SCD stearoyl-CoA desaturase -7.22e-01 1.38e-04 4.42e-03
VIM vimentin 3.76e-01 1.38e-04 4.42e-03
NAMPT nicotinamide phosphoribosyltransferase -7.13e-01 1.46e-04 4.64e-03
ZNF706 zinc finger protein 706 -8.19e-01 1.47e-04 4.65e-03
CD55 CD55 molecule (Cromer blood group) 6.90e-01 1.47e-04 4.65e-03
SLC43A3 solute carrier family 43 member 3 -7.17e-01 1.50e-04 4.73e-03
SNAPC1 small nuclear RNA activating complex polypeptide 1 5.43e-01 1.52e-04 4.77e-03
C6orf62 chromosome 6 open reading frame 62 -5.69e-01 1.55e-04 4.86e-03
RALA RAS like proto-oncogene A 6.40e-01 1.56e-04 4.87e-03
ATP6V1D ATPase H+ transporting V1 subunit D 5.98e-01 1.57e-04 4.89e-03
FIBP FGF1 intracellular binding protein -6.94e-01 1.58e-04 4.91e-03
RFK riboflavin kinase 7.67e-01 1.58e-04 4.91e-03
MTATP6P1 MT-ATP6 pseudogene 1 2.83e-01 1.61e-04 4.98e-03
FILIP1L filamin A interacting protein 1 like 6.73e-01 1.62e-04 4.98e-03
HAS2 hyaluronan synthase 2 -9.12e-01 1.62e-04 4.98e-03
NAPG NSF attachment protein gamma 6.34e-01 1.61e-04 4.98e-03
FAM71D family with sequence similarity 71 member D 6.72e-01 1.64e-04 5.03e-03
CD74 CD74 molecule -5.86e-01 1.68e-04 5.15e-03
LRIF1 ligand dependent nuclear receptor interacting factor 1 6.99e-01 1.69e-04 5.16e-03
ZNF345 zinc finger protein 345 6.50e-01 1.71e-04 5.19e-03
ESF1 ESF1 nucleolar pre-rRNA processing protein homolog 5.79e-01 1.72e-04 5.22e-03
NCOR1 nuclear receptor corepressor 1 5.91e-01 1.77e-04 5.33e-03
RBM3 RNA binding motif protein 3 -4.92e-01 1.76e-04 5.33e-03
ZNF521 zinc finger protein 521 7.99e-01 1.84e-04 5.55e-03
ASB6 ankyrin repeat and SOCS box containing 6 7.38e-01 1.86e-04 5.59e-03
RHOC ras homolog family member C -5.42e-01 1.90e-04 5.70e-03
KLF5 Kruppel like factor 5 6.70e-01 1.98e-04 5.92e-03
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 -4.10e-01 2.00e-04 5.95e-03
CHORDC1 cysteine and histidine rich domain containing 1 5.96e-01 2.00e-04 5.96e-03
TCF25 transcription factor 25 6.20e-01 2.02e-04 5.98e-03
BTN2A1 butyrophilin subfamily 2 member A1 7.50e-01 2.06e-04 6.08e-03
CHD2 chromodomain helicase DNA binding protein 2 6.47e-01 2.07e-04 6.12e-03
HINT2 histidine triad nucleotide binding protein 2 -9.75e-01 2.08e-04 6.13e-03
MRPL57 mitochondrial ribosomal protein L57 -3.91e-01 2.11e-04 6.19e-03
FAM98A family with sequence similarity 98 member A 6.17e-01 2.13e-04 6.22e-03
ZNF267 zinc finger protein 267 6.89e-01 2.14e-04 6.26e-03
MRPS7 mitochondrial ribosomal protein S7 -5.91e-01 2.15e-04 6.27e-03
CSF2 colony stimulating factor 2 -7.42e-01 2.17e-04 6.29e-03
PSMB4 proteasome 20S subunit beta 4 -4.60e-01 2.19e-04 6.35e-03
HPRT1 hypoxanthine phosphoribosyltransferase 1 -6.35e-01 2.21e-04 6.40e-03
CIB1 calcium and integrin binding 1 -6.95e-01 2.27e-04 6.55e-03
CNBP CCHC-type zinc finger nucleic acid binding protein 4.15e-01 2.29e-04 6.58e-03
IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon 7.02e-01 2.30e-04 6.62e-03
TAF15 TATA-box binding protein associated factor 15 -7.54e-01 2.33e-04 6.66e-03
GRAMD1A GRAM domain containing 1A 6.65e-01 2.34e-04 6.70e-03
TRIP11 thyroid hormone receptor interactor 11 -8.98e-01 2.39e-04 6.81e-03
PPP1R7 protein phosphatase 1 regulatory subunit 7 -8.45e-01 2.41e-04 6.83e-03
ZBTB38 zinc finger and BTB domain containing 38 6.45e-01 2.41e-04 6.83e-03
SPAG1 sperm associated antigen 1 -9.39e-01 2.48e-04 7.02e-03
WDR54 WD repeat domain 54 -7.22e-01 2.50e-04 7.05e-03
RNF115 ring finger protein 115 6.37e-01 2.56e-04 7.22e-03
DCAF4L1 DDB1 and CUL4 associated factor 4 like 1 6.61e-01 2.57e-04 7.23e-03
GCLM glutamate-cysteine ligase modifier subunit 6.57e-01 2.60e-04 7.28e-03
RBBP8 RB binding protein 8, endonuclease -9.54e-01 2.61e-04 7.30e-03
MTRNR2L12 MT-RNR2 like 12 4.07e-01 2.62e-04 7.32e-03
CAVIN3 caveolae associated protein 3 -5.35e-01 2.66e-04 7.41e-03
RYBP RING1 and YY1 binding protein 7.69e-01 2.73e-04 7.57e-03
LZTFL1 leucine zipper transcription factor like 1 8.34e-01 2.74e-04 7.60e-03
NUSAP1 nucleolar and spindle associated protein 1 -5.53e-01 2.79e-04 7.70e-03
SUMO1 small ubiquitin like modifier 1 4.06e-01 2.83e-04 7.80e-03
MORN4 MORN repeat containing 4 6.79e-01 2.85e-04 7.85e-03
COMMD3 COMM domain containing 3 -7.31e-01 2.87e-04 7.88e-03
RBM33 RNA binding motif protein 33 6.82e-01 2.88e-04 7.89e-03
LRRC69 leucine rich repeat containing 69 2.38e-01 2.91e-04 7.93e-03
RERE arginine-glutamic acid dipeptide repeats 7.53e-01 2.91e-04 7.93e-03
EIF1 eukaryotic translation initiation factor 1 3.25e-01 2.93e-04 7.98e-03
SPTY2D1 SPT2 chromatin protein domain containing 1 6.33e-01 2.96e-04 8.02e-03
P3H2 prolyl 3-hydroxylase 2 6.44e-01 2.97e-04 8.03e-03
AK2 adenylate kinase 2 4.06e-01 3.00e-04 8.06e-03
ASCC2 activating signal cointegrator 1 complex subunit 2 5.94e-01 2.99e-04 8.06e-03
NDUFS6 NADH:ubiquinone oxidoreductase subunit S6 5.24e-01 3.00e-04 8.06e-03
ARGLU1 arginine and glutamate rich 1 5.22e-01 3.03e-04 8.13e-03
RSU1 Ras suppressor protein 1 -6.41e-01 3.08e-04 8.24e-03
SYNE1 spectrin repeat containing nuclear envelope protein 1 6.36e-01 3.13e-04 8.36e-03
PMM1 phosphomannomutase 1 -9.53e-01 3.15e-04 8.36e-03
SART3 spliceosome associated factor 3, U4/U6 recycling protein 6.50e-01 3.15e-04 8.36e-03
USP10 ubiquitin specific peptidase 10 6.70e-01 3.15e-04 8.36e-03
TIAF1 TGFB1-induced anti-apoptotic factor 1 6.59e-01 3.20e-04 8.47e-03
INSIG1 insulin induced gene 1 -7.77e-01 3.22e-04 8.49e-03
GOLGA4 golgin A4 5.28e-01 3.27e-04 8.61e-03
SMAD2 SMAD family member 2 5.60e-01 3.29e-04 8.64e-03
NOSIP nitric oxide synthase interacting protein -6.71e-01 3.30e-04 8.66e-03
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -7.31e-01 3.31e-04 8.66e-03
PCLAF PCNA clamp associated factor -5.84e-01 3.32e-04 8.67e-03
C15orf48 chromosome 15 open reading frame 48 -6.10e-01 3.37e-04 8.71e-03
NBPF14 NBPF member 14 5.58e-01 3.38e-04 8.71e-03
PPP4R3B protein phosphatase 4 regulatory subunit 3B 7.13e-01 3.36e-04 8.71e-03
QRICH1 glutamine rich 1 6.37e-01 3.37e-04 8.71e-03
RPL7A ribosomal protein L7a 5.63e-01 3.37e-04 8.71e-03
ZCCHC17 zinc finger CCHC-type containing 17 -7.59e-01 3.38e-04 8.71e-03
ZNF317 zinc finger protein 317 7.17e-01 3.47e-04 8.91e-03
BDNF brain derived neurotrophic factor 7.09e-01 3.48e-04 8.94e-03
DDX1 DEAD-box helicase 1 -6.06e-01 3.52e-04 8.96e-03
DYNC1H1 dynein cytoplasmic 1 heavy chain 1 -5.41e-01 3.51e-04 8.96e-03
FBXO6 F-box protein 6 6.47e-01 3.51e-04 8.96e-03
ADIPOR1 adiponectin receptor 1 6.35e-01 3.56e-04 9.03e-03
PSMD6 proteasome 26S subunit, non-ATPase 6 5.04e-01 3.56e-04 9.03e-03
ARL2 ADP ribosylation factor like GTPase 2 -5.19e-01 3.63e-04 9.13e-03
CENPS centromere protein S -7.93e-01 3.61e-04 9.13e-03
RPP40 ribonuclease P/MRP subunit p40 5.95e-01 3.62e-04 9.13e-03
TMEM156 transmembrane protein 156 6.30e-01 3.62e-04 9.13e-03
ARHGEF1 Rho guanine nucleotide exchange factor 1 6.24e-01 3.72e-04 9.31e-03
PLPP4 phospholipid phosphatase 4 7.08e-01 3.72e-04 9.31e-03
PPM1D protein phosphatase, Mg2+/Mn2+ dependent 1D 6.26e-01 3.72e-04 9.31e-03
SEPTIN7 septin 7 4.24e-01 3.80e-04 9.46e-03
SF3B4 splicing factor 3b subunit 4 7.29e-01 3.80e-04 9.46e-03
DNAJC7 DnaJ heat shock protein family (Hsp40) member C7 5.21e-01 3.89e-04 9.66e-03
SLCO4A1 solute carrier organic anion transporter family member 4A1 -6.13e-01 3.90e-04 9.66e-03
IER5 immediate early response 5 5.84e-01 3.97e-04 9.81e-03
KPNA2 karyopherin subunit alpha 2 3.48e-01 4.00e-04 9.85e-03
PLEKHB2 pleckstrin homology domain containing B2 5.49e-01 4.00e-04 9.85e-03
PFN1 profilin 1 -3.41e-01 4.06e-04 9.98e-03
ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 3.58e-01 4.14e-04 1.01e-02
NDUFAF3 NADH:ubiquinone oxidoreductase complex assembly factor 3 -5.52e-01 4.14e-04 1.01e-02
PRCC proline rich mitotic checkpoint control factor 7.02e-01 4.13e-04 1.01e-02
TCERG1 transcription elongation regulator 1 5.63e-01 4.13e-04 1.01e-02
FKBP3 FKBP prolyl isomerase 3 -6.30e-01 4.17e-04 1.01e-02
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 5.49e-01 4.23e-04 1.03e-02
CLSPN claspin -6.01e-01 4.27e-04 1.03e-02
NELFCD negative elongation factor complex member C/D 6.90e-01 4.29e-04 1.04e-02
LAMB3 laminin subunit beta 3 -5.54e-01 4.41e-04 1.06e-02
BLVRB biliverdin reductase B -6.58e-01 4.44e-04 1.07e-02
FYTTD1 forty-two-three domain containing 1 5.76e-01 4.45e-04 1.07e-02
CKS1B CDC28 protein kinase regulatory subunit 1B 3.27e-01 4.47e-04 1.07e-02
H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase -8.32e-01 4.52e-04 1.08e-02
RPS8 ribosomal protein S8 -2.51e-01 4.53e-04 1.08e-02
C11orf98 chromosome 11 open reading frame 98 -6.11e-01 4.60e-04 1.10e-02
INO80 INO80 complex ATPase subunit 7.16e-01 4.66e-04 1.11e-02
NDUFAB1 NADH:ubiquinone oxidoreductase subunit AB1 4.62e-01 4.72e-04 1.12e-02
PSMG4 proteasome assembly chaperone 4 -9.19e-01 4.71e-04 1.12e-02
CCDC9B coiled-coil domain containing 9B -7.04e-01 4.74e-04 1.12e-02
ATP1B3 ATPase Na+/K+ transporting subunit beta 3 5.08e-01 4.77e-04 1.13e-02
SRSF10 serine and arginine rich splicing factor 10 -4.40e-01 4.87e-04 1.15e-02
PPP1R2 protein phosphatase 1 regulatory inhibitor subunit 2 5.84e-01 4.91e-04 1.15e-02
DHX38 DEAH-box helicase 38 7.40e-01 5.02e-04 1.17e-02
NBPF20 NBPF member 20 6.63e-01 5.21e-04 1.21e-02
NSUN5P2 NSUN5 pseudogene 2 5.55e-01 5.22e-04 1.21e-02
PSMA1 proteasome 20S subunit alpha 1 -4.67e-01 5.20e-04 1.21e-02
RBM22 RNA binding motif protein 22 6.88e-01 5.26e-04 1.22e-02
PHLDB2 pleckstrin homology like domain family B member 2 7.01e-01 5.46e-04 1.27e-02
MTRNR2L4 MT-RNR2 like 4 4.74e-01 5.54e-04 1.28e-02
F3 coagulation factor III, tissue factor -4.47e-01 5.63e-04 1.30e-02
NDUFA12 NADH:ubiquinone oxidoreductase subunit A12 3.13e-01 5.64e-04 1.30e-02
TMEM101 transmembrane protein 101 -7.68e-01 5.73e-04 1.32e-02
LPXN leupaxin -6.64e-01 5.79e-04 1.33e-02
POU2F2 POU class 2 homeobox 2 -8.36e-01 5.78e-04 1.33e-02
PCIF1 phosphorylated CTD interacting factor 1 7.49e-01 5.90e-04 1.35e-02
CTPS1 CTP synthase 1 -8.20e-01 5.95e-04 1.36e-02
EMC3 ER membrane protein complex subunit 3 4.77e-01 5.97e-04 1.36e-02
C3orf33 chromosome 3 open reading frame 33 6.80e-01 6.02e-04 1.37e-02
MORC4 MORC family CW-type zinc finger 4 -6.99e-01 6.05e-04 1.37e-02
COX6C cytochrome c oxidase subunit 6C 2.94e-01 6.11e-04 1.38e-02
DDX27 DEAD-box helicase 27 4.91e-01 6.19e-04 1.40e-02
TIMM8B translocase of inner mitochondrial membrane 8 homolog B 3.84e-01 6.29e-04 1.42e-02
CEP43 centrosomal protein 43 6.15e-01 6.33e-04 1.43e-02
OR2A25 olfactory receptor family 2 subfamily A member 25 6.68e-01 6.40e-04 1.44e-02
C19orf53 chromosome 19 open reading frame 53 2.96e-01 6.46e-04 1.45e-02
SAT1 spermidine/spermine N1-acetyltransferase 1 4.23e-01 6.46e-04 1.45e-02
CARF calcium responsive transcription factor 8.16e-01 6.51e-04 1.45e-02
TIMM10B translocase of inner mitochondrial membrane 10B 6.36e-01 6.60e-04 1.47e-02
DPP6 dipeptidyl peptidase like 6 6.07e-01 6.61e-04 1.47e-02
SLFN12 schlafen family member 12 7.73e-01 6.76e-04 1.50e-02
AFF4 AF4/FMR2 family member 4 6.01e-01 6.79e-04 1.50e-02
SGO2 shugoshin 2 5.59e-01 6.79e-04 1.50e-02
RCHY1 ring finger and CHY zinc finger domain containing 1 5.66e-01 6.85e-04 1.51e-02
YARS2 tyrosyl-tRNA synthetase 2 6.71e-01 6.84e-04 1.51e-02
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 3.45e-01 6.89e-04 1.51e-02
RNF8 ring finger protein 8 6.41e-01 6.92e-04 1.52e-02
PSMA2 proteasome 20S subunit alpha 2 3.16e-01 6.95e-04 1.52e-02
TPT1 tumor protein, translationally-controlled 1 3.71e-01 7.06e-04 1.54e-02
AK5 adenylate kinase 5 6.79e-01 7.15e-04 1.56e-02
LLPH LLP homolog, long-term synaptic facilitation factor 5.28e-01 7.14e-04 1.56e-02
CTSC cathepsin C 4.21e-01 7.20e-04 1.56e-02
CMTR2 cap methyltransferase 2 6.96e-01 7.42e-04 1.61e-02
XPR1 xenotropic and polytropic retrovirus receptor 1 5.39e-01 7.42e-04 1.61e-02
PLAU plasminogen activator, urokinase -5.34e-01 7.44e-04 1.61e-02
XKR4 XK related 4 6.11e-01 7.48e-04 1.61e-02
LAPTM5 lysosomal protein transmembrane 5 -7.59e-01 7.50e-04 1.61e-02
KMT5B lysine methyltransferase 5B 6.04e-01 7.56e-04 1.63e-02
WNT5B Wnt family member 5B 7.54e-01 7.58e-04 1.63e-02
MYC MYC proto-oncogene, bHLH transcription factor 5.77e-01 7.78e-04 1.67e-02
ARSK arylsulfatase family member K 6.71e-01 7.83e-04 1.67e-02
TMEM154 transmembrane protein 154 -7.36e-01 7.93e-04 1.69e-02
COX6A1 cytochrome c oxidase subunit 6A1 2.13e-01 8.09e-04 1.72e-02
IFITM3 interferon induced transmembrane protein 3 2.90e-01 8.13e-04 1.73e-02
CENPM centromere protein M -6.75e-01 8.16e-04 1.73e-02
SBF2 SET binding factor 2 5.44e-01 8.20e-04 1.74e-02
ZRANB1 zinc finger RANBP2-type containing 1 7.62e-01 8.29e-04 1.75e-02
TRAK1 trafficking kinesin protein 1 6.37e-01 8.31e-04 1.75e-02
TRIM16L tripartite motif containing 16 like 7.03e-01 8.35e-04 1.76e-02
SLC7A5 solute carrier family 7 member 5 7.11e-01 8.38e-04 1.76e-02
APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 -5.84e-01 8.43e-04 1.77e-02
FZD2 frizzled class receptor 2 6.38e-01 8.44e-04 1.77e-02
AMMECR1L AMMECR1 like 5.88e-01 8.46e-04 1.77e-02
CAMLG calcium modulating ligand 6.22e-01 8.58e-04 1.79e-02
L3MBTL1 L3MBTL histone methyl-lysine binding protein 1 6.56e-01 8.64e-04 1.80e-02
RAB18 RAB18, member RAS oncogene family 5.10e-01 8.74e-04 1.82e-02
PRPF39 pre-mRNA processing factor 39 5.09e-01 8.87e-04 1.84e-02
RPS3 ribosomal protein S3 -4.40e-01 8.90e-04 1.85e-02
ATP6V1E1 ATPase H+ transporting V1 subunit E1 5.31e-01 8.95e-04 1.85e-02
RAP1GDS1 Rap1 GTPase-GDP dissociation stimulator 1 -7.54e-01 9.06e-04 1.87e-02
BNIP3 BCL2 interacting protein 3 -5.05e-01 9.16e-04 1.88e-02
RAB13 RAB13, member RAS oncogene family -5.53e-01 9.15e-04 1.88e-02
RUNX1 RUNX family transcription factor 1 6.78e-01 9.16e-04 1.88e-02
THYN1 thymocyte nuclear protein 1 -5.32e-01 9.16e-04 1.88e-02
HUS1 HUS1 checkpoint clamp component 5.85e-01 9.23e-04 1.89e-02
SLC37A3 solute carrier family 37 member 3 5.83e-01 9.29e-04 1.90e-02
AGO3 argonaute RISC catalytic component 3 5.52e-01 9.39e-04 1.91e-02
SHCBP1 SHC binding and spindle associated 1 7.14e-01 9.36e-04 1.91e-02
UBE2E2 ubiquitin conjugating enzyme E2 E2 6.90e-01 9.38e-04 1.91e-02
VSIG10 V-set and immunoglobulin domain containing 10 -8.13e-01 9.38e-04 1.91e-02
ACTB actin beta 2.66e-01 9.44e-04 1.91e-02
POLD2 DNA polymerase delta 2, accessory subunit -6.68e-01 9.44e-04 1.91e-02
ZNF37BP zinc finger protein 37B, pseudogene 6.65e-01 9.58e-04 1.94e-02
AAK1 AP2 associated kinase 1 5.51e-01 9.74e-04 1.97e-02
MED13L mediator complex subunit 13L 6.36e-01 9.82e-04 1.98e-02
RPL36AL ribosomal protein L36a like 2.11e-01 9.92e-04 1.99e-02
CHMP4A charged multivesicular body protein 4A -6.60e-01 1.00e-03 2.01e-02
CASP6 caspase 6 -7.70e-01 1.01e-03 2.01e-02
RFXANK regulatory factor X associated ankyrin containing protein -7.66e-01 1.01e-03 2.01e-02
GPS2 G protein pathway suppressor 2 -8.05e-01 1.02e-03 2.03e-02
CDK2AP1 cyclin dependent kinase 2 associated protein 1 5.44e-01 1.02e-03 2.04e-02
FTH1 ferritin heavy chain 1 4.07e-01 1.03e-03 2.06e-02
YIPF3 Yip1 domain family member 3 -6.56e-01 1.04e-03 2.06e-02
OTUD1 OTU deubiquitinase 1 6.73e-01 1.04e-03 2.07e-02
PWP1 PWP1 homolog, endonuclein -5.30e-01 1.04e-03 2.07e-02
GTPBP4 GTP binding protein 4 4.19e-01 1.05e-03 2.08e-02
PSME2 proteasome activator subunit 2 -3.98e-01 1.06e-03 2.08e-02
NR3C1 nuclear receptor subfamily 3 group C member 1 5.96e-01 1.06e-03 2.09e-02
NUCB2 nucleobindin 2 -5.83e-01 1.06e-03 2.09e-02
DCAF13 DDB1 and CUL4 associated factor 13 4.56e-01 1.08e-03 2.12e-02
KNSTRN kinetochore localized astrin (SPAG5) binding protein -7.26e-01 1.10e-03 2.16e-02
QPRT quinolinate phosphoribosyltransferase 5.84e-01 1.11e-03 2.17e-02
RBM27 RNA binding motif protein 27 7.03e-01 1.11e-03 2.17e-02
CYB561D2 cytochrome b561 family member D2 -7.23e-01 1.13e-03 2.20e-02
PCNX4 pecanex 4 5.57e-01 1.13e-03 2.20e-02
RPL12 ribosomal protein L12 -4.21e-01 1.13e-03 2.20e-02
FAM50A family with sequence similarity 50 member A -4.76e-01 1.15e-03 2.22e-02
ATP5IF1 ATP synthase inhibitory factor subunit 1 -3.26e-01 1.15e-03 2.23e-02
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 4.22e-01 1.15e-03 2.23e-02
CISD1 CDGSH iron sulfur domain 1 3.68e-01 1.18e-03 2.28e-02
UNC13D unc-13 homolog D -7.00e-01 1.18e-03 2.28e-02
MTRNR2L1 MT-RNR2 like 1 3.24e-01 1.20e-03 2.32e-02
GUSBP2 GUSB pseudogene 2 7.28e-01 1.21e-03 2.32e-02
KRT7 keratin 7 -7.79e-01 1.22e-03 2.34e-02
SNRNP70 small nuclear ribonucleoprotein U1 subunit 70 5.65e-01 1.22e-03 2.34e-02
TRNAU1AP tRNA selenocysteine 1 associated protein 1 -7.69e-01 1.23e-03 2.34e-02
CBY1 chibby family member 1, beta catenin antagonist -8.58e-01 1.25e-03 2.38e-02
LUC7L3 LUC7 like 3 pre-mRNA splicing factor 4.73e-01 1.25e-03 2.38e-02
NAE1 NEDD8 activating enzyme E1 subunit 1 -6.92e-01 1.25e-03 2.38e-02
SRA1 steroid receptor RNA activator 1 -4.79e-01 1.25e-03 2.38e-02
ZNF263 zinc finger protein 263 3.99e-01 1.27e-03 2.40e-02
PLAG1 PLAG1 zinc finger 6.03e-01 1.27e-03 2.40e-02
AMZ2 archaelysin family metallopeptidase 2 -8.02e-01 1.27e-03 2.41e-02
EIF6 eukaryotic translation initiation factor 6 -4.05e-01 1.29e-03 2.42e-02
LACTB2 lactamase beta 2 -8.00e-01 1.29e-03 2.43e-02
IFI27L2 interferon alpha inducible protein 27 like 2 -4.80e-01 1.30e-03 2.44e-02
GNG5 G protein subunit gamma 5 3.08e-01 1.30e-03 2.44e-02
IL10RB interleukin 10 receptor subunit beta -7.29e-01 1.30e-03 2.44e-02
RIPPLY3 ripply transcriptional repressor 3 6.91e-01 1.31e-03 2.46e-02
ZNF326 zinc finger protein 326 4.86e-01 1.32e-03 2.46e-02
WWC2 WW and C2 domain containing 2 6.85e-01 1.33e-03 2.47e-02
DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory -8.27e-01 1.33e-03 2.48e-02
CRIPT CXXC repeat containing interactor of PDZ3 domain 5.18e-01 1.37e-03 2.53e-02
GPATCH8 G-patch domain containing 8 5.62e-01 1.37e-03 2.54e-02
SYNPO2L synaptopodin 2 like 6.99e-01 1.37e-03 2.54e-02
DAPK3 death associated protein kinase 3 5.89e-01 1.38e-03 2.55e-02
SPOP speckle type BTB/POZ protein 5.36e-01 1.39e-03 2.56e-02
ZNHIT2 zinc finger HIT-type containing 2 7.25e-01 1.40e-03 2.58e-02
ZNF93 zinc finger protein 93 7.07e-01 1.40e-03 2.58e-02
U2AF1L4 U2 small nuclear RNA auxiliary factor 1 like 4 6.80e-01 1.42e-03 2.60e-02
CGRRF1 cell growth regulator with ring finger domain 1 6.42e-01 1.43e-03 2.61e-02
TATDN2 TatD DNase domain containing 2 6.26e-01 1.43e-03 2.61e-02
NT5C 5', 3'-nucleotidase, cytosolic -8.33e-01 1.44e-03 2.63e-02
MIF4GD MIF4G domain containing -6.69e-01 1.45e-03 2.64e-02
CROCCP2 CROCC pseudogene 2 5.99e-01 1.46e-03 2.65e-02
RICTOR RPTOR independent companion of MTOR complex 2 6.31e-01 1.46e-03 2.66e-02
TCF7L1 transcription factor 7 like 1 4.42e-01 1.49e-03 2.70e-02
ATP6V1G1 ATPase H+ transporting V1 subunit G1 3.83e-01 1.50e-03 2.72e-02
APRT adenine phosphoribosyltransferase -4.67e-01 1.50e-03 2.72e-02
ADGRE5 adhesion G protein-coupled receptor E5 -5.73e-01 1.52e-03 2.75e-02
JAGN1 jagunal homolog 1 -8.33e-01 1.54e-03 2.77e-02
ABCC6 ATP binding cassette subfamily C member 6 6.16e-01 1.56e-03 2.78e-02
AKR1A1 aldo-keto reductase family 1 member A1 -6.07e-01 1.55e-03 2.78e-02
MRPL54 mitochondrial ribosomal protein L54 5.66e-01 1.55e-03 2.78e-02
OCIAD2 OCIA domain containing 2 4.68e-01 1.55e-03 2.78e-02
PLCG2 phospholipase C gamma 2 7.86e-01 1.56e-03 2.78e-02
SLC3A2 solute carrier family 3 member 2 5.45e-01 1.55e-03 2.78e-02
RGS4 regulator of G protein signaling 4 7.31e-01 1.57e-03 2.79e-02
TRIM8 tripartite motif containing 8 -7.55e-01 1.57e-03 2.79e-02
ACSL6 acyl-CoA synthetase long chain family member 6 5.29e-01 1.59e-03 2.83e-02
SEC31A SEC31 homolog A, COPII coat complex component 4.94e-01 1.59e-03 2.83e-02
PAK4 p21 (RAC1) activated kinase 4 6.44e-01 1.62e-03 2.87e-02
NDUFV1 NADH:ubiquinone oxidoreductase core subunit V1 -6.78e-01 1.64e-03 2.90e-02
GON7 GON7 subunit of KEOPS complex -7.46e-01 1.64e-03 2.91e-02
TRAPPC10 trafficking protein particle complex subunit 10 7.33e-01 1.67e-03 2.95e-02
DDX6 DEAD-box helicase 6 4.67e-01 1.68e-03 2.96e-02
UBE2O ubiquitin conjugating enzyme E2 O 6.72e-01 1.68e-03 2.96e-02
P4HA1 prolyl 4-hydroxylase subunit alpha 1 -6.94e-01 1.70e-03 2.99e-02
RDX radixin -6.83e-01 1.73e-03 3.04e-02
PTPMT1 protein tyrosine phosphatase mitochondrial 1 -7.26e-01 1.76e-03 3.08e-02
ENY2 ENY2 transcription and export complex 2 subunit 3.26e-01 1.76e-03 3.08e-02
TOMM6 translocase of outer mitochondrial membrane 6 3.47e-01 1.79e-03 3.12e-02
PDE6B phosphodiesterase 6B 4.43e-01 1.80e-03 3.14e-02
ZNF519 zinc finger protein 519 6.97e-01 1.82e-03 3.17e-02
RPL13 ribosomal protein L13 -3.57e-01 1.83e-03 3.18e-02
ADAM8 ADAM metallopeptidase domain 8 -7.75e-01 1.84e-03 3.20e-02
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 2.25e-01 1.84e-03 3.20e-02
MRPL17 mitochondrial ribosomal protein L17 -4.08e-01 1.86e-03 3.22e-02
SMG7 SMG7 nonsense mediated mRNA decay factor 6.83e-01 1.86e-03 3.22e-02
ACAT1 acetyl-CoA acetyltransferase 1 -5.56e-01 1.88e-03 3.25e-02
ZNF716 zinc finger protein 716 6.00e-01 1.88e-03 3.25e-02
NDUFS7 NADH:ubiquinone oxidoreductase core subunit S7 -5.52e-01 1.89e-03 3.25e-02
SMIM29 small integral membrane protein 29 -8.68e-01 1.91e-03 3.29e-02
ZNF350 zinc finger protein 350 6.70e-01 1.92e-03 3.30e-02
TRMT112 tRNA methyltransferase subunit 11-2 3.00e-01 1.93e-03 3.31e-02
CWC27 CWC27 spliceosome associated cyclophilin 5.26e-01 1.94e-03 3.32e-02
HELLS helicase, lymphoid specific -6.06e-01 1.94e-03 3.32e-02
BAP1 BRCA1 associated protein 1 4.37e-01 1.96e-03 3.35e-02
PSME3IP1 proteasome activator subunit 3 interacting protein 1 -7.71e-01 1.97e-03 3.35e-02
SLC35A3 solute carrier family 35 member A3 5.38e-01 1.98e-03 3.38e-02
NONO non-POU domain containing octamer binding -4.01e-01 1.99e-03 3.39e-02
PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 5.78e-01 2.00e-03 3.39e-02
VPS28 VPS28 subunit of ESCRT-I -5.99e-01 2.00e-03 3.39e-02
H2AC13 H2A clustered histone 13 -7.91e-01 2.02e-03 3.41e-02
P4HB prolyl 4-hydroxylase subunit beta -4.45e-01 2.03e-03 3.42e-02
SMIM7 small integral membrane protein 7 3.59e-01 2.03e-03 3.42e-02
ABRAXAS2 abraxas 2, BRISC complex subunit 6.36e-01 2.03e-03 3.43e-02
RNF181 ring finger protein 181 -3.55e-01 2.05e-03 3.45e-02
VPS25 vacuolar protein sorting 25 homolog -5.17e-01 2.05e-03 3.45e-02
UPF2 UPF2 regulator of nonsense mediated mRNA decay 4.75e-01 2.06e-03 3.45e-02
RPL14 ribosomal protein L14 3.53e-01 2.06e-03 3.46e-02
RAMAC RNA guanine-7 methyltransferase activating subunit 5.19e-01 2.08e-03 3.48e-02
HDGF heparin binding growth factor 4.56e-01 2.08e-03 3.48e-02
FEN1 flap structure-specific endonuclease 1 -4.07e-01 2.09e-03 3.50e-02
DTYMK deoxythymidylate kinase -6.21e-01 2.12e-03 3.53e-02
NDUFC2 NADH:ubiquinone oxidoreductase subunit C2 2.50e-01 2.12e-03 3.54e-02
EIF3L eukaryotic translation initiation factor 3 subunit L -6.13e-01 2.13e-03 3.54e-02
TIMP1 TIMP metallopeptidase inhibitor 1 -3.18e-01 2.13e-03 3.54e-02
TMEM9B TMEM9 domain family member B 5.68e-01 2.16e-03 3.58e-02
CYB5R4 cytochrome b5 reductase 4 5.70e-01 2.17e-03 3.59e-02
COL13A1 collagen type XIII alpha 1 chain -6.99e-01 2.19e-03 3.62e-02
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 5.97e-01 2.21e-03 3.64e-02
HES1 hes family bHLH transcription factor 1 5.71e-01 2.22e-03 3.66e-02
AVL9 AVL9 cell migration associated 5.63e-01 2.25e-03 3.69e-02
SUMO3 small ubiquitin like modifier 3 5.19e-01 2.25e-03 3.69e-02
SEC14L6 SEC14 like lipid binding 6 6.98e-01 2.25e-03 3.70e-02
C11orf58 chromosome 11 open reading frame 58 2.81e-01 2.27e-03 3.71e-02
FLNA filamin A -6.38e-01 2.27e-03 3.71e-02
IFT20 intraflagellar transport 20 -7.10e-01 2.28e-03 3.71e-02
DAD1 defender against cell death 1 2.72e-01 2.28e-03 3.72e-02
RPL37 ribosomal protein L37 2.21e-01 2.29e-03 3.73e-02
MFSD9 major facilitator superfamily domain containing 9 6.48e-01 2.31e-03 3.76e-02
AK4 adenylate kinase 4 5.00e-01 2.33e-03 3.78e-02
CCDC113 coiled-coil domain containing 113 5.18e-01 2.34e-03 3.78e-02
NEPRO nucleolus and neural progenitor protein 6.35e-01 2.33e-03 3.78e-02
CHMP2B charged multivesicular body protein 2B 5.49e-01 2.35e-03 3.79e-02
ESAM endothelial cell adhesion molecule 4.91e-01 2.35e-03 3.80e-02
PRORP protein only RNase P catalytic subunit 5.50e-01 2.36e-03 3.80e-02
RALBP1 ralA binding protein 1 4.19e-01 2.37e-03 3.80e-02
RNF44 ring finger protein 44 5.58e-01 2.37e-03 3.80e-02
NFYC nuclear transcription factor Y subunit gamma 5.78e-01 2.37e-03 3.81e-02
HSPG2 heparan sulfate proteoglycan 2 4.29e-01 2.38e-03 3.82e-02
SPDEF SAM pointed domain containing ETS transcription factor -8.09e-01 2.38e-03 3.82e-02
TACC2 transforming acidic coiled-coil containing protein 2 5.55e-01 2.40e-03 3.83e-02
STMP1 short transmembrane mitochondrial protein 1 -5.62e-01 2.42e-03 3.85e-02
CAPNS1 calpain small subunit 1 -5.56e-01 2.42e-03 3.85e-02
OR2A5 olfactory receptor family 2 subfamily A member 5 5.76e-01 2.44e-03 3.88e-02
DDX47 DEAD-box helicase 47 5.45e-01 2.47e-03 3.92e-02
TMEM130 transmembrane protein 130 6.03e-01 2.47e-03 3.92e-02
VAMP4 vesicle associated membrane protein 4 6.71e-01 2.47e-03 3.92e-02
MAP1S microtubule associated protein 1S 5.59e-01 2.48e-03 3.93e-02
RGMA repulsive guidance molecule BMP co-receptor a 5.81e-01 2.49e-03 3.93e-02
CALM3 calmodulin 3 -6.12e-01 2.54e-03 4.01e-02
CEP250 centrosomal protein 250 -6.08e-01 2.56e-03 4.03e-02
NELFA negative elongation factor complex member A 6.69e-01 2.56e-03 4.03e-02
UBE2T ubiquitin conjugating enzyme E2 T -5.08e-01 2.60e-03 4.09e-02
CYBA cytochrome b-245 alpha chain -7.05e-01 2.62e-03 4.11e-02
CUTA cutA divalent cation tolerance homolog -5.05e-01 2.63e-03 4.11e-02
SYPL1 synaptophysin like 1 5.14e-01 2.62e-03 4.11e-02
C18orf21 chromosome 18 open reading frame 21 5.98e-01 2.64e-03 4.12e-02
DCBLD2 discoidin, CUB and LCCL domain containing 2 -4.39e-01 2.64e-03 4.12e-02
GDI2 GDP dissociation inhibitor 2 -4.40e-01 2.64e-03 4.12e-02
BSDC1 BSD domain containing 1 5.77e-01 2.67e-03 4.16e-02
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 5.63e-01 2.67e-03 4.16e-02
SDE2 SDE2 telomere maintenance homolog 5.88e-01 2.68e-03 4.16e-02
PGF placental growth factor 5.06e-01 2.69e-03 4.16e-02
DRAM2 DNA damage regulated autophagy modulator 2 6.07e-01 2.69e-03 4.17e-02
UHRF1 ubiquitin like with PHD and ring finger domains 1 -7.52e-01 2.70e-03 4.17e-02
SWI5 SWI5 homologous recombination repair protein -7.74e-01 2.70e-03 4.17e-02
OXSM 3-oxoacyl-ACP synthase, mitochondrial -6.20e-01 2.72e-03 4.20e-02
BPTF bromodomain PHD finger transcription factor 5.29e-01 2.74e-03 4.22e-02
AHCY adenosylhomocysteinase -5.49e-01 2.79e-03 4.30e-02
H2AC14 H2A clustered histone 14 -7.23e-01 2.80e-03 4.30e-02
SEC62 SEC62 homolog, preprotein translocation factor 3.44e-01 2.82e-03 4.33e-02
ANKRD45 ankyrin repeat domain 45 5.01e-01 2.84e-03 4.34e-02
HABP4 hyaluronan binding protein 4 7.89e-01 2.83e-03 4.34e-02
SUMF2 sulfatase modifying factor 2 -4.82e-01 2.85e-03 4.35e-02
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -5.08e-01 2.85e-03 4.35e-02
EIF4G3 eukaryotic translation initiation factor 4 gamma 3 -7.12e-01 2.86e-03 4.36e-02
CA5A carbonic anhydrase 5A 5.82e-01 2.88e-03 4.38e-02
CDYL chromodomain Y like 6.39e-01 2.88e-03 4.38e-02
IGHMBP2 immunoglobulin mu DNA binding protein 2 6.40e-01 2.88e-03 4.38e-02
PGS1 phosphatidylglycerophosphate synthase 1 6.32e-01 2.89e-03 4.39e-02
FAM107B family with sequence similarity 107 member B 5.69e-01 2.91e-03 4.40e-02
LBH LBH regulator of WNT signaling pathway 6.82e-01 2.91e-03 4.40e-02
SPATA21 spermatogenesis associated 21 5.72e-01 2.91e-03 4.40e-02
HMBS hydroxymethylbilane synthase -6.95e-01 2.92e-03 4.41e-02
MPHOSPH6 M-phase phosphoprotein 6 -5.62e-01 2.95e-03 4.45e-02
ANXA6 annexin A6 -5.30e-01 2.97e-03 4.47e-02
KLB klotho beta 5.83e-01 2.97e-03 4.47e-02
ELOVL6 ELOVL fatty acid elongase 6 -6.09e-01 3.01e-03 4.51e-02
ANKRD12 ankyrin repeat domain 12 5.18e-01 3.01e-03 4.52e-02
CRIM1 cysteine rich transmembrane BMP regulator 1 3.98e-01 3.06e-03 4.56e-02
GSS glutathione synthetase -5.59e-01 3.05e-03 4.56e-02
RPAP2 RNA polymerase II associated protein 2 4.81e-01 3.06e-03 4.56e-02
SLC7A11 solute carrier family 7 member 11 5.52e-01 3.06e-03 4.56e-02
STAG2 stromal antigen 2 -2.01e-01 3.06e-03 4.56e-02
TBPL1 TATA-box binding protein like 1 6.27e-01 3.06e-03 4.56e-02
MED17 mediator complex subunit 17 5.16e-01 3.07e-03 4.56e-02
IFITM2 interferon induced transmembrane protein 2 4.01e-01 3.08e-03 4.57e-02
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -6.47e-01 3.10e-03 4.60e-02
ANKRD13D ankyrin repeat domain 13D 6.65e-01 3.17e-03 4.69e-02
ATP5F1C ATP synthase F1 subunit gamma -3.22e-01 3.20e-03 4.73e-02
PRPS2 phosphoribosyl pyrophosphate synthetase 2 -5.99e-01 3.21e-03 4.74e-02
ZNF619 zinc finger protein 619 5.42e-01 3.24e-03 4.78e-02
RIC8A RIC8 guanine nucleotide exchange factor A -5.69e-01 3.26e-03 4.80e-02
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 5.43e-01 3.30e-03 4.85e-02
ZNF543 zinc finger protein 543 6.02e-01 3.30e-03 4.85e-02
MT1X metallothionein 1X -3.11e-01 3.31e-03 4.86e-02
CSTF1 cleavage stimulation factor subunit 1 5.11e-01 3.31e-03 4.86e-02
AVIL advillin 5.84e-01 3.32e-03 4.86e-02
DNAJC19 DnaJ heat shock protein family (Hsp40) member C19 -5.14e-01 3.32e-03 4.86e-02
PELO pelota mRNA surveillance and ribosome rescue factor 5.19e-01 3.34e-03 4.88e-02
ATP6V0B ATPase H+ transporting V0 subunit b 3.75e-01 3.38e-03 4.91e-02
FAM98B family with sequence similarity 98 member B 5.18e-01 3.38e-03 4.91e-02
GTF2H3 general transcription factor IIH subunit 3 -6.86e-01 3.37e-03 4.91e-02
ZNF430 zinc finger protein 430 5.98e-01 3.38e-03 4.91e-02
PHF19 PHD finger protein 19 4.83e-01 3.40e-03 4.93e-02
SLC25A29 solute carrier family 25 member 29 7.18e-01 3.41e-03 4.94e-02
FAM227A family with sequence similarity 227 member A 5.46e-01 3.41e-03 4.94e-02
BOP1 BOP1 ribosomal biogenesis factor -7.90e-01 3.42e-03 4.95e-02
PYURF PIGY upstream open reading frame 4.67e-01 3.42e-03 4.95e-02
ARSJ arylsulfatase family member J 5.47e-01 3.47e-03 4.99e-02
CALR calreticulin -2.92e-01 3.48e-03 4.99e-02
COX16 cytochrome c oxidase assembly factor COX16 3.83e-01 3.47e-03 4.99e-02
FOXF2 forkhead box F2 7.12e-01 3.47e-03 4.99e-02
KRT15 keratin 15 4.70e-01 3.46e-03 4.99e-02
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -5.30e-01 3.47e-03 4.99e-02

Gene Set Enrichment Analysis

The GSEA method was applied for all genes whose knockout resulted in at least 20 significantly differentially expressed genes.

ID Name p-value p-value (adj.) log2 Error ES NES
go:0044281 small molecule metabolic process 2.66e-11 1.04e-07 8.63e-01 -3.30e-01 -1.79e+00
go:0016491 oxidoreductase activity 2.29e-08 4.47e-05 7.34e-01 -3.67e-01 -1.87e+00
go:0048037 3.44e-08 4.48e-05 7.20e-01 -4.14e-01 -2.00e+00
go:0044282 small molecule catabolic process 1.06e-07 8.27e-05 7.05e-01 -4.48e-01 -2.06e+00
go:1901135 carbohydrate derivative metabolic process 8.50e-08 8.27e-05 7.05e-01 -3.46e-01 -1.77e+00
go:0006082 organic acid metabolic process 1.33e-07 8.67e-05 6.90e-01 -3.41e-01 -1.75e+00
go:0016607 nuclear speck 1.93e-07 1.08e-04 6.90e-01 3.70e-01 1.85e+00
go:0050662 1.32e-06 5.74e-04 6.44e-01 -4.35e-01 -1.97e+00
go:1901137 carbohydrate derivative biosynthetic process 2.56e-06 9.98e-04 6.27e-01 -3.56e-01 -1.78e+00
go:0003700 DNA-binding transcription factor activity 2.90e-06 1.03e-03 6.27e-01 3.09e-01 1.63e+00
go:0044283 small molecule biosynthetic process 5.52e-06 1.80e-03 6.11e-01 -3.38e-01 -1.69e+00
reactome:R-HSA-69190 DNA strand elongation 9.07e-06 2.73e-03 5.93e-01 -6.64e-01 -2.19e+00
go:0016071 mRNA metabolic process 9.93e-06 2.74e-03 5.93e-01 2.96e-01 1.56e+00
go:0016853 isomerase activity 1.05e-05 2.74e-03 5.93e-01 -4.75e-01 -1.98e+00
msig:M2044 KEGG_SPLICEOSOME 1.16e-05 2.83e-03 5.93e-01 4.25e-01 1.91e+00
msig:M5907 HALLMARK_ESTROGEN_RESPONSE_LATE 1.28e-05 2.95e-03 5.93e-01 -4.80e-01 -1.99e+00
go:0016054 organic acid catabolic process 1.65e-05 3.58e-03 5.76e-01 -4.52e-01 -1.92e+00
go:0005759 mitochondrial matrix 2.11e-05 4.35e-03 5.76e-01 -3.23e-01 -1.63e+00
go:0051262 protein tetramerization 2.41e-05 4.58e-03 5.76e-01 -5.02e-01 -2.01e+00
msig:M5925 HALLMARK_E2F_TARGETS 2.46e-05 4.58e-03 5.76e-01 -3.80e-01 -1.78e+00
go:0016829 lyase activity 3.07e-05 5.45e-03 5.57e-01 -4.74e-01 -1.95e+00
msig:M5935 HALLMARK_FATTY_ACID_METABOLISM 3.65e-05 5.57e-03 5.57e-01 -4.38e-01 -1.87e+00
go:0000375 RNA splicing, via transesterification reactions 3.78e-05 5.57e-03 5.57e-01 3.19e-01 1.62e+00
go:0072522 purine-containing compound biosynthetic process 3.47e-05 5.57e-03 5.57e-01 -4.21e-01 -1.83e+00
go:0032787 monocarboxylic acid metabolic process 4.67e-05 6.51e-03 5.57e-01 -3.69e-01 -1.73e+00
go:0055086 nucleobase-containing small molecule metabolic process 6.75e-05 8.79e-03 5.38e-01 -3.72e-01 -1.73e+00
go:0008380 RNA splicing 6.74e-05 8.79e-03 5.38e-01 3.05e-01 1.58e+00
msig:M16853 KEGG_DNA_REPLICATION 7.33e-05 9.24e-03 5.38e-01 -6.11e-01 -2.10e+00
go:0140097 catalytic activity, acting on DNA 8.38e-05 1.02e-02 5.38e-01 -4.40e-01 -1.85e+00
go:0072329 monocarboxylic acid catabolic process 8.59e-05 1.02e-02 5.38e-01 -5.13e-01 -2.00e+00
msig:M1386 KEGG_PENTOSE_PHOSPHATE_PATHWAY 1.17e-04 1.35e-02 5.38e-01 -7.17e-01 -2.06e+00
reactome:R-HSA-69205 G1/S-Specific Transcription 1.30e-04 1.45e-02 5.19e-01 -7.07e-01 -2.07e+00
go:0006281 DNA repair 1.37e-04 1.49e-02 5.19e-01 -3.03e-01 -1.54e+00
go:0006259 DNA metabolic process 1.89e-04 1.99e-02 5.19e-01 -2.84e-01 -1.49e+00
go:0051289 protein homotetramerization 2.19e-04 2.14e-02 5.19e-01 -5.33e-01 -1.96e+00
go:0006635 fatty acid beta-oxidation 2.14e-04 2.14e-02 5.19e-01 -5.47e-01 -1.99e+00
go:0051186 2.18e-04 2.14e-02 5.19e-01 -3.42e-01 -1.65e+00
go:0090407 organophosphate biosynthetic process 2.32e-04 2.21e-02 5.19e-01 -3.19e-01 -1.58e+00
go:0004536 deoxyribonuclease activity 2.38e-04 2.22e-02 5.19e-01 -6.42e-01 -2.03e+00
go:0046634 regulation of alpha-beta T cell activation 2.59e-04 2.30e-02 4.98e-01 6.71e-01 2.07e+00
go:0016604 nuclear body 2.55e-04 2.30e-02 4.98e-01 2.69e-01 1.43e+00
go:0008134 transcription factor binding 3.05e-04 2.59e-02 4.98e-01 2.94e-01 1.52e+00
go:0006261 DNA-dependent DNA replication 3.68e-04 3.06e-02 4.98e-01 -4.03e-01 -1.70e+00
go:0009062 fatty acid catabolic process 4.22e-04 3.44e-02 4.98e-01 -4.86e-01 -1.87e+00
go:0005684 U2-type spliceosomal complex 4.38e-04 3.48e-02 4.98e-01 4.33e-01 1.81e+00
go:0007517 muscle organ development 4.52e-04 3.48e-02 4.98e-01 3.86e-01 1.72e+00
go:0006260 DNA replication 4.68e-04 3.52e-02 4.98e-01 -3.48e-01 -1.63e+00
go:0035710 CD4-positive, alpha-beta T cell activation 4.78e-04 3.52e-02 4.98e-01 6.99e-01 2.02e+00
reactome:R-HSA-71387 Metabolism of carbohydrates 6.23e-04 4.50e-02 4.77e-01 -3.77e-01 -1.69e+00
go:0042440 pigment metabolic process 6.88e-04 4.52e-02 4.77e-01 -5.29e-01 -1.92e+00
go:0016614 oxidoreductase activity, acting on CH-OH group of donors 6.57e-04 4.52e-02 4.77e-01 -4.87e-01 -1.86e+00
reactome:R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 6.76e-04 4.52e-02 4.77e-01 -6.19e-01 -1.95e+00
go:0050661 NADP binding 6.49e-04 4.52e-02 4.77e-01 -6.20e-01 -1.96e+00
go:0005681 spliceosomal complex 7.07e-04 4.52e-02 4.77e-01 3.47e-01 1.64e+00
go:1903524 positive regulation of blood circulation 6.85e-04 4.52e-02 4.77e-01 6.60e-01 1.97e+00
reactome:R-HSA-72172 mRNA Splicing 7.17e-04 4.52e-02 4.77e-01 3.32e-01 1.59e+00
reactome:R-HSA-2299718 Condensation of Prophase Chromosomes 7.08e-04 4.52e-02 4.77e-01 6.18e-01 1.94e+00
reactome:R-HSA-69242 S Phase 7.46e-04 4.60e-02 4.77e-01 -3.68e-01 -1.65e+00
go:0044429 7.65e-04 4.60e-02 4.77e-01 -2.51e-01 -1.35e+00
reactome:R-HSA-69306 DNA Replication 7.64e-04 4.60e-02 4.77e-01 -3.85e-01 -1.66e+00
go:0005975 carbohydrate metabolic process 8.34e-04 4.87e-02 4.77e-01 -3.17e-01 -1.53e+00
go:0046631 alpha-beta T cell activation 8.27e-04 4.87e-02 4.77e-01 6.12e-01 1.98e+00
go:0044815 DNA packaging complex 8.84e-04 5.08e-02 4.77e-01 5.55e-01 1.92e+00
go:0005685 U1 snRNP 9.25e-04 5.24e-02 4.77e-01 6.94e-01 1.97e+00
go:0016053 organic acid biosynthetic process 9.77e-04 5.45e-02 4.55e-01 -3.77e-01 -1.64e+00
reactome:R-HSA-8978868 Fatty acid metabolism 1.01e-03 5.54e-02 4.55e-01 -4.47e-01 -1.79e+00
go:1901293 nucleoside phosphate biosynthetic process 1.04e-03 5.64e-02 4.55e-01 -3.49e-01 -1.61e+00
reactome:R-HSA-73933 Resolution of Abasic Sites (AP sites) 1.07e-03 5.66e-02 4.55e-01 -5.51e-01 -1.89e+00
go:0046390 ribose phosphate biosynthetic process 1.07e-03 5.66e-02 4.55e-01 -3.74e-01 -1.63e+00
go:0016860 intramolecular oxidoreductase activity 1.14e-03 5.79e-02 4.55e-01 -5.75e-01 -1.92e+00
reactome:R-HSA-1640170 Cell Cycle 1.14e-03 5.79e-02 4.55e-01 -2.71e-01 -1.40e+00
go:0016052 carbohydrate catabolic process 1.13e-03 5.79e-02 4.55e-01 -4.00e-01 -1.68e+00
go:1900034 regulation of cellular response to heat 1.20e-03 6.01e-02 4.55e-01 4.53e-01 1.77e+00
go:0098632 cell-cell adhesion mediator activity 1.26e-03 6.21e-02 4.55e-01 5.93e-01 1.84e+00
go:0044843 cell cycle G1/S phase transition 1.39e-03 6.46e-02 4.55e-01 -3.44e-01 -1.59e+00
go:0006270 DNA replication initiation 1.38e-03 6.46e-02 4.55e-01 -5.68e-01 -1.89e+00
go:0034440 lipid oxidation 1.38e-03 6.46e-02 4.55e-01 -4.84e-01 -1.83e+00
reactome:R-HSA-1912422 Pre-NOTCH Expression and Processing 1.36e-03 6.46e-02 4.55e-01 5.08e-01 1.83e+00
reactome:R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 1.43e-03 6.50e-02 4.55e-01 5.66e-01 1.90e+00
go:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 1.43e-03 6.50e-02 4.55e-01 5.06e-01 1.82e+00
reactome:R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 1.46e-03 6.55e-02 4.55e-01 3.07e-01 1.52e+00
reactome:R-HSA-977225 Amyloid fiber formation 1.52e-03 6.59e-02 4.55e-01 5.63e-01 1.91e+00