USP49 Data Analysis

HGNC Gene Name
ubiquitin specific peptidase 49
HGNC Gene Symbol
USP49
Identifiers
hgnc:20078 NCBIGene:25862 uniprot:Q70CQ1
Orthologs
mgi:2685391 rgd:1310513
INDRA Statements
deubiquitinations all statements
Pathway Commons
Search for USP49
Number of Papers
30 retrieved on 2022-05-22

DepMap Analysis

The Dependency Map (DepMap) is a genome-wide pooled CRISPR-Cas9 knockout proliferation screen conducted in more than 700 cancer cell lines spanning many different tumor lineages. Each cell line in the DepMap contains a unique barcode, and each gene knockout is assigned a “dependency score” on a per cell-line basis which quantifies the rate of CRISPR-Cas9 guide drop. It has been found that proteins with similar DepMap scores across cell lines, a phenomenon known as co-dependent genes, have closely related biological functions. This can include activity in the same or parallel pathways or membership in the same protein complex or the same pathway.

We identified the strongest seven co-dependent genes (“Symbol”) for DUBs and ran GO enrichment analysis. We used Biogrid, IntAct, and Pathway Commons PPIDs, and the NURSA protein-protein interaction databases (PPIDs) to determine whether co-dependent genes interact with one another. The “Evidence” column contains the PPIDs in which the interaction appears as well as whether there is support for the association by an INDRA statement. As another approach to identify potential interactors, we looked at proteomics data from the Broad Institute's Cancer Cell Line Encyclopedia (CCLE) for proteins whose expression across ~375 cell lines strongly correlated with the abundance of each DUB; it has previously been observed that proteins in the same complex are frequently significantly co-expressed. The correlations and associated p-values in the CCLE proteomics dataset are provided. And, we determined whether co-dependent genes yield similar transcriptomic signatures in the Broad Institute's Connectivity Map (CMap). A CMap score greater than 90 is considered significantly similar.

DepMap Correlations

Symbol Name DepMap Correlation Evidence CCLE Correlation CCLE Z-score CCLE p-value (adj) CCLE Significant CMAP Score CMAP Type

Dependency GO Term Enrichment

Gene set enrichment analysis was done on the genes correlated with USP49using the terms from Gene Ontology and gene sets derived from the Gene Ontology Annotations database via MSigDB.

Using the biological processes and other Gene Ontology terms from well characterized DUBs as a positive control, several gene set enrichment analyses were considered. Threshold-less methods like GSEA had relatively poor results. Over-representation analysis with a threshold of of the top 7 highest absolute value Dependency Map correlations yielded the best results and is reported below.

GO Identifier GO Name GO Type p-value p-value (adj.) q-value

Literature Mining

INDRA was used to automatically assemble known mechanisms related to USP49 from literature and knowledge bases. The first section shows only DUB activity and the second shows all other results.

Deubiquitinase Activity

psp cbn pc bel_lc signor biogrid lincs_drug tas hprd trrust ctd vhn pe drugbank omnipath conib crog dgi | rlimsp isi tees geneways eidos trips medscan sparser reach
USP49 deubiquitinates Histone_H2B. 6 / 6
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Usp49 in complex with RVB1 and SUG1 yeast homologues deubiquitinates H2B, this modification is required for efficient co-transcriptional splicing of a large set of exons.

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Here we report the purification of ubiquitin specific peptidase 49 (USP49) as a histone H2B specific deubiquitinase and demonstrate that H2B deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons.

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USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.

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It has been reported that USP49 deubiquitinates histone H2B and regulates co-transcriptional pre-mRNA splicing; interestingly, p53 is also mainly localized to the nucleus.

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Silencing Usp49 induces relatively small changes in gene expression, however alterations in H2B ubiquitination levels caused by Usp49 regulate U1A and U2B association with chromatin and binding to nascent pre-mRNA.

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USP49 forms a complex with RuvB-like1 (RVB1) and SUG1 and specifically deubiquitinates histone H2B in vitro and in vivo.
USP49 leads to the deubiquitination of TP53. 3 / 3
| 3

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Investigation of the mechanism revealed that USP49 interacts with the N terminus of p53 and suppresses several types of p53 ubiquitination.

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USP49 suppresses p53 ubiquitination.

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To assess this, we co-transfected HA-p53, Myc-ubiquitin, and Flag-USP49 into 293T cells, and found that USP49 suppressed ubiquitination of HA-p53.
USP49 deubiquitinates FKBP4. 2 / 2
| 1

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Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP 's capability to dephosphorylate AKT Furthermore, USP49 inhibited pancreatic cancer cell proliferation and enhanced cellular response to gemcitabine in a FKBP51-AKT-dependent manner.

ubibrowser
Here we report that a deubiquitinase, USP49, is a new regulator of the AKT pathway.| Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP's capability to dephosphorylate AKT Furthermore, USP49 inhibited pancreatic cancer cell proliferation and enhanced cellular response to gemcitabine in a FKBP51-AKT-dependent manner.
USP49 deubiquitinates H2BC21. 2 / 2
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ubibrowser
No evidence text available

ubibrowser
USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing.
USP49 deubiquitinates STING1. 2 / 2
| 1

ubibrowser
Mechanistically, USP49 removes K63-linked ubiquitin chains from MITA after HSV-1 infection which inhibits the aggregation of MITA and the subsequent recruitment of TBK1 to the signaling complex.

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Here, we report that USP49 interacts with and deubiquitinates MITA after HSV-1 infection, thereby turning down cellular antiviral responses.
USP49 deubiquitinates DUSP1. 1 / 1
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ubibrowser
Moreover, USP49 positively regulated DUSP1 expression through deubiquitinating DUSP1.
USP49 deubiquitinates H2BC10. 1 / 1
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USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing
USP49 deubiquitinates FKBP5. 1 / 1
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ubibrowser
Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP's capability to dephosphorylate AKT Furthermore, USP49 inhibited pancreatic cancer cell proliferation and enhanced cellular response to gemcitabine in a FKBP51-AKT-dependent manner.
USP49 deubiquitinates PTEN. 1 / 1
| 1

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Further studies indicated that USP49 deubiquitinated PTEN and stabilized PTEN protein, which suggested that USP49 inhibited PI3K and AKT signaling by stabilizing PTEN in NSCLC cells.

Other Statements

psp cbn pc bel_lc signor biogrid lincs_drug tas hprd trrust ctd vhn pe drugbank omnipath conib crog dgi | rlimsp isi tees geneways eidos trips medscan sparser reach
7 |
Valproic acid decreases the amount of USP49.
6 |
Valproic acid decreases the amount of USP49. 6 / 6
6 |

ctd
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Valproic acid increases the amount of USP49.
1 |
Valproic acid increases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
TFDP1 affects USP49
4 |
TFDP1 decreases the amount of USP49. 4 / 4
4 |

biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available
USP49 affects TP53
| 4
USP49 activates TP53.
| 3
USP49 activates TP53. 3 / 3
| 3

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USP49 upregulates p53 protein stability.

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However, knockdown of USP49 by shRNA reduced the level of p53 protein in HCT116 cells treated with or without Eto.

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To explore the mechanism by which USP49 enhances p53 stability and taking into consideration that USP49 is a member of the USP family of deubiquitinating enzymes, we hypothesized that USP49 may have an effect on p53 ubiquitination.
USP49 increases the amount of TP53.
| 1
Modified USP49 increases the amount of TP53. 1 / 1
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Overexpression of USP49 downregulated the expression levels of Cyclin D1, and upregulated p53 expression.
USP49 affects AKT
| 4
USP49 inhibits AKT.
| 3
USP49 inhibits AKT. 3 / 3
| 3

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Further studies indicated that USP49 deubiquitinated PTEN and stabilized PTEN protein, which suggested that USP49 inhibited PI3K and AKT signaling by stabilizing PTEN in NSCLC cells.

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In mechanism, overexpression of USP49 inhibited PI3K and AKT signaling, but knockdown of USP49 enhanced this signaling.

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In contrast, another DUB, USP49, inhibits AKT pathway by promoting interaction of PHLPP1 to AKT, thus facilitating the de-phosphorylation of AKT.
USP49 activates AKT.
| 1
USP49 activates AKT. 1 / 1
| 1

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In conclusion, we demonstrated that USP49 was functional in NSCLC cells, and inhibited NSCLC cell growth by suppressing PI3K and AKT signaling, suggesting that USP49 could be as a novel target for NSCLC therapy.
3 |
Trichostatin A decreases the amount of USP49. 3 / 3
3 |

ctd
No evidence text available

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ctd
No evidence text available
USP49 affects PI3K
| 3
USP49 inhibits PI3K.
| 2
USP49 inhibits PI3K. 2 / 2
| 2

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In mechanism, overexpression of USP49 inhibited PI3K and AKT signaling, but knockdown of USP49 enhanced this signaling.

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Further studies indicated that USP49 deubiquitinated PTEN and stabilized PTEN protein, which suggested that USP49 inhibited PI3K and AKT signaling by stabilizing PTEN in NSCLC cells.
USP49 activates PI3K.
| 1
USP49 activates PI3K. 1 / 1
| 1

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In conclusion, we demonstrated that USP49 was functional in NSCLC cells, and inhibited NSCLC cell growth by suppressing PI3K and AKT signaling, suggesting that USP49 could be as a novel target for NSCLC therapy.
Vorinostat affects USP49
2 |
Vorinostat decreases the amount of USP49. 2 / 2
2 |

ctd
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Phenylmercury acetate decreases the amount of USP49. 2 / 2
2 |

ctd
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No evidence text available
2 |
Panobinostat decreases the amount of USP49. 2 / 2
2 |

ctd
No evidence text available

ctd
No evidence text available
USP49 affects gemcitabine
| 2
| 2

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Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP 's capability to dephosphorylate AKT Furthermore, USP49 inhibited pancreatic cancer cell proliferation and enhanced cellular response to gemcitabine in a FKBP51-AKT-dependent manner.

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Luo et al. [XREF_BIBR] found that FKBP51 could promote PHLPP-Akt interaction and following Akt dephosphorylation at ser473, so that USP49 enhanced cellular response to gemcitabine through FKBP51-Akt signaling.

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Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP 's capability to dephosphorylate AKT Furthermore, USP49 inhibited pancreatic cancer cell proliferation and enhanced cellular response to gemcitabine in a FKBP51-AKT-dependent manner.

sparser
Mechanistically, USP49 deubiquitinates and stabilizes FKBP51, which in turn enhances PHLPP's capability to dephosphorylate AKT Furthermore, USP49 inhibited pancreatic cancer cell proliferation and enhanced cellular response to gemcitabine in a FKBP51-AKT-dependent manner.
USP49 affects cell growth
| 2
| 2

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As a result, overexpression of USP49 significantly inhibited cell growth of NSCLC cells.

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In conclusion, we demonstrated that USP49 was functional in NSCLC cells, and inhibited NSCLC cell growth by suppressing PI3K and AKT signaling, suggesting that USP49 could be as a novel target for NSCLC therapy.
LEF1 affects USP49
2 |
LEF1 decreases the amount of USP49. 2 / 2
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biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available
GTF3A affects USP49
2 |
GTF3A decreases the amount of USP49. 2 / 2
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biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available
E2F1 affects USP49
2 |
E2F1 decreases the amount of USP49. 2 / 2
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biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available
6-propyl-2-thiouracil decreases the amount of USP49. 2 / 2
2 |

ctd
No evidence text available

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2 |
Pirinixic acid decreases the amount of USP49.
1 |
Pirinixic acid decreases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
Pirinixic acid activates USP49.
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ctd
No evidence text available
Bisphenol A affects USP49
2 |
Bisphenol A increases the amount of USP49.
1 |
Bisphenol A increases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
Bisphenol A decreases the amount of USP49.
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Bisphenol A decreases the amount of USP49. 1 / 1
1 |

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No evidence text available
| 2
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USP49 inhibits ischemia-reperfusion-induced cell viability suppression and apoptosis in human AC16 cardiomyocytes through DUSP1-JNK1/2 signaling.
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Inhibiting JNK1/2 activation significantly inhibited USP49 knockdown induced the cell viability inhibition, apoptosis and the JNK1/2 activation in AC16 cardiomyocytes.
| 2
USP49 inhibits Cell Survival.
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Inhibiting JNK1/2 activation significantly inhibited USP49 knockdown induced the cell viability inhibition, apoptosis and the JNK1/2 activation in AC16 cardiomyocytes.
USP49 activates Cell Survival.
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USP49 inhibits ischemia-reperfusion-induced cell viability suppression and apoptosis in human AC16 cardiomyocytes through DUSP1-JNK1/2 signaling.
USP49 affects BBC3
| 2
Modified USP49 increases the amount of BBC3. 1 / 1
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Overexpression of USP49 significantly increased p21, BAX, and PUMA mRNA levels, whereas knockdown of USP49 suppressed p21, BAX, and PUMA levels when HCT116 cells were exposed to Eto.
USP49 increases the amount of BBC3. 1 / 1
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Overexpression of USP49 significantly increased p21, BAX, and PUMA mRNA levels, whereas knockdown of USP49 suppressed p21, BAX, and PUMA levels when HCT116 cells were exposed to Eto.

ctd
No evidence text available
Torcetrapib affects USP49
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Torcetrapib increases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
Thimerosal affects USP49
1 |
Thimerosal decreases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
Tetrachloromethane decreases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
Sunitinib affects USP49
1 |
Sunitinib decreases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
1 |
Silicon dioxide increases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
1 |
Schizandrin B decreases the amount of USP49. 1 / 1
1 |

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No evidence text available
1 |
Progesterone decreases the amount of USP49. 1 / 1
1 |

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No evidence text available
Pentanal affects USP49
1 |
Pentanal decreases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
Methylmercury chloride decreases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
Methyl methanesulfonate increases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
Hydralazine affects USP49
1 |
Hydralazine increases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
1 |
Hsa-miR-939-3p decreases the amount of USP49. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-6890-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-6852-5p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-6836-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-6829-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-6791-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-6783-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-6778-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-6756-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-6742-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-6741-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-6738-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-5088-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-5001-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-4749-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-4727-5p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-4638-5p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-4284 decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-324-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-3127-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-23b-5p decreases the amount of USP49. 1 / 1
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No evidence text available
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Hsa-miR-23a-5p decreases the amount of USP49. 1 / 1
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No evidence text available
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Hsa-miR-210-5p decreases the amount of USP49. 1 / 1
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No evidence text available
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Hsa-miR-1913 decreases the amount of USP49. 1 / 1
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No evidence text available
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Hsa-miR-1343-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-1307-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-1237-3p decreases the amount of USP49. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Formaldehyde increases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
Ethyl methanesulfonate increases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
Entinostat affects USP49
1 |
Entinostat decreases the amount of USP49. 1 / 1
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ctd
No evidence text available
Endosulfan affects USP49
1 |
Endosulfan increases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
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Dorsomorphin decreases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
| 1
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To this end, HCT116 cells stably transfected with or without Flag-USP49 were treated with 50mug/ml cycloheximide (CHX) for various time points, and the results showed a longer half-life of the p53 protein in cells overexpressing USP49.
Copper atom affects USP49
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Copper atom increases the amount of USP49. 1 / 1
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ctd
No evidence text available
All-trans-retinoic acid decreases the amount of USP49. 1 / 1
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No evidence text available
Abrine affects USP49
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Abrine increases the amount of USP49. 1 / 1
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ctd
No evidence text available
| 1
[6]-gingerol increases the amount of USP49. 1 / 1
| 1

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Interestingly, we also found that [6]-gingerol, an anti-OA drug, could upregulate the protein level of Usp49 and suppress the Wnt and beta-catenin signaling cascade in primary rat chondrocytes.
ZIC1 affects USP49
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ZIC1 decreases the amount of USP49. 1 / 1
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biopax:msigdb
No evidence text available
VDR affects USP49
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VDR decreases the amount of USP49. 1 / 1
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biopax:msigdb
No evidence text available
| 1
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Taken together, our study not only demonstrates that Usp49 can negatively regulate the progression of OA by inhibiting the Wnt and beta-catenin signaling cascade, but also elucidates the underlying molecular mechanisms.
USP49 affects mgl-1
| 1
USP49 decreases the amount of mgl-1. 1 / 1
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In contrast, a catalytic mutant USP11 (C266S) and USP49 which were used as negative controls, failed to reduce the ubiquitination level of Mgl-1.
USP49 affects etoposide
| 1
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Finally, we found that USP49 can increase cell sensitivity to etoposide (Eto)-induced DNA damage and that USP49-knockout mice are more susceptible to colorectal cancer induced by azoxymethane and dextran sulfate sodium (AOM and DSS).
USP49 affects cell cycle
| 1
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Further flow cytometry analysis showed that overexpressed USP49 induced cell cycle arrest at G0/G1 phase.
USP49 affects Wnt
| 1
USP49 activates Wnt. 1 / 1
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Taken together, our study not only demonstrates that Usp49 can negatively regulate the progression of OA by inhibiting the Wnt and beta-catenin signaling cascade, but also elucidates the underlying molecular mechanisms.

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PTPLAD2 and USP49 Involved in the Pathogenesis of Smoke Induced COPD by Integrative Bioinformatics Analysis.
USP49 affects PTEN
| 1
USP49 inhibits PTEN. 1 / 1
| 1

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Further studies indicated that USP49 deubiquitinated PTEN and stabilized PTEN protein, which suggested that USP49 inhibited PI3K and AKT signaling by stabilizing PTEN in NSCLC cells.
USP49 affects PHLPP1
| 1
USP49 inhibits PHLPP1. 1 / 1
| 1

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In contrast, another DUB, USP49, inhibits AKT pathway by promoting interaction of PHLPP1 to AKT, thus facilitating the de-phosphorylation of AKT.
USP49 affects JNK
| 1
USP49 activates JNK. 1 / 1
| 1

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Inhibiting JNK1/2 activation significantly inhibited USP49 knockdown induced the cell viability inhibition, apoptosis and the JNK1/2 activation in AC16 cardiomyocytes.
USP49 affects Histone_H2B
| 1
USP49 decreases the amount of Histone_H2B. 1 / 1
| 1

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Silencing Usp49 induces relatively small changes in gene expression, however alterations in H2B ubiquitination levels caused by Usp49 regulate U1A and U2B association with chromatin and binding to nascent pre-mRNA.
USP49 affects DUSP1
| 1
USP49 increases the amount of DUSP1. 1 / 1
| 1

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Moreover, USP49 positively regulated DUSP1 expression through deubiquitinating DUSP1.
USP49 affects CTNNB1
| 1
USP49 activates CTNNB1. 1 / 1
| 1

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Taken together, our study not only demonstrates that Usp49 can negatively regulate the progression of OA by inhibiting the Wnt and beta-catenin signaling cascade, but also elucidates the underlying molecular mechanisms.
TNF affects USP49
| 1
TNF activates USP49. 1 / 1
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Nonetheless, a minimum of two siRNA molecules led to increased levels of nuclear NF-kappaB in A549 cells depleted of A20, USP7, USP49, USP54, or FBXO36 and treated with TNF for 120min.
TFAP2C affects USP49
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TFAP2C decreases the amount of USP49. 1 / 1
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biopax:msigdb
No evidence text available
TFAP2A affects USP49
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TFAP2A decreases the amount of USP49. 1 / 1
1 |

biopax:msigdb
No evidence text available
Soman affects USP49
1 |
Soman increases the amount of USP49. 1 / 1
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ctd
No evidence text available
REPIN1 affects USP49
1 |
REPIN1 decreases the amount of USP49. 1 / 1
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biopax:msigdb
No evidence text available
PCB 180 affects USP49
1 |
PCB 180 increases the amount of USP49. 1 / 1
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ctd
No evidence text available
NSC 689534 affects USP49
1 |
NSC 689534 increases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
N-methyl-4-phenylpyridinium increases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
MYOD1 affects USP49
1 |
MYOD1 decreases the amount of USP49. 1 / 1
1 |

biopax:msigdb
No evidence text available
HAND1 affects USP49
1 |
HAND1 decreases the amount of USP49. 1 / 1
1 |

biopax:msigdb
No evidence text available
FOXO4 affects USP49
1 |
FOXO4 decreases the amount of USP49. 1 / 1
1 |

biopax:msigdb
No evidence text available
1 |
Dietary Fats increases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
1 |
C646 compound increases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available

ctd
No evidence text available
2-hydroxypropanoic acid increases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
1 |

ctd
No evidence text available
2,4,4'-trichlorobiphenyl increases the amount of USP49. 1 / 1
1 |

ctd
No evidence text available
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ctd
No evidence text available
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ctd
No evidence text available
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ctd
No evidence text available