USP36 Data Analysis

HGNC Gene Name
ubiquitin specific peptidase 36
HGNC Gene Symbol
USP36
Identifiers
hgnc:20062 NCBIGene:57602 uniprot:Q9P275
Orthologs
mgi:1919594 rgd:1309937
INDRA Statements
deubiquitinations all statements
Pathway Commons
Search for USP36
Number of Papers
50 retrieved on 2022-05-22

DepMap Analysis

The Dependency Map (DepMap) is a genome-wide pooled CRISPR-Cas9 knockout proliferation screen conducted in more than 700 cancer cell lines spanning many different tumor lineages. Each cell line in the DepMap contains a unique barcode, and each gene knockout is assigned a “dependency score” on a per cell-line basis which quantifies the rate of CRISPR-Cas9 guide drop. It has been found that proteins with similar DepMap scores across cell lines, a phenomenon known as co-dependent genes, have closely related biological functions. This can include activity in the same or parallel pathways or membership in the same protein complex or the same pathway.

We identified the strongest seven co-dependent genes (“Symbol”) for DUBs and ran GO enrichment analysis. We used Biogrid, IntAct, and Pathway Commons PPIDs, and the NURSA protein-protein interaction databases (PPIDs) to determine whether co-dependent genes interact with one another. The “Evidence” column contains the PPIDs in which the interaction appears as well as whether there is support for the association by an INDRA statement. As another approach to identify potential interactors, we looked at proteomics data from the Broad Institute's Cancer Cell Line Encyclopedia (CCLE) for proteins whose expression across ~375 cell lines strongly correlated with the abundance of each DUB; it has previously been observed that proteins in the same complex are frequently significantly co-expressed. The correlations and associated p-values in the CCLE proteomics dataset are provided. And, we determined whether co-dependent genes yield similar transcriptomic signatures in the Broad Institute's Connectivity Map (CMap). A CMap score greater than 90 is considered significantly similar.

DepMap Correlations

Symbol Name DepMap Correlation Evidence CCLE Correlation CCLE Z-score CCLE p-value (adj) CCLE Significant CMAP Score CMAP Type
ANAPC11 anaphase promoting complex subunit 11 0.235 0.12 0.55 1.43e-01
TBCD tubulin folding cofactor D 0.22 -0.07 -0.50 2.50e-01
EIF4A3 eukaryotic translation initiation factor 4A3 0.212 0.20 1.00 5.18e-04
NPLOC4 NPL4 homolog, ubiquitin recognition factor 0.21 0.04 0.11 6.21e-01
CARS1 cysteinyl-tRNA synthetase 1 0.207 -0.18 -1.06 2.21e-03
DHX37 DEAH-box helicase 37 0.2 0.49 2.60 5.52e-22
RRP12 ribosomal RNA processing 12 homolog 0.199 0.43 2.29 7.87e-17

Dependency GO Term Enrichment

Gene set enrichment analysis was done on the genes correlated with USP36using the terms from Gene Ontology and gene sets derived from the Gene Ontology Annotations database via MSigDB.

Using the biological processes and other Gene Ontology terms from well characterized DUBs as a positive control, several gene set enrichment analyses were considered. Threshold-less methods like GSEA had relatively poor results. Over-representation analysis with a threshold of of the top 7 highest absolute value Dependency Map correlations yielded the best results and is reported below.

GO Identifier GO Name GO Type p-value p-value (adj.) q-value
GO:0003724 RNA helicase activity Molecular Function 1.31e-04 2.82e-02 1.04e-02
GO:0140098 catalytic activity, acting on RNA Molecular Function 2.04e-04 4.42e-02 1.04e-02

Transcriptomics

The following table shows the significantly differentially expressed genes after knocking out USP36 using CRISPR-Cas9.

Knockout Differential Expression

Symbol Name log2-fold-change p-value p-value (adj.)
RPL17-C18orf32 RPL17-C18orf32 readthrough 1.17e+00 7.25e-10 1.60e-05
RPL17 ribosomal protein L17 1.12e+00 2.33e-08 2.57e-04
ATP5MC2 ATP synthase membrane subunit c locus 2 4.72e-01 1.51e-06 1.11e-02

Gene Set Enrichment Analysis

There were too few differentially expressed genes to run a meaningful GSEA.

Literature Mining

INDRA was used to automatically assemble known mechanisms related to USP36 from literature and knowledge bases. The first section shows only DUB activity and the second shows all other results.

Deubiquitinase Activity

psp cbn pc bel_lc signor biogrid lincs_drug tas hprd trrust ctd vhn pe drugbank omnipath conib crog dgi | rlimsp isi tees geneways eidos trips medscan sparser reach
USP36 deubiquitinates MYC. 5 / 5
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USP36 interacts with and deubiquitinates c-Myc in cells and in vitro, leading to the stabilization of c-Myc.

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Recent evidence has revealed that c-Myc can be deubiquitylated and regulated by USP28, USP36 and USP37.

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45 USP36 deubiquitinates and stabilizes c-Myc through interactions with FBW7gamma in the nucleolus.

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The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc.
USP36 deubiquitinates NPM1. 2 / 2
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We also tested whether a nucleolar deubiquitinase USP36, which deubiquitinates NPM XREF_BIBR, affects the MG132 caused NPM nucleolar retention in the UV treated cells.

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It was shown that NPM1 is deubiquitinated by USP36 (ubiquitin specific peptidase 36) in the nucleolus stabilizing NPM1 [52], which is in turn required for USP36 accumulation [53].
USP36 deubiquitinates Imd. 1 / 1
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USP36 deubiquitinates Imd for its degradation and, thus, represses Imd signaling.
USP36 leads to the deubiquitination of SNAI1. 1 / 1
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Subsequent sub-screening identified 23 DUBs that interact with SNAI1, out of which USP29, USP36, and USP37 upregulate and reduce polyubiquitination of the SNAI1 protein.
| PMC
USP36 deubiquitinates fibrillarin. 1 / 1
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USP36 deubiquitylated the nucleolar proteins nucleophosmin and B23 and fibrillarin, and stabilized them by counteracting ubiquitylation mediated proteasomal degradation.
USP36 deubiquitinates CFTR. 1 / 1
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USP36 associated with immunoprecipitated p.Phe508del-CFTR (XREF_FIG) and deubiquitinated CFTR in Rab5 + and more so Rab9 + endosomes in Talpha1 treated cells (XREF_FIG).
USP36 deubiquitinates Histone_H2B. 1 / 1
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Scrawny is an ubiquitin specific protease, homologue of human USP36 and yeast UBP10, which deubiquitylates histone H2B and functions in gene silencing.
USP36 deubiquitinates POLR1A. 1 / 1
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?In particular, we discovered that the largest subunit of RNA polymerase I (RNAPI) is stabilized via Ubp10-mediated deubiquitination.|USP36, the human ortholog of Ubp10, complements the ubp10螖 allele for RNAPI stability, pre-rRNA processing, and cell growth in yeast, suggesting that deubiquitination of RNAPI may be conserved in eukaryotes.
USP36 leads to the deubiquitination of guanine. 1 / 1
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Further investigation into the mechanisms proved that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt and beta-catenin signaling pathway and induce EMT.
USP36 deubiquitinates DHX33. 1 / 1
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Collectively, these results support that Usp36 is essential for cell and organism viability because of its role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, by regulating DHX33 stability.
Modified USP36 leads to the deubiquitination of NTRK1. 1 / 1
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Instead, USP36 interfered with the binding of Nedd4-2 to TrkA, and hence USP36 expression impaired the Nedd4-2-mediated ubiquitination of TrkA [XREF_BIBR].
USP36 deubiquitinates PPME1. 1 / 1
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ubibrowser
we demonstrate that USP36 regulates PME-1 through its deubiquitinating enzyme activity. USP36 increases PME-1 stability, and depletion of USP36 decreases the PME-1 expression level.
USP36 leads to the deubiquitination of dedicator of cytokinesis. 1 / 1
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Further investigation into the mechanisms proved that USP36 could directly bind to and mediate the deubiquitination of dedicator of cytokinesis 4 (DOCK4), a guanine nucleotide exchange factor (GEF) that could activate Wnt and beta-catenin signaling pathway and induce EMT.
USP36 deubiquitinates MYCN. 1 / 1
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These results indicate that USP36 interacts with and deubiquitinates MYCN, thereby promoting the stability of MYCN.
| PMC
USP36 deubiquitinates SOD2. 1 / 1
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we identified a deubiquitinating enzyme USP36 that regulates the protein stability of SOD2
USP36 deubiquitinates B23. 1 / 1
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USP36 deubiquitylated the nucleolar proteins nucleophosmin and B23 and fibrillarin, and stabilized them by counteracting ubiquitylation mediated proteasomal degradation.
USP36 deubiquitinates H2BC21. 1 / 1
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No evidence text available

Other Statements

psp cbn pc bel_lc signor biogrid lincs_drug tas hprd trrust ctd vhn pe drugbank omnipath conib crog dgi | rlimsp isi tees geneways eidos trips medscan sparser reach
USP36 affects autophagy
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| 1 6

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A prior study revealed that silencing of USP36, one of the deubiquitinating enzymes, could trigger selective autophagy via a p62 dependent pathway.

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As the above study revealed, USP36 promoted the cell proliferation and inhibited autophagy, while inhibiting autophagy have no impact on the cell proliferation.

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Therefore, USP36 inhibits the selective autophagy of protein aggregates at an early stage by removing the ubiquitin signal.

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USP36 seems to antagonize different autophagy related processes in a context dependent manner.

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On the contrary, silencing of USP36 triggered autophagy via a p62 dependent pathway.

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The deletion of USP36 of Drosophila melanogaster results in an inhibition of larval growth and activated constitutively autophagy in an mTOR independent manner.

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Therefore, USP36 inhibits the selective autophagy of protein aggregates at an early stage by removing the ubiquitin signal.

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USP36 Promotes NB Cell Proliferation and Tumor Phenotype.
| PMC

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Depletion of USP36 by shRNA in SK-N-BE ( 2 ) and IMR-32 resulted in a decrease in cell proliferation ( Figure 3A ) and reduced colony formation ( Figure 3B ) .
| PMC

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As the above study revealed, USP36 promoted the cell proliferation and inhibited autophagy, while inhibiting autophagy have no impact on the cell proliferation.

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Similar to the growth deficit, we observed with ubp10Delta yeast cells, knockdown of USP36 levels reduced proliferation of HeLa cells, and deletion of scrawny reduced the proliferation of follicle and intestinal stem cells in Drosophila.
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Pirinixic acid decreases the amount of USP36.
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Pirinixic acid decreases the amount of USP36. 2 / 2
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Pirinixic acid increases the amount of USP36.
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Pirinixic acid increases the amount of USP36. 1 / 1
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Pirinixic acid activates USP36.
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USP36 affects MYC
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USP36 activates MYC.
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USP36 activates MYC. 1 / 2
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XREF_BIBR - XREF_BIBR Moreover, the USP37 and USP36 can promote tumorigenesis by stabilizing c-Myc.
USP36 inhibits MYC.
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USP36 inhibits MYC. 1 / 1
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Thereafter, qRT‐PCR assays were performed on FBXW7, SKP2, USP28, and USP36, which confirmed that Dem could interact with FBXW7 and downregulate the expression of c‐Myc.
| PMC
USP36 increases the amount of MYC.
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USP36 increases the amount of MYC. 1 / 1
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Consistently, knockdown of USP36 reduces the levels of c-Myc and suppresses cell proliferation.
MYC affects USP36
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MYC decreases the amount of USP36. 2 / 3
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No evidence text available

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Cisplatin affects USP36
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Cisplatin decreases the amount of USP36.
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Cisplatin decreases the amount of USP36. 2 / 2
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Cisplatin increases the amount of USP36.
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Cisplatin increases the amount of USP36. 1 / 1
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USP36 affects PPME1
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USP36 activates PPME1.
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USP36 activates PPME1. 2 / 2
| 1 1

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Hence , we speculate that the up-regulation of PME-1 in HCC may be due to USP36 , which need further verified .

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USP36 increases PME-1 stability, and depletion of USP36 decreases the PME-1 expression level.
USP36 decreases the amount of PPME1.
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USP36 decreases the amount of PPME1. 1 / 1
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USP36 increases PME-1 stability, and depletion of USP36 decreases the PME-1 expression level.
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Titanium dioxide increases the amount of USP36. 2 / 2
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Cyclosporin A increases the amount of USP36. 2 / 2
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Bisphenol A affects USP36
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Bisphenol A increases the amount of USP36. 2 / 2
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USP36 affects translation
| 1 1
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Functionally, we show that knockdown of USP36 markedly impairs rRNA processing and translation.

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Functionally , we show that knockdown of USP36 markedly impairs rRNA processing and translation .
USP36 affects IMD
| 2
USP36 inhibits IMD. 2 / 2
| 2

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Another recent study demonstrated that the deubiquitinating enzyme Usp36, which had been shown to negatively regulate the IMD pathway in flies, also negatively regulates p62 dependent selective autophagy in flies and human cells [XREF_BIBR].

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USP36 removes K63-polyubiquitin chains from IMD and then appears to increase the addition of K48-ubiquitin chains and degradation of IMD.
USP36 affects ERK
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USP36 activates ERK. 2 / 2
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The Ubiquitin Specific Peptidase USP36 has been shown to interact with FBW7 to regulate MYC stability and enhance ERK and AKT signaling pathways.

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Furthermore, we demonstrate that USP36 promotes the ERK and Akt signaling pathways.
USP36 affects AKT
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USP36 activates AKT. 2 / 2
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Furthermore, we demonstrate that USP36 promotes the ERK and Akt signaling pathways.

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The Ubiquitin Specific Peptidase USP36 has been shown to interact with FBW7 to regulate MYC stability and enhance ERK and AKT signaling pathways.
JQ1 affects USP36
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JQ1 activates USP36. 2 / 2
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Unbiased integration of RNA-seq data from CASC15-003, NBAT1, USP36, and MYCN knockdowns and neuroblastoma cells treated with MYCN inhibitor JQ1, identified genes that are jointly regulated by the NBAT1/CASC15-003/USP36/MYCN pathway.
| PMC

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These novel MYCN dependent pathways were obtained following an unbiased integration of RNA-seq datasets from CASC15-003, NBAT1, USP36, and MYCN knockdowns and NB cells treated with the MYCN inhibitor JQ1.
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CREB1 affects USP36
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CREB1 decreases the amount of USP36. 2 / 2
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No evidence text available
| 1 1

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Functionally , we show that knockdown of USP36 markedly impairs rRNA processing and translation .

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Functionally, we show that knockdown of USP36 markedly impairs rRNA processing and translation.
| 2
| 1

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Importantly, we found that overexpression of USP36 markedly decreased ischemia induced apoptosis and oxidative stress in HK-2cells, which was accompanied by elevated c-Myc and SOD2 protein levels with alleviated ischemia induced ubiquitination of both proteins.
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Moreover, northern blot analysis has shown that USP36 deficiency induces aberrations in rRNA synthesis and apoptosis at the preimplantation stage of development.
Zinc atom affects USP36
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Zinc atom increases the amount of USP36. 1 / 1
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Vorinostat affects USP36
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Vorinostat decreases the amount of USP36. 1 / 1
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Tunicamycin affects USP36
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Tunicamycin increases the amount of USP36. 1 / 1
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Thapsigargin increases the amount of USP36. 1 / 1
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Sunitinib affects USP36
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Sunitinib increases the amount of USP36. 1 / 1
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Resveratrol affects USP36
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Resveratrol increases the amount of USP36. 1 / 1
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Potassium chromate increases the amount of USP36. 1 / 1
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Methylmercury chloride increases the amount of USP36. 1 / 1
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Mercury dichloride increases the amount of USP36. 1 / 1
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Melphalan affects USP36
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Melphalan increases the amount of USP36. 1 / 1
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Lipoprotein affects USP36
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This study aimed to uncover the function and mechanism of circ-ubiquitin specific peptidase 36 (USP36) in endothelial cells treated with oxidized low-density lipoprotein (ox-LDL).
Leflunomide affects USP36
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Leflunomide increases the amount of USP36. 1 / 1
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Indometacin affects USP36
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Indometacin decreases the amount of USP36. 1 / 1
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No evidence text available
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Hsa-miR-98-5p decreases the amount of USP36. 1 / 1
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Hsa-miR-9500 decreases the amount of USP36. 1 / 1
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No evidence text available
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Hsa-miR-873-3p decreases the amount of USP36. 1 / 1
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Hsa-miR-7515 decreases the amount of USP36. 1 / 1
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Hsa-miR-6849-5p decreases the amount of USP36. 1 / 1
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No evidence text available
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Hsa-miR-6840-3p decreases the amount of USP36. 1 / 1
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No evidence text available
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Hsa-miR-6770-5p decreases the amount of USP36. 1 / 1
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No evidence text available
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Hsa-miR-615-3p decreases the amount of USP36. 1 / 1
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Hsa-miR-6124 decreases the amount of USP36. 1 / 1
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No evidence text available
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Hsa-miR-6080 decreases the amount of USP36. 1 / 1
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No evidence text available
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Hsa-miR-6077 decreases the amount of USP36. 1 / 1
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No evidence text available
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Hsa-miR-582-5p decreases the amount of USP36. 1 / 1
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Hsa-miR-5703 decreases the amount of USP36. 1 / 1
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Hsa-miR-4531 decreases the amount of USP36. 1 / 1
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Hsa-miR-4516 decreases the amount of USP36. 1 / 1
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Hsa-miR-4499 decreases the amount of USP36. 1 / 1
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Hsa-miR-4434 decreases the amount of USP36. 1 / 1
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No evidence text available
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Hsa-miR-3681-5p decreases the amount of USP36. 1 / 1
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Hsa-miR-342-5p decreases the amount of USP36. 1 / 1
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No evidence text available
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Hsa-miR-329-5p decreases the amount of USP36. 1 / 1
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No evidence text available
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Hsa-miR-3154 decreases the amount of USP36. 1 / 1
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No evidence text available
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Hsa-miR-151a-3p decreases the amount of USP36. 1 / 1
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No evidence text available
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Hsa-miR-101-5p decreases the amount of USP36. 1 / 1
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No evidence text available
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Hsa-miR-101-3p decreases the amount of USP36. 1 / 1
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Haloperidol affects USP36
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Haloperidol increases the amount of USP36. 1 / 1
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Gentamycin affects USP36
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Gentamycin increases the amount of USP36. 1 / 1
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Geldanamycin increases the amount of USP36. 1 / 1
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Fluoranthene increases the amount of USP36. 1 / 1
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Fenofibrate affects USP36
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Fenofibrate decreases the amount of USP36. 1 / 1
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Ethanol affects USP36
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Ethanol decreases the amount of USP36. 1 / 1
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Endosulfan affects USP36
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Endosulfan increases the amount of USP36. 1 / 1
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Dicrotophos affects USP36
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Dicrotophos increases the amount of USP36. 1 / 1
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Cyclophosphamide hydrate increases the amount of USP36. 1 / 1
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Crocidolite asbestos increases the amount of USP36. 1 / 1
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Cobalt dichloride increases the amount of USP36. 1 / 1
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Chlordecone affects USP36
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Chlordecone increases the amount of USP36. 1 / 1
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Carbon nanotube decreases the amount of USP36. 1 / 1
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Atrazine affects USP36
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Atrazine decreases the amount of USP36. 1 / 1
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Amphotericin B increases the amount of USP36. 1 / 1
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All-trans-retinoic acid increases the amount of USP36. 1 / 1
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Abrine affects USP36
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Abrine increases the amount of USP36. 1 / 1
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USP36 is a deubiquitylating enzyme that removes ubiquitin from NPM1 leading to stabilization of NPM1 and improved nucleolar function [XREF_BIBR] while depletion of USP36 impairs ribosome biogenesis.
USP36 affects WDR6
| 1
Modified USP36 increases the amount of WDR6. 1 / 1
| 1

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Transcription levels of JMJD6, HSPA1A, WDR6, and MEIS1 were up-regulated by RE-IIBP overexpression and USP36 level was not changed (XREF_SUPPLEMENTARY).
USP36 affects Ubiquitin
| 1
| 1

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Therefore, USP36 inhibits the selective autophagy of protein aggregates at an early stage by removing the ubiquitin signal.
USP36 affects SQSTM1
| 1
USP36 inhibits SQSTM1. 1 / 1
| 1

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Another recent study demonstrated that the deubiquitinating enzyme Usp36, which had been shown to negatively regulate the IMD pathway in flies, also negatively regulates p62 dependent selective autophagy in flies and human cells [XREF_BIBR].
| 1

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USP36 deubiquitinates K29-linked polyubiquitination of PrimPol and increases its protein stability .
USP36 affects POLR1A
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USP36 activates POLR1A. 1 / 1
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Overexpression of USP36 effectively blocked RPA194 degradation, while that of HAUSP did not (XREF_FIG).
USP36 affects Neoplasms
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| 1

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Depletion of USP36 significantly reduced the tumor weight , tumor volume and Ki67 staining , indicating that USP36 harbors oncogenic properties ( Figure 3C and D ) .
| PMC
USP36 affects NTRK1
| 1
USP36 increases the amount of NTRK1. 1 / 1
| 1

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Moreover, USP36 depletion leads to enhanced total and surface TrkA expression that results in increased NGF mediated TrkA activation and signaling that augments PC12 cell differentiation.
USP36 affects MYCN
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USP36 increases the amount of MYCN. 1 / 1
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These results strongly suggest that USP36 positively regulates MYCN protein levels.
| PMC
USP36 affects MEIS1
| 1
Modified USP36 increases the amount of MEIS1. 1 / 1
| 1

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Transcription levels of JMJD6, HSPA1A, WDR6, and MEIS1 were up-regulated by RE-IIBP overexpression and USP36 level was not changed (XREF_SUPPLEMENTARY).
USP36 affects JMJD6
| 1
Modified USP36 increases the amount of JMJD6. 1 / 1
| 1

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Transcription levels of JMJD6, HSPA1A, WDR6, and MEIS1 were up-regulated by RE-IIBP overexpression and USP36 level was not changed (XREF_SUPPLEMENTARY).
USP36 affects Imd
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USP36 inhibits Imd. 1 / 1
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We report here that USP2 and USP34 and Puf, in addition to the previously described USP36 and Scny, prevent inappropriate activation of Imd dependent immune signal in unchallenged conditions.
USP36 affects HSPA1A
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Modified USP36 increases the amount of HSPA1A. 1 / 1
| 1

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Transcription levels of JMJD6, HSPA1A, WDR6, and MEIS1 were up-regulated by RE-IIBP overexpression and USP36 level was not changed (XREF_SUPPLEMENTARY).
USP36 affects HIF1A
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USP36 activates HIF1A. 1 / 1
| 1

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We, therefore, analyzed the expression of Cezanne, a deubiquitinating enzyme 36 that can rescue HIF1alpha from VHL mediated degradation by cleaving ubiquitin from it.
| 1

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207 In addition to Fbw7 , other E3 ligases , such as beta-TrCP1 , CHIP and FBXO32 , can also ubiquitinate c-Myc , mediate its subsequent degradation and inhibit tumorigenesis.208-210 Moreover , the USP37 and USP36 can promote tumorigenesis by stabilizing c-Myc.211 ,212 By mass spectrometry , SUMO ligase protein inhibitor of activated STAT ( PIAS ) and Sentrin-specific protease 7 ( SENP7 ) were also found to control the SUMOylation of c-Myc at K326 and regulate its ubiquitination and degradation ( Fig. 2c ) .213 Ubiquitination regulates p53 p53 , one of the most important tumor suppressors , works in multiple cellular processes , such as cell cycle regulation , DNA repair and apoptosis .
USP36 affects CDKN1A
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USP36 decreases the amount of CDKN1A. 1 / 1
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Consistently, knockdown of USP36 induced the expression of p21 and inhibits cell proliferation.
T-2 Toxin affects USP36
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T-2 Toxin increases the amount of USP36. 1 / 1
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ctd
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Soman affects USP36
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Soman increases the amount of USP36. 1 / 1
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ctd
No evidence text available
Plant Oils affects USP36
1 |
Plant Oils increases the amount of USP36. 1 / 1
1 |

ctd
No evidence text available
PCI 5002 affects USP36
1 |
PCI 5002 increases the amount of USP36. 1 / 1
1 |

ctd
No evidence text available
NPM1 affects USP36
| 1
NPM1 activates USP36. 1 / 1
| 1

reach
Interestingly, NPM1 itself can target USP36 to nucleoli by direct binding [XREF_BIBR].
MXD1 affects USP36
| 1
MXD1 activates USP36. 1 / 1
| 1

reach
Mechanistically, lnc-HZ01 promotes MXD1 mRNA transcription by up-regulating its transcription factor c-JUN and also enhances MXD1 protein stability by up-regulating its deubiquitin enzyme USP36.
MAX affects USP36
1 |
MAX decreases the amount of USP36. 1 / 1
1 |

biopax:msigdb
No evidence text available
1 |
Dietary Fats decreases the amount of USP36. 1 / 1
1 |

ctd
No evidence text available
1 |
D-glucopyranose decreases the amount of USP36. 1 / 1
1 |

ctd
No evidence text available
ATG5 affects USP36
| 1
ATG5 activates mutated USP36. 1 / 1
| 1

reach
However, the inability of Atg5 knockdown to suppress the USP36 mutant phenotype, as well as the accumulation of both GFP-Atg8a and p62 in USP36 mutant cells, suggests a defect in autophagic flux rather than a defect in the formation of autophagosomes.
1 |
17beta-estradiol increases the amount of USP36. 1 / 1
1 |

ctd
No evidence text available
1-phenylpropan-2-amine decreases the amount of USP36. 1 / 1
1 |

ctd
No evidence text available
1-methylanthracene increases the amount of USP36. 1 / 1
1 |

ctd
No evidence text available
1,2-dichloroethane decreases the amount of USP36. 1 / 1
1 |

ctd
No evidence text available
1 |

ctd
No evidence text available