USP34 Data Analysis

HGNC Gene Name
ubiquitin specific peptidase 34
HGNC Gene Symbol
USP34
Identifiers
hgnc:20066 NCBIGene:9736 uniprot:Q70CQ2
Orthologs
mgi:109473 rgd:1565181
INDRA Statements
deubiquitinations all statements
Pathway Commons
Search for USP34
Number of Papers
46 retrieved on 2022-05-22

DepMap Analysis

The Dependency Map (DepMap) is a genome-wide pooled CRISPR-Cas9 knockout proliferation screen conducted in more than 700 cancer cell lines spanning many different tumor lineages. Each cell line in the DepMap contains a unique barcode, and each gene knockout is assigned a “dependency score” on a per cell-line basis which quantifies the rate of CRISPR-Cas9 guide drop. It has been found that proteins with similar DepMap scores across cell lines, a phenomenon known as co-dependent genes, have closely related biological functions. This can include activity in the same or parallel pathways or membership in the same protein complex or the same pathway.

We identified the strongest seven co-dependent genes (“Symbol”) for DUBs and ran GO enrichment analysis. We used Biogrid, IntAct, and Pathway Commons PPIDs, and the NURSA protein-protein interaction databases (PPIDs) to determine whether co-dependent genes interact with one another. The “Evidence” column contains the PPIDs in which the interaction appears as well as whether there is support for the association by an INDRA statement. As another approach to identify potential interactors, we looked at proteomics data from the Broad Institute's Cancer Cell Line Encyclopedia (CCLE) for proteins whose expression across ~375 cell lines strongly correlated with the abundance of each DUB; it has previously been observed that proteins in the same complex are frequently significantly co-expressed. The correlations and associated p-values in the CCLE proteomics dataset are provided. And, we determined whether co-dependent genes yield similar transcriptomic signatures in the Broad Institute's Connectivity Map (CMap). A CMap score greater than 90 is considered significantly similar.

DepMap Correlations

Symbol Name DepMap Correlation Evidence CCLE Correlation CCLE Z-score CCLE p-value (adj) CCLE Significant CMAP Score CMAP Type
LUZP1 leucine zipper protein 1 -0.21 -0.11 -0.68 8.72e-02
PKN1 protein kinase N1 0.207 Reactome (1) 0.15 0.76 1.00e-02
CLEC2A C-type lectin domain family 2 member A -0.203
ZMAT3 zinc finger matrin-type 3 0.203 -0.10 -0.63 2.21e-01
BTBD9 BTB domain containing 9 0.197
ZHX2 zinc fingers and homeoboxes 2 -0.196 Pathway Commons INDRA (1) -0.20 -1.20 4.73e-04
RBP5 retinol binding protein 5 -0.193

Dependency GO Term Enrichment

Gene set enrichment analysis was done on the genes correlated with USP34using the terms from Gene Ontology and gene sets derived from the Gene Ontology Annotations database via MSigDB.

Using the biological processes and other Gene Ontology terms from well characterized DUBs as a positive control, several gene set enrichment analyses were considered. Threshold-less methods like GSEA had relatively poor results. Over-representation analysis with a threshold of of the top 7 highest absolute value Dependency Map correlations yielded the best results and is reported below.

GO Identifier GO Name GO Type p-value p-value (adj.) q-value

Transcriptomics

The following table shows the significantly differentially expressed genes after knocking out USP34 using CRISPR-Cas9.

Knockout Differential Expression

Symbol Name log2-fold-change p-value p-value (adj.)
MCM10 minichromosome maintenance 10 replication initiation factor 8.25e-01 2.69e-06 5.52e-03
PLAT plasminogen activator, tissue type -6.30e-01 1.48e-06 5.52e-03
CALM2 calmodulin 2 -2.54e-01 1.25e-05 1.71e-02
MT-CO2 mitochondrially encoded cytochrome c oxidase II -2.64e-01 1.80e-05 1.85e-02
NOP56 NOP56 ribonucleoprotein 4.16e-01 3.08e-05 2.52e-02
NUDT4 nudix hydrolase 4 -3.92e-01 4.32e-05 2.95e-02
BMP4 bone morphogenetic protein 4 5.62e-01 8.43e-05 3.77e-02
HELLS helicase, lymphoid specific 5.31e-01 7.37e-05 3.77e-02
MTCO2P12 MT-CO2 pseudogene 12 -3.23e-01 9.15e-05 3.77e-02
RANGAP1 Ran GTPase activating protein 1 5.24e-01 9.20e-05 3.77e-02
DTYMK deoxythymidylate kinase 4.56e-01 1.26e-04 4.68e-02

Gene Set Enrichment Analysis

There were too few differentially expressed genes to run a meaningful GSEA.

Literature Mining

INDRA was used to automatically assemble known mechanisms related to USP34 from literature and knowledge bases. The first section shows only DUB activity and the second shows all other results.

Deubiquitinase Activity

psp cbn pc bel_lc signor biogrid lincs_drug tas hprd trrust ctd vhn pe drugbank omnipath conib crog dgi | rlimsp isi tees geneways eidos trips medscan sparser reach
USP34 deubiquitinates NFIC. 5 / 5
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USP34 deubiquitinates and stabilizes NFIC.

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Mechanically, we demonstrated that USP34 deubiquitinates and stabilizes NFIC during odontoblast differentiation.

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XREF_BIBR, XREF_BIBR Our research identified that USP34 deubiquitinates and stabilizes NFIC to promote odontoblast differentiation and thus regulates root formation.

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To test whether USP34 dependent deubiquitination of NFIC is involved in odontogenic differentiation of DPCs, DPCs were infected with Lv-NFIC, or Lv-GFP as control.

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Ubiquitination assay showed increased ubiquitination level of NFIC in USP34 deficient 293T cells, indicating the presence of USP34 dependent deubiquitination of NFIC.
USP34 leads to the deubiquitination of AXIN1. 2 / 2
| 1

ubibrowser
No evidence text available

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USP34 reduced the ubiquitination of AXIN1, but the catalytic mutant of USP34 does not reduce the ubiquitination of AXIN1.
USP34 deubiquitinates RNF168. 2 / 2
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A similar observation was seen when we immunoblotted immunoprecipitated RNF168 proteins with antibodies specific for lys48-ubiquitin linkages (XREF_FIG D), suggesting that USP34 may deubiquitylate and stablize RNF168.

ubibrowser
Review
USP34 deubiquitinates AXIN. 1 / 1
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UBPY and USP8 positively regulates the pathway by modifying Frizzled (Mukai et al., 2010), whereas USP34 deubiquitinates Axin and consequently works as a negative regulator of the WNT pathway (Lui et [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]
USP34 deubiquitinates AXIN1 on lysine. 1 / 1
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biopax:reactome
No evidence text available
USP34 deubiquitinates AXIN2. 1 / 1
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ubibrowser
No evidence text available
USP34 deubiquitinates CFTR. 1 / 1
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For example, in this and a previous study we observed that neither USP34, nor USP8 deubiquitinate CFTR, and only USP10 activity was inhibited by Cif XREF_BIBR, XREF_BIBR.
USP34 deubiquitinates AXIN2 on lysine. 1 / 1
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biopax:reactome
No evidence text available

Other Statements

psp cbn pc bel_lc signor biogrid lincs_drug tas hprd trrust ctd vhn pe drugbank omnipath conib crog dgi | rlimsp isi tees geneways eidos trips medscan sparser reach
USP34 affects Wnt
| 5
USP34 activates Wnt.
| 4
USP34 activates Wnt. 4 / 4
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For example, Christodoulides et al. reported that mutation C256Y in WNT10B was associated with overweight or obesity because the mutation was unable to activate canonical Wnt pathway [XREF_BIBR]; and Choi et al. found that indirubin-3 '-oxime (I3O), also an activator of the Wnt signaling like USP34, inhibited the development of obesity in high-fat diet fed mice [XREF_BIBR].

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Finally, we found the SNORA70B and its hose gene USP34 might directly regulate Wnt signalling pathway to promote tumorigenesis in ccRCC.

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Moreover, USP34 positively regulates Wnt signaling pathway [XREF_BIBR] and plays a role in DNA damage response control [XREF_BIBR].

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Moreover, USP34 positively regulates Wnt signaling pathway [XREF_BIBR], which plays an important role in gender differentiation, folliculogenesis, ovulation and other biological processes in reproduction [XREF_BIBR].
USP34 inhibits Wnt.
| 1
USP34 inhibits Wnt. 1 / 1
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This indicates that USP34 suppresses Wnt and beta-catenin signaling, due to degradation of beta-catenin resulting from increased stability of AXIN1 [XREF_BIBR].
4 |
Benzo[a]pyrene decreases the amount of USP34.
3 |
Benzo[a]pyrene decreases the amount of USP34. 3 / 3
3 |

ctd
No evidence text available

ctd
No evidence text available

ctd
No evidence text available
Benzo[a]pyrene increases the amount of USP34.
1 |
Benzo[a]pyrene increases the amount of USP34. 1 / 1
1 |

ctd
No evidence text available
USP34 affects NFkappaB
| 4
USP34 activates NFkappaB.
| 3
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We present evidence that knockdown of Ubiquitin Specific Protease 34 (USP34) selectively enhanced NF-kappaB activation driven by TCR engagement, similarly to siRNA against the well characterized DUB cylindromatosis (CYLD).

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Combined, these results indicate that USP34 shares some functional similarities with CYLD and selectively targets the NF-kappaB signaling pathway.

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Hence, our results suggest that USP34 likely functions downstream of the CBM-IKK nexus to enhance NF-kappaB activation.
USP34 inhibits NFkappaB.
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| 1

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USP34 also suppresses NFkappaB activation.
MYC affects USP34
3 |
MYC decreases the amount of USP34. 3 / 3
3 |

biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available
CEBPA affects USP34
3 |
CEBPA decreases the amount of USP34. 3 / 3
3 |

biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available
3 |
Trichostatin A decreases the amount of USP34.
2 |
Trichostatin A decreases the amount of USP34. 2 / 2
2 |

ctd
No evidence text available

ctd
No evidence text available
Trichostatin A increases the amount of USP34.
1 |
Trichostatin A increases the amount of USP34. 1 / 1
1 |

ctd
No evidence text available

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Downregulation of USP34 could inhibit proliferation and migration in PANC-1 cells via inhibiting PRR11, and inactivating p38 MAPK signaling.

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In this study, downregulation of USP34 markedly inhibited proliferation and migration, and induced apoptosis in PANC-1 cells.

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In addition, USP34 overexpression promoted PANC-1 cell proliferation and migration via up-regulating the proteins of p-AKT and p-PKC.
USP34 affects RNF168
| 3
USP34 activates RNF168.
| 2
USP34 activates RNF168. 2 / 2
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We concluded that USP34 promotes RNF168 dependent ubiquitylation events at DSBs.

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Specifically, USP34 promotes RNF168 dependent functions at DSBs.
USP34 inhibits RNF168.
| 1
USP34 inhibits RNF168. 1 / 1
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Another DUB, USP7, has also been shown to deubiquitinate and stabilize RNF168 [XREF_BIBR]; however, RNF168 is itself polyubiquitinated and destabilized upon IR treatment, which is reversed by USP34, suggesting that USP34 specifically stabilizes RNF168 when DNA becomes damaged [XREF_BIBR].
2 |
Valproic acid decreases the amount of USP34. 2 / 2
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ctd
No evidence text available

ctd
No evidence text available
Succimer affects USP34
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Succimer decreases the amount of USP34. 2 / 2
2 |

ctd
No evidence text available

ctd
No evidence text available
Magnetite nanoparticle decreases the amount of USP34. 2 / 2
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ctd
No evidence text available

ctd
No evidence text available
2 |

ctd
No evidence text available

ctd
No evidence text available
USP34 affects AXIN
| 2
USP34 activates AXIN. 2 / 2
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In colon carcinoma cell lines that show activation of Wnt and beta-catenin signaling downstream of the DC, Axin and USP34 were found to positively regulate beta-catenin-dependent transcription [XREF_BIBR] whereby USP34 supported the nuclear accumulation of Axin [XREF_BIBR].

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For example, USP34 increases the stability of Axin, thereby promoting its nuclear accumulation (Lui et al., 2011).
MAX affects USP34
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MAX decreases the amount of USP34. 2 / 2
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biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available
LEF1 affects USP34
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LEF1 decreases the amount of USP34. 2 / 2
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biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available
2 |

ctd
No evidence text available

ctd
No evidence text available
2 |

ctd
No evidence text available

ctd
No evidence text available
2 |
Formaldehyde increases the amount of USP34.
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Formaldehyde increases the amount of USP34. 1 / 1
1 |

ctd
No evidence text available
Formaldehyde decreases the amount of USP34.
1 |
Formaldehyde decreases the amount of USP34. 1 / 1
1 |

ctd
No evidence text available
USP34 affects tpa-1
| 2
Modified USP34 increases the amount of tpa-1. 1 / 1
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On the other hand, USP34 overexpressing remarkably up-regulated the expression of p-AKT and p-PKC in cells.
USP34 increases the amount of tpa-1. 1 / 1
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Subsequently, western blotting assay indicated that USP34 silencing significantly down-regulated the expression of p-AKT and p-PKC in cells.
USP34 affects PNN
| 2
USP34 decreases the amount of PNN.
| 1
USP34 decreases the amount of PNN. 1 / 1
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Similarly as observed for Dpt, overexpressing USP34 significantly reduced Drs expression at 12 and 24hours after infection with the non pathogenic Gram positive bacteria Micrococcus luteus.
USP34 activates PNN.
| 1
USP34 activates PNN. 1 / 1
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However, while USP2 is also required to prevent excessive activation of the Imd pathway in infected flies, USP34 displays differential requirement depending on the antimicrobial peptide gene analysed : silencing Usp34 enhanced the activation of AttA, Drs and IM1.
USP34 affects NFIC
| 1 1
USP34 inhibits NFIC.
| 1
USP34 inhibits NFIC. 1 / 1
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Furthermore, we treated 293T cells with cycloheximide (CHX), a protein translation inhibitor, and observed that depletion of USP34 accelerated the degradation of NFIC.
USP34 activates NFIC.
| 1
USP34 activates NFIC. 1 / 1
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eidos
Furthermore , we treated 293 T cells with cycloheximide ( CHX ) , a protein translation inhibitor , and observed that depletion of USP34 accelerated the degradation of NFIC ( Fig. 4b , d ) .
USP34 affects CTNNB1
| 2
USP34 inhibits CTNNB1.
| 1
USP34 inhibits CTNNB1. 1 / 1
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This indicates that USP34 suppresses Wnt and beta-catenin signaling, due to degradation of beta-catenin resulting from increased stability of AXIN1 [XREF_BIBR].
USP34 decreases the amount of CTNNB1.
| 1
Modified USP34 decreases the amount of CTNNB1. 1 / 1
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Also, decreased USP34 expression resulted in decreased expression of AXIN1, and increased expression of beta-catenin.
USP34 affects AKT
| 2
Modified USP34 increases the amount of phosphorylated AKT. 1 / 1
| 1

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On the other hand, USP34 overexpressing remarkably up-regulated the expression of p-AKT and p-PKC in cells.
USP34 increases the amount of phosphorylated AKT. 1 / 1
| 1

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Subsequently, western blotting assay indicated that USP34 silencing significantly down-regulated the expression of p-AKT and p-PKC in cells.
Zinc protoporphyrin increases the amount of USP34. 1 / 1
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ctd
No evidence text available
Vorinostat affects USP34
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Vorinostat decreases the amount of USP34. 1 / 1
1 |

ctd
No evidence text available
Vincristine affects USP34
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Vincristine increases the amount of USP34. 1 / 1
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ctd
No evidence text available
Tunicamycin affects USP34
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Tunicamycin decreases the amount of USP34. 1 / 1
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ctd
No evidence text available
Tungsten affects USP34
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Tungsten decreases the amount of USP34. 1 / 1
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ctd
No evidence text available
Topotecan affects USP34
1 |
Topotecan decreases the amount of USP34. 1 / 1
1 |

ctd
No evidence text available
Sunitinib affects USP34
1 |
Sunitinib increases the amount of USP34. 1 / 1
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ctd
No evidence text available
Potassium dichromate decreases the amount of USP34. 1 / 1
1 |

ctd
No evidence text available
Potassium chromate decreases the amount of USP34. 1 / 1
1 |

ctd
No evidence text available
Oxaliplatin affects USP34
1 |
Oxaliplatin decreases the amount of USP34. 1 / 1
1 |

ctd
No evidence text available
Miconazole affects USP34
1 |
Miconazole decreases the amount of USP34. 1 / 1
1 |

ctd
No evidence text available
Methylmercury chloride decreases the amount of USP34. 1 / 1
1 |

ctd
No evidence text available
Methyl methanesulfonate increases the amount of USP34. 1 / 1
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ctd
No evidence text available
1 |

ctd
No evidence text available
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Lead diacetate increases the amount of USP34. 1 / 1
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ctd
No evidence text available
Jinfukang affects USP34
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Jinfukang decreases the amount of USP34. 1 / 1
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ctd
No evidence text available
Indometacin affects USP34
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Indometacin decreases the amount of USP34. 1 / 1
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ctd
No evidence text available
1 |
Hsa-miR-485-5p decreases the amount of USP34. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-23a-3p decreases the amount of USP34. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-218-5p decreases the amount of USP34. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-21-5p decreases the amount of USP34. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-19b-3p decreases the amount of USP34. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-192-5p decreases the amount of USP34. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-127-5p decreases the amount of USP34. 1 / 1
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biopax:mirtarbase
No evidence text available
Etoposide affects USP34
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Paralleling the situation with TCR, knocking down USP34 markedly increased NF-kappaB in cells treated with TNFalpha or etoposide.
Ethanol affects USP34
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Ethanol decreases the amount of USP34. 1 / 1
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ctd
No evidence text available
Doxorubicin affects USP34
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Doxorubicin decreases the amount of USP34. 1 / 1
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ctd
No evidence text available
1 |
Dorsomorphin decreases the amount of USP34. 1 / 1
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ctd
No evidence text available
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Dexamethasone decreases the amount of USP34. 1 / 1
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ctd
No evidence text available
Decabromodiphenyl ether decreases the amount of USP34. 1 / 1
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ctd
No evidence text available
Clobetasol affects USP34
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Clobetasol decreases the amount of USP34. 1 / 1
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ctd
No evidence text available
Cisplatin affects USP34
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Cisplatin decreases the amount of USP34. 1 / 1
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ctd
No evidence text available
1 |
Chlorpyrifos decreases the amount of USP34. 1 / 1
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ctd
No evidence text available
Cadmium dichloride decreases the amount of USP34. 1 / 1
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ctd
No evidence text available
Bisphenol F affects USP34
1 |
Bisphenol F decreases the amount of USP34. 1 / 1
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ctd
No evidence text available
Bisphenol A affects USP34
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Bisphenol A decreases the amount of USP34. 1 / 1
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ctd
No evidence text available
1 |
Aflatoxin B1 increases the amount of USP34. 1 / 1
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ctd
No evidence text available
Abrine affects USP34
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Abrine decreases the amount of USP34. 1 / 1
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ctd
No evidence text available
ZHX2 affects USP34
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ZHX2 decreases the amount of USP34. 1 / 1
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biopax:msigdb
No evidence text available
1 |
Vehicle Emissions increases the amount of USP34. 1 / 1
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ctd
No evidence text available

sparser
However, the authors also suggest that loss of USP34 inhibited β-catenin mediated transcription indicating that USP34 may function downstream of β-catenin to regulate nuclear accumulation of AXIN .
USP34 affects titanium
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Taken together, our data demonstrate that specific deletion of Usp34 in mesenchymal stem cells impairs fixation of titanium implants in mice.

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Finally, we found the SNORA70B and its hose gene USP34 might directly regulate Wnt signalling pathway to promote tumorigenesis in ccRCC.
USP34 affects disulfur
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USP34 inhibits the Toll pathway in S2 cells.
USP34 affects cell growth
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In addition, knockdown of USP34 could significantly inhibit LSCC cell growth, but overexpression of SOX2 could reverse this effect.

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The expression of USP34 in human MSCs increases after osteogenic induction while depletion of USP34 inhibits osteogenic differentiation.
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In this study, downregulation of USP34 markedly inhibited proliferation and migration, and induced apoptosis in PANC-1 cells.
USP34 affects TCR
| 1
USP34 inhibits TCR. 1 / 1
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Another deubiquitinase, USP34, has been shown to inhibit TCR and CD28 stimulated NF-kappaB activation in the Jurkat T-cell line.
USP34 affects SP7
| 1
USP34 activates SP7. 1 / 1
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eidos
Depletion of USP34 in DPCs also led to decreased expression of SP7 and DSPP , the downstream targets of NFIC ( Fig. 3d ) .
USP34 affects SOX2
| 1
USP34 decreases the amount of SOX2. 1 / 1
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Usp9x KD but not Usp34 KD (XREF_FIG) reduced SOX2 levels in both BRAF mutant A375, SK-Mel28 (XREF_FIG), and NRAS-mutant SK-Mel147 (XREF_FIG) melanoma cell lines.
USP34 affects SLPI
| 1
USP34 inhibits SLPI. 1 / 1
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Depeletion of USP34 inhibited the ALP activity and ARS staining.

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Another DUB, USP7, has also been shown to deubiquitinate and stabilize RNF168 [XREF_BIBR]; however, RNF168 is itself polyubiquitinated and destabilized upon IR treatment, which is reversed by USP34, suggesting that USP34 specifically stabilizes RNF168 when DNA becomes damaged [XREF_BIBR].
USP34 affects RIEG2
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USP34 inhibits RIEG2. 1 / 1
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Depeletion of USP34 inhibited the ALP activity and ARS staining.
USP34 affects PRR11
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USP34 increases the amount of PRR11. 1 / 1
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Moreover, silencing of USP34 obviously downregulated the levels of PRR11 and p-p38 in PANC-1 cells.
USP34 affects PP38
| 1
USP34 increases the amount of PP38. 1 / 1
| 1

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Moreover, silencing of USP34 obviously downregulated the levels of PRR11 and p-p38 in PANC-1 cells.
USP34 affects NFKBIA
| 1
USP34 activates NFKBIA. 1 / 1
| 1

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USP34 knockdown in Jurkat cells promotes mitogen stimulated IkappaBalpha degradation without enhancing IKK activation, suggesting that this deubiquitinase may modulate the proteolytic process involved in IkappaBalpha degradation.
USP34 affects Imd
| 1
USP34 inhibits Imd. 1 / 1
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We report here that USP2 and USP34 and Puf, in addition to the previously described USP36 and Scny, prevent inappropriate activation of Imd dependent immune signal in unchallenged conditions.
USP34 affects H4atta
| 1
USP34 activates H4atta. 1 / 1
| 1

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However, while USP2 is also required to prevent excessive activation of the Imd pathway in infected flies, USP34 displays differential requirement depending on the antimicrobial peptide gene analysed : silencing Usp34 enhanced the activation of AttA, Drs and IM1.
USP34 affects DNA Damage
| 1
| 1

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USP34 promotes cellular responses to DNA damage.
USP34 affects CDH1
| 1
USP34 inhibits CDH1. 1 / 1
| 1

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Inhibition of USP34 in NMuMG cells induced EMT, as evidenced by the upregulation of EMT markers including N-cadherin, phospho-Smad3, Snail and active-beta-catenin, as well as the downregulation of Axin 1 and E-cadherin.
USP34 affects CD28
| 1
USP34 inhibits CD28. 1 / 1
| 1

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Another deubiquitinase, USP34, has been shown to inhibit TCR and CD28 stimulated NF-kappaB activation in the Jurkat T-cell line.
USP34 affects Bom1
| 1
USP34 activates Bom1. 1 / 1
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However, while USP2 is also required to prevent excessive activation of the Imd pathway in infected flies, USP34 displays differential requirement depending on the antimicrobial peptide gene analysed : silencing Usp34 enhanced the activation of AttA, Drs and IM1.
USP34 affects AXIN1
| 1
USP34 inhibits AXIN1. 1 / 1
| 1

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Inhibition of USP34 in NMuMG cells induced EMT, as evidenced by the upregulation of EMT markers including N-cadherin, phospho-Smad3, Snail and active-beta-catenin, as well as the downregulation of Axin 1 and E-cadherin.
USP34 affects AMFR
| 1
USP34 activates AMFR. 1 / 1
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We demonstrate that knockdown of USP34 facilitates proteasomal degradation of gp78 and consequently impairs the function of gp78 in regulating lipid droplet formation.
TCR affects USP34
| 1
TCR activates USP34. 1 / 1
| 1

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Consistent with the primary screening, NF-kappaB reporter activity was similarly boosted upon TCR stimulation in USP34- and CYLD silenced Jurkat when compared to control non targeting siRNA transfected cells.
TCF4 affects USP34
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TCF4 decreases the amount of USP34. 1 / 1
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biopax:msigdb
No evidence text available
1 |
Phthalic Acids increases the amount of USP34. 1 / 1
1 |

ctd
No evidence text available
NR6A1 affects USP34
1 |
NR6A1 decreases the amount of USP34. 1 / 1
1 |

biopax:msigdb
No evidence text available
NFIC affects USP34
| 1
NFIC activates USP34. 1 / 1
| 1

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Overexpression of NFIC partially rescues the odontogenic potential of USP34 deficient DPCs.
NFE2L1 affects USP34
1 |
NFE2L1 decreases the amount of USP34. 1 / 1
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biopax:msigdb
No evidence text available
MYCN affects USP34
1 |
MYCN decreases the amount of USP34. 1 / 1
1 |

biopax:msigdb
No evidence text available
MAFG affects USP34
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MAFG decreases the amount of USP34. 1 / 1
1 |

biopax:msigdb
No evidence text available
HSF1 affects USP34
1 |
HSF1 decreases the amount of USP34. 1 / 1
1 |

biopax:msigdb
No evidence text available
FOXF2 affects USP34
1 |
FOXF2 decreases the amount of USP34. 1 / 1
1 |

biopax:msigdb
No evidence text available
FOXD1 affects USP34
1 |
FOXD1 decreases the amount of USP34. 1 / 1
1 |

biopax:msigdb
No evidence text available
CTNNB1 affects USP34
| 1
CTNNB1 increases the amount of USP34. 1 / 1
| 1

reach
However, the authors also suggest that loss of USP34 inhibited beta-catenin mediated transcription indicating that USP34 may function downstream of beta-catenin to regulate nuclear accumulation of AXI[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]
CRX affects USP34
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CRX decreases the amount of USP34. 1 / 1
1 |

biopax:msigdb
No evidence text available
BPTF affects USP34
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BPTF decreases the amount of USP34. 1 / 1
1 |

biopax:msigdb
No evidence text available
Antirheumatic Agents increases the amount of USP34. 1 / 1
1 |

ctd
No evidence text available
Air Pollutants, Occupational increases the amount of USP34. 1 / 1
1 |

ctd
No evidence text available
ATM affects USP34
| 1
ATM activates USP34. 1 / 1
| 1

reach
As chemical inhibition of ATM using KU55933 inhibited USP34 IRIF, we examined whether DSB association of USP34 may require an intact H2AX dependent DNA damage signaling pathway.
1 |

ctd
No evidence text available
2-hydroxypropanoic acid decreases the amount of USP34. 1 / 1
1 |

ctd
No evidence text available
1 |

ctd
No evidence text available
1 |

ctd
No evidence text available
1 |
(-)-demecolcine increases the amount of USP34. 1 / 1
1 |

ctd
No evidence text available
1 |

ctd
No evidence text available
1 |

ctd
No evidence text available