STAMBPL1 Data Analysis

HGNC Gene Name
STAM binding protein like 1
HGNC Gene Symbol
STAMBPL1
Identifiers
hgnc:24105 NCBIGene:57559 uniprot:Q96FJ0
Orthologs
mgi:1923880 rgd:1583011
INDRA Statements
deubiquitinations all statements
Pathway Commons
Search for STAMBPL1
Number of Papers
27 retrieved on 2022-05-22

DepMap Analysis

The Dependency Map (DepMap) is a genome-wide pooled CRISPR-Cas9 knockout proliferation screen conducted in more than 700 cancer cell lines spanning many different tumor lineages. Each cell line in the DepMap contains a unique barcode, and each gene knockout is assigned a “dependency score” on a per cell-line basis which quantifies the rate of CRISPR-Cas9 guide drop. It has been found that proteins with similar DepMap scores across cell lines, a phenomenon known as co-dependent genes, have closely related biological functions. This can include activity in the same or parallel pathways or membership in the same protein complex or the same pathway.

We identified the strongest seven co-dependent genes (“Symbol”) for DUBs and ran GO enrichment analysis. We used Biogrid, IntAct, and Pathway Commons PPIDs, and the NURSA protein-protein interaction databases (PPIDs) to determine whether co-dependent genes interact with one another. The “Evidence” column contains the PPIDs in which the interaction appears as well as whether there is support for the association by an INDRA statement. As another approach to identify potential interactors, we looked at proteomics data from the Broad Institute's Cancer Cell Line Encyclopedia (CCLE) for proteins whose expression across ~375 cell lines strongly correlated with the abundance of each DUB; it has previously been observed that proteins in the same complex are frequently significantly co-expressed. The correlations and associated p-values in the CCLE proteomics dataset are provided. And, we determined whether co-dependent genes yield similar transcriptomic signatures in the Broad Institute's Connectivity Map (CMap). A CMap score greater than 90 is considered significantly similar.

DepMap Correlations

Symbol Name DepMap Correlation Evidence CCLE Correlation CCLE Z-score CCLE p-value (adj) CCLE Significant CMAP Score CMAP Type

Dependency GO Term Enrichment

Gene set enrichment analysis was done on the genes correlated with STAMBPL1using the terms from Gene Ontology and gene sets derived from the Gene Ontology Annotations database via MSigDB.

Using the biological processes and other Gene Ontology terms from well characterized DUBs as a positive control, several gene set enrichment analyses were considered. Threshold-less methods like GSEA had relatively poor results. Over-representation analysis with a threshold of of the top 7 highest absolute value Dependency Map correlations yielded the best results and is reported below.

GO Identifier GO Name GO Type p-value p-value (adj.) q-value

Literature Mining

INDRA was used to automatically assemble known mechanisms related to STAMBPL1 from literature and knowledge bases. The first section shows only DUB activity and the second shows all other results.

Deubiquitinase Activity

psp cbn pc bel_lc signor biogrid lincs_drug tas hprd trrust ctd vhn pe drugbank omnipath conib crog dgi | rlimsp isi tees geneways eidos trips medscan sparser reach
STAMBPL1 leads to the deubiquitination of CNTN2. 1 / 1
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The deubiquitination of Tax-1 can be also mediated by STAM binding protein like 1 (STAMBPL1), which was identified in an RNA interference screen XREF_BIBR.
STAMBPL1 leads to the deubiquitination of Tax. 1 / 1
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Importantly, STAMBPL1 does not induce Tax de-ubiquitination but protects Tax from degradation.

Other Statements

psp cbn pc bel_lc signor biogrid lincs_drug tas hprd trrust ctd vhn pe drugbank omnipath conib crog dgi | rlimsp isi tees geneways eidos trips medscan sparser reach
STAMBPL1 affects BIRC5
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STAMBPL1 inhibits BIRC5.
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Honokiol Enhances TRAIL Mediated Apoptosis through STAMBPL1 Induced Survivin and c-FLIP Degradation.

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Ectopic expression of STAMBPL1 significantly inhibited CEP induced survivin downregulation (XREF_FIG F).

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Next, we investigated whether overexpression of STAMBPL1 prevents CEP induced survivin downregulation.
STAMBPL1 activates BIRC5.
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Knockdown of STAMBPL1 reduced survivin and c-FLIP protein levels, while overexpression of STAMBPL1 inhibited honokinol induced survivin and c-FLIP degradation.

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Our findings provided that honokiol could overcome TRAIL resistance through survivin and c-FLIP degradation induced by inhibition of STAMBPL1 expression.
STAMBPL1 increases the amount of BIRC5.
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STAMBPL1 increases the amount of BIRC5. 1 / 1
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Cepharanthine Enhances TRAIL Mediated Apoptosis Through STAMBPL1 Mediated Downregulation of Survivin Expression in Renal Carcinoma Cells.
STAMBPL1 decreases the amount of BIRC5.
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STAMBPL1 decreases the amount of BIRC5. 1 / 1
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Knockdown of STAMBPL1 reduced survivin and c-FLIP protein levels, while overexpression of STAMBPL1 inhibited honokinol induced survivin and c-FLIP degradation.
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Valproic acid decreases the amount of STAMBPL1.
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Valproic acid decreases the amount of STAMBPL1. 4 / 4
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Valproic acid increases the amount of STAMBPL1.
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Valproic acid increases the amount of STAMBPL1. 1 / 1
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Cyclosporin A increases the amount of STAMBPL1. 3 / 3
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STAMBPL1 RNAi depletion triggered caspase-3/-7-dependent apoptosis in PC3 and DU145 cells.

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Taken together, these studies show that STAMBPL1 depletion induces apoptosis by promoting XIAP lysosomal degradation, and suggest that targeting deubiquitinase STAMBPL1 might offer promising therapeutic strategy for prostate cancer.
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Targeting the Deubiquitinase STAMBPL1 Triggers Apoptosis in Prostate Cancer Cells by Promoting XIAP Degradation.
STAMBPL1 affects STAMBP
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STAMBPL1 inhibits STAMBP.
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Next, we compared the K63-diUb (FRET) cleavage inhibition by the UbVs with STAMBP JAMM to the inhibition of fulllength STAMBP activated by STAM protein and full-length STAMBPL1.
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Next, we compared the K63-diUb (FRET) cleavage inhibition by the UbVs with STAMBPJAMM to the inhibition of full-length STAMBP activated by STAM protein and full-length STAMBPL1.
STAMBPL1 activates STAMBP.
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Next, we compared the K63-diUb (FRET) cleavage inhibition by the UbVs with STAMBPJAMM to the inhibition of full-length STAMBP activated by STAM protein and full-length STAMBPL1.
STAMBPL1 affects NFkappaB
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Silencing of STAMBPL1 with siRNA inhibits Tax activation of both the canonical and noncanonical NF-kappaB signaling pathways.
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Modified STAMBPL1 activates NFkappaB. 1 / 1
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Overexpression of wild-type STAMBPL1, but not a catalytically inactive mutant, enhances Tax mediated NF-kappaB activation and the induction of NF-kappaB target genes.
| PMC
STAMBPL1 affects CFLAR
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STAMBPL1 activates CFLAR.
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Our findings provided that honokiol could overcome TRAIL resistance through survivin and c-FLIP degradation induced by inhibition of STAMBPL1 expression.

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Knockdown of STAMBPL1 reduced survivin and c-FLIP protein levels, while overexpression of STAMBPL1 inhibited honokinol induced survivin and c-FLIP degradation.
STAMBPL1 decreases the amount of CFLAR.
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STAMBPL1 decreases the amount of CFLAR. 1 / 1
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Knockdown of STAMBPL1 reduced survivin and c-FLIP protein levels, while overexpression of STAMBPL1 inhibited honokinol induced survivin and c-FLIP degradation.
STAMBPL1 affects Tax
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STAMBPL1 activates Tax. 2 / 2
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Furthermore, overexpression of STAMBPL1 enhances the stability of Tax by blocking its proteasomal degradation, whereas siRNA silencing of STAMBPL1 promotes Tax degradation.
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Silencing of STAMBPL1 with siRNA inhibits Tax activation of both the canonical and noncanonical NF-kappaB signaling pathways.
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(+)-JQ1 compound decreases the amount of STAMBPL1. 2 / 2
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Silicon dioxide increases the amount of STAMBPL1.
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Silicon dioxide increases the amount of STAMBPL1. 1 / 1
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Silicon dioxide decreases the amount of STAMBPL1.
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Silicon dioxide decreases the amount of STAMBPL1. 1 / 1
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Cisplatin increases the amount of STAMBPL1.
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Cisplatin increases the amount of STAMBPL1. 1 / 1
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Cisplatin decreases the amount of STAMBPL1.
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Cisplatin decreases the amount of STAMBPL1. 1 / 1
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Bisphenol A increases the amount of STAMBPL1.
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Bisphenol A increases the amount of STAMBPL1. 1 / 1
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Bisphenol A decreases the amount of STAMBPL1.
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Bisphenol A decreases the amount of STAMBPL1. 1 / 1
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NFkappaB affects STAMBPL1
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NFkappaB inhibits STAMBPL1.
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Overexpression of wild-type STAMBPL1, but not a catalytically inactive mutant, enhanced Tax mediated NF-kappaB activation, whereas silencing of STAMBPL1 with siRNA impaired Tax activation of both the canonical and noncanonical NF-kappaB signaling pathways.
NFkappaB activates STAMBPL1.
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Overexpression of wild-type STAMBPL1, but not a catalytically inactive mutant, enhanced Tax mediated NF-kappaB activation, whereas silencing of STAMBPL1 with siRNA impaired Tax activation of both the canonical and noncanonical NF-kappaB signaling pathways.
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Vincristine decreases the amount of STAMBPL1. 1 / 1
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Urethane affects STAMBPL1
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Urethane decreases the amount of STAMBPL1. 1 / 1
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Tunicamycin increases the amount of STAMBPL1. 1 / 1
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Triadimefon increases the amount of STAMBPL1. 1 / 1
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Topotecan decreases the amount of STAMBPL1. 1 / 1
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Thapsigargin increases the amount of STAMBPL1. 1 / 1
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Sulforaphane increases the amount of STAMBPL1. 1 / 1
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Resveratrol increases the amount of STAMBPL1. 1 / 1
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Propiconazole increases the amount of STAMBPL1. 1 / 1
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Progesterone decreases the amount of STAMBPL1. 1 / 1
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Potassium chromate decreases the amount of STAMBPL1. 1 / 1
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Paracetamol decreases the amount of STAMBPL1. 1 / 1
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Oxaliplatin decreases the amount of STAMBPL1. 1 / 1
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Nickel sulfate decreases the amount of STAMBPL1. 1 / 1
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Nickel atom increases the amount of STAMBPL1. 1 / 1
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Methyl methanesulfonate decreases the amount of STAMBPL1. 1 / 1
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Methamphetamine decreases the amount of STAMBPL1. 1 / 1
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Melphalan decreases the amount of STAMBPL1. 1 / 1
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Lead diacetate decreases the amount of STAMBPL1. 1 / 1
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Jinfukang decreases the amount of STAMBPL1. 1 / 1
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Ionomycin increases the amount of STAMBPL1. 1 / 1
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Hsa-miR-941 decreases the amount of STAMBPL1. 1 / 1
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biopax:mirtarbase
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Hsa-miR-885-5p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-766-3p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-6868-3p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-6849-3p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-6837-3p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-6754-3p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-6720-5p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-6512-3p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-548p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-5197-5p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-508-5p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-4778-3p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-4633-5p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-412-3p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-23c decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-23b-3p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-23a-3p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-215-5p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-192-5p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-130a-5p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-1248 decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-1237-3p decreases the amount of STAMBPL1. 1 / 1
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Hsa-miR-103a-3p decreases the amount of STAMBPL1. 1 / 1
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Hexabromocyclododecane decreases the amount of STAMBPL1. 1 / 1
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Formaldehyde decreases the amount of STAMBPL1. 1 / 1
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Folic acid increases the amount of STAMBPL1. 1 / 1
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Flutamide increases the amount of STAMBPL1. 1 / 1
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Flusilazole increases the amount of STAMBPL1. 1 / 1
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Fluoranthene increases the amount of STAMBPL1. 1 / 1
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Fenarimol increases the amount of STAMBPL1. 1 / 1
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Ethyl methanesulfonate decreases the amount of STAMBPL1. 1 / 1
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Ethanol affects STAMBPL1
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Ethanol increases the amount of STAMBPL1. 1 / 1
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Entinostat decreases the amount of STAMBPL1. 1 / 1
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Endosulfan increases the amount of STAMBPL1. 1 / 1
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Doxorubicin decreases the amount of STAMBPL1. 1 / 1
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Dorsomorphin decreases the amount of STAMBPL1. 1 / 1
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Choline affects STAMBPL1
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Choline increases the amount of STAMBPL1. 1 / 1
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Calcitriol increases the amount of STAMBPL1. 1 / 1
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Butanal affects STAMBPL1
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Butanal increases the amount of STAMBPL1. 1 / 1
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Benzo[a]pyrene increases the amount of STAMBPL1. 1 / 1
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Atrazine affects STAMBPL1
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Atrazine decreases the amount of STAMBPL1. 1 / 1
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All-trans-retinoic acid increases the amount of STAMBPL1. 1 / 1
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Aflatoxin B1 increases the amount of STAMBPL1. 1 / 1
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Acetamide increases the amount of STAMBPL1. 1 / 1
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Abrine affects STAMBPL1
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Abrine increases the amount of STAMBPL1. 1 / 1
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Tobacco Smoke Pollution decreases the amount of STAMBPL1. 1 / 1
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As a result, viral transcription and replication are greatly suppressed by either LEF1 or STAMBPL1, resulting in selective viral replication in LEF1 and STAMPBPL1 low expressing cells.
STAMBPL1 affects XIAP
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Taken together, these studies show that STAMBPL1 depletion induces apoptosis by promoting XIAP lysosomal degradation, and suggest that targeting deubiquitinase STAMBPL1 might offer promising therapeutic strategy for prostate cancer.
STAMBPL1 affects TGFB
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STAMBPL1 activates TGFB. 1 / 1
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Finally, AMSH-LP and UCHL5 promote TGF-beta responses through their interaction with inhibitory I-SMADs [XREF_BIBR, XREF_BIBR].
STAMBPL1 affects SMAD7
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Similarly, AMSH-LP has been reported to sequester SMAD7, thereby exerting a positive impact on the TGFbeta pathway (XREF_FIG C) XREF_BIBR.
STAMBPL1 affects RPN11
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In fact, whereas the Ins-2 loop of AMSH-LP contacts the proximal ubiquitin, restricting linkage specificity [44], in Rpn11, it anchors the enzyme to the proteasome [45,66].
STAMBPL1 affects MYC
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STAMBPL1 decreases the amount of MYC. 1 / 1
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It is of great interest that the C-terminal-half-deleted mutants of AMSH and AMSH-LP, which lack the JAMM motifs, are unable to induce the IL-2-mediated c- myc expression.
N-nitrosodiethylamine increases the amount of STAMBPL1. 1 / 1
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MYC affects STAMBPL1
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MYC activates mutated STAMBPL1. 1 / 1
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Second, defective intracellular trafficking and localization, originating from D406G germline mutation of STAMBPL1 and enhanced by MYC network activation, inhibit cell polarity establishment and cell differentiation, preventing cell cycle exit.
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L-methionine increases the amount of STAMBPL1. 1 / 1
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FOXO1 affects STAMBPL1
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Transcriptionally active FOXO1 increases the amount of STAMBPL1. 1 / 1
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Supplemental Table S1. Transcripts found in Class I [activated by FKHR]
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Cuprizone decreases the amount of STAMBPL1. 1 / 1
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BRCC3 affects STAMBPL1
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BRCC3 deubiquitinates STAMBPL1. 1 / 1
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To identify the DUB associated with NALP7, we over-expressed plasmids expressing several candidate DUBs including BRCC3, which deubiquitinates NALP3, COPS5, STAMBPL1, USP7 and the endosome associated DUBs, STAMBP and USP8.
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Aroclor 1254 decreases the amount of STAMBPL1. 1 / 1
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Air Pollutants increases the amount of STAMBPL1. 1 / 1
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AZM551248 increases the amount of STAMBPL1. 1 / 1
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2-hydroxypropanoic acid decreases the amount of STAMBPL1. 1 / 1
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2-butoxyethanol decreases the amount of STAMBPL1. 1 / 1
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17beta-estradiol decreases the amount of STAMBPL1. 1 / 1
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1-methylanthracene increases the amount of STAMBPL1. 1 / 1
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1,1-dichloroethene increases the amount of STAMBPL1. 1 / 1
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(-)-demecolcine decreases the amount of STAMBPL1. 1 / 1
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