PSMD7 Data Analysis

HGNC Gene Name
proteasome 26S subunit, non-ATPase 7
HGNC Gene Symbol
PSMD7
Identifiers
hgnc:9565 NCBIGene:5713 uniprot:P51665
Orthologs
mgi:1351511 rgd:1306902
INDRA Statements
deubiquitinations all statements
Pathway Commons
Search for PSMD7
Number of Papers
38 retrieved on 2022-05-22

DepMap Analysis

The Dependency Map (DepMap) is a genome-wide pooled CRISPR-Cas9 knockout proliferation screen conducted in more than 700 cancer cell lines spanning many different tumor lineages. Each cell line in the DepMap contains a unique barcode, and each gene knockout is assigned a “dependency score” on a per cell-line basis which quantifies the rate of CRISPR-Cas9 guide drop. It has been found that proteins with similar DepMap scores across cell lines, a phenomenon known as co-dependent genes, have closely related biological functions. This can include activity in the same or parallel pathways or membership in the same protein complex or the same pathway.

We identified the strongest seven co-dependent genes (“Symbol”) for DUBs and ran GO enrichment analysis. We used Biogrid, IntAct, and Pathway Commons PPIDs, and the NURSA protein-protein interaction databases (PPIDs) to determine whether co-dependent genes interact with one another. The “Evidence” column contains the PPIDs in which the interaction appears as well as whether there is support for the association by an INDRA statement. As another approach to identify potential interactors, we looked at proteomics data from the Broad Institute's Cancer Cell Line Encyclopedia (CCLE) for proteins whose expression across ~375 cell lines strongly correlated with the abundance of each DUB; it has previously been observed that proteins in the same complex are frequently significantly co-expressed. The correlations and associated p-values in the CCLE proteomics dataset are provided. And, we determined whether co-dependent genes yield similar transcriptomic signatures in the Broad Institute's Connectivity Map (CMap). A CMap score greater than 90 is considered significantly similar.

DepMap Correlations

Symbol Name DepMap Correlation Evidence CCLE Correlation CCLE Z-score CCLE p-value (adj) CCLE Significant CMAP Score CMAP Type
RAN RAN, member RAS oncogene family 0.607 Reactome (12) 0.32 1.67 3.35e-09
SNRNP200 small nuclear ribonucleoprotein U5 subunit 200 0.581 IntAct Reactome (1) 0.00 -0.06 9.52e-01
PSMB3 proteasome 20S subunit beta 3 0.545 BioGRID IntAct INDRA (1) Reactome (150) 0.35 1.81 1.08e-10
KPNB1 karyopherin subunit beta 1 0.53 Reactome (19) 0.47 2.49 5.37e-20
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.528 Reactome (5) -0.30 -1.75 3.06e-08
EIF4A3 eukaryotic translation initiation factor 4A3 0.528 Reactome (10) 0.15 0.71 1.40e-02
SMU1 SMU1 DNA replication regulator and spliceosomal factor 0.518 -0.04 -0.28 6.20e-01

Dependency GO Term Enrichment

Gene set enrichment analysis was done on the genes correlated with PSMD7using the terms from Gene Ontology and gene sets derived from the Gene Ontology Annotations database via MSigDB.

Using the biological processes and other Gene Ontology terms from well characterized DUBs as a positive control, several gene set enrichment analyses were considered. Threshold-less methods like GSEA had relatively poor results. Over-representation analysis with a threshold of of the top 7 highest absolute value Dependency Map correlations yielded the best results and is reported below.

GO Identifier GO Name GO Type p-value p-value (adj.) q-value
GO:0005681 spliceosomal complex Cellular Component 2.56e-07 8.67e-05 3.24e-05
GO:0071013 catalytic step 2 spliceosome Cellular Component 3.22e-06 1.09e-03 2.03e-04
GO:0000375 RNA splicing, via transesterification reactions Biological Process 5.18e-06 1.75e-03 2.18e-04
GO:0008380 RNA splicing Biological Process 1.18e-05 3.97e-03 3.71e-04
GO:0003724 RNA helicase activity Molecular Function 1.31e-04 4.41e-02 2.67e-03
GO:0045540 regulation of cholesterol biosynthetic process Biological Process 1.42e-04 4.79e-02 2.67e-03

Literature Mining

INDRA was used to automatically assemble known mechanisms related to PSMD7 from literature and knowledge bases. The first section shows only DUB activity and the second shows all other results.

Deubiquitinase Activity

psp cbn pc bel_lc signor biogrid lincs_drug tas hprd trrust ctd vhn pe drugbank omnipath conib crog dgi | rlimsp isi tees geneways eidos trips medscan sparser reach
PSMD7 leads to the deubiquitination of RAD23B. 1 / 1
| 1

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PSMD7 knockdown enhanced the ubiquitination and degradation of RAD23B protein in GC cells.

Other Statements

psp cbn pc bel_lc signor biogrid lincs_drug tas hprd trrust ctd vhn pe drugbank omnipath conib crog dgi | rlimsp isi tees geneways eidos trips medscan sparser reach
| 7 24
| 7 12

eidos
PSMD7 knockdown induced cell cycle arrest , senescence , and apoptosis and suppressed LUAD tumor growth in a xenograft mouse model .
| PMC

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It is interesting that we, at the first time, reported that PSMD7 knockdown resulted in decreased proliferation and enhanced apoptosis in ESCC cell lines.

eidos
Knockdown of PSMD7 induces cell cycle arrest , senescence , and apoptosis by regulating cell cycle proteins and the p53 pathway in lung cancer cells .
| PMC

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In ESCC xenografts bearing mice with repression of PSMD7, we also proved that invivo ability of PSMD7 inhibition suppresses tumor growth and induces apoptosis.

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PSMD7 knockdown induces cell cycle arrest, senescence and apoptosis in LUAD cells.
| PMC

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PSMD7 knockdown inhibits proliferation and induces apoptosis in ESCC cell line.

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Furthermore, knockdown of PSMD7 reduced proliferation and induced cell cycle arrest, senescence and apoptosis by regulating cell cycle proteins and the p53 pathway in tumor cells.
| PMC

eidos
PSMD7 knockdown also led to an increase in apoptosis ( sub-G1 peak ) in H1299 cells but not in A549 cells ( Figure 3C ) .
| PMC

eidos
Knockdown of PSMD7 induces apoptosis and inhibits tumorigenesis in esophageal squamous cell carcinoma 22 .
| PMC

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A high PSMD7 level predicted poor overall survival (OS) and disease-free survival (DFS) in LUAD patients, and PSMD7 knockdown significantly reduced cell proliferation and induced G0/G1-phase cell cycle arrest, cell senescence and apoptosis.
| PMC
| 12

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Knockdown of PSMD7 induces apoptosis and inhibits tumorigenesis in esophageal squamous cell carcinoma XREF_BIBR.
| PMC

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Knockdown of PSMD7 showed inhibited proliferation and enhanced apoptosis, which is through mTOR and p70S6K signaling pathway.

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Meanwhile, it was associated with increased expression of cleaved PARP and stronger staining of cleaved caspase-3 after PSMD7 inhibition, suggesting that cell apoptosis was induced by PSMD7 knockdown invivo.

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Knockdown of PSMD7 inhibits tumorigenesis and induces cell apoptosis in esophageal squamous cell carcinoma (ESCC) via the mTOR and p70S6K pathway [XREF_BIBR].

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A previous study XREF_BIBR demonstrated that downregulation of PSMD7 led to decreased cell proliferation and increased apoptosis in esophageal squamous cell carcinoma.
| PMC

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PSMD7 promoted cell viability, apoptosis resistance, and DNA damage repair in GC cells upon cisplatin (DDP) treatment.

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Furthermore, PSMD7 downregulation contributed to decelerated tumor growth, inhibition of proteasomal function, induced cell apoptosis and attenuated activity of mTOR and p70S6K pathway invivo.

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Knockdown of PSMD7 induces cell cycle arrest, senescence, and apoptosis by regulating cell cycle proteins and the p53 pathway in lung cancer cells.
| PMC

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PSMD7 downregulation induces apoptosis and suppresses tumorigenesis of esophageal squamous cell carcinoma

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Downregulation of PSMD7 by lentivirus mediated shRNA led to decreased proliferation, increased cell apoptosis, and reduced proteasomal function.
PSMD7 bound to PSMD14 activates apoptotic process. 1 / 1
| 1

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We propose that disruption of the PSMD7 and PSMD14 complex may block p53 degradation in the proteasome and therefore trigger cell cycle arrest, senescence and apoptosis in LUAD cells.
| PMC
PSMD7 affects cell cycle
| 5 11
PSMD7 inhibits cell cycle.
| 9
| 8

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A high PSMD7 level predicted poor overall survival (OS) and disease-free survival (DFS) in LUAD patients, and PSMD7 knockdown significantly reduced cell proliferation and induced G0/G1-phase cell cycle arrest, cell senescence and apoptosis.
| PMC

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PSMD7 knockdown induces cell cycle arrest, senescence and apoptosis in LUAD cells.
| PMC

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PSMD7 knockdown induced cell cycle arrest, senescence, and apoptosis and suppressed LUAD tumor growth in a xenograft mouse model.
| PMC

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Importantly, PSMD7 knockdown induced cell cycle arrest in the G0/G1 phase, leading to cell senescence and apoptosis.

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These findings indicate that P40 anthocyanin extract inhibits cancer cell growth by inducing cell cycle arrest rather than through a cytotoxic effect.

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In conclusion, PSMD7 knockdown induces cell cycle arrest, senescence and apoptosis in LUAD cells.
| PMC

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Down-regulated PSMD7 inhibits the expression of key cell cycle related proteins and promotes the stability of p21 and p27 in breast cancer cells [XREF_BIBR].

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Furthermore, knockdown of PSMD7 reduced proliferation and induced cell cycle arrest, senescence and apoptosis by regulating cell cycle proteins and the p53 pathway in tumor cells.
| PMC
PSMD7 bound to PSMD14 inhibits cell cycle. 1 / 1
| 1

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We propose that disruption of the PSMD7 and PSMD14 complex may block p53 degradation in the proteasome and therefore trigger cell cycle arrest, senescence and apoptosis in LUAD cells.
| PMC
PSMD7 activates cell cycle.
| 5 2
| 5 2

eidos
Knockdown of PSMD7 induces cell cycle arrest , senescence , and apoptosis by regulating cell cycle proteins and the p53 pathway in lung cancer cells .
| PMC

eidos
Importantly , PSMD7 knockdown induced cell cycle arrest in the G0 / G1 phase , leading to cell senescence and apoptosis .

reach
PSMD7 knockdown inhibited the expression of key cell cycle related proteins and promoted the stability of p21 and p27 in breast cancer cells.

eidos
PSMD7 knockdown induces cell cycle arrest , senescence and apoptosis in LUAD cells A previous study 22 demonstrated that downregulation of PSMD7 led to decreased cell proliferation and increased apoptosis in esophageal squamous cell carcinoma .
| PMC

eidos
PSMD7 knockdown induced cell cycle arrest , senescence , and apoptosis and suppressed LUAD tumor growth in a xenograft mouse model .
| PMC

reach
Knockdown of PSMD7 induces cell cycle arrest, senescence, and apoptosis by regulating cell cycle proteins and the p53 pathway in lung cancer cells.
| PMC

eidos
In conclusion , PSMD7 knockdown induces cell cycle arrest , senescence and apoptosis in LUAD cells .
| PMC
| 5 6
| 5 4

eidos
Knockdown of PSMD7 induces cell cycle arrest , senescence , and apoptosis by regulating cell cycle proteins and the p53 pathway in lung cancer cells .
| PMC

eidos
In conclusion , PSMD7 knockdown induces cell cycle arrest , senescence and apoptosis in LUAD cells .
| PMC

reach
Furthermore, knockdown of PSMD7 reduced proliferation and induced cell cycle arrest, senescence and apoptosis by regulating cell cycle proteins and the p53 pathway in tumor cells.
| PMC

reach
PSMD7 knockdown induces cell cycle arrest, senescence and apoptosis in LUAD cells.
| PMC

eidos
PSMD7 knockdown induces cell cycle arrest , senescence and apoptosis in LUAD cells A previous study 22 demonstrated that downregulation of PSMD7 led to decreased cell proliferation and increased apoptosis in esophageal squamous cell carcinoma .
| PMC

eidos
PSMD7 knockdown induced cell cycle arrest , senescence , and apoptosis and suppressed LUAD tumor growth in a xenograft mouse model .
| PMC

eidos
A high PSMD7 level predicted poor overall survival ( OS ) and disease-free survival ( DFS ) in LUAD patients , and PSMD7 knockdown significantly reduced cell proliferation and induced G0 / G1-phase cell cycle arrest , cell senescence and apoptosis .
| PMC

reach
PSMD7 knockdown induced cell cycle arrest, senescence, and apoptosis and suppressed LUAD tumor growth in a xenograft mouse model.
| PMC

reach
In conclusion, PSMD7 knockdown induces cell cycle arrest, senescence and apoptosis in LUAD cells.
| PMC
| 2
PSMD7 bound to PSMD14 activates cellular senescence. 1 / 1
| 1

reach
We propose that disruption of the PSMD7 and PSMD14 complex may block p53 degradation in the proteasome and therefore trigger cell cycle arrest, senescence and apoptosis in LUAD cells.
| PMC

reach
Knockdown of PSMD7 induces cell cycle arrest, senescence, and apoptosis by regulating cell cycle proteins and the p53 pathway in lung cancer cells.
| PMC

reach
Similar with the findings, Shi et al. has reported that knockdown of PSMD7 induced ESCC apoptosis via a caspase-3 dependent pathway and decreased cells proliferation [XREF_BIBR].

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In conclusion, PSMD7 knockdown inhibits proliferation and induces apoptosis in ESCC cells.

reach
PSMD7 knockdown inhibits proliferation and induces apoptosis in ESCC cell line.

reach
A high PSMD7 level predicted poor overall survival (OS) and disease-free survival (DFS) in LUAD patients, and PSMD7 knockdown significantly reduced cell proliferation and induced G0/G1-phase cell cycle arrest, cell senescence and apoptosis.
| PMC

reach
Functionally, we found that PSMD7 knockdown consistently suppressed the proliferation, migration, and invasion of AGS and SGC-7901 cells.

reach
Deubiquitinase PSMD7 promotes the proliferation, invasion, and cisplatin resistance of gastric cancer cells by stabilizing RAD23B.

eidos
A high PSMD7 level predicted poor overall survival ( OS ) and disease-free survival ( DFS ) in LUAD patients , and PSMD7 knockdown significantly reduced cell proliferation and induced G0 / G1-phase cell cycle arrest , cell senescence and apoptosis .
| PMC

reach
Furthermore, knockdown of PSMD7 reduced proliferation and induced cell cycle arrest, senescence and apoptosis by regulating cell cycle proteins and the p53 pathway in tumor cells.
| PMC
PSMD7 affects TP53
| 1 7
PSMD7 inhibits TP53.
| 1 3
PSMD7 inhibits TP53. 3 / 3
| 1 2

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Furthermore, knockdown of PSMD7 reduced proliferation and induced cell cycle arrest, senescence and apoptosis by regulating cell cycle proteins and the p53 pathway in tumor cells.
| PMC

eidos
Depletion of PSMD7 increased p53 levels and induced p21 and puma expression in a p53-dependent manner .
| PMC

reach
PSMD7 downregulation suppresses lung cancer progression by regulating the p53 pathway.
| PMC
PSMD7 bound to PSMD14 inhibits TP53. 1 / 1
| 1

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We propose that disruption of the PSMD7 and PSMD14 complex may block p53 degradation in the proteasome and therefore trigger cell cycle arrest, senescence and apoptosis in LUAD cells.
| PMC
PSMD7 increases the amount of TP53.
| 2
PSMD7 increases the amount of TP53. 2 / 2
| 2

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Depletion of PSMD7 increased p53 levels and induced p21 and puma expression in a p53 dependent manner.
| PMC

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Our data show that PSMD7 can also increase p53 protein levels and activate transcription of Mdm2, p21 and Puma in a p53 dependent manner.
| PMC
PSMD7 activates TP53.
| 2
PSMD7 activates TP53. 2 / 2
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Knockdown of PSMD7 induces cell cycle arrest, senescence, and apoptosis by regulating cell cycle proteins and the p53 pathway in lung cancer cells.
| PMC

reach
PSMD7 knockdown inhibits tumor growth by activating the p53 pathway.
| PMC
Bortezomib affects PSMD7
3 1 1 |
Bortezomib inhibits PSMD7.
3 1 |
3 1 |

tas
No evidence text available
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dgi
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tas
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Bortezomib increases the amount of PSMD7.
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Bortezomib increases the amount of PSMD7. 1 / 1
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ctd
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JUN affects PSMD7
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JUN decreases the amount of PSMD7. 4 / 4
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biopax:msigdb
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Hsa-miR-8076 decreases the amount of PSMD7. 3 / 3
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biopax:mirtarbase
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Hsa-miR-6874-5p decreases the amount of PSMD7. 3 / 3
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Hsa-miR-6864-5p decreases the amount of PSMD7. 3 / 3
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Hsa-miR-6514-5p decreases the amount of PSMD7. 3 / 3
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Hsa-miR-6500-5p decreases the amount of PSMD7. 3 / 3
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Hsa-miR-6126 decreases the amount of PSMD7. 3 / 3
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Hsa-miR-570-5p decreases the amount of PSMD7. 3 / 3
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Hsa-miR-548ba decreases the amount of PSMD7. 3 / 3
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Hsa-miR-548ai decreases the amount of PSMD7. 3 / 3
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Hsa-miR-548ag decreases the amount of PSMD7. 3 / 3
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Hsa-miR-493-3p decreases the amount of PSMD7. 3 / 3
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Hsa-miR-4802-5p decreases the amount of PSMD7. 3 / 3
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Hsa-miR-4633-3p decreases the amount of PSMD7. 3 / 3
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Hsa-miR-4487 decreases the amount of PSMD7. 3 / 3
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Hsa-miR-338-5p decreases the amount of PSMD7. 3 / 3
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Hsa-miR-30e-5p decreases the amount of PSMD7. 3 / 3
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Hsa-miR-30d-5p decreases the amount of PSMD7. 3 / 3
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Hsa-miR-30c-5p decreases the amount of PSMD7. 3 / 3
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Hsa-miR-30b-5p decreases the amount of PSMD7. 3 / 3
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Hsa-miR-30a-5p decreases the amount of PSMD7. 3 / 3
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Hsa-miR-1287-5p decreases the amount of PSMD7. 3 / 3
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biopax:mirtarbase
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Hsa-miR-1277-5p decreases the amount of PSMD7. 3 / 3
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biopax:mirtarbase
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| DOI

tas
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PSMD7 affects RPS6KB1
| 3
PSMD7 activates RPS6KB1.
| 2
PSMD7 activates RPS6KB1. 2 / 2
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These data suggest that inhibition of PSMD7 suppressed the activity of mTOR and p70S6K invivo.

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PSMD7 knockdown blocked the expression levels of mTOR and p70S6K invivo, reduced by 33% and 37%, respectively (P < 0.05).
PSMD7 increases the amount of RPS6KB1.
| 1
PSMD7 increases the amount of RPS6KB1. 1 / 1
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Inhibition of PSMD7 not only reduced the expression of mTOR and p70S6K, but also decreased the expression of p-mTOR Ser2448 and p-p70S6K Thr421 and Ser424, whereas the augmented expression of phosphorylation of mTOR and p70S6K was detected after PSMD7 overexpression in Het-1A cells.
PSMD7 affects MTOR
| 3
PSMD7 activates MTOR.
| 2
PSMD7 activates MTOR. 2 / 2
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These data suggest that inhibition of PSMD7 suppressed the activity of mTOR and p70S6K invivo.

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PSMD7 knockdown blocked the expression levels of mTOR and p70S6K invivo, reduced by 33% and 37%, respectively (P < 0.05).
PSMD7 increases the amount of MTOR.
| 1
PSMD7 increases the amount of MTOR. 1 / 1
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Inhibition of PSMD7 not only reduced the expression of mTOR and p70S6K, but also decreased the expression of p-mTOR Ser2448 and p-p70S6K Thr421 and Ser424, whereas the augmented expression of phosphorylation of mTOR and p70S6K was detected after PSMD7 overexpression in Het-1A cells.
2 |
Valproic acid increases the amount of PSMD7. 2 / 2
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ctd
No evidence text available

ctd
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Phenylmercury acetate increases the amount of PSMD7. 2 / 2
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ctd
No evidence text available

ctd
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Norgestrel affects PSMD7
| 2
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Methods : The 661W photoreceptor cells and retinal explants from P30 to P40 wild-type (wt) C57BL/6 mice were treated with norgestrel over time.

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The 661W photoreceptor cells and retinal explants from P30 to P40 wild-type (wt) C57BL/6 mice were treated with norgestrel over time.
Indometacin affects PSMD7
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Indometacin increases the amount of PSMD7. 2 / 2
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ctd
No evidence text available

ctd
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Carfilzomib affects PSMD7
1 1 |
1 1 |

tas
No evidence text available

dgi
No evidence text available
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Benzo[a]pyrene increases the amount of PSMD7. 2 / 2
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ctd
No evidence text available

ctd
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PSMD7 affects cell
| 2
PSMD7 activates cell. 2 / 2
| 2

eidos
In conclusion , PSMD7 knockdown induces cell cycle arrest , senescence and apoptosis in LUAD cells .
| PMC

eidos
PSMD7 knockdown induces cell cycle arrest , senescence and apoptosis in LUAD cells A previous study 22 demonstrated that downregulation of PSMD7 led to decreased cell proliferation and increased apoptosis in esophageal squamous cell carcinoma .
| PMC
PSMD7 affects RAD23B
| 2
PSMD7 activates RAD23B. 2 / 2
| 2

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Deubiquitinase PSMD7 promotes the proliferation, invasion, and cisplatin resistance of gastric cancer cells by stabilizing RAD23B.

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In summary, PSMD7 was highly expressed in GC and contributed to the malignant behavior and DDP resistance of tumor cells by stabilizing RAD23B.

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Deubiquitinase PSMD7 promotes the proliferation, invasion, and cisplatin resistance of gastric cancer cells by stabilizing RAD23B.

reach
Functionally, we found that PSMD7 knockdown consistently suppressed the proliferation, migration, and invasion of AGS and SGC-7901 cells.
| 2

eidos
Knockdown of PSMD7 inhibits tumorigenesis and induces cell apoptosis in esophageal squamous cell carcinoma ( ESCC ) via the mTOR / p70S6K pathway [ 15 ] .

eidos
Knockdown of PSMD7 induces apoptosis and inhibits tumorigenesis in esophageal squamous cell carcinoma 22 .
| PMC
NFE2 affects PSMD7
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NFE2 decreases the amount of PSMD7. 2 / 2
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biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available
2 |
Cyclosporin A increases the amount of PSMD7.
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Cyclosporin A increases the amount of PSMD7. 1 / 1
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ctd
No evidence text available
Cyclosporin A decreases the amount of PSMD7.
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Cyclosporin A decreases the amount of PSMD7. 1 / 1
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ctd
No evidence text available
| 2
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Notably, the upregulation of PSMD7 closely correlated with malignant clinical parameters and reduced the survival of GC patients.
| 1

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PSMD7 promoted cell viability, apoptosis resistance, and DNA damage repair in GC cells upon cisplatin (DDP) treatment.
PSMD7 affects Proteasome
| 2
PSMD7 inhibits Proteasome.
| 1
| 1

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It may also suggest that the decreased proteasome activity was due to the abnormal function of 19S proteasome caused by PSMD7 knockdown.
PSMD7 activates Proteasome.
| 1
PSMD7 bound to PSMD14 activates Proteasome. 1 / 1
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PSMD7 interacts with PSMD14 to activate proteasome function to regulate ubiquitinated substrate degradation.
| 2
PSMD7 inhibits Cell Survival.
| 1

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Knockdown of PSMD7 considerably decreased the cell viability with ~ 47% of shPSMD7 group compared to shCon group (P < 0.05), suggesting that inhibition of PSMD7 decreased the survival of EC9706 cells.
PSMD7 activates Cell Survival.
| 1
| 1

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PSMD7 promoted cell viability, apoptosis resistance, and DNA damage repair in GC cells upon cisplatin (DDP) treatment.
PSMD7 affects CDKN1A
| 2
PSMD7 inhibits CDKN1A.
| 1
PSMD7 inhibits CDKN1A. 1 / 1
| 1

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PSMD7 knockdown inhibited the expression of key cell cycle related proteins and promoted the stability of p21 and p27 in breast cancer cells.
PSMD7 increases the amount of CDKN1A.
| 1
PSMD7 increases the amount of CDKN1A. 1 / 1
| 1

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Depletion of PSMD7 increased p53 levels and induced p21 and puma expression in a p53 dependent manner.
| PMC
2,2',4,4',5-brominated diphenyl ether increases the amount of PSMD7.
1 |

ctd
No evidence text available
2,2',4,4',5-brominated diphenyl ether decreases the amount of PSMD7.
1 |

ctd
No evidence text available
Valdecoxib affects PSMD7
1 |
Valdecoxib increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Tunicamycin affects PSMD7
1 |
Tunicamycin decreases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Trimellitic anhydride increases the amount of PSMD7. 1 / 1
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ctd
No evidence text available
Torcetrapib affects PSMD7
1 |
Torcetrapib increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Tetrachloromethane increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Tenuigenin affects PSMD7
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Tenuigenin increases the amount of PSMD7. 1 / 1
1 |

bel
Tenuigenin could obviously reduce intracerebral Aβ1–40 accumulation in AD mouse brain by increasing the content of 26S proteasome (Chen et al. 2015)
1 |
Sodium arsenite increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
1 |
Sodium arsenate increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
1 |
Schizandrin B increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Rotenone affects PSMD7
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Rotenone decreases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Quinoline affects PSMD7
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Quinoline increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available

bel
Under physiological conditions, UPS, located in the cytosol and the nucleus in eukaryotic cells, as a major intracellular short-lived protein degradation system (Schwartz and Ciechanover 2009), mediates the clearance of misfolded or other abnormally modified proteins with the help of ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), ubiquitin ligase (E3), and the 26S proteasome for the sake of preventing the accumulation of toxic substances (Shang and Taylor 2011)
Propofol affects PSMD7
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| 1

reach
Propofol induced significant lengthening of CSEPS (P40 : from 37 +/- 10 up to 41 +/- 11 ms; N50 : from 45 +/- 11 up to 51 +/- 14 ms), and a significant decrease in amplitude (from 1.9 +/- 0.9 down to 0.8 +/- 0.4 microV), but these changes were stable from 30 min after the induction to the end of spine surgery.
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Pirinixic acid increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
1 |

ctd
No evidence text available
Phlorizin affects PSMD7
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Phlorizin decreases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
1 |

ctd
No evidence text available
Nefazodone affects PSMD7
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Nefazodone increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Morphine affects PSMD7
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reach
We have previously demonstrated that pre-emptive morphine administration blocks neonatal injury induced thermal and mechanical hypoalgesia in both the injured and uninjured paws in adolescence (P40) and adulthood (P60) [99].
Miconazole affects PSMD7
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Miconazole increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Methylmercury chloride increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Methyl methanesulfonate increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
1 |
Mechlorethamine increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Leflunomide affects PSMD7
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Leflunomide increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Ketone body affects PSMD7
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Ketone body increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
1 |

dgi
No evidence text available
Ionomycin affects PSMD7
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Ionomycin increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
1 |
Hypochlorous acid increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
1 |
Hsa-miR-5003-5p decreases the amount of PSMD7. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-331-3p decreases the amount of PSMD7. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-26b-5p decreases the amount of PSMD7. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-15b-5p decreases the amount of PSMD7. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Formaldehyde increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Flutamide affects PSMD7
1 |
Flutamide increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Finasteride affects PSMD7
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Finasteride increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Ethanol affects PSMD7
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Ethanol increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Doxorubicin affects PSMD7
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Doxorubicin decreases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
1 |
Dorsomorphin increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Dobutamine affects PSMD7
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reach
Intraperitoneal injection of dobutamine at 0.3 and 1 mg/kg increased HR, FS, and COI of the P30 anesthetized mice and the P40 anesthetized rats, respectively, whereas the percent responses of these parameters in KX animals were greater than those in pentobarbital anesthetized ones due to the lower basal values for the cardiac functional parameters.
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Disodium selenite increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Dimethyl-4-toluidine decreases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Dicrotophos affects PSMD7
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Dicrotophos decreases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
1 |
Dibenzothiophene decreases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Diarsenic trioxide increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
1 |
Dexamethasone increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Copper atom affects PSMD7
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Copper atom increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
1 |
Cobalt dichloride increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Chelator affects PSMD7
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| 1

reach
Ovaa et al. reported a mono-Ub probe (Fig. 13e) with a zinc chelator 8-mercaptoquinoline (8-MQ) linked to the C terminus of Ub.129 Inhibition assays showed that the probe can inhibit Rpn11/Rpn8 with an IC50 value about 2 μM.
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Carbon nanotube increases the amount of PSMD7. 1 / 1
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ctd
No evidence text available
CAMP-mediated signaling increases the amount of PSMD7. 1 / 1
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bel
Impairment of 26S proteasome induced by tau can be prevented early in disease through activation of cAMP-PKA signaling, and raising the levels of cAMP with rolipram may enhance tau degradation (Myeku et al. 2016)
Bisphenol F affects PSMD7
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Bisphenol F increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Bisphenol A affects PSMD7
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Bisphenol A increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Ametryn affects PSMD7
1 |
Ametryn decreases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Allergen affects PSMD7
1 |
Allergen increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
All-trans-retinoic acid increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Acrylamide affects PSMD7
1 |
Acrylamide increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Vitallium affects PSMD7
1 |
Vitallium increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
1 |
Vehicle Emissions increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
Ubiquitin affects PSMD7
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| 1

sparser
The ubiquitin activating enzyme Uba1 (E1) and the 19S proteasome regulatory particles Mov34 and Rpn6 have all been implicated in neuronal protein degradation, at least in developmental axon pruning ( xref ).
UBB affects PSMD7
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UBB inhibits PSMD7. 1 / 1
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bel
As is known, the accumulation of frameshift ubiquitin-B (UBB) mutant protein UBB (+1) can block the 26S proteasome in cell lines, and then can reduce Aβ clearance (Hope et al. 2003)
Tobacco Smoke Pollution increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
1 |
Plant Extracts increases the amount of PSMD7. 1 / 1
1 |

ctd
No evidence text available
PSMD7 affects protein
1 |
PSMD7 decreases the amount of protein. 1 / 1
1 |

bel
Under physiological conditions, UPS, located in the cytosol and the nucleus in eukaryotic cells, as a major intracellular short-lived protein degradation system (Schwartz and Ciechanover 2009), mediates the clearance of misfolded or other abnormally modified proteins with the help of ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), ubiquitin ligase (E3), and the 26S proteasome for the sake of preventing the accumulation of toxic substances (Shang and Taylor 2011)
| 1
| 1