The Dependency Map (DepMap) is a genome-wide pooled CRISPR-Cas9 knockout proliferation screen conducted in more than 700 cancer cell lines spanning many different tumor lineages. Each cell line in the DepMap contains a unique barcode, and each gene knockout is assigned a “dependency score” on a per cell-line basis which quantifies the rate of CRISPR-Cas9 guide drop. It has been found that proteins with similar DepMap scores across cell lines, a phenomenon known as co-dependent genes, have closely related biological functions. This can include activity in the same or parallel pathways or membership in the same protein complex or the same pathway.
We identified the strongest seven co-dependent genes (“Symbol”) for DUBs and ran GO enrichment analysis. We used Biogrid, IntAct, and Pathway Commons PPIDs, and the NURSA protein-protein interaction databases (PPIDs) to determine whether co-dependent genes interact with one another. The “Evidence” column contains the PPIDs in which the interaction appears as well as whether there is support for the association by an INDRA statement. As another approach to identify potential interactors, we looked at proteomics data from the Broad Institute's Cancer Cell Line Encyclopedia (CCLE) for proteins whose expression across ~375 cell lines strongly correlated with the abundance of each DUB; it has previously been observed that proteins in the same complex are frequently significantly co-expressed. The correlations and associated p-values in the CCLE proteomics dataset are provided. And, we determined whether co-dependent genes yield similar transcriptomic signatures in the Broad Institute's Connectivity Map (CMap). A CMap score greater than 90 is considered significantly similar.
| Symbol | Name | DepMap Correlation | Evidence | CCLE Correlation | CCLE Z-score | CCLE p-value (adj) | CCLE Significant | CMAP Score | CMAP Type |
|---|---|---|---|---|---|---|---|---|---|
| CHEK1 | checkpoint kinase 1 | 0.525 | Reactome (11) | 0.08 | 0.36 | 2.08e-01 | |||
| SMU1 | SMU1 DNA replication regulator and spliceosomal factor | 0.508 | Reactome (1) | 0.10 | 0.46 | 1.12e-01 | |||
| PSMA6 | proteasome 20S subunit alpha 6 | 0.49 | BioGRID INDRA (1) Reactome (150) | 0.62 | 3.32 | 2.76e-38 | |||
| PSMD7 | proteasome 26S subunit, non-ATPase 7 | 0.487 | BioGRID IntAct NURSA Pathway Commons INDRA (2) Reactome (151) | 0.53 | 2.85 | 6.91e-27 | |||
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | 0.484 | Reactome (5) | -0.13 | -0.80 | 1.69e-01 | |||
| PSMA1 | proteasome 20S subunit alpha 1 | 0.46 | BioGRID IntAct INDRA (1) Reactome (150) | 0.54 | 2.87 | 2.68e-27 | 99.82 | kd | |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | 0.459 | Reactome (5) | 0.26 | 1.37 | 1.66e-06 |
Gene set enrichment analysis was done on the genes correlated with PSMD14using the terms from Gene Ontology and gene sets derived from the Gene Ontology Annotations database via MSigDB.
Using the biological processes and other Gene Ontology terms from well characterized DUBs as a positive control, several gene set enrichment analyses were considered. Threshold-less methods like GSEA had relatively poor results. Over-representation analysis with a threshold of of the top 7 highest absolute value Dependency Map correlations yielded the best results and is reported below.
The following table shows the significantly differentially expressed genes after knocking out PSMD14 using CRISPR-Cas9.
The GSEA method was applied for all genes whose knockout resulted in at least 20 significantly differentially expressed genes.
| ID | Name | p-value | p-value (adj.) | log2 Error | ES | NES |
|---|---|---|---|---|---|---|
| msig:M5925 | HALLMARK_E2F_TARGETS | 3.41e-28 | 1.33e-24 | 1.38e+00 | -6.37e-01 | -3.17e+00 |
| go:0005694 | chromosome | 3.59e-19 | 7.01e-16 | 1.13e+00 | -3.79e-01 | -2.15e+00 |
| msig:M5901 | HALLMARK_G2M_CHECKPOINT | 6.38e-19 | 8.31e-16 | 1.12e+00 | -5.66e-01 | -2.80e+00 |
| go:0000793 | condensed chromosome | 2.19e-16 | 2.14e-13 | 1.05e+00 | -5.75e-01 | -2.74e+00 |
| reactome:R-HSA-449147 | Signaling by Interleukins | 3.82e-15 | 2.98e-12 | 9.97e-01 | 5.14e-01 | 2.34e+00 |
| go:0005773 | vacuole | 1.07e-14 | 7.00e-12 | 9.87e-01 | 4.66e-01 | 2.17e+00 |
| go:0070498 | interleukin-1-mediated signaling pathway | 1.48e-14 | 8.29e-12 | 9.76e-01 | 7.36e-01 | 2.73e+00 |
| go:0098687 | chromosomal region | 2.11e-14 | 1.03e-11 | 9.76e-01 | -4.68e-01 | -2.36e+00 |
| go:0000228 | nuclear chromosome | 4.27e-14 | 1.85e-11 | 9.65e-01 | -4.13e-01 | -2.19e+00 |
| go:0048285 | organelle fission | 1.32e-13 | 5.15e-11 | 9.44e-01 | -4.52e-01 | -2.29e+00 |
| go:0051276 | chromosome organization | 1.53e-13 | 5.44e-11 | 9.44e-01 | -3.28e-01 | -1.86e+00 |
| go:0002764 | immune response-regulating signaling pathway | 4.19e-13 | 1.26e-10 | 9.33e-01 | 5.12e-01 | 2.28e+00 |
| reactome:R-HSA-5358346 | Hedgehog ligand biogenesis | 4.11e-13 | 1.26e-10 | 9.33e-01 | 7.43e-01 | 2.69e+00 |
| go:1905368 | peptidase complex | 5.27e-13 | 1.40e-10 | 9.21e-01 | 6.89e-01 | 2.61e+00 |
| reactome:R-HSA-8953897 | Cellular responses to stimuli | 5.36e-13 | 1.40e-10 | 9.21e-01 | 4.52e-01 | 2.11e+00 |
| reactome:R-HSA-446652 | Interleukin-1 family signaling | 5.96e-13 | 1.45e-10 | 9.21e-01 | 6.76e-01 | 2.57e+00 |
| go:1905369 | endopeptidase complex | 6.79e-13 | 1.56e-10 | 9.21e-01 | 7.28e-01 | 2.66e+00 |
| go:0019221 | cytokine-mediated signaling pathway | 8.00e-13 | 1.74e-10 | 9.21e-01 | 4.69e-01 | 2.16e+00 |
| go:0043620 | regulation of DNA-templated transcription in response to stress | 8.59e-13 | 1.77e-10 | 9.21e-01 | 6.58e-01 | 2.57e+00 |
| reactome:R-HSA-9020702 | Interleukin-1 signaling | 9.13e-13 | 1.78e-10 | 9.10e-01 | 6.99e-01 | 2.62e+00 |
| go:0140014 | mitotic nuclear division | 1.01e-12 | 1.88e-10 | 9.10e-01 | -4.92e-01 | -2.44e+00 |
| go:0070555 | response to interleukin-1 | 1.18e-12 | 2.00e-10 | 9.10e-01 | 6.28e-01 | 2.54e+00 |
| reactome:R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway | 1.13e-12 | 2.00e-10 | 9.10e-01 | 7.17e-01 | 2.65e+00 |
| go:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 1.23e-12 | 2.00e-10 | 9.10e-01 | 7.01e-01 | 2.63e+00 |
| go:0001738 | morphogenesis of a polarized epithelium | 1.49e-12 | 2.33e-10 | 9.10e-01 | 6.70e-01 | 2.55e+00 |
| reactome:R-HSA-5607761 | Dectin-1 mediated noncanonical NF-kB signaling | 2.15e-12 | 3.23e-10 | 8.99e-01 | 7.42e-01 | 2.69e+00 |
| reactome:R-HSA-1280215 | Cytokine Signaling in Immune system | 2.62e-12 | 3.79e-10 | 8.99e-01 | 4.40e-01 | 2.05e+00 |
| reactome:R-HSA-5358351 | Signaling by Hedgehog | 2.92e-12 | 4.08e-10 | 8.99e-01 | 6.49e-01 | 2.53e+00 |
| reactome:R-HSA-1640170 | Cell Cycle | 3.65e-12 | 4.92e-10 | 8.87e-01 | -3.59e-01 | -1.96e+00 |
| go:0038093 | Fc receptor signaling pathway | 4.51e-12 | 5.87e-10 | 8.87e-01 | 6.27e-01 | 2.50e+00 |
| go:0007059 | chromosome segregation | 7.76e-12 | 9.77e-10 | 8.75e-01 | -4.64e-01 | -2.32e+00 |
| reactome:R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA | 8.36e-12 | 1.02e-09 | 8.75e-01 | 7.32e-01 | 2.65e+00 |
| reactome:R-HSA-168249 | Innate Immune System | 8.71e-12 | 1.03e-09 | 8.75e-01 | 4.05e-01 | 1.94e+00 |
| msig:M10680 | KEGG_PROTEASOME | 9.82e-12 | 1.06e-09 | 8.75e-01 | 7.80e-01 | 2.66e+00 |
| reactome:R-HSA-5610780 | Degradation of GLI1 by the proteasome | 9.57e-12 | 1.06e-09 | 8.75e-01 | 7.30e-01 | 2.64e+00 |
| reactome:R-HSA-2871837 | FCERI mediated NF-kB activation | 9.42e-12 | 1.06e-09 | 8.75e-01 | 7.04e-01 | 2.58e+00 |
| reactome:R-HSA-1234174 | Cellular response to hypoxia | 1.01e-11 | 1.06e-09 | 8.75e-01 | 6.73e-01 | 2.54e+00 |
| reactome:R-HSA-5607764 | CLEC7A (Dectin-1) signaling | 1.03e-11 | 1.06e-09 | 8.75e-01 | 6.82e-01 | 2.56e+00 |
| reactome:R-HSA-169911 | Regulation of Apoptosis | 1.30e-11 | 1.30e-09 | 8.75e-01 | 7.38e-01 | 2.63e+00 |
| reactome:R-HSA-8939902 | Regulation of RUNX2 expression and activity | 1.33e-11 | 1.30e-09 | 8.75e-01 | 7.17e-01 | 2.59e+00 |
| reactome:R-HSA-202424 | Downstream TCR signaling | 1.86e-11 | 1.78e-09 | 8.63e-01 | 7.01e-01 | 2.57e+00 |
| reactome:R-HSA-202403 | TCR signaling | 1.97e-11 | 1.79e-09 | 8.63e-01 | 6.78e-01 | 2.54e+00 |
| reactome:R-HSA-1169091 | Activation of NF-kappaB in B cells | 1.95e-11 | 1.79e-09 | 8.63e-01 | 7.16e-01 | 2.60e+00 |
| reactome:R-HSA-180585 | Vif-mediated degradation of APOBEC3G | 2.13e-11 | 1.89e-09 | 8.63e-01 | 7.26e-01 | 2.63e+00 |
| reactome:R-HSA-69278 | Cell Cycle, Mitotic | 2.27e-11 | 1.97e-09 | 8.63e-01 | -3.68e-01 | -1.99e+00 |
| reactome:R-HSA-5610787 | Hedgehog 'off' state | 2.41e-11 | 2.00e-09 | 8.63e-01 | 6.61e-01 | 2.50e+00 |
| go:0000819 | sister chromatid segregation | 2.47e-11 | 2.01e-09 | 8.63e-01 | -5.10e-01 | -2.39e+00 |
| reactome:R-HSA-4608870 | Asymmetric localization of PCP proteins | 2.67e-11 | 2.13e-09 | 8.63e-01 | 7.34e-01 | 2.61e+00 |
| go:0044257 | cellular protein catabolic process | 3.55e-11 | 2.63e-09 | 8.51e-01 | 3.99e-01 | 1.91e+00 |
| reactome:R-HSA-5678895 | Defective CFTR causes cystic fibrosis | 3.57e-11 | 2.63e-09 | 8.51e-01 | 7.19e-01 | 2.60e+00 |
| reactome:R-HSA-4641257 | Degradation of AXIN | 3.45e-11 | 2.63e-09 | 8.51e-01 | 7.37e-01 | 2.61e+00 |
| reactome:R-HSA-5619084 | ABC transporter disorders | 4.40e-11 | 3.17e-09 | 8.51e-01 | 7.10e-01 | 2.58e+00 |
| reactome:R-HSA-9604323 | Negative regulation of NOTCH4 signaling | 4.47e-11 | 3.17e-09 | 8.51e-01 | 7.15e-01 | 2.59e+00 |
| reactome:R-HSA-351202 | Metabolism of polyamines | 4.58e-11 | 3.19e-09 | 8.51e-01 | 7.19e-01 | 2.60e+00 |
| reactome:R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling | 4.87e-11 | 3.34e-09 | 8.51e-01 | 6.51e-01 | 2.48e+00 |
| reactome:R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements | 5.55e-11 | 3.74e-09 | 8.51e-01 | 6.37e-01 | 2.46e+00 |
| go:0098813 | nuclear chromosome segregation | 6.76e-11 | 4.47e-09 | 8.39e-01 | -4.81e-01 | -2.34e+00 |
| go:0050852 | T cell receptor signaling pathway | 7.06e-11 | 4.59e-09 | 8.39e-01 | 6.14e-01 | 2.42e+00 |
| reactome:R-HSA-5621481 | C-type lectin receptors (CLRs) | 8.07e-11 | 5.17e-09 | 8.39e-01 | 6.46e-01 | 2.47e+00 |
| reactome:R-HSA-4641258 | Degradation of DVL | 9.24e-11 | 5.74e-09 | 8.39e-01 | 7.17e-01 | 2.58e+00 |
| reactome:R-HSA-4086400 | PCP/CE pathway | 9.27e-11 | 5.74e-09 | 8.39e-01 | 6.81e-01 | 2.51e+00 |
| reactome:R-HSA-8948751 | Regulation of PTEN stability and activity | 9.40e-11 | 5.74e-09 | 8.39e-01 | 6.91e-01 | 2.53e+00 |
| reactome:R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) | 1.00e-10 | 5.75e-09 | 8.39e-01 | 6.76e-01 | 2.51e+00 |
| go:0038095 | Fc-epsilon receptor signaling pathway | 9.74e-11 | 5.75e-09 | 8.39e-01 | 6.86e-01 | 2.53e+00 |
| reactome:R-HSA-5619115 | Disorders of transmembrane transporters | 9.91e-11 | 5.75e-09 | 8.39e-01 | 6.14e-01 | 2.41e+00 |
| go:0002253 | activation of immune response | 9.60e-11 | 5.75e-09 | 8.39e-01 | 4.79e-01 | 2.15e+00 |
| go:0006521 | regulation of cellular amino acid metabolic process | 1.11e-10 | 6.27e-09 | 8.39e-01 | 7.22e-01 | 2.57e+00 |
| reactome:R-HSA-983705 | Signaling by the B Cell Receptor (BCR) | 1.40e-10 | 7.72e-09 | 8.27e-01 | 6.51e-01 | 2.47e+00 |
| reactome:R-HSA-8941858 | Regulation of RUNX3 expression and activity | 1.39e-10 | 7.72e-09 | 8.27e-01 | 7.27e-01 | 2.57e+00 |
| reactome:R-HSA-5632684 | Hedgehog 'on' state | 1.46e-10 | 7.79e-09 | 8.27e-01 | 6.83e-01 | 2.51e+00 |
| go:0000070 | mitotic sister chromatid segregation | 1.45e-10 | 7.79e-09 | 8.27e-01 | -5.35e-01 | -2.46e+00 |
| reactome:R-HSA-195253 | Degradation of beta-catenin by the destruction complex | 1.89e-10 | 9.96e-09 | 8.27e-01 | 6.64e-01 | 2.50e+00 |
| reactome:R-HSA-382556 | ABC-family proteins mediated transport | 1.93e-10 | 1.01e-08 | 8.27e-01 | 6.85e-01 | 2.53e+00 |
| go:0038061 | NIK/NF-kappaB signaling | 1.99e-10 | 1.02e-08 | 8.27e-01 | 6.00e-01 | 2.39e+00 |
| go:0044433 | 2.29e-10 | 1.16e-08 | 8.27e-01 | 3.62e-01 | 1.77e+00 | |
| reactome:R-HSA-5658442 | Regulation of RAS by GAPs | 2.31e-10 | 1.16e-08 | 8.27e-01 | 6.95e-01 | 2.52e+00 |
| reactome:R-HSA-9013694 | Signaling by NOTCH4 | 2.47e-10 | 1.20e-08 | 8.14e-01 | 6.62e-01 | 2.47e+00 |
| go:0002218 | activation of innate immune response | 2.44e-10 | 1.20e-08 | 8.14e-01 | 5.37e-01 | 2.27e+00 |
| reactome:R-HSA-1236978 | Cross-presentation of soluble exogenous antigens (endosomes) | 2.61e-10 | 1.26e-08 | 8.14e-01 | 7.46e-01 | 2.58e+00 |
| go:0031329 | regulation of cellular catabolic process | 2.92e-10 | 1.39e-08 | 8.14e-01 | 3.94e-01 | 1.89e+00 |
| reactome:R-HSA-3858494 | Beta-catenin independent WNT signaling | 3.29e-10 | 1.55e-08 | 8.14e-01 | 6.13e-01 | 2.37e+00 |
| go:0030163 | protein catabolic process | 3.55e-10 | 1.65e-08 | 8.14e-01 | 3.80e-01 | 1.83e+00 |
| reactome:R-HSA-5689603 | UCH proteinases | 3.62e-10 | 1.66e-08 | 8.14e-01 | 6.35e-01 | 2.43e+00 |
| go:0000779 | condensed chromosome, centromeric region | 3.89e-10 | 1.77e-08 | 8.14e-01 | -5.65e-01 | -2.46e+00 |
| go:0033238 | regulation of cellular amine metabolic process | 4.48e-10 | 2.01e-08 | 8.14e-01 | 7.01e-01 | 2.54e+00 |
| go:0080134 | regulation of response to stress | 6.29e-10 | 2.79e-08 | 8.01e-01 | 3.64e-01 | 1.77e+00 |
| go:0050851 | antigen receptor-mediated signaling pathway | 6.88e-10 | 2.99e-08 | 8.01e-01 | 5.86e-01 | 2.37e+00 |
| go:0003735 | structural constituent of ribosome | 6.89e-10 | 2.99e-08 | 8.01e-01 | -4.65e-01 | -2.27e+00 |
| go:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 1.02e-09 | 4.27e-08 | 7.88e-01 | 6.46e-01 | 2.42e+00 |
| go:0009894 | regulation of catabolic process | 1.07e-09 | 4.38e-08 | 7.88e-01 | 3.74e-01 | 1.80e+00 |
| go:0009308 | amine metabolic process | 1.09e-09 | 4.42e-08 | 7.88e-01 | 6.35e-01 | 2.39e+00 |
| reactome:R-HSA-1236975 | Antigen processing-Cross presentation | 1.10e-09 | 4.43e-08 | 7.88e-01 | 6.60e-01 | 2.47e+00 |
| go:1901532 | regulation of hematopoietic progenitor cell differentiation | 1.22e-09 | 4.88e-08 | 7.88e-01 | 6.69e-01 | 2.47e+00 |
| go:0051301 | cell division | 1.25e-09 | 4.94e-08 | 7.88e-01 | -3.49e-01 | -1.88e+00 |
| reactome:R-HSA-69541 | Stabilization of p53 | 1.37e-09 | 5.28e-08 | 7.88e-01 | 6.86e-01 | 2.48e+00 |
| go:0071453 | cellular response to oxygen levels | 1.36e-09 | 5.28e-08 | 7.88e-01 | 5.28e-01 | 2.24e+00 |
| reactome:R-HSA-5687128 | MAPK6/MAPK4 signaling | 1.44e-09 | 5.50e-08 | 7.88e-01 | 6.29e-01 | 2.38e+00 |
| go:2000736 | regulation of stem cell differentiation | 1.50e-09 | 5.69e-08 | 7.88e-01 | 6.31e-01 | 2.39e+00 |
| reactome:R-HSA-8951664 | Neddylation | 1.60e-09 | 6.01e-08 | 7.88e-01 | 5.25e-01 | 2.23e+00 |
| reactome:R-HSA-195258 | RHO GTPase Effectors | 2.23e-09 | 8.31e-08 | 7.75e-01 | -4.29e-01 | -2.15e+00 |
| go:0044391 | ribosomal subunit | 2.45e-09 | 9.03e-08 | 7.75e-01 | -4.34e-01 | -2.15e+00 |
| go:0060218 | hematopoietic stem cell differentiation | 2.50e-09 | 9.12e-08 | 7.75e-01 | 6.70e-01 | 2.44e+00 |
| go:0023056 | positive regulation of signaling | 2.70e-09 | 9.77e-08 | 7.75e-01 | 3.53e-01 | 1.73e+00 |
| go:0051783 | regulation of nuclear division | 2.88e-09 | 1.03e-07 | 7.75e-01 | -4.94e-01 | -2.28e+00 |
| go:0061919 | process utilizing autophagic mechanism | 3.63e-09 | 1.29e-07 | 7.75e-01 | 4.46e-01 | 2.03e+00 |
| go:1901565 | organonitrogen compound catabolic process | 4.06e-09 | 1.43e-07 | 7.61e-01 | 3.55e-01 | 1.73e+00 |
| go:0010565 | regulation of cellular ketone metabolic process | 4.21e-09 | 1.46e-07 | 7.61e-01 | 6.14e-01 | 2.34e+00 |
| go:0010498 | proteasomal protein catabolic process | 4.23e-09 | 1.46e-07 | 7.61e-01 | 4.18e-01 | 1.93e+00 |
| go:0034097 | response to cytokine | 4.42e-09 | 1.50e-07 | 7.61e-01 | 3.74e-01 | 1.80e+00 |
| go:0045088 | regulation of innate immune response | 4.43e-09 | 1.50e-07 | 7.61e-01 | 4.82e-01 | 2.11e+00 |
| go:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 4.47e-09 | 1.51e-07 | 7.61e-01 | 6.69e-01 | 2.42e+00 |
| go:0043632 | modification-dependent macromolecule catabolic process | 4.70e-09 | 1.57e-07 | 7.61e-01 | 3.99e-01 | 1.88e+00 |
| go:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 4.76e-09 | 1.58e-07 | 7.61e-01 | 6.36e-01 | 2.38e+00 |
| go:0048863 | stem cell differentiation | 5.64e-09 | 1.82e-07 | 7.61e-01 | 5.54e-01 | 2.24e+00 |
| go:0022626 | cytosolic ribosome | 6.00e-09 | 1.92e-07 | 7.61e-01 | -5.17e-01 | -2.33e+00 |
| go:0006259 | DNA metabolic process | 6.51e-09 | 2.07e-07 | 7.61e-01 | -3.19e-01 | -1.78e+00 |
| reactome:R-HSA-382551 | Transport of small molecules | 6.74e-09 | 2.12e-07 | 7.61e-01 | 4.48e-01 | 2.03e+00 |
| reactome:R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 | 7.01e-09 | 2.17e-07 | 7.61e-01 | 6.66e-01 | 2.42e+00 |
| go:0006260 | DNA replication | 7.19e-09 | 2.21e-07 | 7.61e-01 | -4.27e-01 | -2.12e+00 |
| go:0050778 | positive regulation of immune response | 8.47e-09 | 2.58e-07 | 7.48e-01 | 4.24e-01 | 1.94e+00 |
| msig:M5890 | HALLMARK_TNFA_SIGNALING_VIA_NFKB | 8.85e-09 | 2.68e-07 | 7.48e-01 | 5.52e-01 | 2.24e+00 |
| go:0048585 | negative regulation of response to stimulus | 8.91e-09 | 2.68e-07 | 7.48e-01 | 3.53e-01 | 1.72e+00 |
| go:0070646 | protein modification by small protein removal | 9.31e-09 | 2.74e-07 | 7.48e-01 | 4.80e-01 | 2.10e+00 |
| go:0033209 | tumor necrosis factor-mediated signaling pathway | 9.32e-09 | 2.74e-07 | 7.48e-01 | 5.85e-01 | 2.28e+00 |
| go:0000775 | chromosome, centromeric region | 9.22e-09 | 2.74e-07 | 7.48e-01 | -4.60e-01 | -2.19e+00 |
| go:0006323 | DNA packaging | 1.13e-08 | 3.28e-07 | 7.48e-01 | -5.11e-01 | -2.30e+00 |
| go:0044815 | DNA packaging complex | 1.34e-08 | 3.88e-07 | 7.48e-01 | -7.23e-01 | -2.56e+00 |
| go:1905330 | regulation of morphogenesis of an epithelium | 1.47e-08 | 4.20e-07 | 7.48e-01 | 5.76e-01 | 2.23e+00 |
| go:0042180 | cellular ketone metabolic process | 1.47e-08 | 4.20e-07 | 7.48e-01 | 5.67e-01 | 2.27e+00 |
| go:0016236 | macroautophagy | 1.55e-08 | 4.39e-07 | 7.34e-01 | 4.91e-01 | 2.12e+00 |
| reactome:R-HSA-69615 | G1/S DNA Damage Checkpoints | 1.57e-08 | 4.42e-07 | 7.34e-01 | 6.49e-01 | 2.37e+00 |
| go:0010499 | proteasomal ubiquitin-independent protein catabolic process | 1.62e-08 | 4.53e-07 | 7.34e-01 | 8.49e-01 | 2.47e+00 |
| go:0023057 | negative regulation of signaling | 1.64e-08 | 4.54e-07 | 7.34e-01 | 3.60e-01 | 1.74e+00 |
| reactome:R-HSA-8878159 | Transcriptional regulation by RUNX3 | 1.65e-08 | 4.55e-07 | 7.34e-01 | 6.21e-01 | 2.34e+00 |
| reactome:R-HSA-5683057 | MAPK family signaling cascades | 1.79e-08 | 4.87e-07 | 7.34e-01 | 4.95e-01 | 2.11e+00 |
| reactome:R-HSA-194315 | Signaling by Rho GTPases | 1.80e-08 | 4.87e-07 | 7.34e-01 | -4.04e-01 | -2.04e+00 |
| msig:M189 | KEGG_RIBOSOME | 1.81e-08 | 4.89e-07 | 7.34e-01 | -5.41e-01 | -2.35e+00 |
| reactome:R-HSA-5688426 | Deubiquitination | 1.87e-08 | 4.99e-07 | 7.34e-01 | 4.74e-01 | 2.05e+00 |
| msig:M5893 | HALLMARK_MITOTIC_SPINDLE | 1.97e-08 | 5.23e-07 | 7.34e-01 | -4.47e-01 | -2.15e+00 |
| go:2000027 | regulation of animal organ morphogenesis | 2.54e-08 | 6.70e-07 | 7.34e-01 | 5.42e-01 | 2.19e+00 |
| go:0051304 | chromosome separation | 2.58e-08 | 6.76e-07 | 7.34e-01 | -6.00e-01 | -2.41e+00 |
| go:0002684 | positive regulation of immune system process | 2.64e-08 | 6.87e-07 | 7.34e-01 | 3.99e-01 | 1.87e+00 |
| reactome:R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 | 3.12e-08 | 8.06e-07 | 7.20e-01 | 6.29e-01 | 2.32e+00 |
| go:0044437 | 3.54e-08 | 9.11e-07 | 7.20e-01 | 4.12e-01 | 1.88e+00 | |
| go:0034612 | response to tumor necrosis factor | 3.60e-08 | 9.19e-07 | 7.20e-01 | 5.10e-01 | 2.16e+00 |
| reactome:R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint | 3.86e-08 | 9.80e-07 | 7.20e-01 | 6.17e-01 | 2.31e+00 |
| reactome:R-HSA-5689880 | Ub-specific processing proteases | 4.32e-08 | 1.09e-06 | 7.20e-01 | 5.29e-01 | 2.20e+00 |
| go:0005840 | ribosome | 4.72e-08 | 1.18e-06 | 7.20e-01 | -3.93e-01 | -1.99e+00 |
| go:1902750 | negative regulation of cell cycle G2/M phase transition | 4.72e-08 | 1.18e-06 | 7.20e-01 | 5.92e-01 | 2.27e+00 |
| go:0035567 | non-canonical Wnt signaling pathway | 4.82e-08 | 1.19e-06 | 7.20e-01 | 5.92e-01 | 2.26e+00 |
| go:0006520 | cellular amino acid metabolic process | 5.26e-08 | 1.29e-06 | 7.20e-01 | 4.67e-01 | 2.03e+00 |
| go:0030177 | positive regulation of Wnt signaling pathway | 5.23e-08 | 1.29e-06 | 7.20e-01 | 5.57e-01 | 2.20e+00 |
| reactome:R-HSA-449836 | Other interleukin signaling | 6.11e-08 | 1.48e-06 | 7.05e-01 | 5.05e-01 | 2.14e+00 |
| go:0050776 | regulation of immune response | 6.78e-08 | 1.64e-06 | 7.05e-01 | 3.96e-01 | 1.85e+00 |
| go:0051321 | meiotic cell cycle | 6.88e-08 | 1.65e-06 | 7.05e-01 | -4.93e-01 | -2.23e+00 |
| reactome:R-HSA-68877 | Mitotic Prometaphase | 7.36e-08 | 1.75e-06 | 7.05e-01 | -4.33e-01 | -2.11e+00 |
| go:0031349 | positive regulation of defense response | 7.42e-08 | 1.76e-06 | 7.05e-01 | 4.53e-01 | 1.98e+00 |
| go:0000209 | protein polyubiquitination | 7.56e-08 | 1.78e-06 | 7.05e-01 | 4.53e-01 | 1.98e+00 |
| reactome:R-HSA-8878166 | Transcriptional regulation by RUNX2 | 8.19e-08 | 1.92e-06 | 7.05e-01 | 5.85e-01 | 2.23e+00 |
| reactome:R-HSA-162909 | Host Interactions of HIV factors | 9.03e-08 | 2.10e-06 | 7.05e-01 | 5.34e-01 | 2.17e+00 |
| go:0015934 | large ribosomal subunit | 9.41e-08 | 2.17e-06 | 7.05e-01 | -4.77e-01 | -2.20e+00 |
| reactome:R-HSA-73886 | Chromosome Maintenance | 1.04e-07 | 2.38e-06 | 7.05e-01 | -5.82e-01 | -2.37e+00 |
| reactome:R-HSA-2500257 | Resolution of Sister Chromatid Cohesion | 1.20e-07 | 2.72e-06 | 6.90e-01 | -4.84e-01 | -2.18e+00 |
| go:0005819 | spindle | 1.29e-07 | 2.91e-06 | 6.90e-01 | -3.84e-01 | -1.93e+00 |
| go:0006310 | DNA recombination | 1.33e-07 | 2.99e-06 | 6.90e-01 | -4.31e-01 | -2.08e+00 |
| go:0006457 | protein folding | 1.53e-07 | 3.42e-06 | 6.90e-01 | 4.89e-01 | 2.09e+00 |
| go:0000776 | kinetochore | 1.56e-07 | 3.46e-06 | 6.90e-01 | -4.86e-01 | -2.20e+00 |
| reactome:R-HSA-68949 | Orc1 removal from chromatin | 1.72e-07 | 3.79e-06 | 6.90e-01 | 6.01e-01 | 2.25e+00 |
| go:0001775 | cell activation | 1.95e-07 | 4.25e-06 | 6.90e-01 | 3.52e-01 | 1.70e+00 |
| msig:M16853 | KEGG_DNA_REPLICATION | 1.94e-07 | 4.25e-06 | 6.90e-01 | -7.07e-01 | -2.48e+00 |
| go:0006952 | defense response | 1.99e-07 | 4.32e-06 | 6.90e-01 | 3.48e-01 | 1.68e+00 |
| reactome:R-HSA-983169 | Class I MHC mediated antigen processing & presentation | 2.17e-07 | 4.68e-06 | 6.90e-01 | 4.33e-01 | 1.92e+00 |
| reactome:R-HSA-2990846 | SUMOylation | 2.18e-07 | 4.68e-06 | 6.90e-01 | -4.80e-01 | -2.21e+00 |
| reactome:R-HSA-69190 | DNA strand elongation | 2.20e-07 | 4.70e-06 | 6.90e-01 | -7.30e-01 | -2.48e+00 |
| go:0009628 | response to abiotic stimulus | 2.28e-07 | 4.84e-06 | 6.90e-01 | 3.46e-01 | 1.67e+00 |
| go:0006508 | proteolysis | 2.82e-07 | 5.93e-06 | 6.75e-01 | 3.15e-01 | 1.56e+00 |
| reactome:R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane | 3.08e-07 | 6.44e-06 | 6.75e-01 | -4.63e-01 | -2.13e+00 |
| go:0090263 | positive regulation of canonical Wnt signaling pathway | 3.17e-07 | 6.55e-06 | 6.75e-01 | 5.65e-01 | 2.18e+00 |
| go:0000781 | chromosome, telomeric region | 3.17e-07 | 6.55e-06 | 6.75e-01 | -4.83e-01 | -2.16e+00 |
| go:0031347 | regulation of defense response | 3.38e-07 | 6.92e-06 | 6.75e-01 | 4.10e-01 | 1.86e+00 |
| reactome:R-HSA-68867 | Assembly of the pre-replicative complex | 3.38e-07 | 6.92e-06 | 6.75e-01 | 6.07e-01 | 2.24e+00 |
| reactome:R-HSA-6807070 | PTEN Regulation | 3.42e-07 | 6.97e-06 | 6.75e-01 | 5.28e-01 | 2.14e+00 |
| msig:M5924 | HALLMARK_MTORC1_SIGNALING | 3.68e-07 | 7.44e-06 | 6.75e-01 | 4.47e-01 | 1.95e+00 |
| go:0005776 | autophagosome | 3.94e-07 | 7.94e-06 | 6.75e-01 | 6.70e-01 | 2.32e+00 |
| msig:M15569 | KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY | 3.97e-07 | 7.95e-06 | 6.75e-01 | 7.48e-01 | 2.32e+00 |
| go:0002274 | myeloid leukocyte activation | 4.46e-07 | 8.85e-06 | 6.75e-01 | 3.87e-01 | 1.79e+00 |
| go:0070482 | response to oxygen levels | 4.67e-07 | 9.22e-06 | 6.75e-01 | 4.25e-01 | 1.89e+00 |
| reactome:R-HSA-72613 | Eukaryotic Translation Initiation | 4.71e-07 | 9.24e-06 | 6.75e-01 | -4.47e-01 | -2.08e+00 |
| go:0033044 | regulation of chromosome organization | 4.97e-07 | 9.66e-06 | 6.59e-01 | -3.75e-01 | -1.90e+00 |
| go:0022625 | cytosolic large ribosomal subunit | 5.02e-07 | 9.70e-06 | 6.59e-01 | -5.64e-01 | -2.26e+00 |
| go:0051983 | regulation of chromosome segregation | 5.19e-07 | 1.00e-05 | 6.59e-01 | -5.20e-01 | -2.22e+00 |
| reactome:R-HSA-2408522 | Selenoamino acid metabolism | 5.28e-07 | 1.01e-05 | 6.59e-01 | -4.57e-01 | -2.11e+00 |
| reactome:R-HSA-5653656 | Vesicle-mediated transport | 5.36e-07 | 1.02e-05 | 6.59e-01 | 3.76e-01 | 1.76e+00 |
| go:0006613 | cotranslational protein targeting to membrane | 5.64e-07 | 1.07e-05 | 6.59e-01 | -4.69e-01 | -2.11e+00 |
| go:0048002 | antigen processing and presentation of peptide antigen | 5.74e-07 | 1.08e-05 | 6.59e-01 | 5.02e-01 | 2.08e+00 |
| go:0006333 | chromatin assembly or disassembly | 6.06e-07 | 1.14e-05 | 6.59e-01 | -4.91e-01 | -2.14e+00 |
| go:0002682 | regulation of immune system process | 6.12e-07 | 1.14e-05 | 6.59e-01 | 3.40e-01 | 1.64e+00 |
| msig:M5938 | HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY | 6.55e-07 | 1.22e-05 | 6.59e-01 | 6.86e-01 | 2.31e+00 |
| reactome:R-HSA-9612973 | Autophagy | 6.81e-07 | 1.26e-05 | 6.59e-01 | 5.68e-01 | 2.14e+00 |
| go:0062012 | regulation of small molecule metabolic process | 7.07e-07 | 1.30e-05 | 6.59e-01 | 4.59e-01 | 1.98e+00 |
| reactome:R-HSA-69052 | Switching of origins to a post-replicative state | 9.38e-07 | 1.72e-05 | 6.59e-01 | 5.58e-01 | 2.13e+00 |
| go:1903046 | meiotic cell cycle process | 9.40e-07 | 1.72e-05 | 6.59e-01 | -5.04e-01 | -2.14e+00 |
| go:0061013 | regulation of mRNA catabolic process | 9.73e-07 | 1.77e-05 | 6.44e-01 | 4.71e-01 | 2.00e+00 |
| go:1905818 | regulation of chromosome separation | 1.04e-06 | 1.88e-05 | 6.44e-01 | -5.95e-01 | -2.27e+00 |
| go:0045087 | innate immune response | 1.09e-06 | 1.96e-05 | 6.44e-01 | 3.77e-01 | 1.75e+00 |
| go:0048729 | tissue morphogenesis | 1.11e-06 | 1.98e-05 | 6.44e-01 | 4.11e-01 | 1.86e+00 |
| go:0071103 | DNA conformation change | 1.19e-06 | 2.13e-05 | 6.44e-01 | -3.88e-01 | -1.91e+00 |
| go:0055085 | transmembrane transport | 1.21e-06 | 2.15e-05 | 6.44e-01 | 3.49e-01 | 1.67e+00 |
| go:0006281 | DNA repair | 1.28e-06 | 2.26e-05 | 6.44e-01 | -3.22e-01 | -1.70e+00 |
| reactome:R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs | 1.32e-06 | 2.32e-05 | 6.44e-01 | 5.79e-01 | 2.17e+00 |
| reactome:R-HSA-2299718 | Condensation of Prophase Chromosomes | 1.46e-06 | 2.56e-05 | 6.44e-01 | -7.33e-01 | -2.40e+00 |
| go:2001251 | negative regulation of chromosome organization | 1.59e-06 | 2.77e-05 | 6.44e-01 | -4.86e-01 | -2.12e+00 |
| go:0006261 | DNA-dependent DNA replication | 1.63e-06 | 2.83e-05 | 6.44e-01 | -4.62e-01 | -2.09e+00 |
| go:0006468 | protein phosphorylation | 1.67e-06 | 2.89e-05 | 6.44e-01 | 3.13e-01 | 1.54e+00 |
| go:0019882 | antigen processing and presentation | 1.72e-06 | 2.95e-05 | 6.44e-01 | 4.74e-01 | 2.01e+00 |
| reactome:R-HSA-927802 | Nonsense-Mediated Decay (NMD) | 1.82e-06 | 3.13e-05 | 6.44e-01 | -4.40e-01 | -2.01e+00 |
| reactome:R-HSA-73894 | DNA Repair | 1.95e-06 | 3.32e-05 | 6.27e-01 | -3.61e-01 | -1.82e+00 |
| reactome:R-HSA-5663220 | RHO GTPases Activate Formins | 1.96e-06 | 3.32e-05 | 6.27e-01 | -4.56e-01 | -2.07e+00 |
| go:0101002 | ficolin-1-rich granule | 1.96e-06 | 3.32e-05 | 6.27e-01 | 5.23e-01 | 2.09e+00 |
| go:0002009 | morphogenesis of an epithelium | 2.16e-06 | 3.62e-05 | 6.27e-01 | 4.24e-01 | 1.88e+00 |
| go:0005839 | proteasome core complex | 2.16e-06 | 3.62e-05 | 6.27e-01 | 8.29e-01 | 2.27e+00 |
| go:0000794 | condensed nuclear chromosome | 2.29e-06 | 3.82e-05 | 6.27e-01 | -5.99e-01 | -2.27e+00 |
| reactome:R-HSA-73884 | Base Excision Repair | 2.29e-06 | 3.82e-05 | 6.27e-01 | -5.85e-01 | -2.23e+00 |
| reactome:R-HSA-69618 | Mitotic Spindle Checkpoint | 2.52e-06 | 4.18e-05 | 6.27e-01 | -4.73e-01 | -2.07e+00 |
| go:0002244 | hematopoietic progenitor cell differentiation | 2.66e-06 | 4.39e-05 | 6.27e-01 | 5.32e-01 | 2.06e+00 |
| go:0044784 | metaphase/anaphase transition of cell cycle | 2.69e-06 | 4.41e-05 | 6.27e-01 | -6.18e-01 | -2.32e+00 |
| go:0002753 | cytoplasmic pattern recognition receptor signaling pathway | 2.75e-06 | 4.49e-05 | 6.27e-01 | 7.21e-01 | 2.25e+00 |
| go:0006325 | chromatin organization | 2.78e-06 | 4.53e-05 | 6.27e-01 | -2.96e-01 | -1.61e+00 |
| reactome:R-HSA-157579 | Telomere Maintenance | 3.10e-06 | 5.02e-05 | 6.27e-01 | -6.17e-01 | -2.30e+00 |
| reactome:R-HSA-6798695 | Neutrophil degranulation | 3.12e-06 | 5.04e-05 | 6.27e-01 | 3.93e-01 | 1.79e+00 |
| go:0006974 | cellular response to DNA damage stimulus | 3.20e-06 | 5.15e-05 | 6.27e-01 | -2.81e-01 | -1.56e+00 |
| reactome:R-HSA-162906 | HIV Infection | 3.34e-06 | 5.35e-05 | 6.27e-01 | 4.26e-01 | 1.86e+00 |
| go:0000278 | mitotic cell cycle | 3.87e-06 | 6.12e-05 | 6.11e-01 | -2.65e-01 | -1.49e+00 |
| go:0035966 | response to topologically incorrect protein | 3.93e-06 | 6.19e-05 | 6.11e-01 | 4.83e-01 | 2.01e+00 |
| reactome:R-HSA-5693532 | DNA Double-Strand Break Repair | 4.23e-06 | 6.63e-05 | 6.11e-01 | -4.61e-01 | -2.03e+00 |
| go:0098754 | detoxification | 4.38e-06 | 6.84e-05 | 6.11e-01 | 6.06e-01 | 2.19e+00 |
| go:0022402 | cell cycle process | 4.58e-06 | 7.10e-05 | 6.11e-01 | -2.53e-01 | -1.46e+00 |
| reactome:R-HSA-5357801 | Programmed Cell Death | 4.66e-06 | 7.20e-05 | 6.11e-01 | 4.65e-01 | 1.95e+00 |
| reactome:R-HSA-1474165 | Reproduction | 4.81e-06 | 7.40e-05 | 6.11e-01 | -5.90e-01 | -2.23e+00 |
| reactome:R-HSA-9006925 | Intracellular signaling by second messengers | 6.44e-06 | 9.87e-05 | 6.11e-01 | 4.52e-01 | 1.93e+00 |
| go:0060429 | epithelium development | 6.58e-06 | 1.00e-04 | 6.11e-01 | 3.43e-01 | 1.64e+00 |
| go:0000922 | spindle pole | 6.69e-06 | 1.02e-04 | 6.11e-01 | -4.45e-01 | -2.02e+00 |
| go:0006887 | exocytosis | 7.12e-06 | 1.07e-04 | 6.11e-01 | 3.48e-01 | 1.65e+00 |
| reactome:R-HSA-912446 | Meiotic recombination | 7.61e-06 | 1.14e-04 | 6.11e-01 | -6.75e-01 | -2.29e+00 |
| reactome:R-HSA-168255 | Influenza Infection | 7.84e-06 | 1.17e-04 | 5.93e-01 | -3.96e-01 | -1.91e+00 |
| go:0002444 | myeloid leukocyte mediated immunity | 8.11e-06 | 1.21e-04 | 5.93e-01 | 3.78e-01 | 1.73e+00 |
| go:0046903 | secretion | 8.70e-06 | 1.29e-04 | 5.93e-01 | 3.13e-01 | 1.52e+00 |
| go:0006873 | cellular ion homeostasis | 8.79e-06 | 1.30e-04 | 5.93e-01 | 4.12e-01 | 1.81e+00 |
| go:0005198 | structural molecule activity | 9.37e-06 | 1.38e-04 | 5.93e-01 | -3.01e-01 | -1.61e+00 |
| go:0045132 | meiotic chromosome segregation | 9.35e-06 | 1.38e-04 | 5.93e-01 | -6.36e-01 | -2.28e+00 |
| reactome:R-HSA-453274 | Mitotic G2-G2/M phases | 9.40e-06 | 1.38e-04 | 5.93e-01 | 4.40e-01 | 1.88e+00 |
| reactome:R-HSA-3371556 | Cellular response to heat stress | 9.59e-06 | 1.39e-04 | 5.93e-01 | 5.35e-01 | 2.02e+00 |
| go:0099503 | secretory vesicle | 9.63e-06 | 1.39e-04 | 5.93e-01 | 3.45e-01 | 1.63e+00 |
| reactome:R-HSA-69002 | DNA Replication Pre-Initiation | 9.61e-06 | 1.39e-04 | 5.93e-01 | 5.34e-01 | 2.04e+00 |
| go:0002443 | leukocyte mediated immunity | 1.03e-05 | 1.49e-04 | 5.93e-01 | 3.64e-01 | 1.70e+00 |
| go:0030261 | chromosome condensation | 1.13e-05 | 1.63e-04 | 5.93e-01 | -6.55e-01 | -2.23e+00 |
| go:0061077 | chaperone-mediated protein folding | 1.18e-05 | 1.68e-04 | 5.93e-01 | 6.34e-01 | 2.16e+00 |
| go:0070647 | protein modification by small protein conjugation or removal | 1.31e-05 | 1.86e-04 | 5.93e-01 | 3.12e-01 | 1.52e+00 |
| go:0016050 | vesicle organization | 1.32e-05 | 1.88e-04 | 5.93e-01 | 4.16e-01 | 1.82e+00 |
| msig:M7963 | KEGG_CELL_CYCLE | 1.34e-05 | 1.89e-04 | 5.93e-01 | -4.69e-01 | -2.04e+00 |
| go:0003682 | chromatin binding | 1.35e-05 | 1.90e-04 | 5.93e-01 | -3.20e-01 | -1.66e+00 |
| go:0002252 | immune effector process | 1.39e-05 | 1.95e-04 | 5.93e-01 | 3.29e-01 | 1.57e+00 |
| reactome:R-HSA-69205 | G1/S-Specific Transcription | 1.48e-05 | 2.07e-04 | 5.93e-01 | -7.50e-01 | -2.28e+00 |
| reactome:R-HSA-1500620 | Meiosis | 1.57e-05 | 2.19e-04 | 5.76e-01 | -5.89e-01 | -2.21e+00 |
| reactome:R-HSA-212300 | PRC2 methylates histones and DNA | 1.64e-05 | 2.28e-04 | 5.76e-01 | -6.97e-01 | -2.29e+00 |
| go:0019080 | viral gene expression | 1.69e-05 | 2.34e-04 | 5.76e-01 | -3.67e-01 | -1.80e+00 |
| go:0031098 | stress-activated protein kinase signaling cascade | 1.72e-05 | 2.37e-04 | 5.76e-01 | 4.73e-01 | 1.94e+00 |
| go:0030141 | secretory granule | 1.89e-05 | 2.60e-04 | 5.76e-01 | 3.51e-01 | 1.64e+00 |
| go:0030178 | negative regulation of Wnt signaling pathway | 2.05e-05 | 2.81e-04 | 5.76e-01 | 4.89e-01 | 1.95e+00 |
| go:0050801 | ion homeostasis | 2.06e-05 | 2.82e-04 | 5.76e-01 | 3.82e-01 | 1.73e+00 |
| reactome:R-HSA-5693538 | Homology Directed Repair | 2.25e-05 | 3.05e-04 | 5.76e-01 | -4.86e-01 | -2.04e+00 |
| go:0002263 | cell activation involved in immune response | 2.25e-05 | 3.05e-04 | 5.76e-01 | 3.63e-01 | 1.68e+00 |
| go:0010256 | endomembrane system organization | 2.31e-05 | 3.12e-04 | 5.76e-01 | 3.92e-01 | 1.74e+00 |
| go:0060070 | canonical Wnt signaling pathway | 2.58e-05 | 3.46e-04 | 5.76e-01 | 4.38e-01 | 1.85e+00 |
| reactome:R-HSA-72766 | Translation | 2.59e-05 | 3.46e-04 | 5.76e-01 | -3.12e-01 | -1.62e+00 |
| go:0000407 | phagophore assembly site | 2.71e-05 | 3.60e-04 | 5.76e-01 | 7.58e-01 | 2.16e+00 |
| go:1905037 | autophagosome organization | 2.71e-05 | 3.60e-04 | 5.76e-01 | 5.90e-01 | 2.08e+00 |
| go:0051082 | unfolded protein binding | 2.73e-05 | 3.62e-04 | 5.76e-01 | 5.08e-01 | 1.96e+00 |
| reactome:R-HSA-1280218 | Adaptive Immune System | 2.75e-05 | 3.62e-04 | 5.76e-01 | 3.55e-01 | 1.66e+00 |
| go:0031983 | vesicle lumen | 2.85e-05 | 3.74e-04 | 5.76e-01 | 4.08e-01 | 1.77e+00 |
| go:0005775 | vacuolar lumen | 2.85e-05 | 3.74e-04 | 5.76e-01 | 5.03e-01 | 1.94e+00 |
| go:0061024 | membrane organization | 2.86e-05 | 3.74e-04 | 5.76e-01 | 3.38e-01 | 1.60e+00 |
| reactome:R-HSA-201681 | TCF dependent signaling in response to WNT | 2.93e-05 | 3.82e-04 | 5.76e-01 | 4.65e-01 | 1.89e+00 |
| go:0006458 | 'de novo' protein folding | 3.04e-05 | 3.94e-04 | 5.76e-01 | 6.82e-01 | 2.13e+00 |
| go:1903706 | regulation of hemopoiesis | 3.04e-05 | 3.94e-04 | 5.76e-01 | 4.06e-01 | 1.78e+00 |
| reactome:R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange | 3.10e-05 | 3.98e-04 | 5.57e-01 | -6.56e-01 | -2.18e+00 |
| go:0043687 | post-translational protein modification | 3.09e-05 | 3.98e-04 | 5.57e-01 | 4.04e-01 | 1.79e+00 |
| go:0044265 | cellular macromolecule catabolic process | 3.27e-05 | 4.19e-04 | 5.57e-01 | 2.99e-01 | 1.47e+00 |
| go:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 3.29e-05 | 4.20e-04 | 5.57e-01 | -4.15e-01 | -1.91e+00 |
| go:0051784 | negative regulation of nuclear division | 3.42e-05 | 4.35e-04 | 5.57e-01 | -5.79e-01 | -2.14e+00 |
| go:0030111 | regulation of Wnt signaling pathway | 3.69e-05 | 4.68e-04 | 5.57e-01 | 4.21e-01 | 1.81e+00 |
| go:0016209 | antioxidant activity | 3.95e-05 | 5.00e-04 | 5.57e-01 | 6.20e-01 | 2.09e+00 |
| go:0022603 | regulation of anatomical structure morphogenesis | 4.10e-05 | 5.17e-04 | 5.57e-01 | 3.42e-01 | 1.61e+00 |
| go:0005657 | replication fork | 4.17e-05 | 5.24e-04 | 5.57e-01 | -5.28e-01 | -2.06e+00 |
| go:0010639 | negative regulation of organelle organization | 4.23e-05 | 5.30e-04 | 5.57e-01 | -3.36e-01 | -1.69e+00 |
| go:0022624 | proteasome accessory complex | 4.32e-05 | 5.38e-04 | 5.57e-01 | 7.01e-01 | 2.14e+00 |
| go:0016197 | endosomal transport | 4.54e-05 | 5.64e-04 | 5.57e-01 | 4.52e-01 | 1.88e+00 |
| go:0005774 | vacuolar membrane | 5.08e-05 | 6.28e-04 | 5.57e-01 | 3.91e-01 | 1.73e+00 |
| reactome:R-HSA-453276 | Regulation of mitotic cell cycle | 5.26e-05 | 6.48e-04 | 5.57e-01 | 5.10e-01 | 1.95e+00 |
| go:0055065 | metal ion homeostasis | 5.56e-05 | 6.83e-04 | 5.57e-01 | 3.98e-01 | 1.74e+00 |
| reactome:R-HSA-5250913 | Positive epigenetic regulation of rRNA expression | 5.60e-05 | 6.86e-04 | 5.57e-01 | -5.44e-01 | -2.09e+00 |
| reactome:R-HSA-3371571 | HSF1-dependent transactivation | 5.69e-05 | 6.94e-04 | 5.57e-01 | 7.46e-01 | 2.13e+00 |
| go:0000785 | chromatin | 5.75e-05 | 6.99e-04 | 5.57e-01 | -3.00e-01 | -1.57e+00 |
| go:0009887 | animal organ morphogenesis | 5.96e-05 | 7.23e-04 | 5.57e-01 | 3.54e-01 | 1.64e+00 |
| go:0006082 | organic acid metabolic process | 6.13e-05 | 7.42e-04 | 5.38e-01 | 3.29e-01 | 1.56e+00 |
| reactome:R-HSA-68886 | M Phase | 6.22e-05 | 7.50e-04 | 5.38e-01 | -3.01e-01 | -1.56e+00 |
| go:0198738 | cell-cell signaling by wnt | 6.34e-05 | 7.62e-04 | 5.38e-01 | 3.79e-01 | 1.69e+00 |
| go:0031145 | anaphase-promoting complex-dependent catabolic process | 6.69e-05 | 7.99e-04 | 5.38e-01 | 5.05e-01 | 1.91e+00 |
| go:0060968 | regulation of gene silencing | 7.02e-05 | 8.36e-04 | 5.38e-01 | -4.32e-01 | -1.88e+00 |
| reactome:R-HSA-69473 | G2/M DNA damage checkpoint | 7.08e-05 | 8.41e-04 | 5.38e-01 | -5.21e-01 | -2.03e+00 |
| go:0007254 | JNK cascade | 7.13e-05 | 8.44e-04 | 5.38e-01 | 5.07e-01 | 1.91e+00 |
| go:0009896 | positive regulation of catabolic process | 7.19e-05 | 8.49e-04 | 5.38e-01 | 3.84e-01 | 1.71e+00 |
| reactome:R-HSA-195721 | Signaling by WNT | 7.55e-05 | 8.88e-04 | 5.38e-01 | 4.15e-01 | 1.77e+00 |
| go:0016241 | regulation of macroautophagy | 7.61e-05 | 8.92e-04 | 5.38e-01 | 4.84e-01 | 1.90e+00 |
| reactome:R-HSA-69620 | Cell Cycle Checkpoints | 7.85e-05 | 9.18e-04 | 5.38e-01 | -3.27e-01 | -1.65e+00 |
| go:1903052 | positive regulation of proteolysis involved in cellular protein catabolic process | 7.96e-05 | 9.29e-04 | 5.38e-01 | 5.14e-01 | 1.93e+00 |
| reactome:R-HSA-110373 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway | 8.01e-05 | 9.32e-04 | 5.38e-01 | -6.58e-01 | -2.16e+00 |
| go:0070997 | neuron death | 8.25e-05 | 9.57e-04 | 5.38e-01 | 4.16e-01 | 1.77e+00 |
| go:0045595 | regulation of cell differentiation | 8.37e-05 | 9.68e-04 | 5.38e-01 | 2.98e-01 | 1.46e+00 |
| go:0010506 | regulation of autophagy | 8.65e-05 | 9.97e-04 | 5.38e-01 | 4.16e-01 | 1.78e+00 |
| go:0009057 | macromolecule catabolic process | 9.11e-05 | 1.04e-03 | 5.38e-01 | 2.86e-01 | 1.42e+00 |
| go:0007267 | cell-cell signaling | 9.11e-05 | 1.04e-03 | 5.38e-01 | 3.19e-01 | 1.53e+00 |
| reactome:R-HSA-8878171 | Transcriptional regulation by RUNX1 | 9.52e-05 | 1.08e-03 | 5.38e-01 | 4.43e-01 | 1.83e+00 |
| reactome:R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence | 9.57e-05 | 1.09e-03 | 5.38e-01 | -6.14e-01 | -2.11e+00 |
| go:1903364 | positive regulation of cellular protein catabolic process | 1.03e-04 | 1.16e-03 | 5.38e-01 | 4.90e-01 | 1.89e+00 |
| reactome:R-HSA-180786 | Extension of Telomeres | 1.07e-04 | 1.20e-03 | 5.38e-01 | -6.30e-01 | -2.12e+00 |
| go:0004175 | endopeptidase activity | 1.09e-04 | 1.23e-03 | 5.38e-01 | 4.45e-01 | 1.83e+00 |
| go:0097530 | granulocyte migration | 1.13e-04 | 1.26e-03 | 5.38e-01 | 6.00e-01 | 2.00e+00 |
| reactome:R-HSA-1221632 | Meiotic synapsis | 1.13e-04 | 1.27e-03 | 5.38e-01 | -6.49e-01 | -2.15e+00 |
| msig:M4741 | KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS | 1.14e-04 | 1.27e-03 | 5.38e-01 | -6.27e-01 | -2.09e+00 |
| reactome:R-HSA-68962 | Activation of the pre-replicative complex | 1.15e-04 | 1.28e-03 | 5.38e-01 | -6.18e-01 | -2.10e+00 |
| go:0034508 | centromere complex assembly | 1.16e-04 | 1.29e-03 | 5.38e-01 | -5.69e-01 | -2.06e+00 |
| reactome:R-HSA-73772 | RNA Polymerase I Promoter Escape | 1.18e-04 | 1.30e-03 | 5.38e-01 | -5.73e-01 | -2.08e+00 |
| reactome:R-HSA-8936459 | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function | 1.18e-04 | 1.30e-03 | 5.38e-01 | -6.05e-01 | -2.11e+00 |
| reactome:R-HSA-3371568 | Attenuation phase | 1.27e-04 | 1.39e-03 | 5.19e-01 | 7.58e-01 | 2.08e+00 |
| go:0051247 | positive regulation of protein metabolic process | 1.27e-04 | 1.40e-03 | 5.19e-01 | 2.92e-01 | 1.44e+00 |
| go:0048770 | pigment granule | 1.28e-04 | 1.40e-03 | 5.19e-01 | 4.94e-01 | 1.87e+00 |
| msig:M16817 | KEGG_OOCYTE_MEIOSIS | 1.32e-04 | 1.44e-03 | 5.19e-01 | -4.77e-01 | -1.92e+00 |
| reactome:R-HSA-5625740 | RHO GTPases activate PKNs | 1.32e-04 | 1.44e-03 | 5.19e-01 | -5.81e-01 | -2.09e+00 |
| reactome:R-HSA-3214858 | RMTs methylate histone arginines | 1.37e-04 | 1.48e-03 | 5.19e-01 | -6.06e-01 | -2.08e+00 |
| reactome:R-HSA-1912422 | Pre-NOTCH Expression and Processing | 1.44e-04 | 1.55e-03 | 5.19e-01 | -5.52e-01 | -2.04e+00 |
| go:0010941 | regulation of cell death | 1.45e-04 | 1.56e-03 | 5.19e-01 | 2.91e-01 | 1.44e+00 |
| go:0051085 | chaperone cofactor-dependent protein refolding | 1.46e-04 | 1.58e-03 | 5.19e-01 | 7.11e-01 | 2.08e+00 |
| go:0001664 | G protein-coupled receptor binding | 1.47e-04 | 1.58e-03 | 5.19e-01 | 5.33e-01 | 1.95e+00 |
| reactome:R-HSA-68875 | Mitotic Prophase | 1.51e-04 | 1.62e-03 | 5.19e-01 | -4.48e-01 | -1.91e+00 |
| go:0046329 | negative regulation of JNK cascade | 1.56e-04 | 1.67e-03 | 5.19e-01 | 7.43e-01 | 2.08e+00 |
| go:0006826 | iron ion transport | 1.59e-04 | 1.69e-03 | 5.19e-01 | 6.19e-01 | 1.98e+00 |
| reactome:R-HSA-212165 | Epigenetic regulation of gene expression | 1.67e-04 | 1.76e-03 | 5.19e-01 | -4.32e-01 | -1.84e+00 |
| reactome:R-HSA-73933 | Resolution of Abasic Sites (AP sites) | 1.68e-04 | 1.78e-03 | 5.19e-01 | -5.94e-01 | -2.09e+00 |
| go:0032446 | protein modification by small protein conjugation | 1.76e-04 | 1.85e-03 | 5.19e-01 | 3.12e-01 | 1.50e+00 |
| go:0009266 | response to temperature stimulus | 1.76e-04 | 1.85e-03 | 5.19e-01 | 4.34e-01 | 1.80e+00 |
| go:0003684 | damaged DNA binding | 1.75e-04 | 1.85e-03 | 5.19e-01 | -5.33e-01 | -2.00e+00 |
| go:0034976 | response to endoplasmic reticulum stress | 1.84e-04 | 1.92e-03 | 5.19e-01 | 3.99e-01 | 1.73e+00 |
| reactome:R-HSA-176187 | Activation of ATR in response to replication stress | 1.84e-04 | 1.92e-03 | 5.19e-01 | -5.97e-01 | -2.08e+00 |
| reactome:R-HSA-73864 | RNA Polymerase I Transcription | 1.88e-04 | 1.95e-03 | 5.19e-01 | -5.11e-01 | -1.99e+00 |
| reactome:R-HSA-174417 | Telomere C-strand (Lagging Strand) Synthesis | 1.90e-04 | 1.97e-03 | 5.19e-01 | -6.62e-01 | -2.10e+00 |
| go:0038127 | ERBB signaling pathway | 1.92e-04 | 1.99e-03 | 5.19e-01 | 4.88e-01 | 1.85e+00 |
| msig:M5941 | HALLMARK_UV_RESPONSE_UP | 1.94e-04 | 2.00e-03 | 5.19e-01 | 4.59e-01 | 1.83e+00 |
| go:0044430 | 1.96e-04 | 2.01e-03 | 5.19e-01 | -2.40e-01 | -1.37e+00 | |
| go:0034728 | nucleosome organization | 2.04e-04 | 2.10e-03 | 5.19e-01 | -4.22e-01 | -1.79e+00 |
| go:0006612 | protein targeting to membrane | 2.12e-04 | 2.17e-03 | 5.19e-01 | -3.65e-01 | -1.72e+00 |
| go:1901988 | negative regulation of cell cycle phase transition | 2.14e-04 | 2.18e-03 | 5.19e-01 | 3.95e-01 | 1.71e+00 |
| go:0046916 | cellular transition metal ion homeostasis | 2.19e-04 | 2.22e-03 | 5.19e-01 | 5.29e-01 | 1.92e+00 |
| go:0007093 | mitotic cell cycle checkpoint | 2.31e-04 | 2.34e-03 | 5.19e-01 | -3.88e-01 | -1.77e+00 |
| go:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 2.41e-04 | 2.44e-03 | 5.19e-01 | 3.66e-01 | 1.65e+00 |
| go:1902749 | regulation of cell cycle G2/M phase transition | 2.45e-04 | 2.48e-03 | 4.98e-01 | 4.02e-01 | 1.72e+00 |
| go:0007033 | vacuole organization | 2.49e-04 | 2.50e-03 | 4.98e-01 | 4.67e-01 | 1.82e+00 |
| reactome:R-HSA-157118 | Signaling by NOTCH | 2.49e-04 | 2.50e-03 | 4.98e-01 | 4.20e-01 | 1.76e+00 |
| go:0045862 | positive regulation of proteolysis | 2.50e-04 | 2.51e-03 | 4.98e-01 | 3.85e-01 | 1.68e+00 |
| go:1903362 | regulation of cellular protein catabolic process | 2.59e-04 | 2.58e-03 | 4.98e-01 | 3.98e-01 | 1.70e+00 |
| go:0043005 | neuron projection | 2.64e-04 | 2.63e-03 | 4.98e-01 | 3.18e-01 | 1.51e+00 |
| go:0070303 | negative regulation of stress-activated protein kinase signaling cascade | 2.70e-04 | 2.68e-03 | 4.98e-01 | 6.67e-01 | 2.00e+00 |
| go:0032201 | telomere maintenance via semi-conservative replication | 2.77e-04 | 2.75e-03 | 4.98e-01 | -6.32e-01 | -2.07e+00 |
| go:0000790 | chromatin | 2.80e-04 | 2.77e-03 | 4.98e-01 | -3.32e-01 | -1.65e+00 |
| reactome:R-HSA-375276 | Peptide ligand-binding receptors | 2.87e-04 | 2.83e-03 | 4.98e-01 | 6.97e-01 | 2.04e+00 |
| go:0016234 | inclusion body | 2.96e-04 | 2.91e-03 | 4.98e-01 | 5.80e-01 | 1.93e+00 |
| go:0034724 | DNA replication-independent nucleosome organization | 2.96e-04 | 2.91e-03 | 4.98e-01 | -5.58e-01 | -2.02e+00 |
| reactome:R-HSA-69186 | Lagging Strand Synthesis | 2.97e-04 | 2.91e-03 | 4.98e-01 | -6.87e-01 | -2.07e+00 |
| go:0070192 | chromosome organization involved in meiotic cell cycle | 3.00e-04 | 2.93e-03 | 4.98e-01 | -6.49e-01 | -2.11e+00 |
| go:0009408 | response to heat | 3.03e-04 | 2.95e-03 | 4.98e-01 | 4.59e-01 | 1.83e+00 |
| go:0030001 | metal ion transport | 3.04e-04 | 2.95e-03 | 4.98e-01 | 3.63e-01 | 1.63e+00 |
| go:0040029 | regulation of gene expression, epigenetic | 3.17e-04 | 3.07e-03 | 4.98e-01 | -3.17e-01 | -1.60e+00 |
| go:0045732 | positive regulation of protein catabolic process | 3.38e-04 | 3.24e-03 | 4.98e-01 | 4.33e-01 | 1.77e+00 |
| go:0090734 | site of DNA damage | 3.39e-04 | 3.24e-03 | 4.98e-01 | -4.91e-01 | -1.91e+00 |
| go:1901796 | regulation of signal transduction by p53 class mediator | 3.38e-04 | 3.24e-03 | 4.98e-01 | -3.78e-01 | -1.73e+00 |
| reactome:R-HSA-917937 | Iron uptake and transport | 3.37e-04 | 3.24e-03 | 4.98e-01 | 5.94e-01 | 1.94e+00 |
| go:0045202 | synapse | 3.44e-04 | 3.29e-03 | 4.98e-01 | 3.21e-01 | 1.51e+00 |
| reactome:R-HSA-4615885 | SUMOylation of DNA replication proteins | 3.46e-04 | 3.29e-03 | 4.98e-01 | -5.26e-01 | -1.93e+00 |
| go:0034605 | cellular response to heat | 3.58e-04 | 3.40e-03 | 4.98e-01 | 4.79e-01 | 1.83e+00 |
| reactome:R-HSA-3371453 | Regulation of HSF1-mediated heat shock response | 3.59e-04 | 3.40e-03 | 4.98e-01 | 5.07e-01 | 1.86e+00 |
| reactome:R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis | 3.75e-04 | 3.55e-03 | 4.98e-01 | 5.14e-01 | 1.88e+00 |
| go:0032200 | telomere organization | 3.86e-04 | 3.64e-03 | 4.98e-01 | -3.89e-01 | -1.76e+00 |
| go:0051174 | regulation of phosphorus metabolic process | 3.86e-04 | 3.64e-03 | 4.98e-01 | 2.89e-01 | 1.41e+00 |
| go:0032993 | protein-DNA complex | 3.88e-04 | 3.65e-03 | 4.98e-01 | -4.16e-01 | -1.80e+00 |
| reactome:R-HSA-3299685 | Detoxification of Reactive Oxygen Species | 3.96e-04 | 3.70e-03 | 4.98e-01 | 6.62e-01 | 2.00e+00 |
| go:0080135 | regulation of cellular response to stress | 3.96e-04 | 3.70e-03 | 4.98e-01 | 3.28e-01 | 1.53e+00 |
| go:0006302 | double-strand break repair | 3.99e-04 | 3.72e-03 | 4.98e-01 | -3.63e-01 | -1.70e+00 |
| msig:M5902 | HALLMARK_APOPTOSIS | 4.07e-04 | 3.78e-03 | 4.98e-01 | 4.44e-01 | 1.79e+00 |
| go:0044839 | cell cycle G2/M phase transition | 4.12e-04 | 3.82e-03 | 4.98e-01 | 3.76e-01 | 1.65e+00 |
| go:0043202 | lysosomal lumen | 4.12e-04 | 3.82e-03 | 4.98e-01 | 5.66e-01 | 1.93e+00 |
| go:0042592 | homeostatic process | 4.19e-04 | 3.87e-03 | 4.98e-01 | 2.84e-01 | 1.39e+00 |
| go:1902100 | negative regulation of metaphase/anaphase transition of cell cycle | 4.31e-04 | 3.97e-03 | 4.98e-01 | -5.89e-01 | -2.00e+00 |
| go:0000075 | cell cycle checkpoint | 4.31e-04 | 3.97e-03 | 4.98e-01 | -3.54e-01 | -1.68e+00 |
| go:0072599 | establishment of protein localization to endoplasmic reticulum | 4.38e-04 | 4.01e-03 | 4.98e-01 | -3.81e-01 | -1.75e+00 |
| go:0031492 | nucleosomal DNA binding | 4.44e-04 | 4.06e-03 | 4.98e-01 | -5.72e-01 | -1.99e+00 |
| go:0046545 | development of primary female sexual characteristics | 4.52e-04 | 4.13e-03 | 4.98e-01 | 5.78e-01 | 1.96e+00 |
| reactome:R-HSA-72312 | rRNA processing | 4.61e-04 | 4.20e-03 | 4.98e-01 | -3.17e-01 | -1.59e+00 |
| reactome:R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand | 4.75e-04 | 4.32e-03 | 4.98e-01 | 5.73e-01 | 1.93e+00 |
| go:0055076 | transition metal ion homeostasis | 4.98e-04 | 4.51e-03 | 4.77e-01 | 4.55e-01 | 1.73e+00 |
| go:0055006 | cardiac cell development | 5.15e-04 | 4.66e-03 | 4.77e-01 | -5.93e-01 | -2.00e+00 |
| reactome:R-HSA-168638 | NOD1/2 Signaling Pathway | 5.21e-04 | 4.70e-03 | 4.77e-01 | 6.98e-01 | 2.03e+00 |
| go:0044463 | 5.38e-04 | 4.84e-03 | 4.77e-01 | 3.06e-01 | 1.47e+00 | |
| go:0012506 | vesicle membrane | 5.41e-04 | 4.85e-03 | 4.77e-01 | 3.29e-01 | 1.52e+00 |
| reactome:R-HSA-69306 | DNA Replication | 5.63e-04 | 5.03e-03 | 4.77e-01 | 4.23e-01 | 1.72e+00 |
| reactome:R-HSA-5578749 | Transcriptional regulation by small RNAs | 5.95e-04 | 5.30e-03 | 4.77e-01 | -4.73e-01 | -1.86e+00 |
| reactome:R-HSA-5651801 | PCNA-Dependent Long Patch Base Excision Repair | 5.95e-04 | 5.30e-03 | 4.77e-01 | -6.52e-01 | -2.05e+00 |
| go:0002698 | negative regulation of immune effector process | 6.08e-04 | 5.38e-03 | 4.77e-01 | 5.60e-01 | 1.86e+00 |
| go:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | 6.07e-04 | 5.38e-03 | 4.77e-01 | -5.88e-01 | -1.96e+00 |
| msig:M14314 | KEGG_PURINE_METABOLISM | 6.26e-04 | 5.53e-03 | 4.77e-01 | -4.13e-01 | -1.76e+00 |
| go:0090068 | positive regulation of cell cycle process | 6.35e-04 | 5.59e-03 | 4.77e-01 | -3.33e-01 | -1.62e+00 |
| msig:M16848 | KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION | 6.45e-04 | 5.67e-03 | 4.77e-01 | 5.66e-01 | 1.91e+00 |
| go:0031055 | chromatin remodeling at centromere | 6.60e-04 | 5.77e-03 | 4.77e-01 | -5.80e-01 | -1.97e+00 |
| go:0061912 | selective autophagy | 6.60e-04 | 5.77e-03 | 4.77e-01 | 6.67e-01 | 1.97e+00 |
| reactome:R-HSA-8856828 | Clathrin-mediated endocytosis | 6.88e-04 | 6.00e-03 | 4.77e-01 | 4.55e-01 | 1.76e+00 |
| go:0048878 | chemical homeostasis | 7.02e-04 | 6.10e-03 | 4.77e-01 | 3.24e-01 | 1.51e+00 |
| go:0042175 | nuclear outer membrane-endoplasmic reticulum membrane network | 7.09e-04 | 6.14e-03 | 4.77e-01 | 3.01e-01 | 1.45e+00 |
| go:0061136 | regulation of proteasomal protein catabolic process | 7.10e-04 | 6.14e-03 | 4.77e-01 | 4.27e-01 | 1.76e+00 |
| go:0031491 | nucleosome binding | 7.21e-04 | 6.20e-03 | 4.77e-01 | -4.65e-01 | -1.86e+00 |
| go:0070302 | regulation of stress-activated protein kinase signaling cascade | 7.21e-04 | 6.20e-03 | 4.77e-01 | 4.65e-01 | 1.78e+00 |
| go:0016233 | telomere capping | 7.25e-04 | 6.22e-03 | 4.77e-01 | -6.01e-01 | -1.99e+00 |
| go:0000725 | recombinational repair | 7.28e-04 | 6.24e-03 | 4.77e-01 | -4.14e-01 | -1.72e+00 |
| reactome:R-HSA-5250941 | Negative epigenetic regulation of rRNA expression | 7.58e-04 | 6.45e-03 | 4.77e-01 | -4.81e-01 | -1.87e+00 |
| go:0045787 | positive regulation of cell cycle | 7.58e-04 | 6.45e-03 | 4.77e-01 | -3.09e-01 | -1.56e+00 |
| msig:M9809 | KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION | 7.69e-04 | 6.53e-03 | 4.77e-01 | 5.32e-01 | 1.87e+00 |
| go:0032467 | positive regulation of cytokinesis | 7.99e-04 | 6.77e-03 | 4.77e-01 | -6.45e-01 | -2.03e+00 |
| reactome:R-HSA-422475 | Axon guidance | 8.09e-04 | 6.84e-03 | 4.77e-01 | 3.26e-01 | 1.50e+00 |
| go:0005813 | centrosome | 8.15e-04 | 6.88e-03 | 4.77e-01 | -2.77e-01 | -1.45e+00 |
| msig:M11266 | KEGG_LYSOSOME | 8.19e-04 | 6.89e-03 | 4.77e-01 | 4.53e-01 | 1.72e+00 |
| go:0042176 | regulation of protein catabolic process | 8.21e-04 | 6.90e-03 | 4.77e-01 | 3.64e-01 | 1.61e+00 |
| go:0071384 | cellular response to corticosteroid stimulus | 8.45e-04 | 7.08e-03 | 4.77e-01 | 5.94e-01 | 1.92e+00 |
| go:0042582 | azurophil granule | 8.61e-04 | 7.20e-03 | 4.77e-01 | 4.42e-01 | 1.75e+00 |
| go:0071559 | response to transforming growth factor beta | 8.71e-04 | 7.27e-03 | 4.77e-01 | 4.31e-01 | 1.74e+00 |
| reactome:R-HSA-5685938 | HDR through Single Strand Annealing (SSA) | 8.75e-04 | 7.29e-03 | 4.77e-01 | -6.22e-01 | -1.98e+00 |
| go:0008608 | attachment of spindle microtubules to kinetochore | 8.94e-04 | 7.43e-03 | 4.77e-01 | -5.62e-01 | -1.93e+00 |
| go:0005768 | endosome | 9.03e-04 | 7.49e-03 | 4.77e-01 | 3.11e-01 | 1.47e+00 |
| go:0035305 | negative regulation of dephosphorylation | 9.15e-04 | 7.57e-03 | 4.77e-01 | 5.38e-01 | 1.86e+00 |
| go:0006812 | cation transport | 9.36e-04 | 7.73e-03 | 4.77e-01 | 3.25e-01 | 1.51e+00 |
| reactome:R-HSA-427389 | ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression | 9.60e-04 | 7.91e-03 | 4.77e-01 | -5.74e-01 | -1.91e+00 |
| msig:M5921 | HALLMARK_COMPLEMENT | 9.68e-04 | 7.96e-03 | 4.77e-01 | 4.35e-01 | 1.69e+00 |
| reactome:R-HSA-448424 | Interleukin-17 signaling | 9.81e-04 | 8.05e-03 | 4.55e-01 | 5.50e-01 | 1.83e+00 |
| go:0008233 | peptidase activity | 1.00e-03 | 8.19e-03 | 4.55e-01 | 3.61e-01 | 1.60e+00 |
| msig:M3261 | KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY | 1.01e-03 | 8.22e-03 | 4.55e-01 | 5.80e-01 | 1.85e+00 |
| go:0046660 | female sex differentiation | 1.02e-03 | 8.27e-03 | 4.55e-01 | 5.33e-01 | 1.84e+00 |
| go:0051087 | chaperone binding | 1.03e-03 | 8.36e-03 | 4.55e-01 | 4.89e-01 | 1.80e+00 |
| go:0044281 | small molecule metabolic process | 1.03e-03 | 8.38e-03 | 4.55e-01 | 2.74e-01 | 1.35e+00 |
| go:0072686 | mitotic spindle | 1.04e-03 | 8.40e-03 | 4.55e-01 | -4.14e-01 | -1.71e+00 |
| go:0051668 | localization within membrane | 1.05e-03 | 8.44e-03 | 4.55e-01 | 4.88e-01 | 1.79e+00 |
| go:0070848 | response to growth factor | 1.07e-03 | 8.61e-03 | 4.55e-01 | 3.21e-01 | 1.48e+00 |
| go:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 1.07e-03 | 8.64e-03 | 4.55e-01 | 5.49e-01 | 1.83e+00 |
| go:1900034 | regulation of cellular response to heat | 1.09e-03 | 8.74e-03 | 4.55e-01 | 4.97e-01 | 1.81e+00 |
| go:0044843 | cell cycle G1/S phase transition | 1.10e-03 | 8.82e-03 | 4.55e-01 | -3.19e-01 | -1.56e+00 |
| msig:M5905 | HALLMARK_ADIPOGENESIS | 1.12e-03 | 8.93e-03 | 4.55e-01 | 4.05e-01 | 1.71e+00 |
| reactome:R-HSA-9614085 | FOXO-mediated transcription | 1.14e-03 | 9.10e-03 | 4.55e-01 | 5.55e-01 | 1.82e+00 |
| go:0035967 | cellular response to topologically incorrect protein | 1.16e-03 | 9.21e-03 | 4.55e-01 | 4.35e-01 | 1.74e+00 |
| msig:M13515 | KEGG_MISMATCH_REPAIR | 1.17e-03 | 9.23e-03 | 4.55e-01 | -6.52e-01 | -1.97e+00 |
| go:0005788 | endoplasmic reticulum lumen | 1.16e-03 | 9.23e-03 | 4.55e-01 | -3.61e-01 | -1.67e+00 |
| go:0097529 | myeloid leukocyte migration | 1.17e-03 | 9.23e-03 | 4.55e-01 | 5.04e-01 | 1.82e+00 |
| go:0005770 | late endosome | 1.17e-03 | 9.24e-03 | 4.55e-01 | 4.03e-01 | 1.70e+00 |
| msig:M5500 | KEGG_BASE_EXCISION_REPAIR | 1.18e-03 | 9.32e-03 | 4.55e-01 | -5.90e-01 | -1.95e+00 |
| go:0045814 | negative regulation of gene expression, epigenetic | 1.19e-03 | 9.35e-03 | 4.55e-01 | -4.16e-01 | -1.70e+00 |
| reactome:R-HSA-199992 | trans-Golgi Network Vesicle Budding | 1.19e-03 | 9.36e-03 | 4.55e-01 | 4.93e-01 | 1.79e+00 |
| msig:M5951 | HALLMARK_SPERMATOGENESIS | 1.21e-03 | 9.45e-03 | 4.55e-01 | -5.07e-01 | -1.89e+00 |
| go:0051648 | vesicle localization | 1.22e-03 | 9.50e-03 | 4.55e-01 | 3.97e-01 | 1.67e+00 |
| go:0006984 | ER-nucleus signaling pathway | 1.23e-03 | 9.63e-03 | 4.55e-01 | 5.45e-01 | 1.81e+00 |
| go:0030424 | axon | 1.24e-03 | 9.65e-03 | 4.55e-01 | 3.58e-01 | 1.57e+00 |
| go:0035872 | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | 1.25e-03 | 9.75e-03 | 4.55e-01 | 6.92e-01 | 1.93e+00 |
| go:0006879 | cellular iron ion homeostasis | 1.28e-03 | 9.86e-03 | 4.55e-01 | 5.69e-01 | 1.84e+00 |
| msig:M18937 | KEGG_NUCLEOTIDE_EXCISION_REPAIR | 1.27e-03 | 9.86e-03 | 4.55e-01 | -5.04e-01 | -1.88e+00 |
| go:0071824 | protein-DNA complex subunit organization | 1.29e-03 | 9.95e-03 | 4.55e-01 | -3.25e-01 | -1.58e+00 |
| go:0090100 | positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 1.29e-03 | 9.96e-03 | 4.55e-01 | 5.30e-01 | 1.81e+00 |
| go:0005929 | cilium | 1.30e-03 | 1.00e-02 | 4.55e-01 | 3.61e-01 | 1.58e+00 |
| go:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | 1.32e-03 | 1.01e-02 | 4.55e-01 | 4.01e-01 | 1.66e+00 |
| reactome:R-HSA-2559583 | Cellular Senescence | 1.35e-03 | 1.03e-02 | 4.55e-01 | -3.65e-01 | -1.63e+00 |
| go:0002520 | immune system development | 1.37e-03 | 1.05e-02 | 4.55e-01 | 3.21e-01 | 1.51e+00 |
| go:0044092 | negative regulation of molecular function | 1.38e-03 | 1.05e-02 | 4.55e-01 | 2.98e-01 | 1.42e+00 |
| go:0006270 | DNA replication initiation | 1.39e-03 | 1.06e-02 | 4.55e-01 | -5.60e-01 | -1.90e+00 |
| reactome:R-HSA-446203 | Asparagine N-linked glycosylation | 1.39e-03 | 1.06e-02 | 4.55e-01 | 3.61e-01 | 1.57e+00 |
| go:0072507 | divalent inorganic cation homeostasis | 1.40e-03 | 1.06e-02 | 4.55e-01 | 4.10e-01 | 1.70e+00 |
| go:0043408 | regulation of MAPK cascade | 1.40e-03 | 1.06e-02 | 4.55e-01 | 3.32e-01 | 1.51e+00 |
| reactome:R-HSA-418594 | G alpha (i) signalling events | 1.42e-03 | 1.07e-02 | 4.55e-01 | 4.55e-01 | 1.71e+00 |
| go:0051383 | kinetochore organization | 1.44e-03 | 1.09e-02 | 4.55e-01 | -6.46e-01 | -1.96e+00 |
| reactome:R-HSA-376176 | Signaling by ROBO receptors | 1.54e-03 | 1.16e-02 | 4.55e-01 | 3.60e-01 | 1.57e+00 |
| go:0034401 | chromatin organization involved in regulation of transcription | 1.57e-03 | 1.17e-02 | 4.55e-01 | -4.30e-01 | -1.75e+00 |
| go:1990266 | neutrophil migration | 1.56e-03 | 1.17e-02 | 4.55e-01 | 5.95e-01 | 1.88e+00 |
| msig:M10792 | KEGG_MAPK_SIGNALING_PATHWAY | 1.56e-03 | 1.17e-02 | 4.55e-01 | 4.21e-01 | 1.70e+00 |
| go:1902532 | negative regulation of intracellular signal transduction | 1.58e-03 | 1.18e-02 | 4.55e-01 | 3.40e-01 | 1.53e+00 |
| reactome:R-HSA-3371511 | HSF1 activation | 1.68e-03 | 1.25e-02 | 4.55e-01 | 6.44e-01 | 1.89e+00 |
| go:0005730 | nucleolus | 1.68e-03 | 1.25e-02 | 4.55e-01 | -2.31e-01 | -1.31e+00 |
| reactome:R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | 1.69e-03 | 1.26e-02 | 4.55e-01 | 6.11e-01 | 1.89e+00 |
| go:0016482 | cytosolic transport | 1.72e-03 | 1.27e-02 | 4.55e-01 | 4.36e-01 | 1.68e+00 |
| reactome:R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) | 1.72e-03 | 1.28e-02 | 4.55e-01 | 6.11e-01 | 1.89e+00 |
| reactome:R-HSA-75893 | TNF signaling | 1.75e-03 | 1.29e-02 | 4.55e-01 | 6.36e-01 | 1.88e+00 |
| go:0051129 | negative regulation of cellular component organization | 1.75e-03 | 1.29e-02 | 4.55e-01 | -2.67e-01 | -1.41e+00 |
| go:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process | 1.83e-03 | 1.34e-02 | 4.55e-01 | 4.37e-01 | 1.66e+00 |
| reactome:R-HSA-5663205 | Infectious disease | 1.84e-03 | 1.35e-02 | 4.55e-01 | 3.16e-01 | 1.46e+00 |
| go:0072522 | purine-containing compound biosynthetic process | 1.87e-03 | 1.37e-02 | 4.55e-01 | -3.48e-01 | -1.61e+00 |
| go:0005794 | Golgi apparatus | 1.91e-03 | 1.39e-02 | 4.55e-01 | 2.73e-01 | 1.33e+00 |
| go:0051233 | spindle midzone | 1.91e-03 | 1.39e-02 | 4.55e-01 | -5.55e-01 | -1.87e+00 |
| go:0061659 | ubiquitin-like protein ligase activity | 1.93e-03 | 1.40e-02 | 4.55e-01 | 3.99e-01 | 1.62e+00 |
| go:0005102 | signaling receptor binding | 1.94e-03 | 1.40e-02 | 4.55e-01 | 2.95e-01 | 1.41e+00 |
| go:0000226 | microtubule cytoskeleton organization | 1.96e-03 | 1.41e-02 | 4.32e-01 | -2.70e-01 | -1.40e+00 |
| go:0000041 | transition metal ion transport | 1.96e-03 | 1.41e-02 | 4.32e-01 | 4.95e-01 | 1.78e+00 |
| go:0051402 | neuron apoptotic process | 1.96e-03 | 1.41e-02 | 4.32e-01 | 3.99e-01 | 1.61e+00 |
| go:0045930 | negative regulation of mitotic cell cycle | 1.96e-03 | 1.41e-02 | 4.32e-01 | 3.46e-01 | 1.53e+00 |
| go:1990868 | response to chemokine | 1.97e-03 | 1.41e-02 | 4.32e-01 | 6.71e-01 | 1.91e+00 |
| go:0005125 | cytokine activity | 2.00e-03 | 1.43e-02 | 4.32e-01 | 5.53e-01 | 1.79e+00 |
| go:0034404 | nucleobase-containing small molecule biosynthetic process | 2.00e-03 | 1.43e-02 | 4.32e-01 | -4.39e-01 | -1.75e+00 |
| go:0045815 | positive regulation of gene expression, epigenetic | 2.02e-03 | 1.44e-02 | 4.32e-01 | -4.88e-01 | -1.79e+00 |
| go:0045935 | positive regulation of nucleobase-containing compound metabolic process | 2.06e-03 | 1.47e-02 | 4.32e-01 | -3.29e-01 | -1.55e+00 |
| go:0002683 | negative regulation of immune system process | 2.06e-03 | 1.47e-02 | 4.32e-01 | 3.72e-01 | 1.57e+00 |
| go:0010608 | posttranscriptional regulation of gene expression | 2.09e-03 | 1.48e-02 | 4.32e-01 | 2.96e-01 | 1.40e+00 |
| reactome:R-HSA-2980766 | Nuclear Envelope Breakdown | 2.10e-03 | 1.48e-02 | 4.32e-01 | -4.66e-01 | -1.76e+00 |
| go:0006275 | regulation of DNA replication | 2.10e-03 | 1.48e-02 | 4.32e-01 | -4.11e-01 | -1.68e+00 |
| go:1901987 | regulation of cell cycle phase transition | 2.12e-03 | 1.49e-02 | 4.32e-01 | 3.23e-01 | 1.48e+00 |
| go:0006903 | vesicle targeting | 2.13e-03 | 1.50e-02 | 4.32e-01 | 4.73e-01 | 1.74e+00 |
| go:0001816 | cytokine production | 2.20e-03 | 1.55e-02 | 4.32e-01 | 3.27e-01 | 1.49e+00 |
| go:0005876 | spindle microtubule | 2.24e-03 | 1.57e-02 | 4.32e-01 | -4.70e-01 | -1.78e+00 |
| reactome:R-HSA-69481 | G2/M Checkpoints | 2.35e-03 | 1.64e-02 | 4.32e-01 | 4.05e-01 | 1.67e+00 |
| go:0001818 | negative regulation of cytokine production | 2.35e-03 | 1.64e-02 | 4.32e-01 | 4.30e-01 | 1.66e+00 |
| go:0031401 | positive regulation of protein modification process | 2.42e-03 | 1.69e-02 | 4.32e-01 | 2.85e-01 | 1.36e+00 |
| go:0060590 | ATPase regulator activity | 2.44e-03 | 1.70e-02 | 4.32e-01 | 5.55e-01 | 1.77e+00 |
| go:0043086 | negative regulation of catalytic activity | 2.46e-03 | 1.70e-02 | 4.32e-01 | 3.10e-01 | 1.44e+00 |
| go:0051984 | positive regulation of chromosome segregation | 2.46e-03 | 1.70e-02 | 4.32e-01 | -5.65e-01 | -1.87e+00 |
| go:0060548 | negative regulation of cell death | 2.47e-03 | 1.71e-02 | 4.32e-01 | 2.95e-01 | 1.41e+00 |
| go:0019725 | cellular homeostasis | 2.50e-03 | 1.73e-02 | 4.32e-01 | 3.07e-01 | 1.43e+00 |
| go:0060420 | regulation of heart growth | 2.54e-03 | 1.75e-02 | 4.32e-01 | -5.48e-01 | -1.85e+00 |
| go:0051881 | regulation of mitochondrial membrane potential | 2.54e-03 | 1.75e-02 | 4.32e-01 | 5.21e-01 | 1.79e+00 |
| msig:M5910 | HALLMARK_PROTEIN_SECRETION | 2.55e-03 | 1.75e-02 | 4.32e-01 | 4.48e-01 | 1.71e+00 |
| reactome:R-HSA-500792 | GPCR ligand binding | 2.56e-03 | 1.76e-02 | 4.32e-01 | 5.11e-01 | 1.77e+00 |
| go:0030433 | ubiquitin-dependent ERAD pathway | 2.58e-03 | 1.77e-02 | 4.32e-01 | 4.85e-01 | 1.75e+00 |
| go:0045910 | negative regulation of DNA recombination | 2.61e-03 | 1.79e-02 | 4.32e-01 | -6.29e-01 | -1.91e+00 |
| reactome:R-HSA-69242 | S Phase | 2.63e-03 | 1.80e-02 | 4.32e-01 | 3.81e-01 | 1.62e+00 |
| go:0030522 | intracellular receptor signaling pathway | 2.69e-03 | 1.83e-02 | 4.32e-01 | 3.84e-01 | 1.61e+00 |
| go:0010562 | positive regulation of phosphorus metabolic process | 2.70e-03 | 1.84e-02 | 4.32e-01 | 3.06e-01 | 1.44e+00 |
| msig:M5898 | HALLMARK_DNA_REPAIR | 2.76e-03 | 1.88e-02 | 4.32e-01 | -3.47e-01 | -1.60e+00 |
| go:0007051 | spindle organization | 2.77e-03 | 1.88e-02 | 4.32e-01 | -3.54e-01 | -1.63e+00 |
| go:0043044 | ATP-dependent chromatin remodeling | 2.81e-03 | 1.90e-02 | 4.32e-01 | -4.29e-01 | -1.71e+00 |
| go:0005815 | microtubule organizing center | 2.85e-03 | 1.93e-02 | 4.32e-01 | -2.52e-01 | -1.36e+00 |
| go:0007034 | vacuolar transport | 2.87e-03 | 1.94e-02 | 4.32e-01 | 4.33e-01 | 1.67e+00 |
| go:0008284 | positive regulation of cell population proliferation | 2.89e-03 | 1.95e-02 | 4.32e-01 | -2.61e-01 | -1.38e+00 |
| go:0030219 | megakaryocyte differentiation | 2.95e-03 | 1.98e-02 | 4.32e-01 | -4.92e-01 | -1.78e+00 |
| go:0007041 | lysosomal transport | 2.96e-03 | 1.99e-02 | 4.32e-01 | 4.65e-01 | 1.71e+00 |
| go:2001252 | positive regulation of chromosome organization | 2.97e-03 | 1.99e-02 | 4.32e-01 | -3.55e-01 | -1.63e+00 |
| reactome:R-HSA-9018519 | Estrogen-dependent gene expression | 2.99e-03 | 1.99e-02 | 4.32e-01 | -4.01e-01 | -1.64e+00 |
| reactome:R-HSA-9616222 | Transcriptional regulation of granulopoiesis | 3.00e-03 | 2.00e-02 | 4.32e-01 | -5.43e-01 | -1.83e+00 |
| go:0050660 | flavin adenine dinucleotide binding | 2.99e-03 | 2.00e-02 | 4.32e-01 | 5.45e-01 | 1.77e+00 |
| go:0055001 | muscle cell development | 3.01e-03 | 2.00e-02 | 4.32e-01 | -4.30e-01 | -1.72e+00 |
| reactome:R-HSA-5693607 | Processing of DNA double-strand break ends | 3.05e-03 | 2.02e-02 | 4.32e-01 | -4.42e-01 | -1.72e+00 |
| go:1901215 | negative regulation of neuron death | 3.07e-03 | 2.02e-02 | 4.32e-01 | 4.32e-01 | 1.66e+00 |
| go:0019898 | extrinsic component of membrane | 3.14e-03 | 2.07e-02 | 4.32e-01 | 4.03e-01 | 1.63e+00 |
| reactome:R-HSA-199977 | ER to Golgi Anterograde Transport | 3.19e-03 | 2.10e-02 | 4.32e-01 | 4.06e-01 | 1.63e+00 |
| reactome:R-HSA-5633007 | Regulation of TP53 Activity | 3.25e-03 | 2.13e-02 | 4.32e-01 | -3.49e-01 | -1.57e+00 |
| go:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 3.27e-03 | 2.14e-02 | 4.32e-01 | 3.80e-01 | 1.59e+00 |
| go:1901137 | carbohydrate derivative biosynthetic process | 3.28e-03 | 2.15e-02 | 4.32e-01 | -2.64e-01 | -1.38e+00 |
| go:0002221 | pattern recognition receptor signaling pathway | 3.29e-03 | 2.15e-02 | 4.32e-01 | 4.49e-01 | 1.69e+00 |
| go:0070972 | protein localization to endoplasmic reticulum | 3.43e-03 | 2.23e-02 | 4.32e-01 | -3.34e-01 | -1.55e+00 |
| reactome:R-HSA-5205647 | Mitophagy | 3.52e-03 | 2.28e-02 | 4.32e-01 | 6.07e-01 | 1.83e+00 |
| go:0061982 | meiosis I cell cycle process | 3.51e-03 | 2.28e-02 | 4.32e-01 | -4.76e-01 | -1.77e+00 |
| go:0036503 | ERAD pathway | 3.57e-03 | 2.31e-02 | 4.32e-01 | 4.65e-01 | 1.72e+00 |
| reactome:R-HSA-5675221 | Negative regulation of MAPK pathway | 3.58e-03 | 2.31e-02 | 4.32e-01 | 5.92e-01 | 1.83e+00 |
| go:0006970 | response to osmotic stress | 3.69e-03 | 2.38e-02 | 4.32e-01 | 5.29e-01 | 1.73e+00 |
| go:0051187 | 3.72e-03 | 2.40e-02 | 4.32e-01 | 6.20e-01 | 1.82e+00 | |
| go:0060191 | regulation of lipase activity | 3.74e-03 | 2.41e-02 | 4.32e-01 | 6.62e-01 | 1.85e+00 |
| go:0044093 | positive regulation of molecular function | 3.84e-03 | 2.47e-02 | 4.32e-01 | 2.66e-01 | 1.31e+00 |
| msig:M5932 | HALLMARK_INFLAMMATORY_RESPONSE | 3.88e-03 | 2.49e-02 | 4.32e-01 | 4.14e-01 | 1.57e+00 |
| go:0015630 | microtubule cytoskeleton | 3.94e-03 | 2.52e-02 | 4.07e-01 | -2.25e-01 | -1.26e+00 |
| go:0009124 | nucleoside monophosphate biosynthetic process | 4.01e-03 | 2.56e-02 | 4.07e-01 | -5.06e-01 | -1.79e+00 |
| go:0031072 | heat shock protein binding | 4.01e-03 | 2.56e-02 | 4.07e-01 | 4.47e-01 | 1.68e+00 |
| go:0030968 | endoplasmic reticulum unfolded protein response | 4.14e-03 | 2.64e-02 | 4.07e-01 | 4.22e-01 | 1.61e+00 |
| go:0031012 | extracellular matrix | 4.20e-03 | 2.67e-02 | 4.07e-01 | 3.85e-01 | 1.56e+00 |
| go:0022602 | ovulation cycle process | 4.21e-03 | 2.67e-02 | 4.07e-01 | 6.60e-01 | 1.81e+00 |
| go:0000803 | sex chromosome | 4.24e-03 | 2.69e-02 | 4.07e-01 | -5.79e-01 | -1.84e+00 |
| go:0038066 | p38MAPK cascade | 4.26e-03 | 2.70e-02 | 4.07e-01 | 6.59e-01 | 1.81e+00 |
| go:0010942 | positive regulation of cell death | 4.27e-03 | 2.70e-02 | 4.07e-01 | 3.05e-01 | 1.41e+00 |
| go:0050900 | leukocyte migration | 4.30e-03 | 2.71e-02 | 4.07e-01 | 3.90e-01 | 1.63e+00 |
| msig:M5939 | HALLMARK_P53_PATHWAY | 4.31e-03 | 2.71e-02 | 4.07e-01 | 3.86e-01 | 1.58e+00 |
| reactome:R-HSA-9010553 | Regulation of expression of SLITs and ROBOs | 4.37e-03 | 2.75e-02 | 4.07e-01 | 3.64e-01 | 1.55e+00 |
| go:0046332 | SMAD binding | 4.41e-03 | 2.77e-02 | 4.07e-01 | 4.97e-01 | 1.69e+00 |
| go:0055007 | cardiac muscle cell differentiation | 4.42e-03 | 2.77e-02 | 4.07e-01 | -4.90e-01 | -1.78e+00 |
| reactome:R-HSA-75153 | Apoptotic execution phase | 4.48e-03 | 2.80e-02 | 4.07e-01 | -4.75e-01 | -1.73e+00 |
| go:0061458 | reproductive system development | 4.55e-03 | 2.84e-02 | 4.07e-01 | 3.58e-01 | 1.55e+00 |
| go:0010563 | negative regulation of phosphorus metabolic process | 4.56e-03 | 2.84e-02 | 4.07e-01 | 3.25e-01 | 1.47e+00 |
| go:0046685 | response to arsenic-containing substance | 4.56e-03 | 2.84e-02 | 4.07e-01 | 6.49e-01 | 1.85e+00 |
| msig:M5109 | KEGG_PYRIMIDINE_METABOLISM | 4.60e-03 | 2.85e-02 | 4.07e-01 | -3.87e-01 | -1.58e+00 |
| go:0005905 | clathrin-coated pit | 4.61e-03 | 2.86e-02 | 4.07e-01 | 5.31e-01 | 1.72e+00 |
| go:0031490 | chromatin DNA binding | 4.68e-03 | 2.90e-02 | 4.07e-01 | -4.40e-01 | -1.72e+00 |
| go:0035308 | negative regulation of protein dephosphorylation | 4.70e-03 | 2.90e-02 | 4.07e-01 | 5.90e-01 | 1.80e+00 |
| go:0000307 | cyclin-dependent protein kinase holoenzyme complex | 4.74e-03 | 2.92e-02 | 4.07e-01 | -5.28e-01 | -1.80e+00 |
| go:0043604 | amide biosynthetic process | 4.78e-03 | 2.95e-02 | 4.07e-01 | -2.29e-01 | -1.27e+00 |
| go:0030234 | enzyme regulator activity | 4.80e-03 | 2.95e-02 | 4.07e-01 | 2.86e-01 | 1.36e+00 |
| go:0051049 | regulation of transport | 4.83e-03 | 2.96e-02 | 4.07e-01 | 2.72e-01 | 1.32e+00 |
| go:0002200 | somatic diversification of immune receptors | 4.83e-03 | 2.96e-02 | 4.07e-01 | -5.27e-01 | -1.79e+00 |
| go:1902807 | negative regulation of cell cycle G1/S phase transition | 4.84e-03 | 2.97e-02 | 4.07e-01 | -3.91e-01 | -1.59e+00 |
| reactome:R-HSA-141405 | Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | 4.85e-03 | 2.97e-02 | 4.07e-01 | -6.07e-01 | -1.83e+00 |
| go:0055024 | regulation of cardiac muscle tissue development | 4.90e-03 | 2.99e-02 | 4.07e-01 | -5.07e-01 | -1.76e+00 |
| reactome:R-HSA-73887 | Death Receptor Signalling | 5.01e-03 | 3.05e-02 | 4.07e-01 | 4.57e-01 | 1.69e+00 |
| go:0043405 | regulation of MAP kinase activity | 5.05e-03 | 3.07e-02 | 4.07e-01 | 3.73e-01 | 1.57e+00 |
| msig:M15902 | KEGG_GLYCEROLIPID_METABOLISM | 5.08e-03 | 3.08e-02 | 4.07e-01 | 6.37e-01 | 1.86e+00 |
| reactome:R-HSA-8863795 | Downregulation of ERBB2 signaling | 5.12e-03 | 3.10e-02 | 4.07e-01 | 6.53e-01 | 1.83e+00 |
| go:0010508 | positive regulation of autophagy | 5.12e-03 | 3.10e-02 | 4.07e-01 | 4.61e-01 | 1.67e+00 |
| go:0009719 | response to endogenous stimulus | 5.13e-03 | 3.10e-02 | 4.07e-01 | 2.70e-01 | 1.32e+00 |
| go:0050777 | negative regulation of immune response | 5.19e-03 | 3.12e-02 | 4.07e-01 | 5.09e-01 | 1.71e+00 |
| reactome:R-HSA-1227986 | Signaling by ERBB2 | 5.18e-03 | 3.12e-02 | 4.07e-01 | 5.77e-01 | 1.79e+00 |
| reactome:R-HSA-5357905 | Regulation of TNFR1 signaling | 5.19e-03 | 3.12e-02 | 4.07e-01 | 6.37e-01 | 1.85e+00 |
| go:0120163 | negative regulation of cold-induced thermogenesis | 5.30e-03 | 3.17e-02 | 4.07e-01 | 6.53e-01 | 1.79e+00 |
| reactome:R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) | 5.31e-03 | 3.18e-02 | 4.07e-01 | -4.35e-01 | -1.66e+00 |
| go:0032147 | activation of protein kinase activity | 5.38e-03 | 3.22e-02 | 4.07e-01 | 3.74e-01 | 1.58e+00 |
| go:0030139 | endocytic vesicle | 5.51e-03 | 3.28e-02 | 4.07e-01 | 3.67e-01 | 1.54e+00 |
| go:1904724 | tertiary granule lumen | 5.52e-03 | 3.28e-02 | 4.07e-01 | 5.43e-01 | 1.73e+00 |
| go:0071216 | cellular response to biotic stimulus | 5.54e-03 | 3.29e-02 | 4.07e-01 | 4.24e-01 | 1.62e+00 |
| go:0006749 | glutathione metabolic process | 5.57e-03 | 3.30e-02 | 4.07e-01 | 6.01e-01 | 1.78e+00 |
| go:0051052 | regulation of DNA metabolic process | 5.61e-03 | 3.32e-02 | 4.07e-01 | -2.94e-01 | -1.44e+00 |
| go:0000422 | autophagy of mitochondrion | 5.62e-03 | 3.32e-02 | 4.07e-01 | 4.85e-01 | 1.69e+00 |
| go:0032594 | protein transport within lipid bilayer | 5.66e-03 | 3.34e-02 | 4.07e-01 | 6.08e-01 | 1.78e+00 |
| go:1905898 | positive regulation of response to endoplasmic reticulum stress | 5.71e-03 | 3.36e-02 | 4.07e-01 | 5.89e-01 | 1.76e+00 |
| go:0090114 | COPII-coated vesicle budding | 5.76e-03 | 3.38e-02 | 4.07e-01 | 4.62e-01 | 1.66e+00 |
| go:1901981 | phosphatidylinositol phosphate binding | 5.76e-03 | 3.38e-02 | 4.07e-01 | 4.73e-01 | 1.68e+00 |
| reactome:R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 5.77e-03 | 3.38e-02 | 4.07e-01 | 5.16e-01 | 1.68e+00 |
| reactome:R-HSA-983231 | Factors involved in megakaryocyte development and platelet production | 5.81e-03 | 3.39e-02 | 4.07e-01 | -3.74e-01 | -1.58e+00 |
| go:0022627 | cytosolic small ribosomal subunit | 5.81e-03 | 3.39e-02 | 4.07e-01 | -4.55e-01 | -1.67e+00 |
| go:0009636 | response to toxic substance | 5.81e-03 | 3.39e-02 | 4.07e-01 | 3.36e-01 | 1.48e+00 |
| go:0030162 | regulation of proteolysis | 5.80e-03 | 3.39e-02 | 4.07e-01 | 3.05e-01 | 1.42e+00 |
| go:0044450 | 5.86e-03 | 3.41e-02 | 4.07e-01 | -3.48e-01 | -1.54e+00 | |
| go:0042391 | regulation of membrane potential | 5.89e-03 | 3.42e-02 | 4.07e-01 | 3.82e-01 | 1.55e+00 |
| go:0000139 | Golgi membrane | 5.94e-03 | 3.45e-02 | 4.07e-01 | 3.01e-01 | 1.40e+00 |
| go:0072331 | signal transduction by p53 class mediator | 5.99e-03 | 3.46e-02 | 4.07e-01 | -3.04e-01 | -1.48e+00 |
| go:0007167 | enzyme linked receptor protein signaling pathway | 5.98e-03 | 3.46e-02 | 4.07e-01 | 2.88e-01 | 1.36e+00 |
| go:0003697 | single-stranded DNA binding | 6.09e-03 | 3.51e-02 | 4.07e-01 | -3.81e-01 | -1.60e+00 |
| go:0043524 | negative regulation of neuron apoptotic process | 6.12e-03 | 3.52e-02 | 4.07e-01 | 4.55e-01 | 1.65e+00 |
| msig:M6370 | KEGG_P53_SIGNALING_PATHWAY | 6.17e-03 | 3.54e-02 | 4.07e-01 | -4.38e-01 | -1.66e+00 |
| go:0072523 | purine-containing compound catabolic process | 6.17e-03 | 3.54e-02 | 4.07e-01 | -5.88e-01 | -1.85e+00 |
| go:0032838 | plasma membrane bounded cell projection cytoplasm | 6.20e-03 | 3.54e-02 | 4.07e-01 | 4.30e-01 | 1.63e+00 |
| go:0071897 | DNA biosynthetic process | 6.19e-03 | 3.54e-02 | 4.07e-01 | -3.32e-01 | -1.52e+00 |
| reactome:R-HSA-211000 | Gene Silencing by RNA | 6.21e-03 | 3.54e-02 | 4.07e-01 | -3.99e-01 | -1.62e+00 |
| go:0140097 | catalytic activity, acting on DNA | 6.23e-03 | 3.55e-02 | 4.07e-01 | -3.34e-01 | -1.47e+00 |
| go:2000058 | regulation of ubiquitin-dependent protein catabolic process | 6.27e-03 | 3.55e-02 | 4.07e-01 | 4.01e-01 | 1.57e+00 |
| go:1901293 | nucleoside phosphate biosynthetic process | 6.27e-03 | 3.55e-02 | 4.07e-01 | -3.02e-01 | -1.47e+00 |
| go:0000313 | organellar ribosome | 6.26e-03 | 3.55e-02 | 4.07e-01 | -3.51e-01 | -1.53e+00 |
| reactome:R-HSA-432722 | Golgi Associated Vesicle Biogenesis | 6.28e-03 | 3.55e-02 | 4.07e-01 | 4.81e-01 | 1.68e+00 |
| go:0008202 | steroid metabolic process | 6.32e-03 | 3.57e-02 | 4.07e-01 | 3.77e-01 | 1.54e+00 |
| go:0031399 | regulation of protein modification process | 6.31e-03 | 3.57e-02 | 4.07e-01 | 2.60e-01 | 1.28e+00 |
| go:0006413 | translational initiation | 6.39e-03 | 3.59e-02 | 4.07e-01 | -2.95e-01 | -1.46e+00 |
| reactome:R-HSA-983712 | Ion channel transport | 6.39e-03 | 3.59e-02 | 4.07e-01 | 4.79e-01 | 1.66e+00 |
| go:0043486 | histone exchange | 6.42e-03 | 3.60e-02 | 4.07e-01 | -4.77e-01 | -1.71e+00 |
| go:0006338 | chromatin remodeling | 6.47e-03 | 3.63e-02 | 4.07e-01 | -3.45e-01 | -1.57e+00 |
| go:0048871 | multicellular organismal homeostasis | 6.57e-03 | 3.67e-02 | 4.07e-01 | 3.70e-01 | 1.56e+00 |
| reactome:R-HSA-187687 | Signalling to ERKs | 6.68e-03 | 3.73e-02 | 4.07e-01 | 6.31e-01 | 1.84e+00 |
| go:0035861 | site of double-strand break | 6.72e-03 | 3.74e-02 | 4.07e-01 | -4.46e-01 | -1.65e+00 |
| reactome:R-HSA-168898 | Toll-like Receptor Cascades | 6.73e-03 | 3.74e-02 | 4.07e-01 | 4.29e-01 | 1.61e+00 |
| go:1903008 | organelle disassembly | 6.79e-03 | 3.77e-02 | 4.07e-01 | 4.43e-01 | 1.63e+00 |
| go:0097237 | cellular response to toxic substance | 6.82e-03 | 3.78e-02 | 4.07e-01 | 3.93e-01 | 1.58e+00 |
| reactome:R-HSA-1538133 | G0 and Early G1 | 6.83e-03 | 3.78e-02 | 4.07e-01 | -6.18e-01 | -1.83e+00 |
| go:0006629 | lipid metabolic process | 6.86e-03 | 3.79e-02 | 4.07e-01 | 2.86e-01 | 1.36e+00 |
| reactome:R-HSA-532668 | N-glycan trimming in the ER and Calnexin/Calreticulin cycle | 6.87e-03 | 3.79e-02 | 4.07e-01 | 5.61e-01 | 1.77e+00 |
| go:0000151 | ubiquitin ligase complex | 6.87e-03 | 3.79e-02 | 4.07e-01 | 3.53e-01 | 1.51e+00 |
| go:0002228 | natural killer cell mediated immunity | 6.88e-03 | 3.79e-02 | 4.07e-01 | 6.35e-01 | 1.81e+00 |
| go:0042110 | T cell activation | 6.91e-03 | 3.80e-02 | 4.07e-01 | 3.70e-01 | 1.56e+00 |
| reactome:R-HSA-166520 | Signaling by NTRKs | 6.94e-03 | 3.81e-02 | 4.07e-01 | 4.67e-01 | 1.66e+00 |
| go:0055072 | iron ion homeostasis | 6.94e-03 | 3.81e-02 | 4.07e-01 | 4.67e-01 | 1.66e+00 |
| reactome:R-HSA-73929 | Base-Excision Repair, AP Site Formation | 6.96e-03 | 3.81e-02 | 4.07e-01 | -5.83e-01 | -1.83e+00 |
| reactome:R-HSA-5685942 | HDR through Homologous Recombination (HRR) | 6.98e-03 | 3.82e-02 | 4.07e-01 | -4.53e-01 | -1.70e+00 |
| go:0030705 | cytoskeleton-dependent intracellular transport | 7.10e-03 | 3.86e-02 | 4.07e-01 | 4.02e-01 | 1.59e+00 |
| go:0050871 | positive regulation of B cell activation | 7.10e-03 | 3.86e-02 | 4.07e-01 | -5.16e-01 | -1.74e+00 |
| reactome:R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) | 7.10e-03 | 3.86e-02 | 4.07e-01 | -5.04e-01 | -1.73e+00 |
| reactome:R-HSA-597592 | Post-translational protein modification | 7.15e-03 | 3.87e-02 | 4.07e-01 | 2.63e-01 | 1.29e+00 |
| go:0051225 | spindle assembly | 7.14e-03 | 3.87e-02 | 4.07e-01 | -3.77e-01 | -1.58e+00 |
| go:0090329 | regulation of DNA-dependent DNA replication | 7.15e-03 | 3.87e-02 | 4.07e-01 | -4.85e-01 | -1.72e+00 |
| go:0045454 | cell redox homeostasis | 7.22e-03 | 3.91e-02 | 4.07e-01 | 4.54e-01 | 1.65e+00 |
| go:1904018 | positive regulation of vasculature development | 7.32e-03 | 3.94e-02 | 4.07e-01 | 4.42e-01 | 1.63e+00 |
| go:0043043 | peptide biosynthetic process | 7.31e-03 | 3.94e-02 | 4.07e-01 | -2.29e-01 | -1.27e+00 |
| go:0097731 | 9+0 non-motile cilium | 7.31e-03 | 3.94e-02 | 4.07e-01 | 5.62e-01 | 1.74e+00 |
| go:0007173 | epidermal growth factor receptor signaling pathway | 7.33e-03 | 3.94e-02 | 4.07e-01 | 4.42e-01 | 1.63e+00 |
| go:0051053 | negative regulation of DNA metabolic process | 7.35e-03 | 3.95e-02 | 4.07e-01 | -4.18e-01 | -1.63e+00 |
| go:0007179 | transforming growth factor beta receptor signaling pathway | 7.38e-03 | 3.96e-02 | 4.07e-01 | 4.18e-01 | 1.61e+00 |
| go:0008088 | axo-dendritic transport | 7.43e-03 | 3.97e-02 | 4.07e-01 | 5.06e-01 | 1.66e+00 |
| msig:M1979 | KEGG_GNRH_SIGNALING_PATHWAY | 7.43e-03 | 3.97e-02 | 4.07e-01 | 5.07e-01 | 1.66e+00 |
| go:0000956 | nuclear-transcribed mRNA catabolic process | 7.43e-03 | 3.97e-02 | 4.07e-01 | -2.94e-01 | -1.45e+00 |
| go:0032637 | interleukin-8 production | 7.47e-03 | 3.99e-02 | 4.07e-01 | 6.01e-01 | 1.76e+00 |
| go:1901701 | cellular response to oxygen-containing compound | 7.59e-03 | 4.05e-02 | 4.07e-01 | 2.80e-01 | 1.33e+00 |
| go:0071396 | cellular response to lipid | 7.78e-03 | 4.14e-02 | 4.07e-01 | 3.26e-01 | 1.45e+00 |
| go:0071496 | cellular response to external stimulus | 7.79e-03 | 4.14e-02 | 4.07e-01 | 3.48e-01 | 1.48e+00 |
| go:0072593 | reactive oxygen species metabolic process | 8.00e-03 | 4.23e-02 | 3.81e-01 | 4.18e-01 | 1.59e+00 |
| go:0035282 | segmentation | 8.05e-03 | 4.26e-02 | 3.81e-01 | -5.58e-01 | -1.77e+00 |
| reactome:R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | 8.08e-03 | 4.26e-02 | 3.81e-01 | 6.28e-01 | 1.79e+00 |
| go:0031348 | negative regulation of defense response | 8.10e-03 | 4.27e-02 | 3.81e-01 | 4.35e-01 | 1.60e+00 |
| go:0070585 | protein localization to mitochondrion | 8.12e-03 | 4.28e-02 | 3.81e-01 | 3.85e-01 | 1.56e+00 |
| go:0045786 | negative regulation of cell cycle | 8.22e-03 | 4.30e-02 | 3.81e-01 | 2.96e-01 | 1.38e+00 |
| go:1902850 | microtubule cytoskeleton organization involved in mitosis | 8.21e-03 | 4.30e-02 | 3.81e-01 | -3.46e-01 | -1.51e+00 |
| go:0043130 | ubiquitin binding | 8.22e-03 | 4.30e-02 | 3.81e-01 | 4.49e-01 | 1.63e+00 |
| reactome:R-HSA-1236394 | Signaling by ERBB4 | 8.22e-03 | 4.30e-02 | 3.81e-01 | 5.80e-01 | 1.74e+00 |
| go:0009267 | cellular response to starvation | 8.21e-03 | 4.30e-02 | 3.81e-01 | 4.10e-01 | 1.56e+00 |
| go:0010948 | negative regulation of cell cycle process | 8.23e-03 | 4.30e-02 | 3.81e-01 | 3.25e-01 | 1.45e+00 |
| go:0032273 | positive regulation of protein polymerization | 8.26e-03 | 4.31e-02 | 3.81e-01 | 4.21e-01 | 1.58e+00 |
| go:1990782 | protein tyrosine kinase binding | 8.29e-03 | 4.32e-02 | 3.81e-01 | 5.11e-01 | 1.66e+00 |
| go:0046486 | glycerolipid metabolic process | 8.33e-03 | 4.34e-02 | 3.81e-01 | 3.98e-01 | 1.51e+00 |
| go:0000027 | ribosomal large subunit assembly | 8.41e-03 | 4.37e-02 | 3.81e-01 | -5.55e-01 | -1.80e+00 |
| go:0005996 | monosaccharide metabolic process | 8.45e-03 | 4.38e-02 | 3.81e-01 | -3.87e-01 | -1.56e+00 |
| go:0090174 | organelle membrane fusion | 8.46e-03 | 4.38e-02 | 3.81e-01 | 4.72e-01 | 1.65e+00 |
| go:0031100 | animal organ regeneration | 8.47e-03 | 4.38e-02 | 3.81e-01 | -4.38e-01 | -1.65e+00 |
| go:0045944 | positive regulation of transcription by RNA polymerase II | 8.50e-03 | 4.39e-02 | 3.81e-01 | 2.76e-01 | 1.31e+00 |
| go:0061053 | somite development | 8.53e-03 | 4.39e-02 | 3.81e-01 | -5.56e-01 | -1.77e+00 |
| go:0002237 | response to molecule of bacterial origin | 8.53e-03 | 4.39e-02 | 3.81e-01 | 3.88e-01 | 1.56e+00 |
| go:0070126 | mitochondrial translational termination | 8.55e-03 | 4.39e-02 | 3.81e-01 | -3.43e-01 | -1.50e+00 |
| go:0006289 | nucleotide-excision repair | 8.56e-03 | 4.40e-02 | 3.81e-01 | -3.48e-01 | -1.50e+00 |
| go:0090305 | nucleic acid phosphodiester bond hydrolysis | 8.64e-03 | 4.43e-02 | 3.81e-01 | -2.85e-01 | -1.40e+00 |
| go:1903846 | positive regulation of cellular response to transforming growth factor beta stimulus | 8.80e-03 | 4.51e-02 | 3.81e-01 | 6.30e-01 | 1.73e+00 |
| go:0031593 | polyubiquitin modification-dependent protein binding | 8.83e-03 | 4.51e-02 | 3.81e-01 | 5.24e-01 | 1.67e+00 |
| go:0071383 | cellular response to steroid hormone stimulus | 8.83e-03 | 4.51e-02 | 3.81e-01 | 3.70e-01 | 1.52e+00 |
| reactome:R-HSA-5696398 | Nucleotide Excision Repair | 8.88e-03 | 4.52e-02 | 3.81e-01 | -3.27e-01 | -1.44e+00 |
| go:0098632 | cell-cell adhesion mediator activity | 8.87e-03 | 4.52e-02 | 3.81e-01 | 5.88e-01 | 1.74e+00 |
| go:2000060 | positive regulation of ubiquitin-dependent protein catabolic process | 8.93e-03 | 4.54e-02 | 3.81e-01 | 4.52e-01 | 1.63e+00 |
| go:0033673 | negative regulation of kinase activity | 8.99e-03 | 4.56e-02 | 3.81e-01 | 3.80e-01 | 1.56e+00 |
| go:0033363 | secretory granule organization | 9.05e-03 | 4.57e-02 | 3.81e-01 | 6.24e-01 | 1.78e+00 |
| go:0033866 | nucleoside bisphosphate biosynthetic process | 9.09e-03 | 4.59e-02 | 3.81e-01 | -4.35e-01 | -1.64e+00 |
| go:0120111 | neuron projection cytoplasm | 9.17e-03 | 4.60e-02 | 3.81e-01 | 4.69e-01 | 1.62e+00 |
| go:0071806 | protein transmembrane transport | 9.17e-03 | 4.60e-02 | 3.81e-01 | 4.77e-01 | 1.62e+00 |
| go:1905897 | regulation of response to endoplasmic reticulum stress | 9.17e-03 | 4.60e-02 | 3.81e-01 | 4.49e-01 | 1.62e+00 |
| go:0048194 | Golgi vesicle budding | 9.16e-03 | 4.60e-02 | 3.81e-01 | 4.47e-01 | 1.62e+00 |
| go:0016239 | positive regulation of macroautophagy | 9.16e-03 | 4.60e-02 | 3.81e-01 | 5.21e-01 | 1.68e+00 |
| go:0000792 | heterochromatin | 9.19e-03 | 4.60e-02 | 3.81e-01 | -4.09e-01 | -1.61e+00 |
| go:0006665 | sphingolipid metabolic process | 9.38e-03 | 4.69e-02 | 3.81e-01 | 5.08e-01 | 1.65e+00 |
| go:0048634 | regulation of muscle organ development | 9.40e-03 | 4.70e-02 | 3.81e-01 | -4.05e-01 | -1.57e+00 |
| go:0042446 | hormone biosynthetic process | 9.42e-03 | 4.70e-02 | 3.81e-01 | 5.96e-01 | 1.75e+00 |
| go:0030595 | leukocyte chemotaxis | 9.57e-03 | 4.77e-02 | 3.81e-01 | 4.31e-01 | 1.59e+00 |
| go:0043596 | nuclear replication fork | 9.67e-03 | 4.81e-02 | 3.81e-01 | -4.85e-01 | -1.69e+00 |
| reactome:R-HSA-948021 | Transport to the Golgi and subsequent modification | 9.82e-03 | 4.88e-02 | 3.81e-01 | 3.74e-01 | 1.52e+00 |
| msig:M4844 | KEGG_CHEMOKINE_SIGNALING_PATHWAY | 9.84e-03 | 4.88e-02 | 3.81e-01 | 4.43e-01 | 1.60e+00 |
| go:1902751 | positive regulation of cell cycle G2/M phase transition | 9.87e-03 | 4.90e-02 | 3.81e-01 | -5.74e-01 | -1.80e+00 |
| go:0019079 | viral genome replication | 1.00e-02 | 4.97e-02 | 3.81e-01 | -3.63e-01 | -1.53e+00 |
| go:0006921 | cellular component disassembly involved in execution phase of apoptosis | 1.01e-02 | 4.98e-02 | 3.81e-01 | -5.87e-01 | -1.82e+00 |
| reactome:R-HSA-5368287 | Mitochondrial translation | 1.01e-02 | 4.98e-02 | 3.81e-01 | -3.25e-01 | -1.43e+00 |
| go:0044786 | cell cycle DNA replication | 1.02e-02 | 5.02e-02 | 3.81e-01 | -4.01e-01 | -1.60e+00 |
| go:0051651 | maintenance of location in cell | 1.04e-02 | 5.12e-02 | 3.81e-01 | 4.43e-01 | 1.60e+00 |
| go:0010939 | regulation of necrotic cell death | 1.04e-02 | 5.12e-02 | 3.81e-01 | 6.20e-01 | 1.80e+00 |
| go:0007052 | mitotic spindle organization | 1.04e-02 | 5.13e-02 | 3.81e-01 | -3.62e-01 | -1.52e+00 |
| go:0007032 | endosome organization | 1.05e-02 | 5.13e-02 | 3.81e-01 | 4.64e-01 | 1.63e+00 |
| go:0030136 | clathrin-coated vesicle | 1.05e-02 | 5.13e-02 | 3.81e-01 | 4.11e-01 | 1.56e+00 |
| go:0050806 | positive regulation of synaptic transmission | 1.06e-02 | 5.17e-02 | 3.81e-01 | 4.84e-01 | 1.61e+00 |
| go:0045652 | regulation of megakaryocyte differentiation | 1.07e-02 | 5.20e-02 | 3.81e-01 | -4.95e-01 | -1.68e+00 |
| go:0097352 | autophagosome maturation | 1.07e-02 | 5.20e-02 | 3.81e-01 | 5.83e-01 | 1.72e+00 |
| go:0051235 | maintenance of location | 1.07e-02 | 5.23e-02 | 3.81e-01 | 3.65e-01 | 1.52e+00 |
| go:0002931 | response to ischemia | 1.08e-02 | 5.24e-02 | 3.81e-01 | 5.92e-01 | 1.73e+00 |
| go:0035578 | azurophil granule lumen | 1.08e-02 | 5.25e-02 | 3.81e-01 | 4.42e-01 | 1.60e+00 |
| go:0000152 | nuclear ubiquitin ligase complex | 1.10e-02 | 5.34e-02 | 3.81e-01 | -4.93e-01 | -1.67e+00 |
| go:0002020 | protease binding | 1.10e-02 | 5.35e-02 | 3.81e-01 | 4.43e-01 | 1.61e+00 |
| go:1904666 | regulation of ubiquitin protein ligase activity | 1.11e-02 | 5.35e-02 | 3.81e-01 | -6.02e-01 | -1.78e+00 |
| go:0006415 | translational termination | 1.11e-02 | 5.36e-02 | 3.81e-01 | -3.26e-01 | -1.48e+00 |
| go:1901184 | regulation of ERBB signaling pathway | 1.13e-02 | 5.44e-02 | 3.81e-01 | 4.46e-01 | 1.61e+00 |
| msig:M7399 | KEGG_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM | 1.14e-02 | 5.51e-02 | 3.81e-01 | 6.17e-01 | 1.76e+00 |
| msig:M5934 | HALLMARK_XENOBIOTIC_METABOLISM | 1.16e-02 | 5.57e-02 | 3.81e-01 | 3.86e-01 | 1.53e+00 |
| reactome:R-HSA-5357956 | TNFR1-induced NFkappaB signaling pathway | 1.17e-02 | 5.61e-02 | 3.81e-01 | 6.23e-01 | 1.71e+00 |
| go:0045137 | development of primary sexual characteristics | 1.18e-02 | 5.66e-02 | 3.81e-01 | 3.87e-01 | 1.52e+00 |
| reactome:R-HSA-5654732 | Negative regulation of FGFR3 signaling | 1.19e-02 | 5.69e-02 | 3.81e-01 | 6.20e-01 | 1.70e+00 |
| msig:M12467 | KEGG_ERBB_SIGNALING_PATHWAY | 1.19e-02 | 5.69e-02 | 3.81e-01 | 4.88e-01 | 1.66e+00 |
| reactome:R-HSA-5654727 | Negative regulation of FGFR2 signaling | 1.19e-02 | 5.69e-02 | 3.81e-01 | 6.20e-01 | 1.70e+00 |
| go:0002377 | immunoglobulin production | 1.19e-02 | 5.69e-02 | 3.81e-01 | -4.44e-01 | -1.60e+00 |
| go:0098780 | response to mitochondrial depolarisation | 1.19e-02 | 5.69e-02 | 3.81e-01 | 6.22e-01 | 1.70e+00 |
| reactome:R-HSA-1474228 | Degradation of the extracellular matrix | 1.21e-02 | 5.75e-02 | 3.81e-01 | 4.77e-01 | 1.59e+00 |
| go:0000726 | non-recombinational repair | 1.23e-02 | 5.83e-02 | 3.81e-01 | -4.12e-01 | -1.57e+00 |
| go:0042826 | histone deacetylase binding | 1.24e-02 | 5.87e-02 | 3.81e-01 | -3.93e-01 | -1.57e+00 |
| go:0035051 | cardiocyte differentiation | 1.24e-02 | 5.87e-02 | 3.81e-01 | -4.16e-01 | -1.59e+00 |
| go:0042594 | response to starvation | 1.25e-02 | 5.93e-02 | 3.81e-01 | 3.89e-01 | 1.54e+00 |
| go:0044389 | ubiquitin-like protein ligase binding | 1.26e-02 | 5.93e-02 | 3.81e-01 | 3.20e-01 | 1.41e+00 |
| go:0002685 | regulation of leukocyte migration | 1.26e-02 | 5.93e-02 | 3.81e-01 | 4.22e-01 | 1.55e+00 |
| go:0007062 | sister chromatid cohesion | 1.26e-02 | 5.95e-02 | 3.81e-01 | -4.22e-01 | -1.59e+00 |
| go:0051091 | positive regulation of DNA-binding transcription factor activity | 1.28e-02 | 6.02e-02 | 3.81e-01 | 3.76e-01 | 1.50e+00 |
| msig:M5923 | HALLMARK_PI3K_AKT_MTOR_SIGNALING | 1.29e-02 | 6.05e-02 | 3.81e-01 | 4.28e-01 | 1.58e+00 |
| go:0009617 | response to bacterium | 1.30e-02 | 6.11e-02 | 3.81e-01 | 3.38e-01 | 1.44e+00 |
| go:0006401 | RNA catabolic process | 1.31e-02 | 6.12e-02 | 3.81e-01 | 2.95e-01 | 1.36e+00 |
| go:0000932 | P-body | 1.31e-02 | 6.12e-02 | 3.81e-01 | 4.34e-01 | 1.57e+00 |
| go:0015849 | organic acid transport | 1.31e-02 | 6.13e-02 | 3.81e-01 | 3.97e-01 | 1.51e+00 |
| go:0099536 | synaptic signaling | 1.33e-02 | 6.21e-02 | 3.81e-01 | 3.37e-01 | 1.43e+00 |
| go:0031935 | regulation of chromatin silencing | 1.33e-02 | 6.21e-02 | 3.81e-01 | -5.69e-01 | -1.73e+00 |
| go:0048193 | Golgi vesicle transport | 1.34e-02 | 6.22e-02 | 3.81e-01 | 3.22e-01 | 1.43e+00 |
| go:0009055 | electron transfer activity | 1.34e-02 | 6.23e-02 | 3.81e-01 | 3.98e-01 | 1.52e+00 |
| go:0098793 | presynapse | 1.35e-02 | 6.27e-02 | 3.81e-01 | 3.52e-01 | 1.49e+00 |
| go:0045934 | negative regulation of nucleobase-containing compound metabolic process | 1.35e-02 | 6.28e-02 | 3.81e-01 | -3.34e-01 | -1.46e+00 |
| reactome:R-HSA-6782135 | Dual incision in TC-NER | 1.36e-02 | 6.28e-02 | 3.81e-01 | -3.76e-01 | -1.52e+00 |
| go:0030155 | regulation of cell adhesion | 1.36e-02 | 6.28e-02 | 3.81e-01 | 3.03e-01 | 1.37e+00 |
| go:0032527 | protein exit from endoplasmic reticulum | 1.36e-02 | 6.28e-02 | 3.81e-01 | 5.10e-01 | 1.64e+00 |
| reactome:R-HSA-2555396 | Mitotic Metaphase and Anaphase | 1.37e-02 | 6.33e-02 | 3.81e-01 | 3.33e-01 | 1.44e+00 |
| go:0005126 | cytokine receptor binding | 1.38e-02 | 6.36e-02 | 3.81e-01 | 4.05e-01 | 1.54e+00 |
| go:0072665 | protein localization to vacuole | 1.38e-02 | 6.37e-02 | 3.81e-01 | 4.70e-01 | 1.56e+00 |
| go:0006900 | vesicle budding from membrane | 1.39e-02 | 6.41e-02 | 3.81e-01 | 4.01e-01 | 1.51e+00 |
| reactome:R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation | 1.40e-02 | 6.42e-02 | 3.81e-01 | -3.76e-01 | -1.51e+00 |
| go:0006954 | inflammatory response | 1.41e-02 | 6.48e-02 | 3.81e-01 | 3.24e-01 | 1.41e+00 |
| reactome:R-HSA-193704 | p75 NTR receptor-mediated signalling | 1.42e-02 | 6.50e-02 | 3.81e-01 | 4.69e-01 | 1.60e+00 |
| go:0044770 | cell cycle phase transition | 1.42e-02 | 6.51e-02 | 3.81e-01 | 2.82e-01 | 1.33e+00 |
| go:0032870 | cellular response to hormone stimulus | 1.44e-02 | 6.58e-02 | 3.81e-01 | 3.02e-01 | 1.38e+00 |
| go:0016491 | oxidoreductase activity | 1.45e-02 | 6.63e-02 | 3.81e-01 | 2.90e-01 | 1.35e+00 |
| go:0003006 | developmental process involved in reproduction | 1.46e-02 | 6.66e-02 | 3.81e-01 | 3.14e-01 | 1.42e+00 |
| go:0061025 | membrane fusion | 1.46e-02 | 6.66e-02 | 3.81e-01 | 4.32e-01 | 1.60e+00 |
| go:0050863 | regulation of T cell activation | 1.48e-02 | 6.73e-02 | 3.81e-01 | 3.79e-01 | 1.49e+00 |
| go:0051130 | positive regulation of cellular component organization | 1.50e-02 | 6.81e-02 | 3.81e-01 | 2.65e-01 | 1.28e+00 |
| go:0032432 | actin filament bundle | 1.50e-02 | 6.81e-02 | 3.81e-01 | -4.50e-01 | -1.62e+00 |
| go:0005814 | centriole | 1.50e-02 | 6.81e-02 | 3.81e-01 | -3.56e-01 | -1.49e+00 |
| go:0006644 | phospholipid metabolic process | 1.50e-02 | 6.81e-02 | 3.81e-01 | 4.01e-01 | 1.52e+00 |
| go:0018022 | peptidyl-lysine methylation | 1.51e-02 | 6.83e-02 | 3.81e-01 | -3.75e-01 | -1.52e+00 |
| go:0040011 | locomotion | 1.52e-02 | 6.85e-02 | 3.81e-01 | 2.62e-01 | 1.27e+00 |
| reactome:R-HSA-5654726 | Negative regulation of FGFR1 signaling | 1.53e-02 | 6.91e-02 | 3.81e-01 | 6.04e-01 | 1.69e+00 |
| go:0001678 | cellular glucose homeostasis | 1.53e-02 | 6.91e-02 | 3.81e-01 | -3.73e-01 | -1.50e+00 |
| go:0045071 | negative regulation of viral genome replication | 1.54e-02 | 6.94e-02 | 3.81e-01 | -4.68e-01 | -1.63e+00 |
| go:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 1.56e-02 | 6.99e-02 | 3.81e-01 | 3.87e-01 | 1.49e+00 |
| go:1904115 | axon cytoplasm | 1.56e-02 | 7.00e-02 | 3.81e-01 | 4.85e-01 | 1.57e+00 |
| go:0003690 | double-stranded DNA binding | 1.57e-02 | 7.06e-02 | 3.52e-01 | -2.41e-01 | -1.28e+00 |
| reactome:R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE | 1.58e-02 | 7.07e-02 | 3.52e-01 | 5.28e-01 | 1.67e+00 |
| msig:M16004 | KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION | 1.58e-02 | 7.09e-02 | 3.52e-01 | 5.38e-01 | 1.66e+00 |
| reactome:R-HSA-71291 | Metabolism of amino acids and derivatives | 1.59e-02 | 7.09e-02 | 3.52e-01 | 3.12e-01 | 1.41e+00 |
| reactome:R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases | 1.59e-02 | 7.09e-02 | 3.52e-01 | 3.18e-01 | 1.41e+00 |
| go:0097193 | intrinsic apoptotic signaling pathway | 1.59e-02 | 7.09e-02 | 3.52e-01 | 3.31e-01 | 1.43e+00 |
| go:0046622 | positive regulation of organ growth | 1.63e-02 | 7.24e-02 | 3.52e-01 | -5.84e-01 | -1.73e+00 |
| go:0048199 | vesicle targeting, to, from or within Golgi | 1.63e-02 | 7.27e-02 | 3.52e-01 | 4.41e-01 | 1.57e+00 |
| reactome:R-HSA-983189 | Kinesins | 1.65e-02 | 7.32e-02 | 3.52e-01 | -4.65e-01 | -1.62e+00 |
| go:0042734 | presynaptic membrane | 1.65e-02 | 7.32e-02 | 3.52e-01 | 5.24e-01 | 1.64e+00 |
| go:0033043 | regulation of organelle organization | 1.65e-02 | 7.32e-02 | 3.52e-01 | -2.11e-01 | -1.20e+00 |
| go:0019068 | virion assembly | 1.67e-02 | 7.40e-02 | 3.52e-01 | 5.02e-01 | 1.60e+00 |
| msig:M15913 | KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY | 1.68e-02 | 7.41e-02 | 3.52e-01 | 5.36e-01 | 1.66e+00 |
| go:0060326 | cell chemotaxis | 1.69e-02 | 7.45e-02 | 3.52e-01 | 3.92e-01 | 1.50e+00 |
| msig:M5926 | HALLMARK_MYC_TARGETS_V1 | 1.77e-02 | 7.80e-02 | 3.52e-01 | -2.62e-01 | -1.33e+00 |
| go:0051445 | regulation of meiotic cell cycle | 1.79e-02 | 7.88e-02 | 3.52e-01 | -5.51e-01 | -1.66e+00 |
| reactome:R-HSA-204005 | COPII-mediated vesicle transport | 1.79e-02 | 7.90e-02 | 3.52e-01 | 4.48e-01 | 1.58e+00 |
| go:1901185 | negative regulation of ERBB signaling pathway | 1.80e-02 | 7.90e-02 | 3.52e-01 | 4.82e-01 | 1.58e+00 |
| go:0071322 | cellular response to carbohydrate stimulus | 1.80e-02 | 7.91e-02 | 3.52e-01 | -3.67e-01 | -1.48e+00 |
| go:1901292 | nucleoside phosphate catabolic process | 1.82e-02 | 7.98e-02 | 3.52e-01 | -4.59e-01 | -1.63e+00 |
| go:0071901 | negative regulation of protein serine/threonine kinase activity | 1.83e-02 | 8.03e-02 | 3.52e-01 | 4.14e-01 | 1.52e+00 |
| go:0060291 | long-term synaptic potentiation | 1.84e-02 | 8.07e-02 | 3.52e-01 | 5.74e-01 | 1.68e+00 |
| go:1903513 | endoplasmic reticulum to cytosol transport | 1.85e-02 | 8.07e-02 | 3.52e-01 | 5.62e-01 | 1.66e+00 |
| go:0006865 | amino acid transport | 1.88e-02 | 8.19e-02 | 3.52e-01 | 5.00e-01 | 1.59e+00 |
| go:0007548 | sex differentiation | 1.88e-02 | 8.20e-02 | 3.52e-01 | 3.60e-01 | 1.45e+00 |
| reactome:R-HSA-428157 | Sphingolipid metabolism | 1.88e-02 | 8.20e-02 | 3.52e-01 | 4.52e-01 | 1.54e+00 |
| go:0061462 | protein localization to lysosome | 1.89e-02 | 8.21e-02 | 3.52e-01 | 5.61e-01 | 1.66e+00 |
| go:0045931 | positive regulation of mitotic cell cycle | 1.89e-02 | 8.21e-02 | 3.52e-01 | -3.14e-01 | -1.39e+00 |
| msig:M1840 | KEGG_GLUTATHIONE_METABOLISM | 1.90e-02 | 8.23e-02 | 3.52e-01 | 4.99e-01 | 1.59e+00 |
| go:0036477 | somatodendritic compartment | 1.92e-02 | 8.32e-02 | 3.76e-01 | 2.92e-01 | 1.33e+00 |
| go:0030545 | receptor regulator activity | 1.93e-02 | 8.33e-02 | 3.52e-01 | 3.81e-01 | 1.47e+00 |
| go:0030544 | Hsp70 protein binding | 1.94e-02 | 8.37e-02 | 3.52e-01 | 5.44e-01 | 1.66e+00 |
| go:1901863 | positive regulation of muscle tissue development | 1.94e-02 | 8.37e-02 | 3.52e-01 | -5.22e-01 | -1.66e+00 |
| reactome:R-HSA-5696400 | Dual Incision in GG-NER | 1.94e-02 | 8.37e-02 | 3.52e-01 | -4.06e-01 | -1.50e+00 |
| go:1903201 | regulation of oxidative stress-induced cell death | 1.94e-02 | 8.37e-02 | 3.52e-01 | 4.65e-01 | 1.57e+00 |
| msig:M3578 | KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION | 1.95e-02 | 8.37e-02 | 3.52e-01 | -4.13e-01 | -1.55e+00 |
| go:0098655 | cation transmembrane transport | 1.96e-02 | 8.43e-02 | 3.76e-01 | 3.01e-01 | 1.36e+00 |
| go:0097190 | apoptotic signaling pathway | 1.98e-02 | 8.49e-02 | 3.52e-01 | 2.86e-01 | 1.33e+00 |
| reactome:R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade | 2.01e-02 | 8.62e-02 | 3.52e-01 | 4.45e-01 | 1.57e+00 |
| go:0030496 | midbody | 2.03e-02 | 8.69e-02 | 3.52e-01 | -3.02e-01 | -1.40e+00 |
| reactome:R-HSA-176412 | Phosphorylation of the APC/C | 2.04e-02 | 8.73e-02 | 3.52e-01 | -5.70e-01 | -1.69e+00 |
| go:0051438 | regulation of ubiquitin-protein transferase activity | 2.05e-02 | 8.74e-02 | 3.52e-01 | -4.20e-01 | -1.53e+00 |
| go:0033572 | transferrin transport | 2.07e-02 | 8.83e-02 | 3.52e-01 | 5.92e-01 | 1.72e+00 |
| go:0030133 | transport vesicle | 2.08e-02 | 8.83e-02 | 3.52e-01 | 3.35e-01 | 1.42e+00 |
| go:0051186 | 2.08e-02 | 8.84e-02 | 3.52e-01 | 3.12e-01 | 1.40e+00 | |
| go:1990778 | protein localization to cell periphery | 2.08e-02 | 8.85e-02 | 3.76e-01 | 3.38e-01 | 1.43e+00 |
| go:0006959 | humoral immune response | 2.09e-02 | 8.88e-02 | 3.52e-01 | 4.97e-01 | 1.60e+00 |
| go:0005875 | microtubule associated complex | 2.10e-02 | 8.89e-02 | 3.52e-01 | -3.38e-01 | -1.42e+00 |
| reactome:R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly | 2.10e-02 | 8.89e-02 | 3.52e-01 | -4.62e-01 | -1.59e+00 |
| reactome:R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition | 2.11e-02 | 8.92e-02 | 3.52e-01 | -5.44e-01 | -1.71e+00 |
| go:0101031 | chaperone complex | 2.12e-02 | 8.92e-02 | 3.52e-01 | 5.91e-01 | 1.65e+00 |
| go:0032465 | regulation of cytokinesis | 2.11e-02 | 8.92e-02 | 3.52e-01 | -3.80e-01 | -1.48e+00 |
| go:0045069 | regulation of viral genome replication | 2.13e-02 | 8.97e-02 | 3.52e-01 | -3.50e-01 | -1.41e+00 |
| go:0009994 | oocyte differentiation | 2.13e-02 | 8.98e-02 | 3.52e-01 | -5.40e-01 | -1.63e+00 |
| reactome:R-HSA-15869 | Metabolism of nucleotides | 2.17e-02 | 9.10e-02 | 3.52e-01 | -3.58e-01 | -1.45e+00 |
| go:1902235 | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | 2.17e-02 | 9.10e-02 | 3.52e-01 | 5.61e-01 | 1.64e+00 |
| reactome:R-HSA-6807878 | COPI-mediated anterograde transport | 2.17e-02 | 9.12e-02 | 3.52e-01 | 4.13e-01 | 1.53e+00 |
| go:0032182 | ubiquitin-like protein binding | 2.19e-02 | 9.19e-02 | 3.52e-01 | 4.00e-01 | 1.50e+00 |
| go:0005680 | anaphase-promoting complex | 2.19e-02 | 9.19e-02 | 3.52e-01 | -5.65e-01 | -1.68e+00 |
| go:0071985 | multivesicular body sorting pathway | 2.21e-02 | 9.23e-02 | 3.52e-01 | 5.27e-01 | 1.63e+00 |
| go:0010469 | regulation of signaling receptor activity | 2.21e-02 | 9.24e-02 | 3.52e-01 | 3.54e-01 | 1.45e+00 |
| go:0050000 | chromosome localization | 2.23e-02 | 9.28e-02 | 3.52e-01 | -3.78e-01 | -1.47e+00 |
| go:0048525 | negative regulation of viral process | 2.23e-02 | 9.29e-02 | 3.52e-01 | -3.84e-01 | -1.50e+00 |
| go:0042147 | retrograde transport, endosome to Golgi | 2.23e-02 | 9.29e-02 | 3.52e-01 | 4.41e-01 | 1.55e+00 |
| go:0033500 | carbohydrate homeostasis | 2.24e-02 | 9.30e-02 | 3.52e-01 | -3.26e-01 | -1.40e+00 |
| go:0030666 | endocytic vesicle membrane | 2.24e-02 | 9.30e-02 | 3.52e-01 | 3.98e-01 | 1.49e+00 |
| go:1901652 | response to peptide | 2.26e-02 | 9.39e-02 | 3.52e-01 | 3.10e-01 | 1.37e+00 |
| go:0007030 | Golgi organization | 2.27e-02 | 9.39e-02 | 3.76e-01 | 3.96e-01 | 1.48e+00 |
| go:0051249 | regulation of lymphocyte activation | 2.27e-02 | 9.40e-02 | 3.52e-01 | 3.47e-01 | 1.46e+00 |
| go:0001659 | temperature homeostasis | 2.29e-02 | 9.46e-02 | 3.76e-01 | 4.05e-01 | 1.47e+00 |
| go:0045178 | basal part of cell | 2.29e-02 | 9.46e-02 | 3.52e-01 | 5.55e-01 | 1.64e+00 |
| go:0007346 | regulation of mitotic cell cycle | 2.29e-02 | 9.46e-02 | 3.32e-01 | 2.74e-01 | 1.29e+00 |
| go:1903844 | regulation of cellular response to transforming growth factor beta stimulus | 2.29e-02 | 9.46e-02 | 3.76e-01 | 4.10e-01 | 1.47e+00 |
| go:0005871 | kinesin complex | 2.31e-02 | 9.51e-02 | 3.52e-01 | -4.71e-01 | -1.59e+00 |
| go:0006414 | translational elongation | 2.33e-02 | 9.59e-02 | 3.52e-01 | -2.93e-01 | -1.36e+00 |
| go:0000018 | regulation of DNA recombination | 2.34e-02 | 9.59e-02 | 3.52e-01 | -3.74e-01 | -1.45e+00 |
| reactome:R-HSA-3214841 | PKMTs methylate histone lysines | 2.34e-02 | 9.60e-02 | 3.52e-01 | -4.81e-01 | -1.64e+00 |
| go:0010906 | regulation of glucose metabolic process | 2.34e-02 | 9.60e-02 | 3.52e-01 | -4.97e-01 | -1.64e+00 |
| go:0009607 | response to biotic stimulus | 2.35e-02 | 9.62e-02 | 3.32e-01 | 2.80e-01 | 1.30e+00 |
| go:0008289 | lipid binding | 2.37e-02 | 9.67e-02 | 3.42e-01 | 3.02e-01 | 1.35e+00 |
| go:1904029 | regulation of cyclin-dependent protein kinase activity | 2.38e-02 | 9.68e-02 | 3.52e-01 | -3.60e-01 | -1.45e+00 |
| go:0045023 | G0 to G1 transition | 2.39e-02 | 9.71e-02 | 3.52e-01 | -4.58e-01 | -1.57e+00 |
| go:0007249 | I-kappaB kinase/NF-kappaB signaling | 2.39e-02 | 9.71e-02 | 3.52e-01 | 3.42e-01 | 1.43e+00 |
| go:0007017 | microtubule-based process | 2.40e-02 | 9.71e-02 | 3.52e-01 | -2.22e-01 | -1.20e+00 |
| go:0099513 | polymeric cytoskeletal fiber | 2.40e-02 | 9.71e-02 | 3.52e-01 | -2.47e-01 | -1.28e+00 |
| go:0009799 | specification of symmetry | 2.40e-02 | 9.71e-02 | 3.52e-01 | 4.62e-01 | 1.57e+00 |
| reactome:R-HSA-2559580 | Oxidative Stress Induced Senescence | 2.40e-02 | 9.71e-02 | 3.52e-01 | -3.63e-01 | -1.45e+00 |
| go:0046649 | lymphocyte activation | 2.41e-02 | 9.73e-02 | 3.42e-01 | 3.07e-01 | 1.36e+00 |
| reactome:R-HSA-556833 | Metabolism of lipids | 2.41e-02 | 9.73e-02 | 3.32e-01 | 2.86e-01 | 1.32e+00 |
| reactome:R-HSA-177929 | Signaling by EGFR | 2.42e-02 | 9.75e-02 | 3.76e-01 | 4.80e-01 | 1.55e+00 |
| go:1903409 | reactive oxygen species biosynthetic process | 2.42e-02 | 9.75e-02 | 3.76e-01 | 4.74e-01 | 1.54e+00 |
| go:0016875 | ligase activity, forming carbon-oxygen bonds | 2.43e-02 | 9.78e-02 | 3.76e-01 | 4.95e-01 | 1.56e+00 |
| go:0098586 | cellular response to virus | 2.45e-02 | 9.86e-02 | 3.52e-01 | 5.41e-01 | 1.63e+00 |
| msig:M5891 | HALLMARK_HYPOXIA | 2.46e-02 | 9.86e-02 | 3.52e-01 | 3.59e-01 | 1.48e+00 |
| go:0010632 | regulation of epithelial cell migration | 2.46e-02 | 9.86e-02 | 3.52e-01 | 3.59e-01 | 1.44e+00 |
| go:0090066 | regulation of anatomical structure size | 2.47e-02 | 9.90e-02 | 3.42e-01 | 3.19e-01 | 1.38e+00 |
| go:1903039 | positive regulation of leukocyte cell-cell adhesion | 2.47e-02 | 9.90e-02 | 3.52e-01 | 4.06e-01 | 1.48e+00 |
| go:0010921 | regulation of phosphatase activity | 2.47e-02 | 9.90e-02 | 3.52e-01 | 3.79e-01 | 1.44e+00 |
| go:0010821 | regulation of mitochondrion organization | 2.47e-02 | 9.90e-02 | 3.52e-01 | 3.62e-01 | 1.45e+00 |
INDRA was used to automatically assemble known mechanisms related to PSMD14 from literature and knowledge bases. The first section shows only DUB activity and the second shows all other results.