OTULINL Data Analysis

HGNC Gene Name
OTU deubiquitinase with linear linkage specificity like
HGNC Gene Symbol
OTULINL
Identifiers
hgnc:25629 NCBIGene:54491 uniprot:Q9NUU6
Orthologs
mgi:2687281 rgd:1563205
INDRA Statements
deubiquitinations all statements
Pathway Commons
Search for OTULINL
Number of Papers
2 retrieved on 2022-05-22

DepMap Analysis

The Dependency Map (DepMap) is a genome-wide pooled CRISPR-Cas9 knockout proliferation screen conducted in more than 700 cancer cell lines spanning many different tumor lineages. Each cell line in the DepMap contains a unique barcode, and each gene knockout is assigned a “dependency score” on a per cell-line basis which quantifies the rate of CRISPR-Cas9 guide drop. It has been found that proteins with similar DepMap scores across cell lines, a phenomenon known as co-dependent genes, have closely related biological functions. This can include activity in the same or parallel pathways or membership in the same protein complex or the same pathway.

We identified the strongest seven co-dependent genes (“Symbol”) for DUBs and ran GO enrichment analysis. We used Biogrid, IntAct, and Pathway Commons PPIDs, and the NURSA protein-protein interaction databases (PPIDs) to determine whether co-dependent genes interact with one another. The “Evidence” column contains the PPIDs in which the interaction appears as well as whether there is support for the association by an INDRA statement. As another approach to identify potential interactors, we looked at proteomics data from the Broad Institute's Cancer Cell Line Encyclopedia (CCLE) for proteins whose expression across ~375 cell lines strongly correlated with the abundance of each DUB; it has previously been observed that proteins in the same complex are frequently significantly co-expressed. The correlations and associated p-values in the CCLE proteomics dataset are provided. And, we determined whether co-dependent genes yield similar transcriptomic signatures in the Broad Institute's Connectivity Map (CMap). A CMap score greater than 90 is considered significantly similar.

DepMap Correlations

Symbol Name DepMap Correlation Evidence CCLE Correlation CCLE Z-score CCLE p-value (adj) CCLE Significant CMAP Score CMAP Type

Dependency GO Term Enrichment

Gene set enrichment analysis was done on the genes correlated with OTULINLusing the terms from Gene Ontology and gene sets derived from the Gene Ontology Annotations database via MSigDB.

Using the biological processes and other Gene Ontology terms from well characterized DUBs as a positive control, several gene set enrichment analyses were considered. Threshold-less methods like GSEA had relatively poor results. Over-representation analysis with a threshold of of the top 7 highest absolute value Dependency Map correlations yielded the best results and is reported below.

GO Identifier GO Name GO Type p-value p-value (adj.) q-value

Literature Mining

INDRA was used to automatically assemble known mechanisms related to OTULINL from literature and knowledge bases. The first section shows only DUB activity and the second shows all other results.

Deubiquitinase Activity

Other Statements

psp cbn pc bel_lc signor biogrid lincs_drug tas hprd trrust ctd vhn pe drugbank omnipath conib crog dgi | rlimsp isi tees geneways eidos trips medscan sparser reach
4 |
Valproic acid increases the amount of OTULINL. 4 / 4
4 |

ctd
No evidence text available

ctd
No evidence text available

ctd
No evidence text available

ctd
No evidence text available
4 |
Progesterone increases the amount of OTULINL. 4 / 4
4 |

ctd
No evidence text available

ctd
No evidence text available

ctd
No evidence text available

ctd
No evidence text available
4 |
Hsa-let-7b-5p decreases the amount of OTULINL. 4 / 4
4 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-98-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-7851-3p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-7106-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-6883-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-6831-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-6799-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-6785-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
Hsa-miR-6780a-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-6779-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-6516-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-6499-3p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-6086 decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-490-3p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-4728-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-455-3p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-4537 decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-4500 decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-4458 decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-4451 decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-3927-3p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-377-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-3689c decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
Hsa-miR-3689b-3p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
Hsa-miR-3689a-3p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-3192-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-30b-3p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-miR-149-3p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
Hsa-miR-1273h-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-let-7i-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-let-7g-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-let-7f-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-let-7e-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-let-7d-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-let-7c-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
3 |
Hsa-let-7a-5p decreases the amount of OTULINL. 3 / 3
3 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
2 |
Hsa-miR-7843-3p decreases the amount of OTULINL. 2 / 2
2 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
2 |
Hsa-miR-6814-5p decreases the amount of OTULINL. 2 / 2
2 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
2 |
Hsa-miR-584-3p decreases the amount of OTULINL. 2 / 2
2 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
2 |
Hsa-miR-5186 decreases the amount of OTULINL. 2 / 2
2 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
2 |
Hsa-miR-4635 decreases the amount of OTULINL. 2 / 2
2 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
2 |
Hsa-miR-382-5p decreases the amount of OTULINL. 2 / 2
2 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
2 |
Hsa-miR-127-5p decreases the amount of OTULINL. 2 / 2
2 |

biopax:mirtarbase
No evidence text available

biopax:mirtarbase
No evidence text available
Cisplatin affects OTULINL
2 |
Cisplatin increases the amount of OTULINL. 2 / 2
2 |

ctd
No evidence text available

ctd
No evidence text available
2 |
Bisphenol A decreases the amount of OTULINL. 2 / 2
2 |

ctd
No evidence text available

ctd
No evidence text available
17beta-estradiol increases the amount of OTULINL. 2 / 2
2 |

ctd
No evidence text available

ctd
No evidence text available
1 |
Vorinostat increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1 |
Vinclozolin increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1 |
Trichostatin A increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1 |
Thimerosal increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1 |
Testosterone increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1 |
Sulforaphane decreases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1 |
Silicon dioxide increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1 |
Selenium atom decreases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
Propanal affects OTULINL
1 |
Propanal increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
Potassium chromate increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1 |

ctd
No evidence text available
Pentanal affects OTULINL
1 |
Pentanal increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
Jinfukang affects OTULINL
1 |
Jinfukang increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
Ionomycin affects OTULINL
1 |
Ionomycin decreases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
Hsa-miR-550b-2-5p decreases the amount of OTULINL. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-4252 decreases the amount of OTULINL. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-26b-5p decreases the amount of OTULINL. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-18a-3p decreases the amount of OTULINL. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-136-5p decreases the amount of OTULINL. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-124-3p decreases the amount of OTULINL. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-1227-3p decreases the amount of OTULINL. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Gentamycin increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
Flutamide affects OTULINL
1 |
Flutamide increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1 |
Dorsomorphin increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
Disodium selenite increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
Copper(II) sulfate increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1 |
Copper atom decreases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1 |
Carbon nanotube increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1 |
Calcitriol increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
Butanal affects OTULINL
1 |
Butanal increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1 |
Benzo[a]pyrene decreases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
All-trans-retinoic acid increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
Aldehyde affects OTULINL
1 |
Aldehyde increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
Acetamide affects OTULINL
1 |
Acetamide increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
Soman affects OTULINL
1 |
Soman increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1 |
Plant Extracts increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
PAX4 affects OTULINL
1 |
PAX4 decreases the amount of OTULINL. 1 / 1
1 |

biopax:msigdb
No evidence text available

reach
It is possible that FAM105A promotes myofibroblast apoptosis, thereby affecting muscle fiber numbers.
OTULINL affects BAX
| 1
Modified OTULINL increases the amount of BAX. 1 / 1
| 1

reach
Overexpression of FAM105A was found to increase levels of the pro apoptotic factor Bax, while decreasing levels of the anti-apoptotic factor Bcl-2 [XREF_BIBR].
OTULIN affects OTULINL
| 1
OTULIN deubiquitinates OTULINL. 1 / 1
| 1

reach
Intriguingly, the OTULIN pseudo deubiquitinating enzyme FAM105A (OTULINL) shares ~ 33% amino acid sequence identity with OTULIN, but lacks Met1 Ub catalytic activity or the ability to interact with Ub or LUBAC [XREF_BIBR, XREF_BIBR].
1 |
NSC 689534 decreases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
N-nitrosodimethylamine increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
FOXO4 affects OTULINL
1 |
FOXO4 decreases the amount of OTULINL. 1 / 1
1 |

biopax:msigdb
No evidence text available
FOXO3 affects OTULINL
1 |
FOXO3 decreases the amount of OTULINL. 1 / 1
1 |

biopax:msigdb
No evidence text available
FOXJ2 affects OTULINL
1 |
FOXJ2 decreases the amount of OTULINL. 1 / 1
1 |

biopax:msigdb
No evidence text available
Cuprizone affects OTULINL
1 |
Cuprizone increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
Antirheumatic Agents decreases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1 |
Air Pollutants decreases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
4-hydroxyphenyl retinamide decreases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
3-methylcholanthrene increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available

ctd
No evidence text available
1-naphthyl isothiocyanate increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1,1-dichloroethene increases the amount of OTULINL. 1 / 1
1 |

ctd
No evidence text available
1 |

ctd
No evidence text available