OTUD4 Data Analysis

HGNC Gene Name
OTU deubiquitinase 4
HGNC Gene Symbol
OTUD4
Identifiers
hgnc:24949 NCBIGene:54726 uniprot:Q01804
Orthologs
mgi:1098801 rgd:1305606
INDRA Statements
deubiquitinations all statements
Pathway Commons
Search for OTUD4
Number of Papers
29 retrieved on 2023-02-19

DepMap Analysis

The Dependency Map (DepMap) is a genome-wide pooled CRISPR-Cas9 knockout proliferation screen conducted in more than 700 cancer cell lines spanning many different tumor lineages. Each cell line in the DepMap contains a unique barcode, and each gene knockout is assigned a “dependency score” on a per cell-line basis which quantifies the rate of CRISPR-Cas9 guide drop. It has been found that proteins with similar DepMap scores across cell lines, a phenomenon known as co-dependent genes, have closely related biological functions. This can include activity in the same or parallel pathways or membership in the same protein complex or the same pathway.

We identified the strongest seven co-dependent genes (“Symbol”) for DUBs and ran GO enrichment analysis. We used Biogrid, IntAct, and Pathway Commons PPIDs, and the NURSA protein-protein interaction databases (PPIDs) to determine whether co-dependent genes interact with one another. The “Evidence” column contains the PPIDs in which the interaction appears as well as whether there is support for the association by an INDRA statement. As another approach to identify potential interactors, we looked at proteomics data from the Broad Institute's Cancer Cell Line Encyclopedia (CCLE) for proteins whose expression across ~375 cell lines strongly correlated with the abundance of each DUB; it has previously been observed that proteins in the same complex are frequently significantly co-expressed. The correlations and associated p-values in the CCLE proteomics dataset are provided. And, we determined whether co-dependent genes yield similar transcriptomic signatures in the Broad Institute's Connectivity Map (CMap). A CMap score greater than 90 is considered significantly similar.

DepMap Correlations

Symbol Name DepMap Correlation Evidence CCLE Correlation CCLE Z-score CCLE p-value (adj) CCLE Significant CMAP Score CMAP Type

Dependency GO Term Enrichment

Gene set enrichment analysis was done on the genes correlated with OTUD4using the terms from Gene Ontology and gene sets derived from the Gene Ontology Annotations database via MSigDB.

Using the biological processes and other Gene Ontology terms from well characterized DUBs as a positive control, several gene set enrichment analyses were considered. Threshold-less methods like GSEA had relatively poor results. Over-representation analysis with a threshold of of the top 7 highest absolute value Dependency Map correlations yielded the best results and is reported below.

GO Identifier GO Name GO Type p-value p-value (adj.) q-value

Literature Mining

INDRA was used to automatically assemble known mechanisms related to OTUD4 from literature and knowledge bases. The first section shows only DUB activity and the second shows all other results.

Deubiquitinase Activity

psp cbn pc bel_lc signor biogrid tas hprd trrust ctd vhn pe drugbank omnipath conib crog dgi minerva creeds ubibrowser acsn | geneways tees gnbr semrep isi trips rlimsp medscan eidos sparser reach
OTUD4 deubiquitinates XPC. 3 / 3
1 | 2

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We speculate that deubiquitination of XPC by OTUD4 could be responsible for the removal of XPC from damage sites, possibly leading to XPC recycling.

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It is not known whether OTUD4 works independently or cooperatively with USP7 to deubiquitinate XPC.

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Importantly, we validated the XPC-OTUD4 interaction by co-IP and provided evidence that OTUD4 knockdown in human cells indeed affects the levels of ubiquitinated XPC, supporting a hypothesis that the OTUD4 deubiquitinase is involved in XPC recycling by cleaving the ubiquitin moiety.
OTUD4 leads to the deubiquitination of MAVS. 2 / 2
1 | 1

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However, OTUD4 positively regulates IFN signaling and enhances host antiviral activities by deubiquitinating K48-Ub on MAVS (66).

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Induction of OTUD4 by viral infection promotes antiviral responses through deubiquitinating and stabilizing MAVS

Other Statements

psp cbn pc bel_lc signor biogrid tas hprd trrust ctd vhn pe drugbank omnipath conib crog dgi minerva creeds ubibrowser acsn | geneways tees gnbr semrep isi trips rlimsp medscan eidos sparser reach
OTUD4 affects AKT
| 4
OTUD4 inhibits AKT.
| 2
OTUD4 inhibits AKT. 2 / 2
| 2

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Akt pathway activity repressed by HIN-1 was enhanced in HIF-2alpha-deficient human NSCLC cells and xenografts [XREF_BIBR].

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Expression of HIN-1 also inhibits Akt mediated retention of p27 in the cytoplasm.
| PMC
OTUD4 decreases the amount of AKT.
| 1
Modified OTUD4 decreases the amount of phosphorylated AKT. 1 / 1
| 1

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Furthermore, overexpression of HIN-1 reduces the expression of phosphorated-AKT (p-AKT), c-myc, Bcl-2 and cyclinD1 while Bax was increased.
OTUD4 activates AKT.
| 1
OTUD4 activates AKT. 1 / 1
| 1

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AKT signaling pathway activated by HIN-1 methylation in non small cell lung cancer.
OTUD4 affects TGFB
| 2 1
OTUD4 activates TGFB. 3 / 3
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OTUD4 enhances TGFbeta signalling through regulation of the TGFbeta receptor complex.

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Specifically , we find that OTUD4 enhances TGFbeta signalling by promoting the membrane presence of TGFbeta receptor I. Furthermore , we demonstrate that OTUD4 inactivates the TGFbeta negative regulator SMURF2 suggesting that OTUD4 regulates multiple nodes of the TGFbeta pathway to enhance TGFbeta activity .

eidos
OTUD4 enhances TGFbeta signalling through regulation of the TGFbeta receptor complex .
Bisphenol A affects OTUD4
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Bisphenol A increases the amount of OTUD4.
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Bisphenol A increases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
Bisphenol A decreases the amount of OTUD4.
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Bisphenol A decreases the amount of OTUD4. 1 / 1
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No evidence text available
OTUD4 affects NFkappaB
| 3
OTUD4 activates NFkappaB.
| 2
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Knockout or knockdown of OTUD4 impairs RNA virus triggered activation of IRF3 and NF-kappaB, expression of their downstream target genes, and potentiates VSV replication in vitro and in vivo.

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Additionally, the knockout of OTUD4 impairs RNA virus-triggered activation of IRF3 and NF-kB and the expression of their downstream target genes, and potentiates VSV replication in vitro and in vivo (66) .
OTUD4 inhibits NFkappaB.
| 1
| 1

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Additionally, the liver inflammatory response and tissue damage were ameliorated in mice overexpressing OTUD4.Taken together, these results show that OTUD4 can negatively regulate NF-kappaB activation by suppressing the K63 linked ubiquitination of TRAF6, thus alleviating hepatic ischemia-reperfusion injury.
Vasotocin affects OTUD4
| 1 1
| 1 1

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XREF_FIG d, AVT also decreases Otud4, Otud5 and Otud7b in addition to Otub1 and c-Maf.

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As shown in Fig. 5d , AVT also decreases Otud4 , Otud5 and Otud7b in addition to Otub1 / c-Maf .
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Trichostatin A decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-6875-3p decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-6809-3p decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-6516-5p decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-5571-5p decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-513a-5p decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
Hsa-miR-498 affects OTUD4
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Hsa-miR-498 decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-4778-3p decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-4760-3p decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-4753-3p decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-4714-3p decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-455-3p decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-4282 decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-4272 decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-30b-5p decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-27b-3p decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-27a-3p decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-19b-3p decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
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Hsa-miR-130b-5p decreases the amount of OTUD4. 2 / 2
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No evidence text available

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No evidence text available
RARB affects OTUD4
| 2
RARB activates OTUD4. 2 / 2
| 2

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RARbeta causes cell cycle arrest, growth inhibition and induction of apoptosis, and HIN-1 in cycle reentry [XREF_BIBR].

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RARbeta causes cell cycle arrest, growth inhibition and induction of apoptosis, and HIN-1 in cycle reentry [XREF_BIBR].
OTUD4 affects cisplatin
| 2
| 2

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In this study, overexpression of HIN-1 enhanced ES2 cell sensitivity to paclitaxel and cisplatin through inhibiting cell growth and enhancing apoptosis.

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Furthermore, overexpression of HIN-1 enhanced ES2 cell sensitivity to paclitaxel and cisplatin through significantly inhibiting cell growth and increasing early and late apoptosis, which supports the results of HIN-1 promoter methylation with downregulation of HIN-1 expression causing poor survival outcomes in OCCA patients.
| 2

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Overexpression of OTUD4 increases radiosensitivity of NSCLC cells exhibiting as impaired clonogenic formation ability, enhanced cell cycle arrest and increased cell apoptosis.

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Expression of HIN-1 in synchronized cells inhibits cell cycle re-entry and the phosphorylation of the retinoblastoma protein (Rb), while in exponentially growing cells HIN-1 induces apoptosis without apparent cell cycle arrest or an effect on Rb phosphorylation.
| PMC

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Furthermore, overexpression of OTUD4 could inhibit tumor cell proliferation, migration and invasion of breast, liver and lung cancer cells through inhibiting the AKT signaling pathway.

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As further evidence that HIN-1 can influence invasive behavior, expression of HIN-1 markedly inhibited the invasion and migration of breast cancer cell lines in Boyden chamber assays.
| PMC
OTUD4 affects IRF3
| 2
OTUD4 activates IRF3. 2 / 2
| 2

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Knockout or knockdown of OTUD4 impairs RNA virus triggered activation of IRF3 and NF-kappaB, expression of their downstream target genes, and potentiates VSV replication in vitro and in vivo.

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Additionally, the knockout of OTUD4 impairs RNA virus-triggered activation of IRF3 and NF-kB and the expression of their downstream target genes, and potentiates VSV replication in vitro and in vivo (66) .
OTUD4 affects ESS2
| 2
OTUD4 activates ESS2. 2 / 2
| 2

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In this study, overexpression of HIN-1 enhanced ES2 cell sensitivity to paclitaxel and cisplatin through inhibiting cell growth and enhancing apoptosis.

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Furthermore, overexpression of HIN-1 enhanced ES2 cell sensitivity to paclitaxel and cisplatin through significantly inhibiting cell growth and increasing early and late apoptosis, which supports the results of HIN-1 promoter methylation with downregulation of HIN-1 expression causing poor survival outcomes in OCCA patients.
Smoke affects OTUD4
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Smoke increases the amount of OTUD4.
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Smoke increases the amount of OTUD4. 1 / 1
1 |

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No evidence text available
Smoke decreases the amount of OTUD4.
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Smoke decreases the amount of OTUD4. 1 / 1
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No evidence text available
OTUD4 affects OTUD4
| 2
OTUD4 decreases the amount of OTUD4.
| 1
Methylated OTUD4 decreases the amount of OTUD4. 1 / 1
| 1

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We also identified that methylation of HIN-1 downregulated the expression of HIN-1 in OCCA cell lines and cancerous tissues according to RT-PCR, Western blot, and IHC analyses.
OTUD4 activates OTUD4.
| 1
OTUD4 activates OTUD4. 1 / 1
| 1

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To investigate the role of WRKY46 in plant defense, we analyzed expression of a luciferase (LUC) reporter driven by a routinely used W-box-containing defense related promoter, NDR1 and HIN1 like 10 (NHL10), in Arabidopsis protoplasts co-expressing either different variants of WRKY46 or CFP (as a control for expression of a defense unrelated protein).
Coal affects OTUD4
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Coal increases the amount of OTUD4.
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Coal increases the amount of OTUD4. 1 / 1
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No evidence text available
Coal decreases the amount of OTUD4.
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Coal decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Air Pollutants increases the amount of OTUD4.
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Air Pollutants increases the amount of OTUD4. 1 / 1
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No evidence text available
Air Pollutants decreases the amount of OTUD4.
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Air Pollutants decreases the amount of OTUD4. 1 / 1
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No evidence text available
17alpha-ethynylestradiol increases the amount of OTUD4.
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17alpha-ethynylestradiol increases the amount of OTUD4. 1 / 1
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No evidence text available
17alpha-ethynylestradiol decreases the amount of OTUD4.
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17alpha-ethynylestradiol decreases the amount of OTUD4. 1 / 1
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ctd
No evidence text available
Vorinostat affects OTUD4
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Vorinostat decreases the amount of OTUD4. 1 / 1
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No evidence text available
Vinclozolin affects OTUD4
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Vinclozolin decreases the amount of OTUD4. 1 / 1
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No evidence text available
| 1
Valproic acid increases the amount of OTUD4. 1 / 1
| 1

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In this study we demonstrated that the expression of HIN1 was upregulated by VPA and is associated with modulation of NB phenotype.
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Troglitazone decreases the amount of OTUD4. 1 / 1
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No evidence text available

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No evidence text available
Torcetrapib affects OTUD4
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Torcetrapib increases the amount of OTUD4. 1 / 1
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No evidence text available
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Thioacetamide increases the amount of OTUD4. 1 / 1
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No evidence text available
Thimerosal affects OTUD4
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Thimerosal decreases the amount of OTUD4. 1 / 1
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No evidence text available
Tetrachloromethane increases the amount of OTUD4. 1 / 1
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No evidence text available
Succimer affects OTUD4
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Succimer decreases the amount of OTUD4. 1 / 1
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No evidence text available
Spermine affects OTUD4
| 1
| 1

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Gene expression analysis in different plant species showed that Spm mediates the induction of several defense genes, such as members of the hairpin induced 1 (HIN1) family, proteinase inhibitors, the transcription repressor ZFT1, and HR associated factors.
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Sodium dichromate increases the amount of OTUD4. 1 / 1
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No evidence text available
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Sodium arsenate increases the amount of OTUD4. 1 / 1
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No evidence text available
Potassium dichromate decreases the amount of OTUD4. 1 / 1
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No evidence text available

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Overexpression of CC A 309 and ANL620, but not CC A 10-1, resulted in significantly higher transcription of several genes, including the HR cell death marker gene Harpin induced 1 (Hin1), a transcription factor for physiological substrates of mitogen activated protein kinases, WRKY8, a cytochrome P450 involved in sesquiterpene phytoalexin biosynthesis, CYP71D20, and Pathogenesis related gene 1 (PR1) (Gopalan et al., 1996; Glazebrook, 2005; Ishihama et al., 2011; Weitzel & Simonsen, 2015).
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No evidence text available
Pentanal affects OTUD4
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Pentanal decreases the amount of OTUD4. 1 / 1
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No evidence text available
Paracetamol affects OTUD4
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Paracetamol decreases the amount of OTUD4. 1 / 1
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No evidence text available
Magnetite nanoparticle decreases the amount of OTUD4. 1 / 1
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No evidence text available
Leflunomide affects OTUD4
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Leflunomide increases the amount of OTUD4. 1 / 1
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No evidence text available
Jinfukang affects OTUD4
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Jinfukang decreases the amount of OTUD4. 1 / 1
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No evidence text available
Ionomycin affects OTUD4
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Ionomycin increases the amount of OTUD4. 1 / 1
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No evidence text available
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Hypochlorous acid increases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-93-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-767-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-766-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-744-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-7111-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-7106-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-6887-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-6885-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-6871-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-6870-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-6859-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-6825-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-6807-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-6795-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-6751-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-675-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-6513-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-570-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-5698 decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-5682 decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-5582-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-548x-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-548j-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-548aq-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-548am-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-548aj-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-548ah-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-548ae-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-526b-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-524-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-520d-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-519d-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-486-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-4796-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-4749-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-4723-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-4709-3p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-4706 decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-4699-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-4466 decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-4465 decreases the amount of OTUD4. 1 / 1
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No evidence text available
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Hsa-miR-4255 decreases the amount of OTUD4. 1 / 1
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No evidence text available
1 |
Hsa-miR-3916 decreases the amount of OTUD4. 1 / 1
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No evidence text available
1 |
Hsa-miR-3675-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
1 |
Hsa-miR-3662 decreases the amount of OTUD4. 1 / 1
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No evidence text available
1 |
Hsa-miR-3646 decreases the amount of OTUD4. 1 / 1
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No evidence text available
1 |
Hsa-miR-3591-5p decreases the amount of OTUD4. 1 / 1
1 |

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No evidence text available
1 |
Hsa-miR-3163 decreases the amount of OTUD4. 1 / 1
1 |

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No evidence text available
1 |
Hsa-miR-3125 decreases the amount of OTUD4. 1 / 1
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No evidence text available
1 |
Hsa-miR-31-5p decreases the amount of OTUD4. 1 / 1
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No evidence text available
1 |
Hsa-miR-30e-5p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-30d-5p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-30c-5p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-30a-5p decreases the amount of OTUD4. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-29c-3p decreases the amount of OTUD4. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-29b-3p decreases the amount of OTUD4. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-29a-3p decreases the amount of OTUD4. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-26b-5p decreases the amount of OTUD4. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-26a-5p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-2681-5p decreases the amount of OTUD4. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-219b-3p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-219a-2-3p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-219a-1-3p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-20b-5p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-20a-5p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-19a-3p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-18a-3p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-183-5p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-17-5p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-152-3p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-148b-3p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-148a-3p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-142-3p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-130b-3p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-1297 decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-1256 decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-1199-5p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-106b-5p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-106a-5p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
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Hsa-miR-101-3p decreases the amount of OTUD4. 1 / 1
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biopax:mirtarbase
No evidence text available
Hrp affects OTUD4
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Hrp activates OTUD4. 1 / 1
| 1

reach
Hrp gene dependent induction of hin1 : a plant gene activated rapidly by both harpins and the avrPto gene mediated signal.
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Geldanamycin increases the amount of OTUD4. 1 / 1
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ctd
No evidence text available
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ctd
No evidence text available
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Dorsomorphin decreases the amount of OTUD4. 1 / 1
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ctd
No evidence text available
Dioxygen affects OTUD4
| 1
Dioxygen increases the amount of OTUD4. 1 / 1
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sparser
CmCP-treated plant leaves showed symptoms of hypersensitive response including electrolyte leakage, reactive oxygen species generation and overexpression of defense-related genes PR-1 , PAD3 , ERF1 , HSR203J , and HIN1 .
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Cupric oxide decreases the amount of OTUD4. 1 / 1
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ctd
No evidence text available
Copper(II) sulfate increases the amount of OTUD4. 1 / 1
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ctd
No evidence text available
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Cobalt dichloride increases the amount of OTUD4. 1 / 1
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ctd
No evidence text available
Butanal affects OTUD4
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Butanal decreases the amount of OTUD4. 1 / 1
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ctd
No evidence text available
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ctd
No evidence text available
Acetamide affects OTUD4
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Acetamide decreases the amount of OTUD4. 1 / 1
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ctd
No evidence text available
| 1

eidos
OTUD4 is induced by virus infection and targets MAVS ubiquitination , triggeringIRF3 and NF-kappaB signaling to sustain antiviral responses [ 85 ] .
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Plant Extracts increases the amount of OTUD4. 1 / 1
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ctd
No evidence text available
PCB 180 affects OTUD4
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PCB 180 increases the amount of OTUD4. 1 / 1
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ctd
No evidence text available

reach
OTUD4 has been shown to deubiquitinate K63-linked chains of 274 myeoloid differentiation primary response 88 (MYD88) and to downregulate NF-kB-dependent 275 inflammation.
| DOI

reach
Furthermore, overexpression of OTUD4 could inhibit tumor cell proliferation, migration and invasion of breast, liver and lung cancer cells through inhibiting the AKT signaling pathway.
| 1

reach
HIN-1 is a potent inhibitor of anchorage dependent and anchorage independent cell growth, cell migration, and invasion [XREF_BIBR, XREF_BIBR].
OTUD4 affects cell growth
| 1
| 1

reach
Reintroduction of HIN-1 into breast cancer cells inhibits cell growth.
OTUD4 affects cell cycle
| 1
| 1

reach
Overexpression of OTUD4 increases radiosensitivity of NSCLC cells exhibiting as impaired clonogenic formation ability, enhanced cell cycle arrest and increased cell apoptosis.
OTUD4 affects arm
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OTUD4 inhibits arm. 1 / 1
| 1

reach
HIn1 (I) extensively suppresses recombination in heterozygotes in the right arm of chromosome I from unc-75 to unc-54.
OTUD4 affects ammonium
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| 1

reach
Furthermore, the silencing of Hsp70 also suppressed l-methionine sulfoximine induced cell death and hin1 expression and caused the over-accumulation of ammonium ions.
OTUD4 affects SMURF2
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OTUD4 inhibits SMURF2. 1 / 1
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sparser
Specifically, we find that OTUD4 enhances TGFβ signalling by promoting the membrane presence of TGFβ receptor I. Furthermore, we demonstrate that OTUD4 inactivates the TGFβ negative regulator SMURF2 suggesting that OTUD4 regulates multiple nodes of the TGFβ pathway to enhance TGFβ activity.
OTUD4 affects RNF216
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OTUD4 inhibits RNF216. 1 / 1
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The syndrome of hypogonadotropic hypogonadism, ataxia, and dementia can be caused by inactivating mutations in RNF216 or by the combination of mutations in RNF216 and OTUD4.
OTUD4 affects Neoplasms
| 1
| 1

reach
The results suggest that CDH1 and HIN1 methylation heterogeneity may increase tumor metastasis.
| PMC

reach
The results suggest that CDH1 and HIN1 methylation heterogeneity may increase tumor metastasis.
| PMC
OTUD4 affects NTS
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OTUD4 activates NTS. 1 / 1
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reach
Transcription of HIN1 was greatly upregulated by inoculation of recombinant TMVs in both Samsun nn and Samsun NN at two different temperatures (25degreesC and 33degreesC) (XREF_FIG).
OTUD4 affects NDRG1
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OTUD4 activates NDRG1. 1 / 1
| 1

reach
To investigate the role of WRKY46 in plant defense, we analyzed expression of a luciferase (LUC) reporter driven by a routinely used W-box-containing defense related promoter, NDR1 and HIN1 like 10 (NHL10), in Arabidopsis protoplasts co-expressing either different variants of WRKY46 or CFP (as a control for expression of a defense unrelated protein).
OTUD4 affects MAVS
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OTUD4 activates MAVS. 1 / 1
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reach
OTUD4, a deubiquitinase, enhances MAVS mediated signaling by stabilizing MAVS and by eliminating K48 linked ubiquitins.
OTUD4 affects Interferon
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OTUD4 increases the amount of Interferon. 1 / 1
| 1

reach
[178] This is supported by the observation that knockout or knockdown of OTUD4 impairs the RNA virus triggered expression of type I interferon and enhances VSV replication, both in vitro and in vivo.
OTUD4 affects CDKN1B
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OTUD4 inhibits CDKN1B. 1 / 1
| 1

reach
Expression of HIN-1 also inhibits Akt mediated retention of p27 in the cytoplasm.
| PMC
NDRG1 affects OTUD4
| 1
NDRG1 activates OTUD4. 1 / 1
| 1

reach
To investigate the role of WRKY46 in plant defense, we analyzed expression of a luciferase (LUC) reporter driven by a routinely used W-box-containing defense related promoter, NDR1 and HIN1 like 10 (NHL10), in Arabidopsis protoplasts co-expressing either different variants of WRKY46 or CFP (as a control for expression of a defense unrelated protein).
L-methionine sulfoximine increases the amount of OTUD4. 1 / 1
| 1

reach
Furthermore, the silencing of Hsp70 also suppressed l-methionine sulfoximine induced cell death and hin1 expression and caused the over-accumulation of ammonium ions.
K 7174 affects OTUD4
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K 7174 increases the amount of OTUD4. 1 / 1
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ctd
No evidence text available
| 1

reach
In this study, we demonstrated that transient overexpression of RipI induces the hypersensitive response (HR), up-regulating the HR marker gene hin1, in Nicotiana benthamiana.
HDAC affects OTUD4
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HDAC increases the amount of OTUD4. 1 / 1
1 |

bel
We next sought to identify a set of genes whose expression was inhibited by both FR235222 and oxamflatin in a pattern similar to that of their transcriptional inhibition of GATA-1. Using GeneSpring software, this analysis identified 80 genes having a good correlation (R > 0.98) with the repression of GATA-1 gene (Fig. 3 and supplementary data).
HCM1 affects OTUD4
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HCM1 activates OTUD4. 1 / 1
| 1

reach
The results showed that HIN1, HSR203J and PR1-a were induced by Hcm1 as by Hpa1, suggesting that the chimeric protein Hcm1, like Hpa1, activates plant defence responses (XREF_FIG).
DDIT3 affects OTUD4
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DDIT3 decreases the amount of OTUD4. 1 / 1
1 |

biopax:msigdb
No evidence text available

reach
Furthermore, AM580 decreases palmitolyation of the surface glycoprotein haemagglutinin of the RNA virus HIN1, thereby impairing replication of influenza59,60.
| PMC
1 |

ctd
No evidence text available
| 1

reach
Highly ABA Induced 1 (HAI1)-Interacting protein HIN1 and drought acclimation enhanced splicing efficiency at intron retention sites.
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ctd
No evidence text available
2,4,4'-trichlorobiphenyl increases the amount of OTUD4. 1 / 1
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ctd
No evidence text available
1 |

ctd
No evidence text available
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ctd
No evidence text available
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ctd
No evidence text available