PSMD14 Data Analysis

HGNC Gene Name

proteasome 26S subunit, non-ATPase 14

HGNC Gene Symbol

PSMD14

Identifiers

hgnc:16889 NCBIGene:10213 uniprot:O00487

Orthologs

mgi:1913284 rgd:1594532

INDRA Statements

deubiquitinations all statements

Pathway Commons

Search for PSMD14

Number of Papers

93 retrieved on 2022-05-22

DepMap Analysis

The Dependency Map (DepMap) is a genome-wide pooled CRISPR-Cas9 knockout proliferation screen conducted in more than 700 cancer cell lines spanning many different tumor lineages. Each cell line in the DepMap contains a unique barcode, and each gene knockout is assigned a “dependency score” on a per cell-line basis which quantifies the rate of CRISPR-Cas9 guide drop. It has been found that proteins with similar DepMap scores across cell lines, a phenomenon known as co-dependent genes, have closely related biological functions. This can include activity in the same or parallel pathways or membership in the same protein complex or the same pathway.

We identified the strongest seven co-dependent genes (“Symbol”) for DUBs and ran GO enrichment analysis. We used Biogrid, IntAct, and Pathway Commons PPIDs, and the NURSA protein-protein interaction databases (PPIDs) to determine whether co-dependent genes interact with one another. The “Evidence” column contains the PPIDs in which the interaction appears as well as whether there is support for the association by an INDRA statement. As another approach to identify potential interactors, we looked at proteomics data from the Broad Institute's Cancer Cell Line Encyclopedia (CCLE) for proteins whose expression across ~375 cell lines strongly correlated with the abundance of each DUB; it has previously been observed that proteins in the same complex are frequently significantly co-expressed. The correlations and associated p-values in the CCLE proteomics dataset are provided. And, we determined whether co-dependent genes yield similar transcriptomic signatures in the Broad Institute's Connectivity Map (CMap). A CMap score greater than 90 is considered significantly similar.

DepMap Correlations

Symbol	Name	DepMap Correlation	Evidence	CCLE Correlation	CCLE Z-score	CCLE p-value (adj)	CCLE Significant	CMAP Score	CMAP Type
CHEK1	checkpoint kinase 1	0.525	Reactome (11)	0.08	0.36	2.08e-01
SMU1	SMU1 DNA replication regulator and spliceosomal factor	0.508		0.10	0.46	1.12e-01
PSMA6	proteasome 20S subunit alpha 6	0.49	BioGRID INDRA (1) Reactome (150)	0.62	3.32	2.76e-38
PSMD7	proteasome 26S subunit, non-ATPase 7	0.487	BioGRID IntAct NURSA Pathway Commons INDRA (2) Reactome (151)	0.53	2.85	6.91e-27
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.484	Reactome (5)	-0.13	-0.80	1.69e-01
PSMA1	proteasome 20S subunit alpha 1	0.46	BioGRID IntAct INDRA (1) Reactome (150)	0.54	2.87	2.68e-27		99.82	kd
SNRPF	small nuclear ribonucleoprotein polypeptide F	0.459	Reactome (5)	0.26	1.37	1.66e-06

Dependency GO Term Enrichment

Gene set enrichment analysis was done on the genes correlated with PSMD14using the terms from Gene Ontology and gene sets derived from the Gene Ontology Annotations database via MSigDB.

Using the biological processes and other Gene Ontology terms from well characterized DUBs as a positive control, several gene set enrichment analyses were considered. Threshold-less methods like GSEA had relatively poor results. Over-representation analysis with a threshold of of the top 7 highest absolute value Dependency Map correlations yielded the best results and is reported below.

GO Identifier	GO Name	GO Type	p-value	p-value (adj.)	q-value
GO:1902750	negative regulation of cell cycle G2/M phase transition	Biological Process	3.06e-08	7.22e-06	2.03e-06
GO:0043620	regulation of DNA-templated transcription in response to stress	Biological Process	6.19e-08	1.46e-05	2.05e-06
GO:1902749	regulation of cell cycle G2/M phase transition	Biological Process	5.46e-07	1.29e-04	1.21e-05
GO:0006521	regulation of cellular amino acid metabolic process	Biological Process	1.10e-06	2.59e-04	1.27e-05
GO:1901988	negative regulation of cell cycle phase transition	Biological Process	1.26e-06	2.97e-04	1.27e-05
GO:1905369	endopeptidase complex	Cellular Component	1.33e-06	3.14e-04	1.27e-05
GO:0044839	cell cycle G2/M phase transition	Biological Process	1.34e-06	3.16e-04	1.27e-05
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	Biological Process	2.14e-06	5.04e-04	1.37e-05
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	Biological Process	2.40e-06	5.67e-04	1.37e-05
GO:0060218	hematopoietic stem cell differentiation	Biological Process	2.40e-06	5.67e-04	1.37e-05
GO:0033238	regulation of cellular amine metabolic process	Biological Process	2.50e-06	5.89e-04	1.37e-05
GO:0031145	anaphase-promoting complex-dependent catabolic process	Biological Process	2.59e-06	6.12e-04	1.37e-05
GO:1901532	regulation of hematopoietic progenitor cell differentiation	Biological Process	2.69e-06	6.35e-04	1.37e-05
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process	3.56e-06	8.41e-04	1.39e-05
GO:1905368	peptidase complex	Cellular Component	3.56e-06	8.41e-04	1.39e-05
GO:0019773	proteasome core complex, alpha-subunit complex	Cellular Component	3.26e-06	7.70e-04	1.39e-05
GO:0045930	negative regulation of mitotic cell cycle	Biological Process	3.20e-06	7.56e-04	1.39e-05
GO:0010948	negative regulation of cell cycle process	Biological Process	4.17e-06	9.84e-04	1.46e-05
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Biological Process	4.19e-06	9.90e-04	1.46e-05
GO:0070498	interleukin-1-mediated signaling pathway	Biological Process	5.05e-06	1.19e-03	1.67e-05
GO:2000736	regulation of stem cell differentiation	Biological Process	6.89e-06	1.63e-03	2.08e-05
GO:0009308	amine metabolic process	Biological Process	1.18e-05	2.79e-03	3.13e-05
GO:0010565	regulation of cellular ketone metabolic process	Biological Process	1.18e-05	2.79e-03	3.13e-05
GO:1901987	regulation of cell cycle phase transition	Biological Process	1.31e-05	3.09e-03	3.24e-05
GO:0001738	morphogenesis of a polarized epithelium	Biological Process	1.32e-05	3.11e-03	3.24e-05
GO:0090263	positive regulation of canonical Wnt signaling pathway	Biological Process	1.44e-05	3.39e-03	3.40e-05
GO:0035567	non-canonical Wnt signaling pathway	Biological Process	1.62e-05	3.83e-03	3.71e-05
GO:0002244	hematopoietic progenitor cell differentiation	Biological Process	2.09e-05	4.92e-03	4.61e-05
GO:0038095	Fc-epsilon receptor signaling pathway	Biological Process	2.33e-05	5.49e-03	4.67e-05
GO:0005839	proteasome core complex	Cellular Component	2.21e-05	5.21e-03	4.67e-05
GO:0033209	tumor necrosis factor-mediated signaling pathway	Biological Process	2.28e-05	5.39e-03	4.67e-05
GO:0070003	threonine-type peptidase activity	Molecular Function	2.44e-05	5.76e-03	4.76e-05
GO:0030177	positive regulation of Wnt signaling pathway	Biological Process	2.58e-05	6.09e-03	4.89e-05
GO:0038061	NIK/NF-kappaB signaling	Biological Process	2.72e-05	6.41e-03	4.90e-05
GO:0005681	spliceosomal complex	Cellular Component	2.76e-05	6.52e-03	4.90e-05
GO:1905330	regulation of morphogenesis of an epithelium	Biological Process	2.81e-05	6.63e-03	4.90e-05
GO:0010499	proteasomal ubiquitin-independent protein catabolic process	Biological Process	2.94e-05	6.94e-03	5.00e-05
GO:0048002	antigen processing and presentation of peptide antigen	Biological Process	3.25e-05	7.68e-03	5.39e-05
GO:0042180	cellular ketone metabolic process	Biological Process	3.47e-05	8.18e-03	5.60e-05
GO:0061013	regulation of mRNA catabolic process	Biological Process	3.80e-05	8.96e-03	5.86e-05
GO:0070555	response to interleukin-1	Biological Process	3.80e-05	8.96e-03	5.86e-05
GO:0050852	T cell receptor signaling pathway	Biological Process	3.97e-05	9.38e-03	5.99e-05
GO:0030178	negative regulation of Wnt signaling pathway	Biological Process	4.34e-05	1.02e-02	6.39e-05
GO:0019882	antigen processing and presentation	Biological Process	5.41e-05	1.28e-02	7.81e-05
GO:0071453	cellular response to oxygen levels	Biological Process	6.25e-05	1.47e-02	8.82e-05
GO:0038093	Fc receptor signaling pathway	Biological Process	6.74e-05	1.59e-02	9.31e-05
GO:0048863	stem cell differentiation	Biological Process	7.43e-05	1.75e-02	1.01e-04
GO:2000027	regulation of animal organ morphogenesis	Biological Process	7.79e-05	1.84e-02	1.03e-04
GO:0071011	precatalytic spliceosome	Cellular Component	1.10e-04	2.59e-02	1.42e-04
GO:0006520	cellular amino acid metabolic process	Biological Process	1.19e-04	2.82e-02	1.52e-04
GO:0070646	protein modification by small protein removal	Biological Process	1.29e-04	3.05e-02	1.62e-04
GO:0050851	antigen receptor-mediated signaling pathway	Biological Process	1.40e-04	3.30e-02	1.71e-04
GO:0000209	protein polyubiquitination	Biological Process	1.43e-04	3.37e-02	1.71e-04
GO:0034612	response to tumor necrosis factor	Biological Process	1.44e-04	3.40e-02	1.71e-04
GO:0002218	activation of innate immune response	Biological Process	1.51e-04	3.56e-02	1.76e-04
GO:0060070	canonical Wnt signaling pathway	Biological Process	1.72e-04	4.05e-02	1.96e-04
GO:0062012	regulation of small molecule metabolic process	Biological Process	1.94e-04	4.58e-02	2.18e-04

Transcriptomics

The following table shows the significantly differentially expressed genes after knocking out PSMD14 using CRISPR-Cas9.

Knockout Differential Expression

Symbol	Name	log2-fold-change	p-value	p-value (adj.)
UBC	ubiquitin C	2.17e+00	2.48e-278	2.61e-274
FTL	ferritin light chain	1.90e+00	9.89e-142	5.20e-138
SQSTM1	sequestosome 1	2.61e+00	7.02e-133	2.46e-129
ANXA1	annexin A1	1.43e+00	5.82e-82	1.53e-78
HSPA8	heat shock protein family A (Hsp70) member 8	1.53e+00	1.51e-73	3.17e-70
MMP1	matrix metallopeptidase 1	1.34e+00	5.13e-65	8.99e-62
LRRC69	leucine rich repeat containing 69	9.60e-01	5.53e-61	8.31e-58
PSMC4	proteasome 26S subunit, ATPase 4	1.55e+00	4.67e-52	6.14e-49
MRNIP	MRN complex interacting protein	2.22e+00	2.89e-50	3.37e-47
MT1X	metallothionein 1X	1.22e+00	8.06e-49	8.48e-46
MLLT11	MLLT11 transcription factor 7 cofactor	2.43e+00	4.69e-46	4.49e-43
CXCL2	C-X-C motif chemokine ligand 2	2.56e+00	3.56e-42	3.12e-39
SOD1	superoxide dismutase 1	1.33e+00	5.25e-42	4.25e-39
BLVRB	biliverdin reductase B	1.58e+00	1.19e-40	8.92e-38
TALDO1	transaldolase 1	1.10e+00	3.52e-40	2.47e-37
GLA	galactosidase alpha	1.87e+00	1.14e-35	7.51e-33
FTH1	ferritin heavy chain 1	1.42e+00	3.14e-35	1.91e-32
HSP90AA1	heat shock protein 90 alpha family class A member 1	1.18e+00	3.27e-35	1.91e-32
CXCL3	C-X-C motif chemokine ligand 3	2.64e+00	1.82e-34	1.01e-31
TTC1	tetratricopeptide repeat domain 1	1.19e+00	8.40e-34	4.42e-31
KLF6	Kruppel like factor 6	1.24e+00	4.96e-32	2.49e-29
ADAMTS1	ADAM metallopeptidase with thrombospondin type 1 motif 1	2.12e+00	5.96e-32	2.85e-29
ATP6V0E1	ATPase H+ transporting V0 subunit e1	9.74e-01	5.18e-30	2.37e-27
RND3	Rho family GTPase 3	1.62e+00	6.43e-30	2.82e-27
MAP1LC3B	microtubule associated protein 1 light chain 3 beta	1.62e+00	8.25e-30	3.47e-27
PSMC5	proteasome 26S subunit, ATPase 5	9.80e-01	1.64e-29	6.61e-27
UBB	ubiquitin B	6.29e-01	3.05e-26	1.19e-23
PSMB7	proteasome 20S subunit beta 7	9.10e-01	2.47e-25	9.28e-23
DUSP1	dual specificity phosphatase 1	2.21e+00	2.65e-25	9.62e-23
CCL26	C-C motif chemokine ligand 26	2.35e+00	3.62e-25	1.27e-22
TFPI2	tissue factor pathway inhibitor 2	1.32e+00	4.47e-25	1.52e-22
PTMA	prothymosin alpha	-6.95e-01	4.72e-25	1.55e-22
ANKRD1	ankyrin repeat domain 1	8.56e-01	5.13e-25	1.59e-22
SAT1	spermidine/spermine N1-acetyltransferase 1	1.14e+00	5.03e-25	1.59e-22
HMOX1	heme oxygenase 1	2.21e+00	7.60e-25	2.28e-22
CYB5R1	cytochrome b5 reductase 1	1.60e+00	2.32e-24	6.78e-22
GPX3	glutathione peroxidase 3	1.57e+00	4.64e-24	1.28e-21
ACOT13	acyl-CoA thioesterase 13	1.08e+00	1.40e-23	3.76e-21
HMGN2	high mobility group nucleosomal binding domain 2	-9.32e-01	1.77e-23	4.65e-21
H4C3	H4 clustered histone 3	-1.41e+00	2.52e-23	6.46e-21
POMP	proteasome maturation protein	7.03e-01	4.93e-23	1.23e-20
IGFBP4	insulin like growth factor binding protein 4	-1.21e+00	2.75e-22	6.72e-20
GLRX	glutaredoxin	1.17e+00	4.47e-22	1.07e-19
ZFAND2A	zinc finger AN1-type containing 2A	1.64e+00	5.85e-22	1.37e-19
PSMB2	proteasome 20S subunit beta 2	8.28e-01	1.23e-21	2.81e-19
HSPA5	heat shock protein family A (Hsp70) member 5	8.09e-01	2.20e-21	4.93e-19
DNAJB1	DnaJ heat shock protein family (Hsp40) member B1	1.45e+00	2.84e-21	6.23e-19
ALDH2	aldehyde dehydrogenase 2 family member	1.40e+00	4.68e-21	1.00e-18
CXCL8	C-X-C motif chemokine ligand 8	1.68e+00	4.75e-20	9.99e-18
RNF181	ring finger protein 181	8.08e-01	7.96e-20	1.64e-17
FTLP3	ferritin light chain pseudogene 3	1.40e+00	1.57e-19	3.17e-17
PSMA7	proteasome 20S subunit alpha 7	5.41e-01	1.60e-19	3.18e-17
PSMB4	proteasome 20S subunit beta 4	8.33e-01	2.74e-19	5.34e-17
RPL41	ribosomal protein L41	-5.71e-01	7.96e-18	1.52e-15
PSMA2	proteasome 20S subunit alpha 2	7.30e-01	8.27e-18	1.55e-15
HMGB2	high mobility group box 2	-1.04e+00	9.17e-18	1.69e-15
SPANXB1	SPANX family member B1	5.39e-01	1.61e-17	2.91e-15
DNAJA1	DnaJ heat shock protein family (Hsp40) member A1	7.14e-01	4.05e-17	7.22e-15
VCP	valosin containing protein	1.11e+00	4.66e-17	8.17e-15
SELENOK	selenoprotein K	8.59e-01	9.33e-17	1.61e-14
HMGB3	high mobility group box 3	-1.15e+00	1.56e-16	2.65e-14
SRGN	serglycin	1.08e+00	2.77e-16	4.63e-14
PSMB6	proteasome 20S subunit beta 6	5.54e-01	2.85e-16	4.68e-14
SKP1	S-phase kinase associated protein 1	6.62e-01	2.97e-16	4.81e-14
PSMD2	proteasome 26S subunit ubiquitin receptor, non-ATPase 2	8.10e-01	3.76e-16	5.99e-14
UFD1	ubiquitin recognition factor in ER associated degradation 1	9.90e-01	3.95e-16	6.20e-14
PTTG1	PTTG1 regulator of sister chromatid separation, securin	-8.89e-01	8.35e-16	1.29e-13
PSMD8	proteasome 26S subunit, non-ATPase 8	7.63e-01	1.14e-15	1.74e-13
HMGB1	high mobility group box 1	-7.19e-01	1.19e-15	1.78e-13
MGST1	microsomal glutathione S-transferase 1	7.93e-01	1.86e-15	2.75e-13
BIRC5	baculoviral IAP repeat containing 5	-1.17e+00	2.01e-15	2.93e-13
PSMD11	proteasome 26S subunit, non-ATPase 11	6.97e-01	4.13e-15	5.95e-13
PSAP	prosaposin	8.64e-01	7.90e-15	1.12e-12
MCUR1	mitochondrial calcium uniporter regulator 1	1.11e+00	1.07e-14	1.50e-12
CCNB1	cyclin B1	-1.04e+00	1.31e-14	1.82e-12
MAP1B	microtubule associated protein 1B	8.22e-01	1.65e-14	2.25e-12
PSMA5	proteasome 20S subunit alpha 5	7.54e-01	1.89e-14	2.55e-12
GSTP1	glutathione S-transferase pi 1	6.22e-01	2.02e-14	2.69e-12
CYSTM1	cysteine rich transmembrane module containing 1	1.06e+00	2.88e-14	3.79e-12
RIOK3	RIO kinase 3	1.18e+00	3.20e-14	4.15e-12
PSMA4	proteasome 20S subunit alpha 4	6.89e-01	6.26e-14	8.03e-12
TXNRD1	thioredoxin reductase 1	1.00e+00	7.70e-14	9.76e-12
DDIT3	DNA damage inducible transcript 3	1.35e+00	7.91e-14	9.91e-12
LGALS1	galectin 1	-5.99e-01	9.68e-14	1.20e-11
NAMPT	nicotinamide phosphoribosyltransferase	9.24e-01	1.40e-13	1.71e-11
TBCA	tubulin folding cofactor A	7.09e-01	1.80e-13	2.16e-11
PSMB1	proteasome 20S subunit beta 1	5.63e-01	2.15e-13	2.54e-11
PSMC6	proteasome 26S subunit, ATPase 6	9.03e-01	2.36e-13	2.76e-11
RB1CC1	RB1 inducible coiled-coil 1	1.33e+00	2.64e-13	3.05e-11
NDUFA4	NDUFA4 mitochondrial complex associated	7.66e-01	3.51e-13	4.01e-11
CTSD	cathepsin D	8.03e-01	4.27e-13	4.83e-11
DAP3	death associated protein 3	9.92e-01	4.95e-13	5.53e-11
GABARAPL1	GABA type A receptor associated protein like 1	1.44e+00	6.39e-13	7.08e-11
ANXA7	annexin A7	8.48e-01	1.22e-12	1.34e-10
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	8.45e-01	1.31e-12	1.42e-10
CXCL1	C-X-C motif chemokine ligand 1	1.38e+00	2.25e-12	2.41e-10
SLC25A5	solute carrier family 25 member 5	-5.56e-01	2.53e-12	2.68e-10
SOD2	superoxide dismutase 2	8.60e-01	3.08e-12	3.24e-10
RIT1	Ras like without CAAX 1	1.09e+00	4.53e-12	4.71e-10
PPIA	peptidylprolyl isomerase A	-5.60e-01	4.95e-12	5.10e-10
GADD45A	growth arrest and DNA damage inducible alpha	1.29e+00	8.26e-12	8.44e-10
EEF1A1	eukaryotic translation elongation factor 1 alpha 1	4.15e-01	9.12e-12	9.22e-10
PIR	pirin	1.32e+00	1.08e-11	1.08e-09
ANXA2	annexin A2	4.84e-01	1.09e-11	1.08e-09
RPL11	ribosomal protein L11	-6.26e-01	1.23e-11	1.21e-09
TXNL1	thioredoxin like 1	8.18e-01	1.53e-11	1.49e-09
RPS14	ribosomal protein S14	-5.63e-01	1.64e-11	1.58e-09
PSMA6	proteasome 20S subunit alpha 6	7.45e-01	2.05e-11	1.96e-09
SEM1	SEM1 26S proteasome subunit	4.97e-01	2.18e-11	2.07e-09
BSCL2	BSCL2 lipid droplet biogenesis associated, seipin	1.26e+00	2.64e-11	2.47e-09
RALA	RAS like proto-oncogene A	1.05e+00	3.37e-11	3.13e-09
AKR1B1	aldo-keto reductase family 1 member B	6.27e-01	6.51e-11	6.01e-09
FEN1	flap structure-specific endonuclease 1	-1.02e+00	7.34e-11	6.71e-09
BEST1	bestrophin 1	1.02e+00	8.50e-11	7.71e-09
AKR1C1	aldo-keto reductase family 1 member C1	1.25e+00	1.20e-10	1.08e-08
TACSTD2	tumor associated calcium signal transducer 2	1.10e+00	1.70e-10	1.52e-08
CALM2	calmodulin 2	-4.16e-01	1.77e-10	1.57e-08
PRDX1	peroxiredoxin 1	7.28e-01	1.81e-10	1.58e-08
GCNT2	glucosaminyl (N-acetyl) transferase 2 (I blood group)	1.06e+00	2.02e-10	1.75e-08
BLOC1S2	biogenesis of lysosomal organelles complex 1 subunit 2	1.03e+00	2.13e-10	1.84e-08
GHITM	growth hormone inducible transmembrane protein	6.17e-01	2.66e-10	2.28e-08
PLAT	plasminogen activator, tissue type	7.48e-01	3.09e-10	2.62e-08
PSMA1	proteasome 20S subunit alpha 1	6.49e-01	3.19e-10	2.69e-08
TMA7	translation machinery associated 7 homolog	-4.41e-01	4.37e-10	3.65e-08
PSMD13	proteasome 26S subunit, non-ATPase 13	8.49e-01	4.42e-10	3.66e-08
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	1.04e+00	4.81e-10	3.95e-08
SLCO4A1	solute carrier organic anion transporter family member 4A1	-1.26e+00	6.47e-10	5.27e-08
CCND1	cyclin D1	-7.47e-01	6.80e-10	5.50e-08
CENPF	centromere protein F	-9.16e-01	6.85e-10	5.50e-08
IL24	interleukin 24	1.33e+00	7.16e-10	5.71e-08
GCLM	glutamate-cysteine ligase modifier subunit	1.05e+00	7.63e-10	6.03e-08
PSMC1	proteasome 26S subunit, ATPase 1	7.38e-01	8.36e-10	6.56e-08
DEK	DEK proto-oncogene	-8.27e-01	9.18e-10	7.10e-08
NUCKS1	nuclear casein kinase and cyclin dependent kinase substrate 1	-6.73e-01	9.13e-10	7.10e-08
TMEM159	lipid droplet assembly factor 1	1.01e+00	1.02e-09	7.80e-08
TAGLN2	transgelin 2	-7.65e-01	1.14e-09	8.65e-08
HSPH1	heat shock protein family H (Hsp110) member 1	1.09e+00	1.21e-09	9.15e-08
DNAJC2	DnaJ heat shock protein family (Hsp40) member C2	1.18e+00	1.28e-09	9.65e-08
EGR1	early growth response 1	1.22e+00	1.58e-09	1.18e-07
ACTG1	actin gamma 1	-3.75e-01	2.16e-09	1.60e-07
ORC3	origin recognition complex subunit 3	1.19e+00	2.61e-09	1.92e-07
TK1	thymidine kinase 1	-9.65e-01	3.09e-09	2.26e-07
RTN4	reticulon 4	6.96e-01	3.45e-09	2.50e-07
TMEM167A	transmembrane protein 167A	6.40e-01	3.53e-09	2.54e-07
SPANXC	SPANX family member C	4.84e-01	3.66e-09	2.62e-07
TUBA1B	tubulin alpha 1b	-4.88e-01	3.69e-09	2.63e-07
ZFP36L1	ZFP36 ring finger protein like 1	8.69e-01	4.34e-09	3.07e-07
TOP2A	DNA topoisomerase II alpha	-1.19e+00	4.59e-09	3.22e-07
MT2A	metallothionein 2A	5.44e-01	5.74e-09	4.00e-07
ABL2	ABL proto-oncogene 2, non-receptor tyrosine kinase	9.57e-01	7.51e-09	5.20e-07
ME1	malic enzyme 1	9.90e-01	8.13e-09	5.59e-07
DPH3	diphthamide biosynthesis 3	9.11e-01	8.41e-09	5.74e-07
FAM241B	family with sequence similarity 241 member B	1.14e+00	8.63e-09	5.86e-07
GSR	glutathione-disulfide reductase	1.05e+00	1.04e-08	7.04e-07
H2AZ1	H2A.Z variant histone 1	-5.37e-01	1.14e-08	7.65e-07
H2AZ2	H2A.Z variant histone 2	-8.38e-01	1.46e-08	9.70e-07
MED13	mediator complex subunit 13	1.15e+00	1.72e-08	1.14e-06
SPANXA1	sperm protein associated with the nucleus, X-linked, family member A1	6.17e-01	1.88e-08	1.23e-06
CKS1B	CDC28 protein kinase regulatory subunit 1B	-6.42e-01	1.96e-08	1.28e-06
TIPRL	TOR signaling pathway regulator	7.64e-01	2.02e-08	1.31e-06
PSMD3	proteasome 26S subunit, non-ATPase 3	9.10e-01	2.13e-08	1.37e-06
AHSA1	activator of HSP90 ATPase activity 1	8.93e-01	2.30e-08	1.48e-06
MAFG	MAF bZIP transcription factor G	1.03e+00	2.59e-08	1.65e-06
KIAA1191	KIAA1191	8.99e-01	3.20e-08	2.03e-06
PSMD12	proteasome 26S subunit, non-ATPase 12	7.17e-01	3.44e-08	2.17e-06
DOCK7	dedicator of cytokinesis 7	3.52e-01	3.67e-08	2.30e-06
NUPR1	nuclear protein 1, transcriptional regulator	8.57e-01	4.08e-08	2.52e-06
YPEL5	yippee like 5	9.51e-01	4.05e-08	2.52e-06
AXL	AXL receptor tyrosine kinase	-7.18e-01	4.41e-08	2.71e-06
STIP1	stress induced phosphoprotein 1	7.19e-01	4.57e-08	2.79e-06
MYC	MYC proto-oncogene, bHLH transcription factor	9.23e-01	5.54e-08	3.37e-06
PHLDA1	pleckstrin homology like domain family A member 1	5.53e-01	5.59e-08	3.38e-06
MORN2	MORN repeat containing 2	1.04e+00	5.88e-08	3.53e-06
WDR83OS	WD repeat domain 83 opposite strand	4.33e-01	5.98e-08	3.58e-06
UBXN4	UBX domain protein 4	6.67e-01	6.25e-08	3.72e-06
MKI67	marker of proliferation Ki-67	-1.10e+00	6.45e-08	3.81e-06
VPS53	VPS53 subunit of GARP complex	8.02e-01	6.61e-08	3.88e-06
KIAA1217	KIAA1217	1.02e+00	6.91e-08	4.04e-06
RPL29	ribosomal protein L29	-5.18e-01	7.63e-08	4.43e-06
SLC7A11	solute carrier family 7 member 11	9.75e-01	7.72e-08	4.44e-06
TAF13	TATA-box binding protein associated factor 13	8.33e-01	7.69e-08	4.44e-06
DNAJB6	DnaJ heat shock protein family (Hsp40) member B6	6.14e-01	7.86e-08	4.49e-06
LDHA	lactate dehydrogenase A	-4.66e-01	8.49e-08	4.83e-06
ABHD4	abhydrolase domain containing 4, N-acyl phospholipase B	9.55e-01	8.59e-08	4.86e-06
DAB2	DAB adaptor protein 2	1.01e+00	9.16e-08	5.15e-06
DYNC1H1	dynein cytoplasmic 1 heavy chain 1	5.89e-01	1.04e-07	5.82e-06
NUSAP1	nucleolar and spindle associated protein 1	-8.83e-01	1.15e-07	6.42e-06
CDC20	cell division cycle 20	-1.01e+00	1.17e-07	6.46e-06
IMPDH2	inosine monophosphate dehydrogenase 2	-7.16e-01	1.20e-07	6.59e-06
ERRFI1	ERBB receptor feedback inhibitor 1	7.69e-01	1.35e-07	7.39e-06
PLAU	plasminogen activator, urokinase	-9.10e-01	1.42e-07	7.74e-06
S100A10	S100 calcium binding protein A10	-4.50e-01	1.71e-07	9.30e-06
PRXL2C	peroxiredoxin like 2C	8.37e-01	1.82e-07	9.82e-06
PLEKHB2	pleckstrin homology domain containing B2	7.70e-01	2.26e-07	1.21e-05
CLIP1	CAP-Gly domain containing linker protein 1	7.69e-01	2.30e-07	1.23e-05
RPLP0	ribosomal protein lateral stalk subunit P0	-4.46e-01	2.42e-07	1.28e-05
RPS8	ribosomal protein S8	-3.75e-01	2.60e-07	1.37e-05
IQGAP3	IQ motif containing GTPase activating protein 3	-1.07e+00	2.78e-07	1.46e-05
MTND1P23	MT-ND1 pseudogene 23	4.39e-01	3.08e-07	1.61e-05
NOG	noggin	-1.10e+00	3.26e-07	1.70e-05
ZPR1	ZPR1 zinc finger	8.81e-01	3.32e-07	1.72e-05
SNRPD1	small nuclear ribonucleoprotein D1 polypeptide	-4.76e-01	3.52e-07	1.82e-05
TUBB2A	tubulin beta 2A class IIa	9.10e-01	3.56e-07	1.83e-05
PPIF	peptidylprolyl isomerase F	8.62e-01	3.63e-07	1.85e-05
RHOQ	ras homolog family member Q	1.05e+00	3.90e-07	1.98e-05
PALM2AKAP2	PALM2 and AKAP2 fusion	8.59e-01	4.01e-07	2.03e-05
CASP4	caspase 4	8.74e-01	4.06e-07	2.04e-05
ARL6IP1	ADP ribosylation factor like GTPase 6 interacting protein 1	-6.64e-01	4.57e-07	2.29e-05
S100A2	S100 calcium binding protein A2	-1.10e+00	4.86e-07	2.42e-05
UBE2V1	ubiquitin conjugating enzyme E2 V1	7.60e-01	4.88e-07	2.42e-05
DNMT1	DNA methyltransferase 1	-7.73e-01	5.46e-07	2.70e-05
TMEM59	transmembrane protein 59	5.62e-01	5.74e-07	2.82e-05
KIF21A	kinesin family member 21A	9.02e-01	6.10e-07	2.99e-05
BSDC1	BSD domain containing 1	9.26e-01	6.50e-07	3.15e-05
DUSP5	dual specificity phosphatase 5	9.31e-01	6.48e-07	3.15e-05
ZWINT	ZW10 interacting kinetochore protein	-8.46e-01	8.25e-07	3.98e-05
HNRNPK	heterogeneous nuclear ribonucleoprotein K	-5.65e-01	8.46e-07	4.06e-05
SUPT16H	SPT16 homolog, facilitates chromatin remodeling subunit	-8.12e-01	8.72e-07	4.17e-05
CDCA3	cell division cycle associated 3	-1.16e+00	9.07e-07	4.32e-05
CRK	CRK proto-oncogene, adaptor protein	8.28e-01	9.36e-07	4.43e-05
BAG3	BAG cochaperone 3	8.53e-01	9.48e-07	4.47e-05
BABAM1	BRISC and BRCA1 A complex member 1	7.12e-01	1.00e-06	4.70e-05
AKR1C3	aldo-keto reductase family 1 member C3	6.92e-01	1.03e-06	4.81e-05
TM4SF19	transmembrane 4 L six family member 19	9.96e-01	1.04e-06	4.85e-05
PSMB5	proteasome 20S subunit beta 5	4.59e-01	1.38e-06	6.37e-05
SUMO2	small ubiquitin like modifier 2	-4.00e-01	1.38e-06	6.37e-05
H3-3B	H3.3 histone B	-3.38e-01	1.43e-06	6.53e-05
PSMD14	proteasome 26S subunit, non-ATPase 14	-8.21e-01	1.43e-06	6.53e-05
NT5C2	5'-nucleotidase, cytosolic II	8.94e-01	1.60e-06	7.28e-05
RRAGC	Ras related GTP binding C	9.50e-01	1.71e-06	7.73e-05
MAPK10	mitogen-activated protein kinase 10	9.66e-01	1.88e-06	8.49e-05
DUSP10	dual specificity phosphatase 10	9.93e-01	1.90e-06	8.55e-05
AKIRIN1	akirin 1	9.22e-01	1.97e-06	8.78e-05
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	-5.16e-01	1.97e-06	8.78e-05
PSMA3	proteasome 20S subunit alpha 3	4.82e-01	2.44e-06	1.08e-04
XRCC5	X-ray repair cross complementing 5	-6.35e-01	2.45e-06	1.08e-04
NPLOC4	NPL4 homolog, ubiquitin recognition factor	7.34e-01	2.56e-06	1.13e-04
SCPEP1	serine carboxypeptidase 1	8.67e-01	2.59e-06	1.13e-04
UBE2T	ubiquitin conjugating enzyme E2 T	-8.77e-01	2.68e-06	1.16e-04
ZC3H12C	zinc finger CCCH-type containing 12C	9.76e-01	2.67e-06	1.16e-04
COX6C	cytochrome c oxidase subunit 6C	3.97e-01	2.79e-06	1.21e-04
UQCC2	ubiquinol-cytochrome c reductase complex assembly factor 2	-6.01e-01	2.98e-06	1.29e-04
RPS6	ribosomal protein S6	-4.26e-01	3.08e-06	1.32e-04
PELO	pelota mRNA surveillance and ribosome rescue factor	7.85e-01	3.38e-06	1.44e-04
MTPN	myotrophin	5.22e-01	3.49e-06	1.49e-04
CTH	cystathionine gamma-lyase	9.32e-01	3.63e-06	1.54e-04
AKAP2	A-kinase anchoring protein 2	7.76e-01	3.71e-06	1.56e-04
EPAS1	endothelial PAS domain protein 1	9.35e-01	3.71e-06	1.56e-04
FAM32A	family with sequence similarity 32 member A	5.51e-01	3.73e-06	1.56e-04
GPATCH2	G-patch domain containing 2	8.52e-01	3.74e-06	1.56e-04
SMG1	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	8.15e-01	3.82e-06	1.59e-04
AP1G1	adaptor related protein complex 1 subunit gamma 1	7.21e-01	3.96e-06	1.64e-04
RAB5IF	RAB5 interacting factor	7.47e-01	4.23e-06	1.74e-04
CACYBP	calcyclin binding protein	4.29e-01	4.46e-06	1.83e-04
APOL2	apolipoprotein L2	8.31e-01	4.86e-06	1.99e-04
TMEM50B	transmembrane protein 50B	8.62e-01	5.08e-06	2.07e-04
DPCD	deleted in primary ciliary dyskinesia homolog (mouse)	9.49e-01	5.32e-06	2.16e-04
CLTC	clathrin heavy chain	7.61e-01	5.47e-06	2.20e-04
LSM5	LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated	-7.38e-01	5.45e-06	2.20e-04
TAX1BP1	Tax1 binding protein 1	6.25e-01	5.72e-06	2.29e-04
TXNL4B	thioredoxin like 4B	8.30e-01	5.70e-06	2.29e-04
PPP1R15A	protein phosphatase 1 regulatory subunit 15A	8.04e-01	5.83e-06	2.32e-04
RPL24	ribosomal protein L24	-5.67e-01	5.88e-06	2.33e-04
TXN	thioredoxin	3.28e-01	5.89e-06	2.33e-04
LAPTM4B	lysosomal protein transmembrane 4 beta	7.73e-01	5.96e-06	2.35e-04
BUB3	BUB3 mitotic checkpoint protein	-4.35e-01	6.05e-06	2.37e-04
FBXO32	F-box protein 32	8.87e-01	6.28e-06	2.46e-04
FLYWCH1	FLYWCH-type zinc finger 1	8.52e-01	6.99e-06	2.72e-04
TMCO1	transmembrane and coiled-coil domains 1	5.54e-01	7.31e-06	2.84e-04
CAVIN3	caveolae associated protein 3	-6.98e-01	7.43e-06	2.88e-04
PSMD4	proteasome 26S subunit ubiquitin receptor, non-ATPase 4	4.06e-01	7.76e-06	2.99e-04
DNTTIP2	deoxynucleotidyltransferase terminal interacting protein 2	6.11e-01	7.81e-06	3.00e-04
AKR1C2	aldo-keto reductase family 1 member C2	7.77e-01	8.07e-06	3.09e-04
BNIP3L	BCL2 interacting protein 3 like	4.89e-01	8.32e-06	3.17e-04
FAM111A	FAM111 trypsin like peptidase A	-1.03e+00	8.36e-06	3.17e-04
CD59	CD59 molecule (CD59 blood group)	-5.04e-01	8.86e-06	3.35e-04
HSPE1	heat shock protein family E (Hsp10) member 1	4.40e-01	9.28e-06	3.50e-04
DCBLD2	discoidin, CUB and LCCL domain containing 2	5.11e-01	9.34e-06	3.51e-04
ATP6V1G1	ATPase H+ transporting V1 subunit G1	5.21e-01	9.45e-06	3.54e-04
COX19	cytochrome c oxidase assembly factor COX19	7.80e-01	9.69e-06	3.59e-04
TEX2	testis expressed 2	8.99e-01	9.69e-06	3.59e-04
TNFRSF10A	TNF receptor superfamily member 10a	8.78e-01	9.68e-06	3.59e-04
ATP2B1	ATPase plasma membrane Ca2+ transporting 1	5.71e-01	9.89e-06	3.65e-04
PSMC3	proteasome 26S subunit, ATPase 3	4.07e-01	1.02e-05	3.77e-04
RPL27A	ribosomal protein L27a	-3.69e-01	1.04e-05	3.81e-04
PRC1	protein regulator of cytokinesis 1	-7.42e-01	1.06e-05	3.86e-04
EIF1	eukaryotic translation initiation factor 1	3.91e-01	1.08e-05	3.92e-04
C6orf62	chromosome 6 open reading frame 62	5.70e-01	1.11e-05	4.02e-04
DNAJB4	DnaJ heat shock protein family (Hsp40) member B4	8.55e-01	1.13e-05	4.08e-04
NDUFB9	NADH:ubiquinone oxidoreductase subunit B9	5.38e-01	1.17e-05	4.19e-04
MT-ND2	mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2	3.28e-01	1.19e-05	4.26e-04
SHOC2	SHOC2 leucine rich repeat scaffold protein	7.06e-01	1.21e-05	4.30e-04
RPL37A	ribosomal protein L37a	-5.16e-01	1.21e-05	4.30e-04
ARPP19	cAMP regulated phosphoprotein 19	7.39e-01	1.25e-05	4.44e-04
TP53	tumor protein p53	-9.03e-01	1.28e-05	4.53e-04
ACTB	actin beta	-3.63e-01	1.33e-05	4.68e-04
NSFL1C	NSFL1 cofactor	8.00e-01	1.42e-05	4.98e-04
RPL8	ribosomal protein L8	-2.93e-01	1.45e-05	5.07e-04
RNASEH2A	ribonuclease H2 subunit A	-6.00e-01	1.47e-05	5.11e-04
PLIN2	perilipin 2	6.44e-01	1.49e-05	5.17e-04
PLP2	proteolipid protein 2	-6.05e-01	1.49e-05	5.17e-04
H3-3A	H3.3 histone A	-4.85e-01	1.61e-05	5.55e-04
PITHD1	PITH domain containing 1	8.20e-01	1.68e-05	5.78e-04
MED10	mediator complex subunit 10	6.23e-01	1.72e-05	5.90e-04
DOCK9	dedicator of cytokinesis 9	9.05e-01	1.77e-05	6.05e-04
XAGE1A	X antigen family member 1A	3.15e-01	1.82e-05	6.21e-04
CCNB2	cyclin B2	-9.13e-01	1.83e-05	6.22e-04
GMNN	geminin DNA replication inhibitor	-7.15e-01	1.91e-05	6.46e-04
UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats	-7.96e-01	1.93e-05	6.51e-04
CCDC186	coiled-coil domain containing 186	7.97e-01	1.95e-05	6.56e-04
CHMP5	charged multivesicular body protein 5	6.24e-01	1.97e-05	6.60e-04
CCDC80	coiled-coil domain containing 80	7.63e-01	1.99e-05	6.61e-04
ZNF556	zinc finger protein 556	8.31e-01	1.98e-05	6.61e-04
SNX29	sorting nexin 29	8.87e-01	2.10e-05	6.97e-04
ARIH1	ariadne RBR E3 ubiquitin protein ligase 1	5.28e-01	2.11e-05	6.97e-04
BEX3	brain expressed X-linked 3	-3.63e-01	2.12e-05	6.98e-04
ZNF114	zinc finger protein 114	8.53e-01	2.19e-05	7.20e-04
BLZF1	basic leucine zipper nuclear factor 1	8.18e-01	2.30e-05	7.53e-04
TGFB2	transforming growth factor beta 2	8.85e-01	2.35e-05	7.68e-04
RPS25	ribosomal protein S25	-3.93e-01	2.39e-05	7.79e-04
PFN1	profilin 1	-4.17e-01	2.50e-05	8.13e-04
GSTM3	glutathione S-transferase mu 3	5.83e-01	2.54e-05	8.21e-04
PSME4	proteasome activator subunit 4	8.11e-01	2.58e-05	8.31e-04
ST13	ST13 Hsp70 interacting protein	6.14e-01	2.59e-05	8.31e-04
PLEC	plectin	-7.36e-01	2.64e-05	8.45e-04
VIM	vimentin	-4.53e-01	2.64e-05	8.45e-04
SH3GLB1	SH3 domain containing GRB2 like, endophilin B1	6.89e-01	2.66e-05	8.48e-04
MRPS16	mitochondrial ribosomal protein S16	-5.75e-01	2.71e-05	8.61e-04
RACK1	receptor for activated C kinase 1	-2.79e-01	2.72e-05	8.61e-04
MACO1	macoilin 1	8.81e-01	2.82e-05	8.91e-04
ITPRIP	inositol 1,4,5-trisphosphate receptor interacting protein	8.27e-01	3.06e-05	9.60e-04
RABEP1	rabaptin, RAB GTPase binding effector protein 1	7.70e-01	3.05e-05	9.60e-04
SEL1L	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase	6.96e-01	3.10e-05	9.69e-04
UBE2M	ubiquitin conjugating enzyme E2 M	7.18e-01	3.10e-05	9.69e-04
PCYT1A	phosphate cytidylyltransferase 1A, choline	7.48e-01	3.25e-05	1.01e-03
TMEM106C	transmembrane protein 106C	-7.45e-01	3.44e-05	1.07e-03
PIH1D1	PIH1 domain containing 1	-7.03e-01	3.45e-05	1.07e-03
MAP4	microtubule associated protein 4	6.69e-01	3.51e-05	1.08e-03
LRRC75A	leucine rich repeat containing 75A	-4.33e-01	3.60e-05	1.11e-03
BOLA3	bolA family member 3	-6.52e-01	3.61e-05	1.11e-03
ZRANB2	zinc finger RANBP2-type containing 2	6.10e-01	3.96e-05	1.21e-03
KCMF1	potassium channel modulatory factor 1	7.01e-01	4.61e-05	1.40e-03
MRPL33	mitochondrial ribosomal protein L33	-4.99e-01	4.66e-05	1.42e-03
ZSWIM6	zinc finger SWIM-type containing 6	8.94e-01	4.93e-05	1.49e-03
HUWE1	HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1	7.30e-01	5.07e-05	1.53e-03
RPL28	ribosomal protein L28	-7.35e-01	5.54e-05	1.67e-03
MXD1	MAX dimerization protein 1	7.99e-01	5.58e-05	1.68e-03
OSER1	oxidative stress responsive serine rich 1	6.40e-01	5.68e-05	1.70e-03
TANGO2	transport and golgi organization 2 homolog	8.32e-01	5.68e-05	1.70e-03
TMEM258	transmembrane protein 258	-4.57e-01	5.91e-05	1.76e-03
PSMD6	proteasome 26S subunit, non-ATPase 6	5.60e-01	5.96e-05	1.77e-03
KLHL21	kelch like family member 21	7.17e-01	6.17e-05	1.83e-03
NEK1	NIMA related kinase 1	7.22e-01	6.18e-05	1.83e-03
PNRC1	proline rich nuclear receptor coactivator 1	8.33e-01	6.25e-05	1.84e-03
JKAMP	JNK1/MAPK8 associated membrane protein	6.49e-01	6.32e-05	1.86e-03
MCM3	minichromosome maintenance complex component 3	-7.71e-01	6.69e-05	1.96e-03
S100A6	S100 calcium binding protein A6	-3.54e-01	6.83e-05	2.00e-03
NUFIP2	nuclear FMR1 interacting protein 2	7.18e-01	7.00e-05	2.04e-03
USP14	ubiquitin specific peptidase 14	6.72e-01	7.25e-05	2.11e-03
NSUN3	NOP2/Sun RNA methyltransferase 3	8.16e-01	7.45e-05	2.16e-03
OXR1	oxidation resistance 1	8.31e-01	7.65e-05	2.21e-03
VLDLR	very low density lipoprotein receptor	7.60e-01	7.85e-05	2.26e-03
TUBG1	tubulin gamma 1	-5.56e-01	7.90e-05	2.27e-03
PBK	PDZ binding kinase	-7.97e-01	8.08e-05	2.31e-03
ATAD2	ATPase family AAA domain containing 2	-7.01e-01	8.13e-05	2.32e-03
ARL1	ADP ribosylation factor like GTPase 1	5.98e-01	8.59e-05	2.45e-03
CDKL5	cyclin dependent kinase like 5	6.83e-01	8.60e-05	2.45e-03
RPS27	ribosomal protein S27	-3.11e-01	8.63e-05	2.45e-03
KCNG4	potassium voltage-gated channel modifier subfamily G member 4	7.61e-01	8.82e-05	2.49e-03
UBE2H	ubiquitin conjugating enzyme E2 H	6.88e-01	8.82e-05	2.49e-03
PFDN5	prefoldin subunit 5	3.99e-01	8.91e-05	2.50e-03
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	-9.32e-01	9.00e-05	2.52e-03
DEPDC1	DEP domain containing 1	-8.20e-01	9.43e-05	2.64e-03
MACF1	microtubule actin crosslinking factor 1	5.97e-01	9.47e-05	2.64e-03
VPS29	VPS29 retromer complex component	3.72e-01	9.87e-05	2.75e-03
WASHC2A	WASH complex subunit 2A	7.92e-01	9.91e-05	2.75e-03
SIRT7	sirtuin 7	7.47e-01	9.99e-05	2.76e-03
IL6ST	interleukin 6 cytokine family signal transducer	6.15e-01	1.00e-04	2.77e-03
GPATCH2L	G-patch domain containing 2 like	7.79e-01	1.02e-04	2.81e-03
TRAM1	translocation associated membrane protein 1	6.70e-01	1.03e-04	2.83e-03
EMC3	ER membrane protein complex subunit 3	5.32e-01	1.07e-04	2.92e-03
HERPUD1	homocysteine inducible ER protein with ubiquitin like domain 1	6.77e-01	1.07e-04	2.93e-03
TOX4	TOX high mobility group box family member 4	6.21e-01	1.08e-04	2.95e-03
RPL13A	ribosomal protein L13a	-3.27e-01	1.09e-04	2.96e-03
NDRG1	N-myc downstream regulated 1	6.78e-01	1.10e-04	2.99e-03
CDK1	cyclin dependent kinase 1	-8.61e-01	1.11e-04	2.99e-03
NXPE3	neurexophilin and PC-esterase domain family member 3	7.86e-01	1.13e-04	3.04e-03
ARL6IP4	ADP ribosylation factor like GTPase 6 interacting protein 4	-7.39e-01	1.14e-04	3.06e-03
SESN2	sestrin 2	6.90e-01	1.17e-04	3.14e-03
KCTD5	potassium channel tetramerization domain containing 5	7.35e-01	1.20e-04	3.17e-03
KIF1B	kinesin family member 1B	6.81e-01	1.20e-04	3.17e-03
LRR1	leucine rich repeat protein 1	-6.98e-01	1.19e-04	3.17e-03
PSMC2	proteasome 26S subunit, ATPase 2	5.21e-01	1.19e-04	3.17e-03
TM2D2	TM2 domain containing 2	6.78e-01	1.20e-04	3.17e-03
ZNF271P	zinc finger protein 271, pseudogene	6.15e-01	1.19e-04	3.17e-03
SRXN1	sulfiredoxin 1	5.94e-01	1.23e-04	3.25e-03
RPL36AL	ribosomal protein L36a like	-2.70e-01	1.25e-04	3.29e-03
SGO1	shugoshin 1	-1.00e+00	1.28e-04	3.37e-03
GDF15	growth differentiation factor 15	7.32e-01	1.31e-04	3.42e-03
IBTK	inhibitor of Bruton tyrosine kinase	7.46e-01	1.33e-04	3.46e-03
PCLAF	PCNA clamp associated factor	-6.37e-01	1.33e-04	3.46e-03
RRM2	ribonucleotide reductase regulatory subunit M2	-6.24e-01	1.33e-04	3.46e-03
SRSF3	serine and arginine rich splicing factor 3	-3.66e-01	1.33e-04	3.46e-03
SLC3A2	solute carrier family 3 member 2	6.45e-01	1.38e-04	3.56e-03
IST1	IST1 factor associated with ESCRT-III	6.81e-01	1.47e-04	3.78e-03
TPX2	TPX2 microtubule nucleation factor	-6.32e-01	1.48e-04	3.81e-03
PLBD2	phospholipase B domain containing 2	7.73e-01	1.50e-04	3.84e-03
ARID3A	AT-rich interaction domain 3A	4.21e-01	1.53e-04	3.90e-03
RHEB	Ras homolog, mTORC1 binding	4.98e-01	1.55e-04	3.94e-03
SERPINB10	serpin family B member 10	9.49e-01	1.55e-04	3.94e-03
TNPO1	transportin 1	6.00e-01	1.55e-04	3.94e-03
GTF2F1	general transcription factor IIF subunit 1	6.18e-01	1.59e-04	4.02e-03
TIMP3	TIMP metallopeptidase inhibitor 3	-5.35e-01	1.61e-04	4.07e-03
NSA2	NSA2 ribosome biogenesis factor	6.00e-01	1.62e-04	4.09e-03
PFDN4	prefoldin subunit 4	5.35e-01	1.67e-04	4.21e-03
FLCN	folliculin	6.10e-01	1.69e-04	4.25e-03
TIMP1	TIMP metallopeptidase inhibitor 1	-3.97e-01	1.75e-04	4.38e-03
RTF2	replication termination factor 2	4.53e-01	1.78e-04	4.43e-03
USP34	ubiquitin specific peptidase 34	6.58e-01	1.78e-04	4.43e-03
UBE2C	ubiquitin conjugating enzyme E2 C	-6.95e-01	1.79e-04	4.46e-03
MARCKSL1	MARCKS like 1	-9.68e-01	1.90e-04	4.70e-03
ECI2	enoyl-CoA delta isomerase 2	4.14e-01	1.90e-04	4.71e-03
VIPAS39	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog	7.36e-01	1.94e-04	4.79e-03
ITGB1	integrin subunit beta 1	-4.26e-01	1.99e-04	4.91e-03
RHBG	Rh family B glycoprotein	7.46e-01	2.01e-04	4.94e-03
EEF1D	eukaryotic translation elongation factor 1 delta	-7.03e-01	2.14e-04	5.26e-03
NAMPTP1	nicotinamide phosphoribosyltransferase pseudogene 1	6.05e-01	2.28e-04	5.56e-03
ETFDH	electron transfer flavoprotein dehydrogenase	5.87e-01	2.28e-04	5.56e-03
RSL24D1	ribosomal L24 domain containing 1	5.91e-01	2.30e-04	5.60e-03
ZFAND3	zinc finger AN1-type containing 3	6.80e-01	2.33e-04	5.65e-03
ENAH	ENAH actin regulator	7.22e-01	2.38e-04	5.77e-03
ANAPC11	anaphase promoting complex subunit 11	-4.09e-01	2.40e-04	5.80e-03
ISG15	ISG15 ubiquitin like modifier	-5.91e-01	2.46e-04	5.92e-03
SUPV3L1	Suv3 like RNA helicase	7.02e-01	2.48e-04	5.97e-03
ILF2	interleukin enhancer binding factor 2	-4.41e-01	2.49e-04	5.97e-03
EIF3F	eukaryotic translation initiation factor 3 subunit F	5.42e-01	2.50e-04	5.98e-03
JMJD6	jumonji domain containing 6, arginine demethylase and lysine hydroxylase	7.24e-01	2.53e-04	6.04e-03
RPS2	ribosomal protein S2	-5.12e-01	2.58e-04	6.14e-03
LHFPL2	LHFPL tetraspan subfamily member 2	7.86e-01	2.59e-04	6.15e-03
SLC13A5	solute carrier family 13 member 5	6.69e-01	2.60e-04	6.16e-03
TBC1D1	TBC1 domain family member 1	7.52e-01	2.72e-04	6.42e-03
RFC4	replication factor C subunit 4	-6.92e-01	2.80e-04	6.60e-03
WIPI2	WD repeat domain, phosphoinositide interacting 2	6.69e-01	2.80e-04	6.60e-03
PTGIR	prostaglandin I2 receptor	7.69e-01	2.87e-04	6.72e-03
TRIM11	tripartite motif containing 11	5.90e-01	2.87e-04	6.72e-03
RPL38	ribosomal protein L38	-3.66e-01	2.91e-04	6.79e-03
UEVLD	UEV and lactate/malate dehyrogenase domains	7.16e-01	2.91e-04	6.79e-03
SPANXD	SPANX family member D	6.29e-01	2.96e-04	6.89e-03
ADORA2B	adenosine A2b receptor	-8.06e-01	2.99e-04	6.94e-03
XPO4	exportin 4	7.63e-01	3.01e-04	6.97e-03
PHKB	phosphorylase kinase regulatory subunit beta	7.25e-01	3.02e-04	6.99e-03
AFMID	arylformamidase	5.14e-01	3.03e-04	7.00e-03
IRF2BPL	interferon regulatory factor 2 binding protein like	3.52e-01	3.23e-04	7.43e-03
SNRPG	small nuclear ribonucleoprotein polypeptide G	-4.38e-01	3.24e-04	7.44e-03
ATP6V1B2	ATPase H+ transporting V1 subunit B2	6.69e-01	3.26e-04	7.47e-03
DHDDS	dehydrodolichyl diphosphate synthase subunit	7.08e-01	3.27e-04	7.47e-03
MTRNR2L12	MT-RNR2 like 12	4.00e-01	3.28e-04	7.47e-03
CSF3	colony stimulating factor 3	8.02e-01	3.30e-04	7.51e-03
KIF20B	kinesin family member 20B	-8.07e-01	3.30e-04	7.51e-03
SLC29A1	solute carrier family 29 member 1 (Augustine blood group)	-6.87e-01	3.35e-04	7.60e-03
PLAC8	placenta associated 8	-6.38e-01	3.38e-04	7.65e-03
AIDA	axin interactor, dorsalization associated	6.96e-01	3.40e-04	7.67e-03
HSD17B12	hydroxysteroid 17-beta dehydrogenase 12	6.46e-01	3.41e-04	7.69e-03
ELOVL6	ELOVL fatty acid elongase 6	-7.60e-01	3.53e-04	7.89e-03
GABRG2	gamma-aminobutyric acid type A receptor subunit gamma2	6.91e-01	3.53e-04	7.89e-03
TGFBRAP1	transforming growth factor beta receptor associated protein 1	6.47e-01	3.52e-04	7.89e-03
TMSB10	thymosin beta 10	-3.04e-01	3.52e-04	7.89e-03
FNDC3B	fibronectin type III domain containing 3B	6.81e-01	3.55e-04	7.90e-03
FAM217B	family with sequence similarity 217 member B	7.04e-01	3.73e-04	8.25e-03
GOLGA3	golgin A3	5.12e-01	3.73e-04	8.25e-03
MRPL34	mitochondrial ribosomal protein L34	-7.69e-01	3.73e-04	8.25e-03
WASHC2C	WASH complex subunit 2C	7.51e-01	3.73e-04	8.25e-03
HSP90AB1	heat shock protein 90 alpha family class B member 1	5.66e-01	3.80e-04	8.38e-03
CDCA8	cell division cycle associated 8	-6.80e-01	3.85e-04	8.47e-03
SOX4	SRY-box transcription factor 4	-7.44e-01	3.89e-04	8.54e-03
DCP1A	decapping mRNA 1A	4.16e-01	3.95e-04	8.61e-03
H2AC14	H2A clustered histone 14	-8.62e-01	3.94e-04	8.61e-03
CHMP1B	charged multivesicular body protein 1B	6.13e-01	3.97e-04	8.64e-03
TMED5	transmembrane p24 trafficking protein 5	5.98e-01	4.01e-04	8.72e-03
RHBDD3	rhomboid domain containing 3	8.18e-01	4.03e-04	8.73e-03
CKLF	chemokine like factor	-5.44e-01	4.16e-04	8.99e-03
CLU	clusterin	6.60e-01	4.16e-04	8.99e-03
PPHLN1	periphilin 1	6.37e-01	4.21e-04	9.07e-03
STMN1	stathmin 1	-3.23e-01	4.29e-04	9.22e-03
TFG	trafficking from ER to golgi regulator	5.52e-01	4.30e-04	9.24e-03
CEP290	centrosomal protein 290	6.74e-01	4.34e-04	9.30e-03
NFAT5	nuclear factor of activated T cells 5	7.15e-01	4.40e-04	9.41e-03
SAMD4B	sterile alpha motif domain containing 4B	6.79e-01	4.45e-04	9.48e-03
SEC14L1	SEC14 like lipid binding 1	5.30e-01	4.50e-04	9.55e-03
HYLS1	HYLS1 centriolar and ciliogenesis associated	-7.49e-01	4.59e-04	9.73e-03
EPDR1	ependymin related 1	7.39e-01	4.62e-04	9.77e-03
HSBP1	heat shock factor binding protein 1	3.46e-01	4.65e-04	9.83e-03
AURKB	aurora kinase B	-6.55e-01	4.67e-04	9.85e-03
MYL12A	myosin light chain 12A	-2.93e-01	4.89e-04	1.03e-02
COLGALT1	collagen beta(1-O)galactosyltransferase 1	-5.99e-01	5.07e-04	1.06e-02
ZNF22	zinc finger protein 22	-6.70e-01	5.07e-04	1.06e-02
DST	dystonin	5.33e-01	5.14e-04	1.07e-02
NENF	neudesin neurotrophic factor	5.60e-01	5.14e-04	1.07e-02
MT-CO3	mitochondrially encoded cytochrome c oxidase III	2.03e-01	5.16e-04	1.07e-02
C2CD3	C2 domain containing 3 centriole elongation regulator	6.75e-01	5.18e-04	1.08e-02
RPS3A	ribosomal protein S3A	-3.41e-01	5.26e-04	1.09e-02
EIF1AX	eukaryotic translation initiation factor 1A X-linked	4.28e-01	5.31e-04	1.10e-02
TMEM33	transmembrane protein 33	5.10e-01	5.34e-04	1.10e-02
CD63	CD63 molecule	3.25e-01	5.42e-04	1.12e-02
NFE2L2	nuclear factor, erythroid 2 like 2	5.96e-01	5.46e-04	1.12e-02
NIT2	nitrilase family member 2	5.38e-01	5.53e-04	1.14e-02
GAS6	growth arrest specific 6	-6.98e-01	5.62e-04	1.15e-02
SCIMP	SLP adaptor and CSK interacting membrane protein	7.04e-01	5.61e-04	1.15e-02
MYEOV	myeloma overexpressed	-7.71e-01	5.64e-04	1.15e-02
GPAA1	glycosylphosphatidylinositol anchor attachment 1	-7.92e-01	5.69e-04	1.16e-02
NMT1	N-myristoyltransferase 1	5.80e-01	5.69e-04	1.16e-02
CACNB4	calcium voltage-gated channel auxiliary subunit beta 4	6.87e-01	5.71e-04	1.16e-02
NDUFAB1	NADH:ubiquinone oxidoreductase subunit AB1	4.58e-01	5.74e-04	1.16e-02
RPA3	replication protein A3	-6.81e-01	5.74e-04	1.16e-02
GOLGA5	golgin A5	7.34e-01	5.78e-04	1.17e-02
HSP90AA2P	heat shock protein 90 alpha family class A member 2, pseudogene	6.69e-01	5.80e-04	1.17e-02
EVI5	ecotropic viral integration site 5	5.61e-01	5.85e-04	1.18e-02
KRT18	keratin 18	-5.27e-01	5.93e-04	1.19e-02
HSBP1L1	heat shock factor binding protein 1 like 1	8.28e-01	6.02e-04	1.21e-02
ETNK2	ethanolamine kinase 2	8.43e-01	6.14e-04	1.23e-02
POP1	POP1 homolog, ribonuclease P/MRP subunit	7.47e-01	6.14e-04	1.23e-02
PCSK1N	proprotein convertase subtilisin/kexin type 1 inhibitor	5.77e-01	6.22e-04	1.24e-02
SELENOF	selenoprotein F	4.16e-01	6.25e-04	1.24e-02
TSC22D2	TSC22 domain family member 2	7.41e-01	6.30e-04	1.25e-02
SETD2	SET domain containing 2, histone lysine methyltransferase	7.04e-01	6.32e-04	1.25e-02
SNX24	sorting nexin 24	5.96e-01	6.31e-04	1.25e-02
MCM4	minichromosome maintenance complex component 4	-8.62e-01	6.40e-04	1.26e-02
SMC1A	structural maintenance of chromosomes 1A	-5.98e-01	6.42e-04	1.26e-02
RNF19B	ring finger protein 19B	6.48e-01	6.48e-04	1.27e-02
ADRM1	ADRM1 26S proteasome ubiquitin receptor	6.82e-01	6.64e-04	1.30e-02
FOXC1	forkhead box C1	6.63e-01	6.67e-04	1.31e-02
KRT7	keratin 7	-8.33e-01	6.74e-04	1.32e-02
MTHFD1	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	-6.39e-01	6.75e-04	1.32e-02
KPNA2	karyopherin subunit alpha 2	-3.94e-01	6.78e-04	1.32e-02
MMACHC	metabolism of cobalamin associated C	5.15e-01	7.02e-04	1.37e-02
ARRDC2	arrestin domain containing 2	6.24e-01	7.08e-04	1.37e-02
KRTCAP2	keratinocyte associated protein 2	-5.19e-01	7.06e-04	1.37e-02
MT-ATP6	mitochondrially encoded ATP synthase membrane subunit 6	2.04e-01	7.07e-04	1.37e-02
IKZF5	IKAROS family zinc finger 5	4.85e-01	7.12e-04	1.37e-02
MTX3	metaxin 3	6.94e-01	7.15e-04	1.38e-02
GBF1	golgi brefeldin A resistant guanine nucleotide exchange factor 1	6.92e-01	7.17e-04	1.38e-02
YIPF1	Yip1 domain family member 1	6.61e-01	7.25e-04	1.39e-02
WASL	WASP like actin nucleation promoting factor	7.58e-01	7.30e-04	1.40e-02
MRPL23	mitochondrial ribosomal protein L23	-9.13e-01	7.36e-04	1.41e-02
HS1BP3	HCLS1 binding protein 3	7.39e-01	7.44e-04	1.42e-02
RPL23	ribosomal protein L23	-3.18e-01	7.43e-04	1.42e-02
PPA1	inorganic pyrophosphatase 1	-4.43e-01	7.46e-04	1.42e-02
ARMCX3	armadillo repeat containing X-linked 3	6.41e-01	7.57e-04	1.44e-02
BEX2	brain expressed X-linked 2	7.25e-01	7.66e-04	1.45e-02
RLIM	ring finger protein, LIM domain interacting	5.61e-01	7.69e-04	1.46e-02
ODC1	ornithine decarboxylase 1	5.06e-01	7.82e-04	1.48e-02
XAGE1B	X antigen family member 1B	4.73e-01	7.86e-04	1.48e-02
H2AJ	H2A.J histone	-6.80e-01	7.97e-04	1.50e-02
EXOC5	exocyst complex component 5	6.07e-01	8.01e-04	1.50e-02
PTPN21	protein tyrosine phosphatase non-receptor type 21	6.54e-01	8.04e-04	1.51e-02
TMEM127	transmembrane protein 127	6.46e-01	8.06e-04	1.51e-02
TEX264	testis expressed 264, ER-phagy receptor	-5.90e-01	8.13e-04	1.52e-02
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	4.78e-01	8.14e-04	1.52e-02
RPL23A	ribosomal protein L23a	-5.00e-01	8.17e-04	1.52e-02
LBHD1	LBH domain containing 1	-5.07e-01	8.19e-04	1.52e-02
ATP5ME	ATP synthase membrane subunit e	-3.88e-01	8.27e-04	1.53e-02
HSF2	heat shock transcription factor 2	7.13e-01	8.26e-04	1.53e-02
CTNNAL1	catenin alpha like 1	-5.92e-01	8.29e-04	1.53e-02
CAMLG	calcium modulating ligand	6.23e-01	8.31e-04	1.53e-02
KRT8	keratin 8	-4.34e-01	8.34e-04	1.54e-02
ATG12	autophagy related 12	5.42e-01	8.45e-04	1.55e-02
TOGARAM1	TOG array regulator of axonemal microtubules 1	6.42e-01	8.44e-04	1.55e-02
FOXK1	forkhead box K1	6.10e-01	8.55e-04	1.57e-02
PRPS2	phosphoribosyl pyrophosphate synthetase 2	-6.90e-01	8.70e-04	1.59e-02
MRPL51	mitochondrial ribosomal protein L51	-4.42e-01	8.76e-04	1.60e-02
NTNG1	netrin G1	6.84e-01	8.84e-04	1.61e-02
SEC62	SEC62 homolog, preprotein translocation factor	3.81e-01	8.89e-04	1.61e-02
SPINT2	serine peptidase inhibitor, Kunitz type 2	-4.63e-01	8.88e-04	1.61e-02
PPP1R12A	protein phosphatase 1 regulatory subunit 12A	5.18e-01	8.92e-04	1.62e-02
TRIM6	tripartite motif containing 6	5.98e-01	8.94e-04	1.62e-02
MT-ND1	mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1	2.36e-01	8.97e-04	1.62e-02
RPL10A	ribosomal protein L10a	4.13e-01	9.04e-04	1.63e-02
MTLN	mitoregulin	-5.11e-01	9.16e-04	1.65e-02
HSPB1	heat shock protein family B (small) member 1	5.42e-01	9.23e-04	1.66e-02
CSDE1	cold shock domain containing E1	4.68e-01	9.29e-04	1.67e-02
RRAS2	RAS related 2	6.07e-01	9.37e-04	1.68e-02
LRRIQ1	leucine rich repeats and IQ motif containing 1	5.23e-01	9.39e-04	1.68e-02
SREK1IP1	SREK1 interacting protein 1	5.20e-01	9.53e-04	1.70e-02
GOLGB1	golgin B1	5.68e-01	9.58e-04	1.71e-02
THBS1	thrombospondin 1	-4.87e-01	9.64e-04	1.71e-02
COX8A	cytochrome c oxidase subunit 8A	-2.87e-01	9.72e-04	1.72e-02
FAM118A	family with sequence similarity 118 member A	5.87e-01	9.70e-04	1.72e-02
LSM4	LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated	-5.85e-01	9.71e-04	1.72e-02
FOXJ3	forkhead box J3	6.31e-01	9.80e-04	1.72e-02
MRPL17	mitochondrial ribosomal protein L17	-4.42e-01	9.79e-04	1.72e-02
TRIM2	tripartite motif containing 2	6.58e-01	9.79e-04	1.72e-02
ZNF687	zinc finger protein 687	5.58e-01	9.78e-04	1.72e-02
TWNK	twinkle mtDNA helicase	6.12e-01	9.85e-04	1.73e-02
BBS4	Bardet-Biedl syndrome 4	7.04e-01	9.96e-04	1.75e-02
BCL2L13	BCL2 like 13	7.39e-01	1.02e-03	1.79e-02
HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	6.30e-01	1.03e-03	1.79e-02
TMEM14A	transmembrane protein 14A	-5.45e-01	1.04e-03	1.82e-02
VMP1	vacuole membrane protein 1	4.82e-01	1.05e-03	1.82e-02
HSPA9	heat shock protein family A (Hsp70) member 9	4.08e-01	1.06e-03	1.83e-02
HTATIP2	HIV-1 Tat interactive protein 2	5.94e-01	1.05e-03	1.83e-02
MORC4	MORC family CW-type zinc finger 4	-6.67e-01	1.06e-03	1.83e-02
TMEM223	transmembrane protein 223	-7.26e-01	1.06e-03	1.83e-02
HNRNPC	heterogeneous nuclear ribonucleoprotein C	-4.17e-01	1.06e-03	1.83e-02
UBTF	upstream binding transcription factor	-8.43e-01	1.06e-03	1.83e-02
GNPDA1	glucosamine-6-phosphate deaminase 1	6.41e-01	1.07e-03	1.84e-02
GOT2	glutamic-oxaloacetic transaminase 2	6.14e-01	1.08e-03	1.86e-02
REXO2	RNA exonuclease 2	4.43e-01	1.08e-03	1.86e-02
CEBPG	CCAAT enhancer binding protein gamma	6.09e-01	1.09e-03	1.86e-02
CST2	cystatin SA	6.20e-01	1.09e-03	1.86e-02
SHLD2	shieldin complex subunit 2	7.50e-01	1.09e-03	1.86e-02
GLRX2	glutaredoxin 2	5.68e-01	1.09e-03	1.86e-02
CYB561D2	cytochrome b561 family member D2	5.50e-01	1.10e-03	1.86e-02
ADK	adenosine kinase	4.35e-01	1.11e-03	1.88e-02
NFKBIB	NFKB inhibitor beta	6.25e-01	1.10e-03	1.88e-02
RAB10	RAB10, member RAS oncogene family	5.93e-01	1.11e-03	1.88e-02
SPAG1	sperm associated antigen 1	-7.91e-01	1.11e-03	1.88e-02
GTF2H5	general transcription factor IIH subunit 5	-5.13e-01	1.12e-03	1.89e-02
PRR11	proline rich 11	-6.20e-01	1.13e-03	1.91e-02
RRN3P3	RRN3 pseudogene 3	4.55e-01	1.13e-03	1.91e-02
AAK1	AP2 associated kinase 1	5.46e-01	1.14e-03	1.91e-02
CDC6	cell division cycle 6	-7.39e-01	1.14e-03	1.91e-02
HMGA2	high mobility group AT-hook 2	6.23e-01	1.15e-03	1.92e-02
DPM3	dolichyl-phosphate mannosyltransferase subunit 3, regulatory	-6.00e-01	1.17e-03	1.96e-02
GOLIM4	golgi integral membrane protein 4	-7.18e-01	1.18e-03	1.97e-02
PHC3	polyhomeotic homolog 3	5.51e-01	1.18e-03	1.97e-02
SEC61B	SEC61 translocon subunit beta	3.11e-01	1.20e-03	1.99e-02
BLOC1S3	biogenesis of lysosomal organelles complex 1 subunit 3	5.93e-01	1.21e-03	2.01e-02
SLC25A16	solute carrier family 25 member 16	6.21e-01	1.21e-03	2.01e-02
UBE2D3	ubiquitin conjugating enzyme E2 D3	4.69e-01	1.23e-03	2.04e-02
MGST3	microsomal glutathione S-transferase 3	4.45e-01	1.24e-03	2.04e-02
SBNO1	strawberry notch homolog 1	4.45e-01	1.24e-03	2.04e-02
FADS1	fatty acid desaturase 1	-5.66e-01	1.24e-03	2.05e-02
CDK2	cyclin dependent kinase 2	-7.36e-01	1.28e-03	2.11e-02
WDR43	WD repeat domain 43	4.79e-01	1.29e-03	2.12e-02
SMC4	structural maintenance of chromosomes 4	-6.27e-01	1.30e-03	2.13e-02
SNX12	sorting nexin 12	-6.05e-01	1.30e-03	2.13e-02
FAM136A	family with sequence similarity 136 member A	-5.09e-01	1.32e-03	2.16e-02
PLPP2	phospholipid phosphatase 2	5.65e-01	1.33e-03	2.17e-02
CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2	6.18e-01	1.34e-03	2.18e-02
RAB9A	RAB9A, member RAS oncogene family	6.09e-01	1.36e-03	2.22e-02
UPRT	uracil phosphoribosyltransferase homolog	4.81e-01	1.36e-03	2.22e-02
PEX26	peroxisomal biogenesis factor 26	5.52e-01	1.38e-03	2.25e-02
ARHGAP21	Rho GTPase activating protein 21	6.22e-01	1.39e-03	2.25e-02
HK1	hexokinase 1	5.46e-01	1.41e-03	2.28e-02
IL6	interleukin 6	6.83e-01	1.43e-03	2.31e-02
MAD2L1	mitotic arrest deficient 2 like 1	-5.09e-01	1.43e-03	2.31e-02
COPS4	COP9 signalosome subunit 4	4.95e-01	1.44e-03	2.32e-02
SHISA2	shisa family member 2	-7.68e-01	1.45e-03	2.32e-02
TMEM237	transmembrane protein 237	-6.02e-01	1.45e-03	2.32e-02
PIMREG	PICALM interacting mitotic regulator	-7.68e-01	1.45e-03	2.33e-02
CDA	cytidine deaminase	4.61e-01	1.46e-03	2.33e-02
IGDCC4	immunoglobulin superfamily DCC subclass member 4	6.04e-01	1.46e-03	2.33e-02
TMPO	thymopoietin	-6.97e-01	1.46e-03	2.33e-02
UBE4A	ubiquitination factor E4A	5.69e-01	1.47e-03	2.34e-02
ZNF350	zinc finger protein 350	6.83e-01	1.47e-03	2.34e-02
CST4	cystatin S	4.34e-01	1.49e-03	2.36e-02
CRIPT	CXXC repeat containing interactor of PDZ3 domain	5.17e-01	1.49e-03	2.36e-02
ADM	adrenomedullin	6.18e-01	1.50e-03	2.38e-02
MPZL1	myelin protein zero like 1	5.82e-01	1.55e-03	2.46e-02
TMEM38A	transmembrane protein 38A	-6.33e-01	1.56e-03	2.46e-02
SAP18	Sin3A associated protein 18	3.73e-01	1.57e-03	2.47e-02
COA8	cytochrome c oxidase assembly factor 8	5.22e-01	1.59e-03	2.49e-02
PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase	4.15e-01	1.58e-03	2.49e-02
BCAP31	B cell receptor associated protein 31	2.94e-01	1.64e-03	2.57e-02
UTP11	UTP11 small subunit processome component	4.08e-01	1.64e-03	2.57e-02
CAV1	caveolin 1	-4.69e-01	1.65e-03	2.58e-02
IFITM1	interferon induced transmembrane protein 1	-6.89e-01	1.65e-03	2.58e-02
PALLD	palladin, cytoskeletal associated protein	5.57e-01	1.65e-03	2.58e-02
ACBD6	acyl-CoA binding domain containing 6	5.56e-01	1.67e-03	2.59e-02
CETN2	centrin 2	5.10e-01	1.66e-03	2.59e-02
NEUROD2	neuronal differentiation 2	1.96e-01	1.71e-03	2.65e-02
ADIPOR1	adiponectin receptor 1	5.64e-01	1.71e-03	2.65e-02
TROAP	trophinin associated protein	-7.58e-01	1.71e-03	2.65e-02
YWHAH	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta	-6.72e-01	1.76e-03	2.72e-02
RAB1A	RAB1A, member RAS oncogene family	5.45e-01	1.76e-03	2.72e-02
ENY2	ENY2 transcription and export complex 2 subunit	-3.84e-01	1.77e-03	2.72e-02
TIA1	TIA1 cytotoxic granule associated RNA binding protein	6.13e-01	1.78e-03	2.74e-02
CREBRF	CREB3 regulatory factor	6.44e-01	1.80e-03	2.77e-02
PAFAH1B1	platelet activating factor acetylhydrolase 1b regulatory subunit 1	5.68e-01	1.82e-03	2.79e-02
TBC1D17	TBC1 domain family member 17	6.70e-01	1.82e-03	2.79e-02
CENPE	centromere protein E	-7.05e-01	1.85e-03	2.83e-02
RPL13	ribosomal protein L13	-3.57e-01	1.85e-03	2.83e-02
ASPM	assembly factor for spindle microtubules	-6.86e-01	1.86e-03	2.83e-02
IDI1	isopentenyl-diphosphate delta isomerase 1	4.42e-01	1.86e-03	2.83e-02
TCHP	trichoplein keratin filament binding	-5.44e-01	1.86e-03	2.83e-02
TADA2B	transcriptional adaptor 2B	6.86e-01	1.87e-03	2.84e-02
RESF1	retroelement silencing factor 1	6.06e-01	1.88e-03	2.85e-02
ADGRE5	adhesion G protein-coupled receptor E5	-5.59e-01	1.89e-03	2.86e-02
GOSR1	golgi SNAP receptor complex member 1	5.09e-01	1.91e-03	2.88e-02
COP1	COP1 E3 ubiquitin ligase	5.13e-01	1.91e-03	2.88e-02
KCTD9	potassium channel tetramerization domain containing 9	5.75e-01	1.93e-03	2.91e-02
TMEM208	transmembrane protein 208	5.49e-01	1.94e-03	2.92e-02
C3orf33	chromosome 3 open reading frame 33	6.19e-01	1.97e-03	2.96e-02
HIRIP3	HIRA interacting protein 3	-6.93e-01	1.97e-03	2.96e-02
MCOLN3	mucolipin TRP cation channel 3	5.48e-01	1.97e-03	2.96e-02
POLR2L	RNA polymerase II, I and III subunit L	-3.06e-01	1.97e-03	2.96e-02
RPL36A	ribosomal protein L36a	-3.81e-01	1.99e-03	2.98e-02
H6PD	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	-7.19e-01	2.00e-03	2.98e-02
PGS1	phosphatidylglycerophosphate synthase 1	6.46e-01	2.00e-03	2.98e-02
MORF4L2	mortality factor 4 like 2	3.12e-01	2.01e-03	2.99e-02
NDUFA7	NADH:ubiquinone oxidoreductase subunit A7	-5.69e-01	2.01e-03	2.99e-02
NRP1	neuropilin 1	-4.62e-01	2.01e-03	2.99e-02
SCOC	short coiled-coil protein	5.28e-01	2.03e-03	3.01e-02
PRCC	proline rich mitotic checkpoint control factor	6.14e-01	2.05e-03	3.04e-02
RPL36	ribosomal protein L36	-2.95e-01	2.08e-03	3.08e-02
CENPM	centromere protein M	-6.14e-01	2.09e-03	3.09e-02
SIVA1	SIVA1 apoptosis inducing factor	-5.07e-01	2.12e-03	3.12e-02
NDUFB1	NADH:ubiquinone oxidoreductase subunit B1	-4.02e-01	2.14e-03	3.16e-02
UQCR10	ubiquinol-cytochrome c reductase, complex III subunit X	-2.43e-01	2.15e-03	3.17e-02
MT1G	metallothionein 1G	6.03e-01	2.16e-03	3.17e-02
CCDC167	coiled-coil domain containing 167	4.05e-01	2.17e-03	3.18e-02
STK17A	serine/threonine kinase 17a	5.21e-01	2.17e-03	3.18e-02
ASB6	ankyrin repeat and SOCS box containing 6	6.04e-01	2.21e-03	3.23e-02
NCBP1	nuclear cap binding protein subunit 1	6.04e-01	2.21e-03	3.23e-02
GSTO1	glutathione S-transferase omega 1	4.31e-01	2.23e-03	3.25e-02
MAP4K5	mitogen-activated protein kinase kinase kinase kinase 5	5.92e-01	2.23e-03	3.25e-02
GOLGA4	golgin A4	4.52e-01	2.24e-03	3.26e-02
UPP1	uridine phosphorylase 1	5.34e-01	2.24e-03	3.26e-02
ETFB	electron transfer flavoprotein subunit beta	-4.89e-01	2.25e-03	3.27e-02
CAB39	calcium binding protein 39	5.64e-01	2.30e-03	3.33e-02
RNF103	ring finger protein 103	6.22e-01	2.33e-03	3.37e-02
DDX3X	DEAD-box helicase 3 X-linked	3.80e-01	2.36e-03	3.41e-02
UFM1	ubiquitin fold modifier 1	5.31e-01	2.36e-03	3.41e-02
ESAM	endothelial cell adhesion molecule	-6.80e-01	2.37e-03	3.42e-02
HNRNPH1	heterogeneous nuclear ribonucleoprotein H1	-3.30e-01	2.39e-03	3.43e-02
RTCA	RNA 3'-terminal phosphate cyclase	5.57e-01	2.39e-03	3.43e-02
AAR2	AAR2 splicing factor	6.15e-01	2.43e-03	3.49e-02
SAT2	spermidine/spermine N1-acetyltransferase family member 2	6.26e-01	2.45e-03	3.51e-02
PPP1R37	protein phosphatase 1 regulatory subunit 37	5.82e-01	2.47e-03	3.53e-02
RGS19	regulator of G protein signaling 19	-5.87e-01	2.48e-03	3.54e-02
ATP6V0B	ATPase H+ transporting V0 subunit b	3.86e-01	2.50e-03	3.56e-02
PARP2	poly(ADP-ribose) polymerase 2	-7.36e-01	2.50e-03	3.57e-02
SLAIN2	SLAIN motif family member 2	6.14e-01	2.54e-03	3.62e-02
C11orf98	chromosome 11 open reading frame 98	-5.15e-01	2.55e-03	3.63e-02
CHRNB4	cholinergic receptor nicotinic beta 4 subunit	5.87e-01	2.57e-03	3.64e-02
ZNF146	zinc finger protein 146	5.26e-01	2.59e-03	3.67e-02
RPL27	ribosomal protein L27	-3.22e-01	2.59e-03	3.67e-02
NEDD8	NEDD8 ubiquitin like modifier	2.39e-01	2.61e-03	3.69e-02
AURKA	aurora kinase A	-5.60e-01	2.62e-03	3.69e-02
FAM133A	family with sequence similarity 133 member A	-6.76e-01	2.61e-03	3.69e-02
ZNF844	zinc finger protein 844	6.40e-01	2.62e-03	3.69e-02
DYNLT3	dynein light chain Tctex-type 3	5.58e-01	2.68e-03	3.76e-02
GOLGA7	golgin A7	5.96e-01	2.68e-03	3.76e-02
NONO	non-POU domain containing octamer binding	-3.91e-01	2.69e-03	3.77e-02
CBX5	chromobox 5	-5.60e-01	2.72e-03	3.79e-02
PSMD7	proteasome 26S subunit, non-ATPase 7	3.08e-01	2.72e-03	3.79e-02
ZFAND5	zinc finger AN1-type containing 5	5.32e-01	2.71e-03	3.79e-02
MKNK2	MAPK interacting serine/threonine kinase 2	5.75e-01	2.74e-03	3.82e-02
TRAPPC2	trafficking protein particle complex subunit 2	5.31e-01	2.77e-03	3.86e-02
CKAP2L	cytoskeleton associated protein 2 like	-6.51e-01	2.78e-03	3.87e-02
TIMP2	TIMP metallopeptidase inhibitor 2	4.77e-01	2.79e-03	3.87e-02
UHRF1BP1L	UHRF1 binding protein 1 like	4.33e-01	2.79e-03	3.87e-02
WDR59	WD repeat domain 59	6.08e-01	2.80e-03	3.87e-02
CAP1	cyclase associated actin cytoskeleton regulatory protein 1	4.98e-01	2.82e-03	3.90e-02
TGIF1	TGFB induced factor homeobox 1	6.15e-01	2.85e-03	3.94e-02
CTNNA1	catenin alpha 1	3.81e-01	2.85e-03	3.94e-02
API5	apoptosis inhibitor 5	5.96e-01	2.88e-03	3.96e-02
RPS5	ribosomal protein S5	-3.02e-01	2.88e-03	3.96e-02
RFC1	replication factor C subunit 1	-6.00e-01	2.92e-03	4.01e-02
SERPINB2	serpin family B member 2	5.35e-01	2.93e-03	4.03e-02
OGFRL1	opioid growth factor receptor like 1	-5.86e-01	2.94e-03	4.03e-02
USP47	ubiquitin specific peptidase 47	5.91e-01	2.96e-03	4.05e-02
NCAPH	non-SMC condensin I complex subunit H	-7.27e-01	2.97e-03	4.06e-02
H2AC13	H2A clustered histone 13	-7.81e-01	2.99e-03	4.07e-02
NAV3	neuron navigator 3	6.61e-01	2.99e-03	4.07e-02
RHOJ	ras homolog family member J	-5.71e-01	2.99e-03	4.07e-02
NDUFC1	NADH:ubiquinone oxidoreductase subunit C1	-3.35e-01	3.06e-03	4.16e-02
SNX19	sorting nexin 19	4.36e-01	3.06e-03	4.16e-02
PSMG3	proteasome assembly chaperone 3	-6.16e-01	3.09e-03	4.19e-02
PWWP2B	PWWP domain containing 2B	5.95e-01	3.10e-03	4.20e-02
SNW1	SNW domain containing 1	3.71e-01	3.13e-03	4.23e-02
IFIT3	interferon induced protein with tetratricopeptide repeats 3	-5.72e-01	3.17e-03	4.28e-02
CKAP2	cytoskeleton associated protein 2	-6.03e-01	3.18e-03	4.29e-02
SMG7	SMG7 nonsense mediated mRNA decay factor	6.48e-01	3.19e-03	4.29e-02
EPRS1	glutamyl-prolyl-tRNA synthetase 1	5.05e-01	3.19e-03	4.30e-02
HDAC1	histone deacetylase 1	-4.85e-01	3.21e-03	4.31e-02
DNAJC8	DnaJ heat shock protein family (Hsp40) member C8	3.09e-01	3.24e-03	4.33e-02
RCOR1	REST corepressor 1	5.42e-01	3.23e-03	4.33e-02
TYMS	thymidylate synthetase	-7.36e-01	3.23e-03	4.33e-02
TRIM28	tripartite motif containing 28	-7.14e-01	3.25e-03	4.35e-02
MAPK12	mitogen-activated protein kinase 12	6.10e-01	3.27e-03	4.36e-02
CHPT1	choline phosphotransferase 1	5.29e-01	3.31e-03	4.41e-02
RNF40	ring finger protein 40	5.49e-01	3.32e-03	4.42e-02
VCL	vinculin	-6.16e-01	3.32e-03	4.42e-02
TRMT10A	tRNA methyltransferase 10A	5.02e-01	3.33e-03	4.42e-02
ABHD3	abhydrolase domain containing 3, phospholipase	6.01e-01	3.35e-03	4.45e-02
ACAA2	acetyl-CoA acyltransferase 2	-6.64e-01	3.36e-03	4.45e-02
OAZ1	ornithine decarboxylase antizyme 1	3.24e-01	3.38e-03	4.47e-02
ARMC10	armadillo repeat containing 10	5.94e-01	3.38e-03	4.47e-02
PHPT1	phosphohistidine phosphatase 1	-4.87e-01	3.39e-03	4.48e-02
PSME2	proteasome activator subunit 2	-3.54e-01	3.40e-03	4.48e-02
RPL32	ribosomal protein L32	-3.33e-01	3.41e-03	4.48e-02
BFAR	bifunctional apoptosis regulator	5.94e-01	3.41e-03	4.49e-02
ALDOA	aldolase, fructose-bisphosphate A	2.56e-01	3.42e-03	4.49e-02
CCNK	cyclin K	6.78e-01	3.43e-03	4.49e-02
TMEM50A	transmembrane protein 50A	4.30e-01	3.43e-03	4.49e-02
SEC22B	SEC22 homolog B, vesicle trafficking protein	3.97e-01	3.43e-03	4.49e-02
OTUD7B	OTU deubiquitinase 7B	5.08e-01	3.48e-03	4.55e-02
NFKBIZ	NFKB inhibitor zeta	6.23e-01	3.50e-03	4.56e-02
FAM91A1	family with sequence similarity 91 member A1	6.43e-01	3.50e-03	4.56e-02
LRRFIP2	LRR binding FLII interacting protein 2	5.77e-01	3.51e-03	4.57e-02
PINK1	PTEN induced kinase 1	4.48e-01	3.52e-03	4.57e-02
NOP58	NOP58 ribonucleoprotein	-4.88e-01	3.54e-03	4.60e-02
CCL5	C-C motif chemokine ligand 5	5.62e-01	3.59e-03	4.65e-02
PPP2CA	protein phosphatase 2 catalytic subunit alpha	4.55e-01	3.60e-03	4.66e-02
HNRNPD	heterogeneous nuclear ribonucleoprotein D	-5.45e-01	3.61e-03	4.68e-02
EPS15	epidermal growth factor receptor pathway substrate 15	5.68e-01	3.63e-03	4.70e-02
PTMAP5	prothymosin alpha pseudogene 5	-5.06e-01	3.64e-03	4.70e-02
HERC1	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	5.91e-01	3.66e-03	4.72e-02
CTSC	cathepsin C	-4.54e-01	3.67e-03	4.72e-02
LAPTM4A	lysosomal protein transmembrane 4 alpha	3.30e-01	3.68e-03	4.73e-02
HTN1	histatin 1	6.26e-01	3.71e-03	4.76e-02
RNF10	ring finger protein 10	4.55e-01	3.73e-03	4.78e-02
INAVA	innate immunity activator	4.24e-01	3.73e-03	4.78e-02
LMNA	lamin A/C	-4.79e-01	3.75e-03	4.80e-02
METTL8	methyltransferase like 8	4.95e-01	3.76e-03	4.81e-02
HAUS1	HAUS augmin like complex subunit 1	-5.75e-01	3.78e-03	4.83e-02
RUBCN	rubicon autophagy regulator	5.58e-01	3.80e-03	4.84e-02
ATP5MC2	ATP synthase membrane subunit c locus 2	-4.37e-01	3.80e-03	4.84e-02
HFE	homeostatic iron regulator	5.49e-01	3.82e-03	4.86e-02
PARK7	Parkinsonism associated deglycase	-2.75e-01	3.82e-03	4.86e-02
PDE6D	phosphodiesterase 6D	-5.69e-01	3.83e-03	4.86e-02
ARF4	ADP ribosylation factor 4	2.88e-01	3.85e-03	4.88e-02
H1-10	H1.10 linker histone	-6.85e-01	3.88e-03	4.90e-02
PLEKHH3	pleckstrin homology, MyTH4 and FERM domain containing H3	6.39e-01	3.87e-03	4.90e-02
RFC2	replication factor C subunit 2	-7.42e-01	3.87e-03	4.90e-02
HPF1	histone PARylation factor 1	-7.14e-01	3.88e-03	4.90e-02
SRA1	steroid receptor RNA activator 1	-4.23e-01	3.89e-03	4.90e-02
ENO1	enolase 1	-1.84e-01	3.89e-03	4.90e-02
TPRG1L	tumor protein p63 regulated 1 like	5.34e-01	3.90e-03	4.90e-02
SAMD1	sterile alpha motif domain containing 1	-7.56e-01	3.91e-03	4.90e-02
KIAA0232	KIAA0232	5.79e-01	3.92e-03	4.91e-02
LOX	lysyl oxidase	5.82e-01	3.92e-03	4.91e-02
BMP4	bone morphogenetic protein 4	-5.74e-01	3.95e-03	4.94e-02
PAICS	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	-4.63e-01	3.95e-03	4.94e-02
MSN	moesin	4.20e-01	3.97e-03	4.95e-02
PSEN1	presenilin 1	5.71e-01	3.98e-03	4.96e-02
PRRG3	proline rich and Gla domain 3	3.18e-01	4.01e-03	4.99e-02
ZHX1	zinc fingers and homeoboxes 1	5.36e-01	4.02e-03	4.99e-02

Gene Set Enrichment Analysis

The GSEA method was applied for all genes whose knockout resulted in at least 20 significantly differentially expressed genes.

ID	Name	p-value	p-value (adj.)	log2 Error	ES	NES
msig:M5925	HALLMARK_E2F_TARGETS	3.41e-28	1.33e-24	1.38e+00	-6.37e-01	-3.17e+00
go:0005694	chromosome	3.59e-19	7.01e-16	1.13e+00	-3.79e-01	-2.15e+00
msig:M5901	HALLMARK_G2M_CHECKPOINT	6.38e-19	8.31e-16	1.12e+00	-5.66e-01	-2.80e+00
go:0000793	condensed chromosome	2.19e-16	2.14e-13	1.05e+00	-5.75e-01	-2.74e+00
reactome:R-HSA-449147	Signaling by Interleukins	3.82e-15	2.98e-12	9.97e-01	5.14e-01	2.34e+00
go:0005773	vacuole	1.07e-14	7.00e-12	9.87e-01	4.66e-01	2.17e+00
go:0070498	interleukin-1-mediated signaling pathway	1.48e-14	8.29e-12	9.76e-01	7.36e-01	2.73e+00
go:0098687	chromosomal region	2.11e-14	1.03e-11	9.76e-01	-4.68e-01	-2.36e+00
go:0000228	nuclear chromosome	4.27e-14	1.85e-11	9.65e-01	-4.13e-01	-2.19e+00
go:0048285