JOSD1 Data Analysis

HGNC Gene Name
Josephin domain containing 1
HGNC Gene Symbol
JOSD1
Identifiers
hgnc:28953 NCBIGene:9929 uniprot:Q15040
Orthologs
mgi:1921408 rgd:1305388
INDRA Statements
deubiquitinations all statements
Pathway Commons
Search for JOSD1
Number of Papers
12 retrieved on 2022-05-22

DepMap Analysis

The Dependency Map (DepMap) is a genome-wide pooled CRISPR-Cas9 knockout proliferation screen conducted in more than 700 cancer cell lines spanning many different tumor lineages. Each cell line in the DepMap contains a unique barcode, and each gene knockout is assigned a “dependency score” on a per cell-line basis which quantifies the rate of CRISPR-Cas9 guide drop. It has been found that proteins with similar DepMap scores across cell lines, a phenomenon known as co-dependent genes, have closely related biological functions. This can include activity in the same or parallel pathways or membership in the same protein complex or the same pathway.

We identified the strongest seven co-dependent genes (“Symbol”) for DUBs and ran GO enrichment analysis. We used Biogrid, IntAct, and Pathway Commons PPIDs, and the NURSA protein-protein interaction databases (PPIDs) to determine whether co-dependent genes interact with one another. The “Evidence” column contains the PPIDs in which the interaction appears as well as whether there is support for the association by an INDRA statement. As another approach to identify potential interactors, we looked at proteomics data from the Broad Institute's Cancer Cell Line Encyclopedia (CCLE) for proteins whose expression across ~375 cell lines strongly correlated with the abundance of each DUB; it has previously been observed that proteins in the same complex are frequently significantly co-expressed. The correlations and associated p-values in the CCLE proteomics dataset are provided. And, we determined whether co-dependent genes yield similar transcriptomic signatures in the Broad Institute's Connectivity Map (CMap). A CMap score greater than 90 is considered significantly similar.

DepMap Correlations

Symbol Name DepMap Correlation Evidence CCLE Correlation CCLE Z-score CCLE p-value (adj) CCLE Significant CMAP Score CMAP Type
TM2D2 TM2 domain containing 2 0.275
C22orf23 chromosome 22 open reading frame 23 0.274
DNAL4 dynein axonemal light chain 4 0.257 0.14 0.68 2.32e-01
SUN2 Sad1 and UNC84 domain containing 2 0.251 0.18 0.89 4.15e-02
TEX33 testis expressed 33 0.242
ARVCF ARVCF delta catenin family member 0.233 0.26 1.37 1.44e-03
FOXRED2 FAD dependent oxidoreductase domain containing 2 0.233

Dependency GO Term Enrichment

Gene set enrichment analysis was done on the genes correlated with JOSD1using the terms from Gene Ontology and gene sets derived from the Gene Ontology Annotations database via MSigDB.

Using the biological processes and other Gene Ontology terms from well characterized DUBs as a positive control, several gene set enrichment analyses were considered. Threshold-less methods like GSEA had relatively poor results. Over-representation analysis with a threshold of of the top 7 highest absolute value Dependency Map correlations yielded the best results and is reported below.

GO Identifier GO Name GO Type p-value p-value (adj.) q-value

Literature Mining

INDRA was used to automatically assemble known mechanisms related to JOSD1 from literature and knowledge bases. The first section shows only DUB activity and the second shows all other results.

Deubiquitinase Activity

psp cbn pc bel_lc signor biogrid lincs_drug tas hprd trrust ctd vhn pe drugbank omnipath conib crog dgi | rlimsp isi tees geneways eidos trips medscan sparser reach
JOSD1 deubiquitinates SOCS1. 1 / 1
|

ubibrowser
JOSD1 Negatively Regulates Type-I Interferon Antiviral Activity by Deubiquitinating and Stabilizing SOCS1

Other Statements

psp cbn pc bel_lc signor biogrid lincs_drug tas hprd trrust ctd vhn pe drugbank omnipath conib crog dgi | rlimsp isi tees geneways eidos trips medscan sparser reach
5 |

ctd
No evidence text available

ctd
No evidence text available

ctd
No evidence text available

ctd
No evidence text available

ctd
No evidence text available
CREB1 affects JOSD1
4 |
CREB1 decreases the amount of JOSD1. 4 / 4
4 |

biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available
3 |
Cyclosporin A increases the amount of JOSD1. 3 / 3
3 |

ctd
No evidence text available

ctd
No evidence text available

ctd
No evidence text available
Bisphenol A affects JOSD1
2 |
Bisphenol A increases the amount of JOSD1. 2 / 2
2 |

ctd
No evidence text available

ctd
No evidence text available
SREBF1 affects JOSD1
2 |
SREBF1 decreases the amount of JOSD1. 2 / 2
2 |

biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available
PITX2 affects JOSD1
2 |
PITX2 decreases the amount of JOSD1. 2 / 2
2 |

biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available
NHLH1 affects JOSD1
2 |
NHLH1 decreases the amount of JOSD1. 2 / 2
2 |

biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available
LEF1 affects JOSD1
2 |
LEF1 decreases the amount of JOSD1. 2 / 2
2 |

biopax:msigdb
No evidence text available

biopax:msigdb
No evidence text available
| 1
| 1

reach
Indeed, time-lapse imaging revealed that JosD1 enhances membrane dynamics and cell motility.
Zinc atom affects JOSD1
1 |
Zinc atom increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
1 |
Valproic acid increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available

ctd
No evidence text available
1 |
Tetrachloroethene increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Sunitinib affects JOSD1
1 |
Sunitinib increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Sulindac affects JOSD1
1 |
Sulindac decreases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available

eidos
We found that NF-kappaB activation through each of these agents elicited a significant increase in APOBEC3B gene expression with less robust activation of APOBEC3C and no effect on JOSD1 .
1 |
Pirinixic acid increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Paracetamol affects JOSD1
1 |
Paracetamol increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Pantogab affects JOSD1
1 |
Pantogab increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Nickel atom affects JOSD1
1 |
Nickel atom increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Nefazodone affects JOSD1
1 |
Nefazodone increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Methyltestosterone decreases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Methyl methanesulfonate increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Leflunomide affects JOSD1
1 |
Leflunomide increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Jinfukang affects JOSD1
1 |
Jinfukang increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Indometacin affects JOSD1
1 |
Indometacin increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
1 |
Hsa-miR-92b-3p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-92a-3p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-7847-3p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-769-5p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-6864-3p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-6849-3p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-6771-5p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-6746-5p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-6500-3p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
Hsa-miR-650 affects JOSD1
1 |
Hsa-miR-650 decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-4802-3p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-4796-3p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-4786-5p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-4524b-3p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-4443 decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-4293 decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-3978 decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-3688-3p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-3672 decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-3614-5p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-3612 decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-32-5p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-30e-5p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-30d-5p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-30c-5p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-30b-5p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-30a-5p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-26b-5p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-2392 decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-186-5p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-1827 decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-1324 decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
Hsa-miR-107 affects JOSD1
1 |
Hsa-miR-107 decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
1 |
Hsa-miR-103a-3p decreases the amount of JOSD1. 1 / 1
1 |

biopax:mirtarbase
No evidence text available
Flutamide affects JOSD1
1 |
Flutamide increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Finasteride affects JOSD1
1 |
Finasteride increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Diuron affects JOSD1
1 |
Diuron increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
1 |
Dibutyl phthalate increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Cisplatin affects JOSD1
1 |
Cisplatin increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Beta-naphthoflavone increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Benzene affects JOSD1
1 |
Benzene increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Abrine affects JOSD1
1 |
Abrine increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
1 |
Zoledronic Acid increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
TCF3 affects JOSD1
1 |
TCF3 decreases the amount of JOSD1. 1 / 1
1 |

biopax:msigdb
No evidence text available
Sesame Oil affects JOSD1
1 |
Sesame Oil increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
SP1 affects JOSD1
1 |
SP1 decreases the amount of JOSD1. 1 / 1
1 |

biopax:msigdb
No evidence text available
POU6F1 affects JOSD1
1 |
POU6F1 decreases the amount of JOSD1. 1 / 1
1 |

biopax:msigdb
No evidence text available
PCI 5002 affects JOSD1
1 |
PCI 5002 increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
PAX2 affects JOSD1
1 |
PAX2 decreases the amount of JOSD1. 1 / 1
1 |

biopax:msigdb
No evidence text available
NFE2L2 affects JOSD1
1 |
NFE2L2 decreases the amount of JOSD1. 1 / 1
1 |

biopax:msigdb
No evidence text available
MYC affects JOSD1
1 |
MYC decreases the amount of JOSD1. 1 / 1
1 |

biopax:msigdb
No evidence text available
MAFG affects JOSD1
1 |
MAFG decreases the amount of JOSD1. 1 / 1
1 |

biopax:msigdb
No evidence text available
LMO2 affects JOSD1
1 |
LMO2 decreases the amount of JOSD1. 1 / 1
1 |

biopax:msigdb
No evidence text available
K 7174 affects JOSD1
1 |
K 7174 increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available

reach
JOSD1 has been identified to negatively regulate IFN-I-induced signaling and the antiviral response by deubiquitinating the K48-linked polyubiquitination of SOCS1, which is an essential negative regulator of many cytokine signaling pathways (120).

reach
JOSD1 promotes proliferation and chemoresistance of head and neck squamous cell carcinoma under the epigenetic regulation of BRD4.
| 1

reach
JOSD1 depletion led to severe apoptosis in gynaecological cancer cells both in vivo and in vitro.
JOSD1 affects MCL1
| 1
JOSD1 activates MCL1. 1 / 1
| 1

reach
JOSD1 overexpression caused chemoresistance in gynaecological cancer by upregulating the MCL1 protein.
ICG 001 affects JOSD1
1 |
ICG 001 increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Grape Seed Proanthocyanidins decreases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
GFI1 affects JOSD1
1 |
GFI1 decreases the amount of JOSD1. 1 / 1
1 |

biopax:msigdb
No evidence text available
E4F1 affects JOSD1
1 |
E4F1 decreases the amount of JOSD1. 1 / 1
1 |

biopax:msigdb
No evidence text available
1 |
D-glucopyranose increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
Air Pollutants, Occupational increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
ATF6 affects JOSD1
1 |
ATF6 decreases the amount of JOSD1. 1 / 1
1 |

biopax:msigdb
No evidence text available
ATF4 affects JOSD1
1 |
ATF4 decreases the amount of JOSD1. 1 / 1
1 |

biopax:msigdb
No evidence text available
ATF2 affects JOSD1
1 |
ATF2 decreases the amount of JOSD1. 1 / 1
1 |

biopax:msigdb
No evidence text available
ARNT affects JOSD1
1 |
ARNT decreases the amount of JOSD1. 1 / 1
1 |

biopax:msigdb
No evidence text available
1 |
2-butoxyethanol increases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
17alpha-ethynylestradiol decreases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
1 |
(+)-catechin decreases the amount of JOSD1. 1 / 1
1 |

ctd
No evidence text available
1 |

ctd
No evidence text available